1. Arrêt de production du chrome-51 (51Cr) a usage clinique : quelles alternatives possibles pour les services de radiopharmacie et de médecine nucléaire ?
- Author
-
Decazes, Pierre, Thureau, Sébastien, Modzelewski, Romain, Damilleville-Martin, Mathilde, Vera, Pierre, Dinet, Juliette, Le Cloirec, Joseph, Becker, Stéphanie, Salles, Alice, Bohn, Pierre, Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Université Le Havre Normandie (ULH), Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Université Le Havre Normandie (ULH), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA), Service de médecine nucléaire [Rouen], CRLCC Haute Normandie-Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen (CLCC Henri Becquerel), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), and Normandie Université (NU)
- Subjects
Adult ,Male ,Positron emission tomography ,MESH: Blood Volume ,Monitoring ,Therapeutic response ,[SDV]Life Sciences [q-bio] ,volume sanguin ,Suivi ,MESH: Chromium Radioisotopes ,Kidney Function Tests ,Radiopharmacy ,Humans ,Radiopharmacie ,Prospective Studies ,Radiothérapie ,MESH: Treatment Outcome ,Réponse thérapeutique ,glomerular filtration rate ,MESH: Humans ,MESH: Middle Aged ,Radiotherapy ,MESH: Technetium Tc 99m Pentetate ,Reproducibility of Results ,débit de filtration glomérulaire ,MESH: Rectal Neoplasms ,MESH: Adult ,Middle Aged ,Chromium Radioisotopes ,MESH: Male ,MESH: Prospective Studies ,Tomographie par émission de positons ,MESH: Reproducibility of Results ,MESH: Uterine Cervical Neoplasms ,MESH: Glomerular Filtration Rate ,blood volume ,Chrome-51 ,MESH: Kidney Function Tests ,MESH: Nuclear Medicine ,Technetium Tc 99m Pentetate ,Nuclear Medicine ,Radiopharmaceuticals ,MESH: Radiopharmaceuticals - Abstract
Last October, the nuclear medicine departments were informed of the closure of the chromium-51 production line for clinical use. This radionuclide has different diagnostic indications in nephrology and hematology. It was therefore essential to set up alternative exploration protocols to overcome this production stoppage.Chromium-51 EDTA has been replaced by technetium-99m DTPA for the determination of glomerular filtration rates. Sodium chromate was substituted by sodium pertechnetate for the determination of globular volumes. A retrospective analysis of the chromium-51 data was performed followed by a prospective study, from January to December 2019 for technetium tracers.One hundred and forty-four patients were included in the study. Forty-two EDTA-The study carried out shows that there is no significant difference between the results obtained with chromium-51 and technetium tracers. As a result, clinical activity was maintained in good conditions.
- Published
- 2020