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22 results on '"Lu, Yanxu"'

8. Silencing immune-infiltrating biomarker CCDC80 inhibits malignant characterization and tumor formation in gastric cancer.

Author

Yu, MeiHong, Peng, Jingxuan, Lu, Yanxu, Li, Sha, and Ding, Ke

Subjects
STOMACH cancer, BIOMARKERS, PROGNOSIS, CANCER prognosis, FACTOR analysis
Abstract

Objective: Tumor immune infiltration leads to poor prognosis of gastric cancer patients and seriously affects the life quality of gastric cancer patients. This study was based on bioinformatics to screen prognostic biomarkers in patients with high degree of immune invasion of gastric cancer. Meanwhile, the action of biomarker CCDC80 was explored in gastric cancer by cell and tumorigenesis experiments, to provide reference for the cure of gastric cancer patients. Methods: Data sets and clinical massage on gastric cancer were collected from TCGA database and GEO database. ConsensusClusterPlus was used to cluster gastric cancer patients based on the 28 immune cells infiltration in ssGSEA. R "Limma" package was applied to analyze differential mRNAs between Cluster 1 and Cluster 2. Differential expression genes were screened by single factor analysis. Stemness markers (SERPINF1, DCN, CCDC80, FBLN5, SPARCL1, CCL14, DPYSL3) were identified for differential expression genes. Prognostic value of CCDC80 was evaluated in gastric cancer. Differences in genomic mutation and tumor microenvironment immune infiltration were assessed between high or low CCDC80. Finally, gastric cancer cells (HGC-27 and MKN-45) were selected to evaluate the action of silencing CCDC80 on malignant characterization, macrophage polarization, and tumor formation. Results: Bioinformatics analysis showed that CCDC80, as a stemness marker, was significantly overexpressed in gastric cancer. CCDC80 was also related to the degree of gastric cancer immune invasion. CCDC80 was up-expressed in cells of gastric cancer. Silencing CCDC80 inhibited malignant characterization and subcutaneous tumor formation of gastric cancer cells. High expression of CCDC80 was positive correspondence with immune invasion. Silencing CCDC80 inhibited M2 polarization and promoted M1 polarization in tumor tissues. In addition, gastric cancer patients were likely to have mutations in CDH1, ACTRT1, GANAB, and CDH10 genes in the High-CCDC80 group. Conclusion: Silencing CCDC80, a prognostic biomarker in patients with immune invasion of gastric cancer, could effectively inhibit the malignant characterization, M2 polarization, and tumor formation of gastric cancer. [ABSTRACT FROM AUTHOR]

Published
2024
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12. A Clean, Rapid, and Controllable Approach for Establishing Bioactive Surfaces on Zirconia Implants.

Author

Chen, Chengxin, Cheng, Qi, Han, Yu, Wang, Ran, Kong, Dejian, Chen, Xiaojing, Zhu, Yuanjing, Lu, Yanxu, and Zhou, Hongbo

Subjects
HYDROXYAPATITE, ZIRCONIUM oxide, FEMTOSECOND lasers, SURFACE preparation, CRYSTAL surfaces, SOLID-state lasers, FLEXURAL strength
Abstract

Zirconia implants have great application prospects due to their favorable biocompatibility and esthetic properties. However, the percentage of osseointegration of zirconia implants is lower than that of titanium implants. This study, structures bioactive surfaces on zirconia using a femtosecond laser combined with hydroxyapatite (HA) crystals and evaluates the surface morphology, functional groups, crystal phase, mechanical performance, and cell response. The results revealed that calcium phosphate deposition coincided with the establishment of micro‐grooves on the zirconia surface. The crystal composition and flexural strength of zirconia showed no significant changes after the surface treatment. Furthermore, the modified surface promoted cell adhesion and proliferation through adjustments in cell morphology. The findings suggest that the combination of femtosecond laser and HA crystals offers a clean, rapid, and controllable approach to preparing bioactive surfaces for zirconia implants. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Efficacy of combination of localized closure, ethacridine lactate dressing, and phototherapy in treatment of severe extravasation injuries: A case series

Author

Wu Ying, Peng-Fei Liang, Ling-Yun Tian, Lu Yanxu, Hui-Ying Mo, and Wu Rongchan

Subjects
medicine.medical_specialty, Closure, business.industry, Closure (topology), macromolecular substances, General Medicine, Phototherapy, Ethacridine lactate, Extravasation, Surgery, Treatment, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Retrospective Study, 030220 oncology & carcinogenesis, medicine, 030211 gastroenterology & hepatology, business, Dressing
Abstract

BACKGROUND The management of severe extravasation injuries is still controversial. Extravasation injuries can be treated in many ways. AIM To present a series of patients with severe extravasation injuries due to infusion who were managed with ethacridine lactate dressing combined with localized closure and phototherapy. METHODS In this study, we evaluated the data of eight patients, including six from the Department of Burn, one (with colorectal carcinoma) from the Veteran Cadre Department, and one (with leukemia) from the Hematology Department. Of these, three patients were male and five were female. Age of the patients ranged from 10 mo to 72 years, including two children (10 and 19 mo of age). In this study, the infusion was stopped immediately when the extravasation was identified. The extravasation event was managed routinely using a blocking solution. A ring-shaped localized closure was performed using the blocking agents. Moreover, ethacridine lactate dressing and phototherapy were applied for 3-5 d. RESULTS In this study, the drugs contained in the infusates were iodixanol, norepinephrine, alprostadil, amino acids, fat emulsion, cefoselis, cefoxitin, and potassium chloride + concentrated sodium chloride. All of the patients achieved complete healing after treatment and no obvious adverse reactions were observed. CONCLUSION The treatment of severe extravasation injuries using a combination of localized closure, ethacridine lactate dressing, and phototherapy resulted in satisfactory outcomes in patients.

Published
2021
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17. Traditional Chinese Medicine Xiaoai Jiedu Recipe Suppresses the Development of Hepatocellular Carcinoma via Regulating the microRNA-29a/Signal Transducer and Activator of Transcription 3 Axis

Author

Shi,Yanfen, Kong,Wuming, Lu,Yanxu, Zheng,Yu, Shi,Yanfen, Kong,Wuming, Lu,Yanxu, and Zheng,Yu

Abstract

Yanfen Shi,1 Wuming Kong,2 Yanxu Lu,1 Yu Zheng3 1Jiaozuo People’s Hospital, Jiaozuo City, Henan Province 454000, People’s Republic of China; 2Department of Gastroenterology, Shanghai University of Medicine & Health Sciences Affiliated Sixth People’s East-Hospital, Shanghai City 201306, People’s Republic of China; 3Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming City, Yunnan, Province 650011, People’s Republic of ChinaCorrespondence: Yu Zheng Department of Spleen and Stomach Disease, No. 25, Dongfeng East Road, Panlong District, Kunming City, Yunnan Province 650011, People’s Republic of ChinaTel +86-0871-63804608Email zsxye81yuyu@126.comObjective: Hepatocellular carcinoma (HCC) is one of the most frequent and lethal tumors affecting human health worldwide. The aim of this study was to investigate the anti-cancer effects of Xiaoai Jiedu Recipe (XJR) on HCC development and its underlying mechanisms.Methods: The expression of microRNA-29a (miR-29a) and signal transducer and activator of transcription 3 (STAT3) in HCC tissues and cells was determined by quantitative real-time polymerase chain reaction. The proliferation, migration, and invasion of HCC cells were measured by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide, wound-healing, and transwell assays, respectively. The regulatory relationship between miR-29a and STAT3 in HCC was predicted by TargetScan and analyzed by luciferase reporter and RNA pull-down assays. The protein expression of matrix metalloproteinase (MMP)-2/9 and STAT3 was detected by Western blotting. A xenograft tumor mouse model was established, and tumor weight and volume were measured.Results: The expression of miR-29a was significantly decreased in HCC tissues and cells compared with that in normal tissues and cells. The up-regulation of miR-29a was related with lymph node metastasis and tumor node metastasis stage. XJR treatment significan

Published
2020

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