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In the originally published online version of this manuscript, in Table 2 all nsph genes were incorrectly listed as MFP1 paralogs instead of as MFP2 paralogs. This error has now been corrected.

Cryptococcal species are the most common fungal pathogens to cause meningitis worldwide. The majority of cases are caused by Cryptococcus neoformans and occur in immunocompromised hosts, while Cryptococcus gattii causes most fungal meningitis in immunocompetent hosts. To date, non- neoformans , non- gattii species of Cryptococcus remain rare causes of human disease, and their clinical courses and preferred treatment regimens remain poorly characterized. We present the case of an otherwise immunocompetent woman with subacute meningoencephalitis diagnosed with Papiliotrema laurentii ( formerly Cryptococcus laurentii) meningitis, who, despite successful fungal eradication, developed hydrocephalus. To our knowledge, this represents the first case of P. laurentii meningitis in an immunocompetent host leading to hydrocephalus, illustrating the diagnostic and therapeutic challenges that remain for atypical fungal meningitis., Competing Interests: Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Study Objective: To assess the efficacy of 10mg intramuscular (IM) methadone in patients with opioid withdrawal syndrome (OWS)., Methods: This was a prospective observational, convenience sample of patients presenting to the ED with mild to moderate OWS. Evaluations included the Clinical Opiate Withdrawal Scale (COWS), Withdrawal Symptoms Scale (WSS), Altered Mental Status Scale (AMSS) and a physician assessment of the patient's WSS (MDWSS). After enrollment, 10mg of IM methadone was administered and patients were reassessed at 30min post-methadone administration. The primary outcome was the change in COWS at baseline and after methadone administration. Secondary outcomes were the differences between AMSS, and WSS post-methadone., Results: Fifty-seven patients had COWS scores recorded at baseline and 30min. Fifty-six had mild to moderate OWS. The COWS improved a mean of 7.6 after methadone administration (P<0.001). The improvement was greater among patients presenting with moderate versus mild withdrawal (mean decrease=-9.1 vs. -5.5, P<0.001). Patients were more likely to self-score themselves as having withdrawal compared to MDs (93.6% vs. 76.6% respectively, P=0.027). Of the 62 patients with baseline and follow-up WSS by self-assessments, 69% improved post-methadone administration. In addition, the AMSS score remained the same or improved among 86% of cases with measurements at baseline and follow-up., Conclusion: A single IM dose of 10mg methadone in the ED reduces the severity of acute mild to moderate OWS by 30min. Larger prospective, randomized controlled, and blinded studies would be needed to confirm these results., (Copyright © 2018 Elsevier Inc. All rights reserved.)

Hyperbolic lattices interpolate between finite-dimensional lattices and Bethe lattices, and they are interesting in their own right, with ordinary percolation exhibiting not one but two phase transitions. We study four constraint percolation models-k-core percolation (for k=1,2,3) and force-balance percolation-on several tessellations of the hyperbolic plane. By comparing these four different models, our numerical data suggest that all of the k-core models, even for k=3, exhibit behavior similar to ordinary percolation, while the force-balance percolation transition is discontinuous. We also provide proof, for some hyperbolic lattices, of the existence of a critical probability that is less than unity for the force-balance model, so that we can place our interpretation of the numerical data for this model on a more rigorous footing. Finally, we discuss improved numerical methods for determining the two critical probabilities on the hyperbolic lattice for the k-core percolation models.