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6 results on '"Luiz, Wilson B."'

1. Cover Image, Volume 95, Number 2, February 2023

Author

Farias, Jéssica P., primary, Pinheiro, Josilene R., additional, Andreata‐Santos, Robert, additional, Fogaça, Mayanna M. C., additional, da Silva Brito, Ruth D., additional, da Cruz, Edgar F., additional, de Castro‐Amarante, Maria F., additional, Pereira, Samuel S., additional, dos Santos Almeida, Shirley, additional, Moreira, Ludimila M., additional, da Conceição Simões, Rafael, additional, Luiz, Wilson B., additional, Birbrair, Alexander, additional, Belmok, Aline, additional, Ribeiro, Bergmann M., additional, Maricato, Juliana T., additional, Braconi, Carla T., additional, de Souza Ferreira, Luís C., additional, Janini, Luiz M. R., additional, and Amorim, Jaime Henrique, additional

Published
2023
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2. The third vaccine dose significantly reduces susceptibility to the B.1.1.529 (Omicron) SARS‐CoV‐2 variant

Author

Farias, Jéssica P., primary, Pinheiro, Josilene R., additional, Andreata‐Santos, Robert, additional, Fogaça, Mayanna M. C., additional, da Silva Brito, Ruth D., additional, da Cruz, Edgar F., additional, de Castro‐Amarante, Maria F., additional, Pereira, Samuel S., additional, dos Santos Almeida, Shirley, additional, Moreira, Ludimila M., additional, da Conceição Simões, Rafael, additional, Luiz, Wilson B., additional, Birbrair, Alexander, additional, Belmok, Aline, additional, Ribeiro, Bergmann M., additional, Maricato, Juliana T., additional, Braconi, Carla T., additional, de Souza Ferreira, Luís C., additional, Janini, Luiz M. R., additional, and Amorim, Jaime Henrique, additional

Published
2023
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3. Impact of Early Pandemic SARS-CoV-2 Lineages Replacement with the Variant of Concern P.1 (Gamma) in Western Bahia, Brazil

Author

Pinheiro, Josilene R., primary, dos Reis, Esther C., additional, Farias, Jéssica P., additional, Fogaça, Mayanna M. C., additional, da Silva, Patrícia de S., additional, Santana, Itana Vivian R., additional, Rocha, Ana Luiza S., additional, Vidal, Paloma O., additional, Simões, Rafael da C., additional, Luiz, Wilson B., additional, Birbrair, Alexander, additional, de Aguiar, Renato S., additional, de Souza, Renan P., additional, Azevedo, Vasco A. de C., additional, Chaves, Gepoliano, additional, Belmok, Aline, additional, Durães-Carvalho, Ricardo, additional, Melo, Fernando L., additional, Ribeiro, Bergmann M., additional, and Amorim, Jaime Henrique, additional

Published
2022
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6. Flagellar Cap Protein FliD Mediates Adherence of Atypical Enteropathogenic Escherichia colito Enterocyte Microvilli

Author

Sampaio, Suely C. F., Luiz, Wilson B., Vieira, Mônica A. M., Ferreira, Rita C. C., Garcia, Bruna G., Sinigaglia-Coimbra, Rita, Sampaio, Jorge L. M., Ferreira, Luís C. S., and Gomes, Tânia A. T.

Abstract

ABSTRACTThe expression of flagella correlates with different aspects of bacterial pathogenicity, ranging from adherence to host cells to activation of inflammatory responses by the innate immune system. In the present study, we investigated the role of flagella in the adherence of an atypical enteropathogenic Escherichia coli(aEPEC) strain (serotype O51:H40) to human enterocytes. Accordingly, isogenic mutants deficient in flagellin (FliC), the flagellar structural subunit; the flagellar cap protein (FliD); or the MotAB proteins, involved in the control of flagellar motion, were generated and tested for binding to differentiated Caco-2 cells. Binding of the aEPEC strain to enterocytes was significantly impaired in strains with the fliCand fliDgenes deleted, both of which could not form flagella on the bacterial surface. A nonmotile but flagellated MotAB mutant also showed impaired adhesion to Caco-2 cells. In accordance with these observations, adhesion of aEPEC strain 1711-4 to Caco-2 cells was drastically reduced after the treatment of Caco-2 cells with purified FliD. In addition, incubation of aEPEC bacteria with specific anti-FliD serum impaired binding to Caco-2 cells. Finally, incubation of Caco-2 cells with purified FliD, followed by immunolabeling, showed that the protein was specifically bound to the microvillus tips of differentiated Caco-2 cells. The aEPEC FliD or anti-FliD serum also reduced the adherence of prototype typical enteropathogenic, enterohemorrhagic, and enterotoxigenic E. colistrains to Caco-2 cells. In conclusion, our findings further strengthened the role of flagella in the adherence of aEPEC to human enterocytes and disclosed the relevant structural and functional involvement of FliD in the adhesion process.

Published
2016
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