17 results on '"M. Minuti"'
Search Results
2. CMOS MAPS upgrade for the Belle II Vertex Detector
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M. Babeluk, M. Barbero, J. Baudot, T. Bergauer, F. Bernlochner, S. Bettarini, F. Bosi, Y. Buch, G. Casarosa, J. Dingfelder, T. Fillinger, C. Finck, A. Frey, C. Hu, C. Irmler, C. Marinas, M. Massa, L. Massaccesi, M. Minuti, H. Pham, G. Rizzo, C. Schwanda, B. Schwenker, M. Schwickardi, C. Wessel, Austrian Academy of Sciences (OeAW), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Universität Bonn = University of Bonn, University of Pisa - Università di Pisa, University of Goettingen, Universitat de València (UV), Belle II VTX, and European Project: 101004761,AIDAinnova
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safety ,Nuclear and High Energy Physics ,geometry ,vertex detector ,BELLE ,length ,Upgrade ,KEK-B ,pixel ,VTX ,structure ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,Instrumentation ,DMAPS ,detector ,background ,carbon ,Belle II ,CMOS ,tracks ,matter ,radiation ,fibre ,technology ,PXD ,semiconductor detector ,SVD ,VXD ,performance - Abstract
International audience; The success of the Belle II experiment in Japan relies on the very high instantaneous luminosity, close to 6 × 1035cm−2s−1, expectedfrom the SuperKEKB collider. The corresponding beam conditions at such luminosity levels generate large rates of backgroundparticles and creates stringent constraints on the vertex detector, adding to the physics requirements. Current prospects for theoccupancy rates in the present vertex detector (VXD) at full luminosity fall close to the acceptable limits and bear large uncertainties.In this context, the Belle II collaboration is considering the possibility to install an upgraded VXD system around 2027 to providea sufficient safety margin with respect to the expected background rate and possibly enhance tracking and vertexing performance.The VTX collaboration has started the design of a fully pixelated VXD, called VTX, based on fast and highly granular DepletedMonolithic Active Pixel Sensors (DMAPS) integrated on light support structures.The two main technical features of the VTX proposal are the usage of a single sensor type over all the layers of the system and theoverall material budget below 2 % of radiation length, compared to the current VXD which has two different sensor technologiesand about 3 % of radiation length. A dedicated sensor (OBELIX), taylored to the specific needs of Belle II, is under development,evolving from the existing TJ-Monopix2 sensor. The time-stamping precision below 100 ns will allow all VTX layers to take part inthe track finding strategy contrary to the current situation. The first two detection layers are designed according to a self-supportedall-silicon ladder concept, where 4 contiguous sensors are diced out of a wafer, thinned and interconnected with post-processedredistribution layers. The outermost detection layers follow a more conventional approach with a cold plate and carbon fibresupport structure, and light flex cables interconnecting the sensors.This document will review the context, technical details and development status of the proposed Belle II VTX.
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- 2022
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3. XPOL-III: A new-generation VLSI CMOS ASIC for high-throughput X-ray polarimetry
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M. Minuti, L. Baldini, R. Bellazzini, A. Brez, M. Ceccanti, F. Krummenacher, L. Latronico, L. Lucchesi, A. Manfreda, L. Orsini, M. Pinchera, A. Profeti, C. Sgrò, and G. Spandre
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Nuclear and High Energy Physics ,X-ray polarimetry ,FOS: Physical sciences ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,Instrumentation - Abstract
While the successful launch and operation in space of the Gas Pixel Detectors onboard the PolarLight cubesat and the Imaging X-ray Polarimetry Explorer demonstrate the viability and the technical soundness of this class of detectors for astronomical X-ray polarimetry, it is clear that the current state of the art is not ready to meet the challenges of the next generation of experiments, such as the enhanced X-ray Timing and Polarimetry mission, designed to allow for a significantly larger data throughput. In this paper we describe the design and test of a new custom, self-triggering readout ASIC, dubbed XPOL-III, specifically conceived to address and overcome these limitations. While building upon the overall architecture of the previous generations, the new chip improves over its predecessors in several, different key areas: the sensitivity of the trigger electronics, the flexibility in the definition of the readout window, as well as the maximum speed for the serial event readout. These design improvements, when combined, allow for almost an order of magnitude smaller dead time per event with no measurable degradation of the polarimetric, spectral, imaging or timing capability of the detector, providing a good match for the next generation of X-ray missions., accepted for publication at Nuclear Inst. and Methods in Physics Research Section A
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- 2022
4. Simulation of an all-layer monolithic pixel vertex detector for the Belle II upgrade
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G. Batignani, F.U. Bernlochner, S. Bettarini, F. Bosi, G. Casarosa, J. Dingfelder, F. Forti, A. Frey, C. Marinas, M. Massa, L. Massaccesi, M. Minuti, S. Mondal, E. Paoloni, G. Rizzo, B. Schwenker, and C. Wessel
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Nuclear and High Energy Physics ,Instrumentation - Published
- 2023
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5. Design and Development of the Back-End Electronics for the IXPE Mission
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Hikmat Nasimi, C. Sgro, A. Manfreda, Saverio Citraro, M. Minuti, M. Barbanera, and C. Magazzu
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Data acquisition ,business.industry ,Computer science ,Payload ,Interface (computing) ,Detector ,Personal computer ,Electronics ,business ,Computer hardware ,VMEbus ,Data transmission - Abstract
The Imaging X-Ray Polarimetry Explorer IXPE mission will perform polarization measures of 2–8 keV X-rays. Imaging, spectroscopy, and timing will complement this measurement for a comprehensive study of soft X-rays. The launch of the IXPE NASA small explorer mission to a low earth orbit is due late 2021. We designed a subsystem of the scientific payload, which has three identical telescopes based on the detector unit. The Gas Pixel Detector and its back-end electronics are the core of these units, performing data acquisition and processing, event sequencing, and on-line data compression. The back-end electronics processes the auto-triggered output of the detector of 300 photons per second with 30% of dead-time. A radiation-tolerant FPGA implements the electronics custom algorithms, including two digital serial interfaces with a central on-board computer. One interface is used for command and control of the unit, while the other for scientific data transmission. We also designed comprehensive test equipment to emulate the on-board computer and to operate the electronics. This equipment uses an FPGA on a VMEbus board as the electrical interface for the electronics, transferring data to a personal computer with dedicated software infrastructure. In this paper, we shall discuss the design process of the back-end electronics and the results of laboratory tests and measurements with X-ray sources.
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- 2020
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6. Ammonia-powered ships: Concept design and feasibility assessment of powertrain systems for a sustainable approach in maritime industry
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S. Di Micco, V. Cigolotti, L. Mastropasqua, J. Brouwer, and M. Minutillo
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Hydrogen carriers ,Ammonia ,Zero-emission vessels ,Maritime industry ,Shipping decarbonization ,Engineering (General). Civil engineering (General) ,TA1-2040 - Abstract
The decarbonization of the shipping industry is pushing towards the introduction of low-carbon fuels such as hydrogen carriers and towards the installation of cleaner propulsion systems. Among different hydrogen carriers, ammonia (NH3) is considered a promising option due to its high volumetric energy density and to its easier storage and transportation in comparison with pure hydrogen. Therefore, this study is focused on the design, modeling, and feasibility assessment of ammonia-based propulsion systems for shipping applications. Two NH3-based fuel cell power generation systems are analyzed: i) a NH3-based Proton exchange membrane Fuel Cell (PEMFC) system and ii) a NH3-based Solid Oxide Fuel Cell (SOFC) system. These systems are designed to replace a conventional diesel powertrain installed on board a container ship. The fuel consumption, according to the ship load profile, is calculated and the analysis on the masses and volumes of the fuel storage tanks and of the ammonia powertrain systems is performed. Results highlight that on board installation of the proposed ammonia-based propulsion technologies causes greater masses and volumes with respect to the conventional diesel system. This criticality, in the face of an advantage in terms of avoided CO2 emissions per cruise, could be overcome by accepting a cargo capacity reduction. It is estimated a cargo reduction in the range 3.3% − 4.8% for the proposed fuel cell-based powertrain solutions. However, by valorizing the avoided CO2 emissions, it is possible to recover the economic penalty due the cargo reduction and break-even with the reference diesel scenario.
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- 2024
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7. Design implementation and test results of the RD53A, a 65 nm large scale chip for next generation pixel detectors at the HL-LHC
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M. Garcia-Sciveres, R. Gaglione, P. Breugnon, Fabian Hügging, R. Beccherle, Fabio Morsani, Steven Bell, Stefano Bonaldo, D. Dzahini, Duccio Abbaneo, Luca Pacher, O. Le Dortz, Ta-Wei Wang, Mohsine Menouni, Guido Magazzu, M. Vogt, Francesco Crescioli, T. Benka, G. Neue, M. Da Rocha Rolo, E. Conti, F. Loddo, L. M. Jara Casas, Sally Seidel, Alexandre Rozanov, V. Gromov, G. Marzocca, Norbert Wermes, Fabrizio Palla, Tom Zimmerman, Valentino Liberali, M. Standke, Angelo Rivetti, Pisana Placidi, Mauro Menichelli, V. Kafka, F. De Canio, A. Paterno, Simone Gerardin, Z. Janoska, A. Krieger, V. Wallangen, Gianluca Traversi, Ennio Monteil, Y. Dieter, Alessandro Paccagnella, Alberto Stabile, Dario Gnani, B. Van Eijk, Serena Mattiazzo, Farah Fahim, Marco Bomben, D. Vogrig, Marta Bagatin, B. Nachman, Marlon Barbero, C. Renteira, S. Godiot, E. M. S. Jimenez, G. Marchiori, T. Liu, P. Pangaud, Luca Frontini, D. Gajanana, F. E. Rarbi, Scott Thomas, M. Karagounis, Hans Krüger, P. Rymaszewski, K. Papadopoulou, Tomasz Hemperek, Richard B. Lipton, Nicola Bacchetta, M.L. Prydderch, A. Andreazza, S. Poulios, Cristoforo Marzocca, R. Kluit, Konstantin Androsov, David-leon Pohl, Valerio Re, K. Moustakas, Sandeep Miryala, A. Vitkovskiy, Timon Heim, G. Calderini, F. Licciulli, Jesper Roy Christiansen, R. Carney, G. M. Bilei, M. Minuti, D. Fougeron, Lodovico Ratti, G. Deptuch, F. R. Palomo, G. De Robertis, G. Dellacasa, Luigi Gaioni, M. Daas, Martin Hoeferkamp, E. Lopez-Morillo, Massimo Manghisoni, G. Mazza, A. Stiller, S. Orfanelli, S. Marconi, Ivan Vila, M. Marcisovsky, C. Vacchi, E. Riceputi, Vaclav Vrba, Natale Demaria, L. Tomasek, D. C. Christian, J. Hoff, Fernando Muñoz, Dario Bisello, Miroslav Havranek, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire d'Annecy de Physique des Particules (LAPP), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS)
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Computer science ,readout electronics ,sensors ,radiation hardness ,Settore ING-INF/01 - Elettronica ,01 natural sciences ,Signal ,CMOS image sensors ,nuclear electronics ,particle tracking ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Microelectronics ,0302 clinical medicine ,Design objective ,mixed analogue-digital integrated circuits ,0103 physical sciences ,[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det] ,[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics ,Large Hadron Collider ,Pixel ,010308 nuclear & particles physics ,business.industry ,Settore FIS/01 - Fisica Sperimentale ,Detector ,Mixed-signal integrated circuit ,Chip ,position sensitive particle detectors ,CMOS ,silicon radiation detectors ,business ,Computer hardware - Abstract
International audience; The RD53A large scale pixel demonstrator chip has been developed in 65 nm CMOS technology by the RD53 collaboration, in order to face the unprecedented design requirements of the pixel 2 phase upgrades of the CMS and ATLAS experiments at CERN. This prototype chip is designed to demonstrate that a set of challenging specifications can be met, such as: high granularity (small pixels of 50×50 or 25× 100 µm2) and large pixel chip size (~2x2 cm2), high hit rate (3 GHz/cm2), high readout speed, very high radiation levels (500 Mrad - 1 Grad) and operation with serial powering. Furthermore, coping with the long latency of the trigger signal (~12.5 µs), used to select only events of interest in order to achieve sustainable output data rates, requires increased buffering resources in the limited pixel area. The RD53A chip has been fabricated in an engineer run. It integrates a matrix of 400×192 pixels and features various design variations in the analog and digital pixel matrix for testing purposes. This paper presents an overview of the chip architecture and of the methodologies used for efficient design of large complex mixed signal chips for harsh radiation environments. Experimental results obtained from the characterization of the RD53A chip are reported to demonstrate that design objectives have been achieved. Moreover, design improvements and new features being developed in the RD53B framework for final ATLAS and CMS production chips are discussed
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- 2018
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8. A Silicon-Based Cosmic Ray Telescope as an External Tracker to Measure Detector Performance
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G. Signorelli, J. J. Walsh, Fabio Morsani, Donato Nicolo, E. Baracchini, F. Tenchini, M. Venturini, S. Bettarini, S. Dussoni, E. Cavallaro, M. Minuti, Filippo Bosi, and Luca Galli
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Physics ,Nuclear and High Energy Physics ,business.industry ,Detector ,Electrical engineering ,BaBar experiment ,Tracking (particle physics) ,Instrumentation and measurement ionizing radiation sensors nuclear measurement particle tracking sensors radiation detectors semiconductor radiation detectors ,law.invention ,Semiconductor detector ,Telescope ,Optics ,Data acquisition ,Nuclear Energy and Engineering ,law ,Gate array ,Personal computer ,Electrical and Electronic Engineering ,business - Abstract
High-energy physics experiments at the high-intensity frontier place ever-greater demands on detectors, and in particular on tracking devices. In order to compare the performance of many possible small-size tracking prototypes, a high-resolution cosmic ray tracker may be used as an external track reference. We have constructed a telescope by assembling four spare ladders of the external layers of the Silicon Vertex Tracker of the BaBar experiment. This test facility, operating at INFN Sezione di Pisa, provides the detector under test with an external track with an intrinsic resolution of 15–30 $~\mu\hbox{m}$ . The DAQ originally used in the BaBar experiment was replaced by custom-designed boards coupled with an acquisition front-end personal computer through commercial field-programmable gate array evaluation boards. We show that the facility is operative, and we present the performance in terms of tracking resolution and efficiency. A first device has been characterized, and some plots from the analysis demonstrating the telescope performance are shown.
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- 2015
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9. Single-Shot X-Ray Phase-Contrast Computed Tomography with Nonmicrofocal Laboratory Sources
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Paul C. Diemoz, Luca Urbani, Charlotte K. Hagen, Alessandro Olivo, M. Minuti, R. Bellazzini, P De Coppi, and Marco Endrizzi
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Physics ,business.industry ,Detector ,X-ray ,General Physics and Astronomy ,Field of view ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Imaging phantom ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Optics ,Feature (computer vision) ,Attenuation coefficient ,0210 nano-technology ,business ,Constant (mathematics) ,Refractive index - Abstract
We present a method that enables performing x-ray phase-contrast imaging (XPCI) computed tomography with a laboratory setup using a single image per projection angle, eliminating the need to move optical elements during acquisition. Theoretical derivation of the method is presented, and its validity conditions are provided. The object is assumed to be quasihomogeneous, i.e., to feature a ratio between the refractive index and the linear attenuation coefficient that is approximately constant across the field of view. The method is experimentally demonstrated on a plastics phantom and on biological samples using a continuous rotation acquisition scheme achieving scan times of a few minutes. Moreover, we show that such acquisition times can be further reduced with the use of a high-efficiency photon-counting detector. Thanks to its ability to substantially simplify the image-acquisition procedure and greatly reduce collection times, we believe this method represents a very important step towards the application of XPCI to real-world problems.
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- 2017
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10. Towards breast tomography with synchrotron radiation at Elettra: first images
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Bruno Golosio, Ubaldo Bottigli, Paolo Russo, R. Bellazzini, G. Spandre, Nico Lanconelli, Pasquale Delogu, Fabrizio Zanconati, Viviana Fanti, A. Brez, Francesco Brun, Christian Fedon, Diego Dreossi, Renata Longo, Fulvia Arfelli, Giuliana Tromba, Piernicola Oliva, M. Pinchera, M. Minuti, Antonio Sarno, Antonio Brunetti, Luigi Rigon, Giovanni Mettivier, F. Di Lillo, Longo, R, Arfelli, F, Bellazzini, R, Bottigli, U, Brez, A, Brunetti, A, Delogu, P, Di Lillo, F, Dreossi, D, Fanti, V, Fedon, C, Golosio, B, Lanconelli, N, Mettivier, G, Minuti, M, Oliva, P, Pinchera, M, Rigon, L, Russo, P, Sarno, A, Spandre, G, Tromba, G, Zanconati, F, Longo, R., Arfelli, F., Bellazzini, R., Bottigli, U., Brez, A., Brun, F., Brunetti, A., Delogu, P., DI LILLO, Francesca, Dreossi, D., Fanti, V., Fedon, C., Golosio, B., Lanconelli, N., Mettivier, Giovanni, Minuti, M., Oliva, P., Pinchera, M., Rigon, L., Russo, Paolo, Sarno, Antonio, Spandre, G., Tromba, G., Zanconati, F., Longo, Renata, Arfelli, Fulvia, Brun, Francesco, Dreossi, Diego, Fedon, Christian, Rigon, Luigi, Tromba, Giuliana, and Zanconati, Fabrizio
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Radiology, Nuclear Medicine and Imaging ,Image quality ,breast tomography ,Synchrotron radiation ,Breast Neoplasms ,phase contrast imaging ,synchrotron radiation ,030218 nuclear medicine & medical imaging ,Synchrotron ,03 medical and health sciences ,0302 clinical medicine ,Optics ,Humans ,Image resolution ,Physics ,Radon transform ,Radiological and Ultrasound Technology ,business.industry ,Medicine (all) ,Detector ,Phase-contrast imaging ,Algorithm ,Simultaneous Algebraic Reconstruction Technique ,030220 oncology & carcinogenesis ,Tomography ,business ,Nuclear medicine ,Tomography, X-Ray Computed ,Breast Neoplasm ,Algorithms ,Synchrotrons ,Human - Abstract
The aim of the SYRMA-CT collaboration is to set-up the first clinical trial of phase-contrast breast CT with synchrotron radiation (SR). In order to combine high image quality and low delivered dose a number of innovative elements are merged: a CdTe single photon counting detector, state-of-theart CT reconstruction and phase retrieval algorithms. To facilitate an accurate exam optimization, a Monte Carlo model was developed for dose calculation using GEANT4. In this study, high isotropic spatial resolution (120 mu m)(3) CT scans of objects with dimensions and attenuation similar to a human breast were acquired, delivering mean glandular doses in the range of those delivered in clinical breast CT (5-25 mGy). Due to the spatial coherence of the SR beam and the long distance between sample and detector, the images contain, not only absorption, but also phase information from the samples. The application of a phase-retrieval procedure increases the contrast-to-noise ratio of the tomographic images, while the contrast remains almost constant. After applying the simultaneous algebraic reconstruction technique to low-dose phase-retrieved data sets (about 5 mGy) with a reduced number of projections, the spatial resolution was found to be equal to filtered back projection utilizing a four fold higher dose, while the contrast-to-noise ratio was reduced by 30%. These first results indicate the feasibility of clinical breast CT with SR.
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- 2016
11. Recent progress of RD53 Collaboration towards next generation Pixel Read-Out Chip for HL-LHC
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Massimo Manghisoni, Scott Thomas, J. Christiansen, Fabrizio Palla, Dario Gnani, T. Kishishita, L. Tomasek, C. Vacchi, Nicola Bacchetta, F. Munoz, Guido Magazzu, Vaclav Vrba, Nigel Hessey, T. Liu, D. Fougeron, P. Pangaud, Gianluca Traversi, Lodovico Ratti, D. Gajanana, F. E. Rarbi, R. Beccherle, F. Licciulli, Miguel Aguirre, Alexander Grillo, Alessandro Paccagnella, M. Garcia-Sciveres, Marco Bomben, F. R. Palomo, V. Zivkovic, L. Pacher, A. Wang, F. Gensolen, E. Conti, Daniele Passeri, G. Marchiori, P. Rymaszewski, Konstantin Toms, P. Valerio, Steven Bell, M.L. Prydderch, J. Wyss, L. Linssen, G. M. Bilei, Alberto Stabile, Sally Seidel, A. Rivetti, Seyed Ruhollah Shojaii, Luca Fanucci, Fabio Morsani, M. Minuti, J.N. De Witt, R. Gaglione, N. Demaria, Ivan Vila, B. Nodari, G. De Robertis, Cristoforo Marzocca, Francesco Corsi, V. Gromov, A. Mekkaoui, F. Loddo, Daniele Comotti, R. Bellazzini, F. De Canio, Pisana Placidi, Duccio Abbaneo, M. Da Rocha Rolo, Norbert Wermes, Hans Krueger, E. Monteil, S. Godiot, Valentino Liberali, V. Kafka, Luigi Gaioni, M. Marcisovsky, Tomasz Hemperek, Mauro Menichelli, D. Dzahini, Andrea Neviani, Richard B. Lipton, G. Calderini, G. Mazza, M. Karagounis, Martin Hoeferkamp, Laura Gonella, D. Vogrig, Marta Bagatin, A. Rizzi, F. Ciciriello, Farah Fahim, N. Alipour Tehrani, R. Kluit, Valerio Re, I. V. Gorelov, O. Le Dortz, Daniel Dobos, L. Ding, Konstantin Androsov, A. Paterno, J. Hoff, S. Marconi, A. Andreazza, S. Poulios, Sergio Saponara, G. Neue, Dario Bisello, Mohsine Menouni, Miroslav Havranek, Fabian Huegging, Serena Mattiazzo, Piero Giubilato, Francesco Crescioli, G. Della Casa, D. C. Christian, Petr Sicho, Marlon Barbero, Tom Zimmerman, Simone Gerardin, Alexandre Rozanov, Heinz Pernegger, Z. Janoska, Dominik Dannheim, E. Lopez-Morillo, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE), Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Pierre et Marie Curie - Paris 6 (UPMC), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), RD53 Collaboration, and Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)
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Computer science ,VLSI circuits ,01 natural sciences ,Settore ING-INF/01 - Elettronica ,Front and back ends ,Analog front-end ,Front-end electronics for detector readout ,0103 physical sciences ,[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex] ,Particle tracking detectors (Solid-state detectors) ,Radiation-hard electronics ,Instrumentation ,Mathematical Physics ,[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics ,Detectors and Experimental Techniques ,010306 general physics ,Digital electronics ,Very-large-scale integration ,Large Hadron Collider ,Pixel ,010308 nuclear & particles physics ,business.industry ,Electrical engineering ,Chip ,CMOS ,business - Abstract
International audience; This paper is a review of recent progress of RD53 Collaboration. Results obtained onthe study of the radiation effects on 65 nm CMOS have matured enough to define first strategies toadopt in the design of analog and digital circuits. Critical building blocks and analog very frontend chains have been designed, tested before and after 5–800 Mrad. Small prototypes of 64 64pixels with complex digital architectures have been produced, and point to address the main issuesof dealing with extremely high pixel rates, while operating at very small in-time thresholds in theanalog front end. The collaboration is now proceeding at full speed towards the design of a largescale prototype, called RD53A, in 65 nm CMOS technology
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- 2016
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12. On the Effect of Different Configurations in Air-Cathode MFCs Fed by Composite Food Waste for Energy Harvesting
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D. Frattini, G. Falcucci, M. Minutillo, C. Ferone, R. Cioffi, and E. Jannelli
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Chemical engineering ,TP155-156 ,Computer engineering. Computer hardware ,TK7885-7895 - Abstract
In this work, experimental results on the behavior of single chamber air-cathode microbial fuel cells, fed by composite food waste, are illustrated. Specific interest has been focused on the presence/absence of a Nafion membrane, the influence of horizontal/vertical cell layout and on the amount of water inside the cells, in order to evaluate the performances in different configurations. A remarkable increment of performances is observed when a Nafion membrane is used or when the composite food waste has a low Solid-to-Liquid ratio. Resultsshowed that values of about 380-550 mV, for the open circuit voltage, and power density of 16-27 mW/m2 areachieved when Nafion/Vertical or Nafion/Conditioned/Horizontal configurations are used. The most limiting factors to power generation can be attributed to the high water losses, when Nafion is absent, and to the high internal resistance, when a thick cathode is used instead of a thin carbon cloth.
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- 2016
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13. Towards breast tomography with synchrotron radiation at Elettra: first images.
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R Longo, F Arfelli, R Bellazzini, U Bottigli, A Brez, F Brun, A Brunetti, P Delogu, F Di Lillo, D Dreossi, V Fanti, C Fedon, B Golosio, N Lanconelli, G Mettivier, M Minuti, P Oliva, M Pinchera, L Rigon, and P Russo
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TOMOSYNTHESIS ,BREAST surgery ,CLINICAL trials ,BREAST implants ,BREAST - Abstract
The aim of the SYRMA-CT collaboration is to set-up the first clinical trial of phase-contrast breast CT with synchrotron radiation (SR). In order to combine high image quality and low delivered dose a number of innovative elements are merged: a CdTe single photon counting detector, state-of-the-art CT reconstruction and phase retrieval algorithms. To facilitate an accurate exam optimization, a Monte Carlo model was developed for dose calculation using GEANT4. In this study, high isotropic spatial resolution (120 μm)
3 CT scans of objects with dimensions and attenuation similar to a human breast were acquired, delivering mean glandular doses in the range of those delivered in clinical breast CT (5–25 mGy). Due to the spatial coherence of the SR beam and the long distance between sample and detector, the images contain, not only absorption, but also phase information from the samples. The application of a phase-retrieval procedure increases the contrast-to-noise ratio of the tomographic images, while the contrast remains almost constant. After applying the simultaneous algebraic reconstruction technique to low-dose phase-retrieved data sets (about 5 mGy) with a reduced number of projections, the spatial resolution was found to be equal to filtered back projection utilizing a four fold higher dose, while the contrast-to-noise ratio was reduced by 30%. These first results indicate the feasibility of clinical breast CT with SR. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF
14. Selective neck dissection of level IIB in cN0 laryngeal cancer: a systematic review and meta-analysis.
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Mauramati S, Veneroni MV, Errico E, Canzi P, Bertino G, Robiolio E, Gelli R, Pedretti F, Minuti M, Crea R, and Benazzo M
- Abstract
Purpose: The primary endpoint of the study was to quantitatively evaluate the presence of IIB neck level metastases in patients with laryngeal carcinoma, to provide valuable evidence to aid surgeons in the decision-making process for neck dissections. As a secondary aim this study analyzed the presence of factors that may be associated with a higher prevalence of metastasis., Methods: Two independent authors (EE, MVV) searched for articles on PubMed, Cochrane, Embase, and Scopus databases. Review of the articles was carried out following 2020 PRISMA guidelines, all articles were assessed for quality according to NICE guidelines. Afterwards the statistical analysis was performed with STATA 18SE software. Studies were also assessed for heterogeneity and risk of publication bias., Results: A total of 19 studies were included, from which data on 1205 subjects was extracted. Out of 997 patients with a cN0 LC, 21 patients developed metastasis. This meta-analysis found the cumulative rate of metastasis to be 1% (95% CI 0-2%). Also, there is a 51% higher probability (OR: 1.51, 95% CI 0.06, 2.92) of occult IIB metastasis in higher stages (T3/T4) compared to lower stages (T1/T2)., Conclusions: Dissection of level IIB may be safely spared in patients with cN0 laryngeal cancer, possibly leading to improved QoL and shoulder function as well as reducing OR times and costs., (© 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2024
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15. Electrochemotherapy (ECT) in treatment of mucosal head and neck tumors. An international network for sharing practices on ECT (InspECT) study group report.
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Bertino G, Minuti M, Groselj A, Jamsek C, Silvestri B, Carpene S, Matteucci P, Riva G, Pecorari G, Mascherini M, Kjær Lønkvist C, Muir T, Kunte C, de Terlizzi F, and Sersa G
- Subjects
- Humans, Male, Female, Middle Aged, Aged, Adult, Laryngeal Neoplasms therapy, Laryngeal Neoplasms drug therapy, Laryngeal Neoplasms pathology, Treatment Outcome, Aged, 80 and over, Pharyngeal Neoplasms therapy, Pharyngeal Neoplasms drug therapy, Pharyngeal Neoplasms pathology, Mouth Neoplasms drug therapy, Mouth Neoplasms therapy, Mouth Neoplasms pathology, Neoplasm Recurrence, Local, Europe, Carcinoma, Squamous Cell therapy, Carcinoma, Squamous Cell drug therapy, Carcinoma, Squamous Cell pathology, Electrochemotherapy methods, Head and Neck Neoplasms therapy, Head and Neck Neoplasms drug therapy, Head and Neck Neoplasms pathology
- Abstract
The aim of this multicenter study was to evaluate the effectiveness and safety of electrochemotherapy (ECT) for the treatment of mucosal tumors in the head and neck. A total of 71 patients with 84 nodules of different histologies in the oral cavity, pharynx and larynx treated by ECT were evaluated. The data were collected from the InspECT database from 10 participating centers throughout Europe. Primary and recurrent/secondary tumors of different histologies were treated. The overall response rate was 65 %, with a 33 % complete response rate with limited side effects. The response rates of the primary and secondary tumors were not different. However, smaller tumors responded better than tumors larger than 3 cm in diameter. Furthermore, the tumors that were treated with curative intent responded significantly better than those treated with palliative intent. This study demonstrated the feasibility, safety and effectiveness of ECT in a larger cohort of patients with mucosal lesions in the head and neck region. Based on the available data, ECT can be used for the treatment of recurrent and, in some cases, primary mucosal tumors located in the oral cavity, larynx, and pharynx. A better response was obtained in patients with smaller primary tumors treated with curative intent., Competing Interests: Declaration of competing interest Francesca de Terlizzi is an IGEA employer. No other authors have conflicts of interest. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2024
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16. A diagnosis you wouldn't expect in a supraclavicular mass.
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Mauramati S, Pedretti F, Herman I, Trisolini G, Luchena A, Gelli R, Robiolio E, Minuti M, Veneroni MV, Bertino G, Feltri M, D'Ambrosio G, Benazzo M, and Morbini P
- Subjects
- Humans, Clavicle pathology, Clavicle diagnostic imaging
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- 2024
- Full Text
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17. Photon-counting hexagonal pixel array CdTe detector: Spatial resolution characteristics for image-guided interventional applications.
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Vedantham S, Shrestha S, Karellas A, Shi L, Gounis MJ, Bellazzini R, Spandre G, Brez A, and Minuti M
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- Alloys, Blood Vessels diagnostic imaging, Fingers diagnostic imaging, Humans, Linear Models, Models, Anatomic, Phantoms, Imaging, Polymethyl Methacrylate, Radiometry methods, Stents, Therapy, Computer-Assisted methods, Wrist diagnostic imaging, X-Rays, Angiography, Digital Subtraction methods, Cadmium Compounds, Photons, Radiometry instrumentation, Tellurium, Therapy, Computer-Assisted instrumentation
- Abstract
Purpose: High-resolution, photon-counting, energy-resolved detector with fast-framing capability can facilitate simultaneous acquisition of precontrast and postcontrast images for subtraction angiography without pixel registration artifacts and can facilitate high-resolution real-time imaging during image-guided interventions. Hence, this study was conducted to determine the spatial resolution characteristics of a hexagonal pixel array photon-counting cadmium telluride (CdTe) detector., Methods: A 650 μm thick CdTe Schottky photon-counting detector capable of concurrently acquiring up to two energy-windowed images was operated in a single energy-window mode to include photons of 10 keV or higher. The detector had hexagonal pixels with apothem of 30 μm resulting in pixel pitch of 60 and 51.96 μm along the two orthogonal directions. The detector was characterized at IEC-RQA5 spectral conditions. Linear response of the detector was determined over the air kerma rate relevant to image-guided interventional procedures ranging from 1.3 nGy/frame to 91.4 μGy/frame. Presampled modulation transfer was determined using a tungsten edge test device. The edge-spread function and the finely sampled line spread function accounted for hexagonal sampling, from which the presampled modulation transfer function (MTF) was determined. Since detectors with hexagonal pixels require resampling to square pixels for distortion-free display, the optimal square pixel size was determined by minimizing the root-mean-squared-error of the aperture functions for the square and hexagonal pixels up to the Nyquist limit., Results: At Nyquist frequencies of 8.33 and 9.62 cycles/mm along the apothem and orthogonal to the apothem directions, the modulation factors were 0.397 and 0.228, respectively. For the corresponding axis, the limiting resolution defined as 10% MTF occurred at 13.3 and 12 cycles/mm, respectively. Evaluation of the aperture functions yielded an optimal square pixel size of 54 μm. After resampling to 54 μm square pixels using trilinear interpolation, the presampled MTF at Nyquist frequency of 9.26 cycles/mm was 0.29 and 0.24 along the orthogonal directions and the limiting resolution (10% MTF) occurred at approximately 12 cycles/mm. Visual analysis of a bar pattern image showed the ability to resolve close to 12 line-pairs/mm and qualitative evaluation of a neurovascular nitinol-stent showed the ability to visualize its struts at clinically relevant conditions., Conclusions: Hexagonal pixel array photon-counting CdTe detector provides high spatial resolution in single-photon counting mode. After resampling to optimal square pixel size for distortion-free display, the spatial resolution is preserved. The dual-energy capabilities of the detector could allow for artifact-free subtraction angiography and basis material decomposition. The proposed high-resolution photon-counting detector with energy-resolving capability can be of importance for several image-guided interventional procedures as well as for pediatric applications.
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- 2016
- Full Text
- View/download PDF
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