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Your search keyword '"Longhi, Marcela R."' showing total 37 results
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37 results on '"Longhi, Marcela R."'

26. Optimization of the Extraction Conditions of Bioactive Compounds from Ocimum basilicum Leaves Using Ultrasound-Assisted Extraction via a Sonotrode.

Author

Aloisio, Carolina, Razola-Díaz, María del Carmen, Aznar-Ramos, María José, Longhi, Marcela R., Andreatta, Alfonsina E., and Verardo, Vito

Subjects
BIOACTIVE compounds, BASIL, PHENOLS, PHENOLIC acids, SUBSTANCE abuse
Abstract

Sweet basil (Ocimum basilicum) leaves are rich in bioactive compounds that present therapeutic benefits for human health. Ultrasonic-assisted extraction (UAE) is frequently used to obtain phenolic compounds from plants/herbal sources. However, few works have developed multi-variable studies to find the optimal conditions to extract the maximum amount of compounds, especially when applied to UAE via a sonotrode. The purpose of this work was to perform a multi-variable study by employing a Box–Behnken design to collect the highest active compound content from Ocimum basilicum leaves. The efficacy of the design was endorsed by ANOVA. The studied parameters for UAE via a sonotrode were the ethanol/water ratio, amplitude, and time. The analyzed responses were the rosmarinic acid, the sum of phenolic acids, and the sum of phenolic compounds content. The optimal conditions were found to be 50% ethanol/water, 50% amplitude, and 5 min. Twenty bioactive compounds were identified by HPLC-ESI-TOF-MS when the extract was collected by applying the optimal conditions. Ocimum basilicum may be appreciated as a valuable source of important bioactive substances for pharmaceutical use. [ABSTRACT FROM AUTHOR]

Published
2023
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32. List of Contributors

Author

Abdelfattah Abdelwadod, Mohammed, Aboda, Ayman, Agrawal, Mukta, Aiassa, Virginia, Ajazuddin, Alexander, Amit, Alves, Cátia G., Andreeva, Daria V., Attia, Iman, Basso, João, Bodenstein, David, Cadoná, Francine Carla, Calin, Manuela, Chauhan, Durgesh Nandini, Chauhan, Nagendra Singh, Correia, Ilídio J., de Melo-Diogo, Duarte, El-Sawy, Hossam S., El-Say, Khalid M., Favarin, Fernanda Reis, Fuior, Elena-Valeria, Gad, Ahmed, Garnero, Claudia, Goyal, Ramesh K., Grabrucker, Andreas M., Gunay, Mine Silindir, Gupta, Madhu, Insin, Numpon, Jeswani, Gunjan, Kanwar, Jagat R., Kanwar, Rupinder Kaur, Karpuz, Merve, Kumar, Vijay, Lima-Sousa, Rita, Longhi, Marcela R., Machado, Alencar Kolinski, Mahmoud Mostafa, Mamdouh, Mazur, Jake, McGourty, Kieran D., Megahed, Mohamed A., Mendes, Maria, Mishra, Vijay, Mohsen, Mahmoud, Moreira, André F., Mulvihill, John J.E., Ourique, Aline Ferreira, Ozer, A. Yekta, Pais, Alberto, Parihar, Arun K., Pradhan, Madhulika, Rai, Vineet Kumar, Rodrigues, Carolina F., Ross, Aisling M., Rossoni, Carina, Roy, Kislay, Saraf, Swarnlata, Saraogi, Gaurav K., Shah, Kamal, Sharma, Vikas, Shigdar, Sarah, Siddique, Sabahuddin, Silva, Jessica, Singh, Deependra, Singh, Manju Rawat, Sousa, João, Srivastava, Nidhi, Srivastava, Saurabh, Srivastava, Shikha, Taha, Wafa, Tekwani, Babu L., Verma, Anita Kamra, Verma, Vinay Sagar, Vitorino, Carla, Yadav, Krishna, Yadav, Narayan Prasad, Yadav, Nishika, and Yadav, Pooja

Published
2020
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37. Design and evaluation of multicomponent systems as a potential strategy to enhance the pharmaceutical performance of albendazole desmotropes.

Author

Bongioanni A, Mezzano BA, Longhi MR, and Garnero C

Abstract

Albendazole, an anthelmintic recognized by the World Health Organization as an essential medicine, is known to have limitations in solubility and bioavailability. To improve these properties, binary and ternary multicomponent systems were designed employing different combinations of albendazole desmotropes with maltodextrin and aspartic acid. The impact of these systems in solution was evaluated through phase solubility analysis. Moreover, solid systems were produced using the kneading method and evaluated with a combination of techniques, including dissolution tests, Fourier-Transform infrared spectroscopy, X-ray powder diffraction, and scanning electron microscopy. These studies demonstrated that multicomponent systems had higher solubility than free desmotropes, with the system formulated using solid form II of albendazole exhibiting the most significant improvement. Additionally, the dissolution percentage of each solid system in simulated gastric fluid was significantly increased. It can therefore be concluded that these innovative systems offer promising alternatives for improving the oral bioavailability of albendazole, generating significant interest in the pharmaceutical field., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)

Published
2024
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