171 results on '"Livinski A"'
Search Results
2. The definitions, assessment, and dimensions of cancer-related fatigue: A scoping review
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Keane, Kayla F., Wickstrom, Jordan, Livinski, Alicia A., Blumhorst, Catherine, Wang, Tzu-fang, and Saligan, Leorey N.
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- 2024
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3. The reporting of social determinants of health in pediatric dermatology clinical trials: a systematic review
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Christy Nwankwo, MD, Alicia A. Livinski, MA, MPH, Candrice R. Heath, MD, and Leslie Castelo-Soccio, MD, PhD
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Dermatology ,RL1-803 - Abstract
Background:. Despite the acknowledgment of the importance of social determinants of health (SDOH) on clinical outcomes, few clinical trials provide information about SDOH. Including these markers in pediatric dermatologic clinical trials may lead to improved care and novel observations about the disease. Objective:. Using a systematic review, assess the use of SDOH in pediatric dermatology clinical trials. Methods:. CINAHL Plus, Cochrane: CENTRAL, Embase, PubMed, and Scopus were searched. English language randomized controlled trials about pediatric dermatology diseases published from January 2011 to May 2022 were included. Two authors independently screened all records using Covidence at 2 levels. Two authors independently collected data using Covidence and Microsoft Excel and assessed study quality. A protocol was registered at Open Science Framework: https://doi.org/10.17605/OSF.IO/B93VY. Results:. A total of 6463 records were retrieved and 4298 were screened at title/abstract. Next, 1738 records were screened at full text and 1085 were included. Of these, 119 reported an SDOH factor for a pediatric dermatology disease. Income or socioeconomic status was the factor most reported followed by social support, location, and health insurance. Most of the studies were conducted outside of the United States. Limitations:. There are a limited number of dermatology clinical trials that include a pediatric population. Conclusion:. Despite including over 1000 pediatric dermatology clinical trials, only 119 used SDOH. Pediatric dermatology researchers must prioritize including and reporting additional SDOH in clinical trials if the goal is to impact and improve clinical care and innovate for diverse populations of patients.
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- 2024
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4. The influence of telehealth-based cancer rehabilitation interventions on disability: a systematic review
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Brick, Rachelle, Padgett, Lynne, Jones, Jennifer, Wood, Kelley Covington, Pergolotti, Mackenzi, Marshall, Timothy F., Campbell, Grace, Eilers, Rachel, Keshavarzi, Sareh, Flores, Ann Marie, Silver, Julie K., Virani, Aneesha, Livinski, Alicia A., Ahmed, Mohammed Faizan, Kendig, Tiffany, Khalid, Bismah, Barnett, Jeremy, Borhani, Anita, Bernard, Graysen, and Lyons, Kathleen Doyle
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- 2023
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5. Self-reporting of psychoneurophysical (PNP) symptoms in adults with four chronic diseases: a protocol for a scoping review
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Carielle Joy Rio, Catherine Blumhorst, Catherine A. Kwiat, Christopher M. Nguyen, Alicia A. Livinski, and Leorey N. Saligan
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Chronic disease ,Psychoneurophysical symptoms ,Racial disparities ,Self-reporting ,Medicine - Abstract
Abstract Background Patient self-reporting of health-specific information, including symptoms, allows healthcare providers to provide more timely, personalized, and patient-centered care to meet their needs. It is critical to acknowledge that symptom reporting draws from the individual’s unique sociocultural background influencing how one perceives health and illness. This scoping review will explore whether racial groups with 4 chronic diseases (cardiovascular diseases, respiratory diseases, cancers, and diabetes) differ in self-reporting of psychoneurophysical (PNP) symptoms. The PNP symptoms of interest include depressive symptoms, fatigue, anxiety, pain, cognitive impairment, sleep impairment, mood impairment, irritability, and shortness of breath. Methods Four databases will be searched by a biomedical librarian: CINAHL Plus (EBSCOhost), Embase (Elsevier), PubMed (NLM), Web of Science: Core Collection (Clarivate Analytics), and limited to publications written in the English language. Two independent reviewers will screen the records’ title, abstract, and then full text and extract the data from included articles using Covidence. A third reviewer will be used for resolving disagreements. Included articles must comprise adult patients with at least one of the specified chronic diseases who self-report at least one of the specified PNP symptoms. Studies that used clinician-administered questionnaires or obtained symptom responses from primary caregiver or patient designee will be excluded. Articles on patient-reported functionality or perceived quality of life will also be excluded from the review. Two reviewers will independently extract data (e.g., demographics, study design, racial group, chronic disease, measure/scale used for self-report) from each included article using Covidence and Microsoft Excel for data cleaning and analyses. Discussion This scoping review may potentially identify the relevant and practical implications related to clinical decision-making and health outcomes for patients experiencing the psychoneurophysical symptoms included in this study. The authors will present how the results can be utilized in clinical practice, health policy, and research planning. Systematic review registration The protocol was registered on Open Science Framework (OSF) at: https://osf.io/ps7aw
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- 2024
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6. Proteomics for heart failure risk stratification: a systematic review
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Kayode O. Kuku, Rebecca Oyetoro, Maryam Hashemian, Alicia A. Livinski, Joseph J. Shearer, Jungnam Joo, Bruce M. Psaty, Daniel Levy, Peter Ganz, and Véronique L. Roger
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Proteomics ,Heart failure ,Aptamer-assay ,Antibody assay ,Systematic review ,Mortality ,Medicine - Abstract
Abstract Background Heart failure (HF) is a complex clinical syndrome with persistently high mortality. High-throughput proteomic technologies offer new opportunities to improve HF risk stratification, but their contribution remains to be clearly defined. We aimed to systematically review prognostic studies using high-throughput proteomics to identify protein signatures associated with HF mortality. Methods We searched four databases and two clinical trial registries for articles published from 2012 to 2023. HF proteomics studies measuring high numbers of proteins using aptamer or antibody-based affinity platforms on human plasma or serum with outcomes of all-cause or cardiovascular death were included. Two reviewers independently screened articles, extracted data, and assessed the risk of bias. A third reviewer resolved conflicts. We assessed the risk of bias using the Risk Of Bias In Non-randomized Studies—of Exposure tool. Results Out of 5131 unique articles identified, nine articles were included in the review. The nine studies were observational; three used the aptamer platform, and six used the antibody platform. We found considerable heterogeneity across studies in measurement panels, HF definitions, ejection fraction categorization, follow-up duration, and outcome definitions, and a lack of risk estimates for most protein associations. Hence, we proceeded with a systematic review rather than a meta-analysis. In two comparable aptamer studies in patients with HF with reduced ejection fraction, 21 proteins were identified in common for the association with all-cause death. Among these, one protein, WAP four-disulfide core domain protein 2 was also reported in an antibody study on HFrEF and for the association with CV death. We proposed standardized reporting criteria to facilitate the interpretation of future studies. Conclusions In this systematic review of nine studies evaluating the association of proteomics with mortality in HF, we identified a limited number of proteins common across several studies. Heterogeneity across studies compromised drawing broad inferences, underscoring the importance of standardized approaches to reporting.
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- 2024
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7. Exploring the impact of music on response to ketamine/esketamine: A scoping review
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Kheirkhah, Mina, Nugent, Allison C., Livinski, Alicia A., Neely, Lucinda, Johnson, Sara C., Henter, Ioline D., Varnosfaderani, Shahaboddin Dabaghi, Price, Rebecca B., Hejazi, Nadia, Yavi, Mani, Jamalabadi, Hamidreza, Javaheripour, Nooshin, Walter, Martin, and Zarate, Carlos A., Jr
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- 2024
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8. Cancer in Costello syndrome: a systematic review and meta-analysis
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Astiazaran-Symonds, Esteban, Ney, Gina M., Higgs, Cecilia, Oba, Leatrisse, Srivastava, Radhika, Livinski, Alicia A., Rosenberg, Philip S., and Stewart, Douglas R.
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- 2023
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9. Implementation Science for the Prevention and Treatment of HIV among Adolescents and Young Adults in Sub-Saharan Africa: A Scoping Review
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Vorkoper, Susan, Tahlil, Kadija M., Sam-Agudu, Nadia A., Tucker, Joseph D., Livinski, Alicia A., Fernando, Frances, and Sturke, Rachel
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- 2023
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10. Examining allergy related diseases in Africa: A scoping review protocol.
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Max Yang Lu, Nadia Shobnam, Alicia A Livinski, Sarini Saksena, Dylan Salters, Michelle Biete, and Ian A Myles
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Medicine ,Science - Abstract
During recent decades, allergy related diseases have emerged as a growing area of concern in developing regions of the world, including Africa. Worldwide prevalence of allergic diseases has grown to an estimated 262 million for asthma, 400 million for allergic rhinitis (or hay fever), 171 million with atopic dermatitis (or eczema), and over 200 million for food allergy. In Africa, considerable variability exists in the data surrounding prevalence at the continent-wide, regional, and study site levels. Furthermore, research conducted in many rural areas and underdeveloped countries in Africa remains limited, and presently, little has been done to characterize and map the extremely heterogeneous body of literature which confounds research efforts. This scoping review will seek to identify studies examining the prevalence, management strategies, outcomes, and associated risk factors for allergy related diseases in Africa. The Joanna Briggs Institute's scoping review methods will be followed, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Review (PRISMA-ScR) was used for writing the protocol. Four databases (Embase, Global Health, PubMed, African Journals Online) will be searched for literature published from 2003 to 2023 in any language. Title and abstract screening and full-text screening will be completed by two independent reviewers using Covidence; conflicts resolved by a third reviewer. Data will be extracted using Covidence by two reviewers independently. To report the results, we will follow the PRISMA-ScR checklist and report descriptive statistics and a narrative summary.
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- 2024
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11. COVID-19 pandemic and mental health among Hispanic/Latino/a immigrants in the USA: protocol for a scoping review
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Faustine Williams, Alicia Livinski, Cameron K Ormiston, Jolyna Chiangong, and Dera Tompkins
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Medicine - Abstract
Introduction The COVID-19 pandemic has had drastic effects on worldwide mental health and laid bare health disparities and inequities among marginalised groups and racial/ethnic minoritised communities in the USA. This is especially the case among Hispanic/Latino/a immigrants who face numerous structural and socioeconomic barriers to well-being. The increased mental health burden on Hispanic/Latino/a immigrants may have far reaching effects if left unaddressed. Thus, by understanding further Hispanic/Latino/a immigrant mental health during the pandemic, communities and health providers may be able to better address this growing issue. This scoping review aims to assess and outline the current literature on the pandemic’s effects on Hispanic/Latino/a immigrant mental health in the USA, identify research gaps and areas of urgent concern, and inform future research and public health interventions and guidelines.Methods and analysis A scoping review following the Joanna Briggs Institute methodology will be conducted. The PsycINFO, PubMed, Scopus and Web of Science: Core Collection databases and five grey literature sources will be searched for articles published in English from 1 January 2020 to 31 December 2022. Two independent reviewers will screen the search results at title and abstract and then full text using Covidence with conflicts resolved by a third reviewer. Data collection will also be performed in duplicate using Microsoft Excel with discrepancies resolved by a third reviewer and consensus discussion.Ethics and dissemination Ethics approval is not required for this scoping review. Results will be published in a peer-reviewed journal as well as presented at local and national conferences and meetings relevant to our field. Furthermore, to make our findings accessible to non-scientific audiences, we will use various mediums, such as graphical abstracts, policy briefs and fact sheets to share the results in both English and Spanish on different platforms.
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- 2023
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12. Reversing the trend: a scoping review of health innovation transfer or exchange from low- and middle-income countries to high-income countries
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Marie Consolatrice Sage Ishimwe, Jepchirchir Kiplagat, Arina Kadam Knowlton, Alicia A Livinski, and Linda E Kupfer
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Medicine (General) ,R5-920 ,Infectious and parasitic diseases ,RC109-216 - Published
- 2023
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13. The impact of caregiving for children with chronic conditions on the HPA axis: A scoping review
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Mountcastle, Lindsey, Zajdel, Melissa, Robinson, Taylor, Keller, Krystyna R., Gelles, Shani, Livinski, Alicia A., Kikani, Bijal, Lea, Dawn E., and Koehly, Laura M.
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- 2023
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14. A scoping review exploring cure definitions and language for inherited hemoglobinopathies
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Baffoe-Bonnie, Marilyn S., Floyd, K. Jameson, Livinski, Alicia A., and Grady, Christine
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- 2023
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15. Tooth retention, health, and quality of life in older adults: a scoping review
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Adejare Jay Atanda, Alicia A. Livinski, Steven D. London, Shahdokht Boroumand, Darien Weatherspoon, Timothy J. Iafolla, and Bruce A. Dye
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Functional dentition ,Shortened dental arch ,Tooth retention ,Tooth loss ,Quality of life ,Dentistry ,RK1-715 - Abstract
Abstract Objective This scoping review describes the relationship between tooth retention, health, and quality of life in older adults. Methods Seven databases were searched for English language articles for subjects ≥ 65 y from 1981 to 2021. Exposure was tooth retention (≥ 20), and outcomes were general/systemic health and quality of life. Methodological quality was assessed using the Newcastle–Ottawa Scale and Cochrane Risk of Bias 2.0 tool. Results 140 articles were included, only four were randomized trials. Inter-rater agreement (κ) regarding study inclusion was 0.924. Most were assessed with low risk of bias (n = 103) and of good quality (n = 96). Most studies were conducted in Japan (n = 60) and Europe (n = 51) and only nine in the US. Tooth retention was referred to as “functional dentition” in 132 studies and “shortened dental arch” in 19 studies. Study outcomes were broadly synthesized as (1) cognitive decline/functional dependence, (2) health status/chronic diseases, (3) nutrition, and (4) quality of life. Discussion There is a positive relationship between tooth retention, overall health, and quality of life. Older adults retaining ≥ 20 teeth are less likely to experience poorer health. Having
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- 2022
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16. A bibliometric analysis of cancer research funders and collaborators in Kenya: 2007–2017
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Vargas, Jasmin S., Livinski, Alicia A., Karagu, Alfred, Cira, Mishka K., Maina, Martha, Lu, Ya-Ling, and Joseph, Anyona O.
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- 2022
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17. Tooth retention, health, and quality of life in older adults: a scoping review
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Atanda, Adejare Jay, Livinski, Alicia A., London, Steven D., Boroumand, Shahdokht, Weatherspoon, Darien, Iafolla, Timothy J., and Dye, Bruce A.
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- 2022
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18. The use of teledentistry in facilitating oral health for older adults: A scoping review
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Ben-Omran, Munder O., Livinski, Alicia A., Kopycka-Kedzierawski, Dorota T., Boroumand, Shahdokht, Williams, Demetres, Weatherspoon, Darien J., Iafolla, Timothy J., Fontelo, Paul, and Dye, Bruce A.
- Published
- 2021
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19. BTK inhibitors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): A systematic review
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Stack, Michael, Sacco, Keith, Castagnoli, Riccardo, Livinski, Alicia A., Notarangelo, Luigi D., and Lionakis, Michail S.
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- 2021
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20. Sensory cue reactivity: Sensitization in alcohol use disorder and obesity
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Agarwal, Khushbu, Manza, Peter, Leggio, Lorenzo, Livinski, Alicia A., Volkow, Nora D., and Joseph, Paule Valery
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- 2021
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21. Meta‐analysis: Incidence of cirrhosis and hepatocellular carcinoma in patients with Fontan palliation.
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Hitawala, Asif A., Gopalakrishna, Harish, Mironova, Maria, Livinski, Alicia A., Wright, Elizabeth C., Downing, Tacy, Ito, Seiji, Fisher, Stacy D., Cedars, Ari M., John, Anitha S., and Heller, Theo
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HEPATIC fibrosis ,HEPATOCELLULAR carcinoma ,CIRRHOSIS of the liver ,LIVER biopsy ,PEDIATRIC surgery - Abstract
Summary: Background and Aims: The Fontan palliation is the final stage of surgery for many children born with univentricular physiology. Almost all Fontan patients develop liver fibrosis which may eventually lead to cirrhosis and hepatocellular carcinoma (HCC). These are important causes of morbidity and mortality in these patients. We performed a systematic review and meta‐analysis to assess the incidence of cirrhosis and HCC in Fontan patients and stratify it based on time since surgery. Methods: A literature search of seven databases identified 1158 records. Studies reporting the number of cirrhosis and HCC cases in Fontan patients and time since Fontan surgery were included. In the cirrhosis cohort, we included only those studies where all patients underwent liver biopsy. Results: A total of 23 studies were included: 12 and 13 studies in the cirrhosis and HCC cohorts, respectively, with two studies included in both cohorts. The incidence of cirrhosis was 0.97 per 100 patient‐years (95% CI 0.57–1.63), with the incidence and cumulative incidence ≥20 years post Fontan surgery being 1.61 per 100 patient‐years (95% CI 1.24–2.08) and 32.2% (95% CI 25.8%–39.4%), respectively. The incidence of HCC was 0.12 per 100 patient‐years (95% CI 0.07–0.21), with the incidence and cumulative incidence ≥20 years post Fontan surgery being 0.20 per 100 patient‐years (95% CI 0.12–0.35) and 3.9% (95% CI 2.2%–6.8%), respectively. Only about 70% of patients with HCC (20/28) had underlying cirrhosis. Conclusion: The incidence of cirrhosis and HCC increases over time, especially at ≥20 years post Fontan surgery. Studies are needed to further identify at‐risk patients in order to streamline surveillance for these highly morbid conditions. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Moving towards an evidence-informed cancer control strategy: A scoping review of oncology research in Kenya
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Manduku, Veronica, Akhavan, Mina, Asiki, Gershim, Brand, Nathan R., Cira, Mishka K., Gura, Zeinab, Kadengye, Damazo T., Karagu, Alfred, Livinski, Alicia A., Meme, Helen, and Kyobutungi, Catherine
- Published
- 2020
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23. Self-reporting of psychoneurophysical (PNP) symptoms in adults with four chronic diseases: a protocol for a scoping review.
- Author
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Rio, Carielle Joy, Blumhorst, Catherine, Kwiat, Catherine A., Nguyen, Christopher M., Livinski, Alicia A., and Saligan, Leorey N.
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NON-communicable diseases ,CHRONIC diseases ,MEDICAL personnel ,ADULTS ,DATA scrubbing ,FATIGUE (Physiology) ,IRRITABILITY (Psychology) - Abstract
Background: Patient self-reporting of health-specific information, including symptoms, allows healthcare providers to provide more timely, personalized, and patient-centered care to meet their needs. It is critical to acknowledge that symptom reporting draws from the individual's unique sociocultural background influencing how one perceives health and illness. This scoping review will explore whether racial groups with 4 chronic diseases (cardiovascular diseases, respiratory diseases, cancers, and diabetes) differ in self-reporting of psychoneurophysical (PNP) symptoms. The PNP symptoms of interest include depressive symptoms, fatigue, anxiety, pain, cognitive impairment, sleep impairment, mood impairment, irritability, and shortness of breath. Methods: Four databases will be searched by a biomedical librarian: CINAHL Plus (EBSCOhost), Embase (Elsevier), PubMed (NLM), Web of Science: Core Collection (Clarivate Analytics), and limited to publications written in the English language. Two independent reviewers will screen the records' title, abstract, and then full text and extract the data from included articles using Covidence. A third reviewer will be used for resolving disagreements. Included articles must comprise adult patients with at least one of the specified chronic diseases who self-report at least one of the specified PNP symptoms. Studies that used clinician-administered questionnaires or obtained symptom responses from primary caregiver or patient designee will be excluded. Articles on patient-reported functionality or perceived quality of life will also be excluded from the review. Two reviewers will independently extract data (e.g., demographics, study design, racial group, chronic disease, measure/scale used for self-report) from each included article using Covidence and Microsoft Excel for data cleaning and analyses. Discussion: This scoping review may potentially identify the relevant and practical implications related to clinical decision-making and health outcomes for patients experiencing the psychoneurophysical symptoms included in this study. The authors will present how the results can be utilized in clinical practice, health policy, and research planning. Systematic review registration: The protocol was registered on Open Science Framework (OSF) at: https://osf.io/ps7aw [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
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24. Examining allergy related diseases in Africa: A scoping review protocol.
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Lu, Max Yang, Shobnam, Nadia, Livinski, Alicia A., Saksena, Sarini, Salters, Dylan, Biete, Michelle, and Myles, Ian A.
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ALLERGIC rhinitis ,DEVELOPING countries ,ATOPIC dermatitis ,FOOD allergy ,ALLERGIES ,RURAL geography - Abstract
During recent decades, allergy related diseases have emerged as a growing area of concern in developing regions of the world, including Africa. Worldwide prevalence of allergic diseases has grown to an estimated 262 million for asthma, 400 million for allergic rhinitis (or hay fever), 171 million with atopic dermatitis (or eczema), and over 200 million for food allergy. In Africa, considerable variability exists in the data surrounding prevalence at the continent-wide, regional, and study site levels. Furthermore, research conducted in many rural areas and underdeveloped countries in Africa remains limited, and presently, little has been done to characterize and map the extremely heterogeneous body of literature which confounds research efforts. This scoping review will seek to identify studies examining the prevalence, management strategies, outcomes, and associated risk factors for allergy related diseases in Africa. The Joanna Briggs Institute's scoping review methods will be followed, and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Review (PRISMA-ScR) was used for writing the protocol. Four databases (Embase, Global Health, PubMed, African Journals Online) will be searched for literature published from 2003 to 2023 in any language. Title and abstract screening and full-text screening will be completed by two independent reviewers using Covidence; conflicts resolved by a third reviewer. Data will be extracted using Covidence by two reviewers independently. To report the results, we will follow the PRISMA-ScR checklist and report descriptive statistics and a narrative summary. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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25. Key Findings from Mental Health Research During the Menopause Transition for Racially and Ethnically Minoritized Women Living in the United States: A Scoping Review.
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Lewis Johnson, Tamara, Rowland, Laura M., Ashraf, Mahela S., Clark, Crystal T., Dotson, Vonetta M., Livinski, Alicia A., and Simon, Melissa
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SCHIZOPHRENIA risk factors ,MENTAL depression risk factors ,MENTAL illness risk factors ,PSYCHIATRY ,MINORITIES ,SYSTEMATIC reviews ,PSYCHOSES ,RACE ,POST-traumatic stress disorder ,TREATMENT effectiveness ,RESEARCH funding ,INTERSECTIONALITY ,MENOPAUSE ,LITERATURE reviews ,HEALTH equity ,WOMEN'S health - Abstract
Background: Racially and ethnically minoritized (REM) women experience social and structural factors that may affect their response to mental health treatment and menopausal symptoms during the menopause transition (MT). This scoping review on mental health during the MT for REM women in the United States was conducted to characterize factors associated with mental health challenges. Materials and Methods: Five databases were searched. Articles were included if focused on MT in REM women in the United States and its territories with specific mental illnesses and published in English from 2005 to 2021. Titles and abstracts and full text were screened. Screening and data collection were completed in duplicate by two reviewers in Covidence. Results: Sixty-five articles were included and indicate that REM women experience a disproportionate burden of depressive symptoms during the MT. Less evidence is reported about anxiety, Post-Traumatic Stress Disorder, psychosis, schizophrenia, and other mental illnesses. The risk factors associated with mental illness during MT are social, structural, and biological. Treatment response to therapeutic interventions is often underpowered to explain REM differences. Conclusion: Depression during the MT is associated with negative outcomes that may impact REM women differentially. Incorporating theoretical frameworks (e.g., intersectionality, weathering) into mental health research will reduce the likelihood that scientists mislabel race as the cause of these inequities, when racism and intersecting systems of oppression are the root causes of differential expression of mental illness among REM women during the MT. There is a need for interdisciplinary research to advance the mental health of REM women. [ABSTRACT FROM AUTHOR]
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- 2024
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26. Cancer in Costello syndrome: a systematic review and meta-analysis
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Esteban Astiazaran-Symonds, Gina M. Ney, Cecilia Higgs, Leatrisse Oba, Radhika Srivastava, Alicia A. Livinski, Philip S. Rosenberg, and Douglas R. Stewart
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Cancer Research ,Oncology - Published
- 2023
27. Exposure to Outdoor Particulate Matter Air Pollution and Risk of Gastrointestinal Cancers in Adults: A Systematic Review and Meta-Analysis of Epidemiologic Evidence
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Pritchett, Natalie, Spangler, Emily C., Gray, George M., Livinski, Alicia A., Sampson, Joshua N., Dawsey, Sanford M., and Jones, Rena R.
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Gastrointestinal cancer -- Risk factors -- Environmental aspects ,Air pollution -- Health aspects ,Particles -- Health aspects -- Environmental aspects ,Environmental issues ,Health - Abstract
BACKGROUND: Outdoor air pollution is a known lung carcinogen, but research investigating the association between particulate matter (PM) and gastrointestinal (GI) cancers is limited. OBJECTIVES: We sought to review the epidemiologic literature on outdoor PM and GI cancers and to put the body of studies into context regarding potential for bias and overall strength of evidence. METHODS: We conducted a systematic review and meta-analysis of epidemiologic studies that evaluated the association of fine PM [PM with an aerodynamic diameter of [less than or equal to]2.5 [micro]m (P[M.sub.2.5])] and P[M.sub.10] (aerodynamic diameter < 10 pm) with GI cancer incidence or mortality in adults. We searched five databases for original research published from 1980 to 2021 in English and summarized findings for studies employing a quantitative estimate of exposure overall and by specific GI cancer subtypes. We evaluated the risk of bias of individual studies and the overall quality and strength of the evidence according to the Navigation Guide methodology, which is tailored for environmental health research. RESULTS: Twenty studies met inclusion criteria and included participants from 14 countries; nearly all were of cohort design. All studies identified positive associations between PM exposure and risk of at least one GI cancer, although in 3 studies these relationships were not statistically significant. Three of 5 studies estimated associations with P[M.sub.10] and satisfied inclusion criteria for meta-analysis, but each assessed a different GI cancer and were therefore excluded. In the random-effects meta-analysis of 13 studies, P[M.sub.2.5] exposure was associated with an increased risk of GI cancer overall [risk ratio (RR) = 1.12; 95% CI: 1.01, 1.24]. The most robust associations were observed for liver cancer (RR = 1.31; 95% CI: 1.07, 1.56) and colorectal cancer (RR = 1.35; 95% CI: 1.08, 1.62), for which all studies identified an increased risk. We rated most studies with 'probably low' risk of bias and the overall body of evidence as 'moderate' quality with 'limited' evidence for this association. We based this determination on the generally positive, but inconsistently statistically significant, effect estimates reported across a small number of studies. CONCLUSION: We concluded there is some evidence of associations between P[M.sub.2.5] and GI cancers, with the strongest evidence for liver and colorectal cancers. Although there is biologic plausibility for these relationships, studies of any one cancer site were few and there remain only a small number overall. Studies in geographic areas with high GI cancer burden, evaluation of the impact of different PM exposure assessment approaches on observed associations, and investigation of cancer subtypes and specific chemical components of PM are important areas of interest for future research. https://doi.org/10.1289/EHP9620, Introduction Gastrointestinal (GI) cancers are a major cause of cancer burden and cancer death. Worldwide, there were an estimated 4.8 million new cases of GI cancers and 3.4 million GI [...]
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- 2022
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28. The Role of Extracellular Vesicles in β-Cell Function and Viability: A Scoping Review
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Stephanie Chidester, Alicia A. Livinski, Anne F. Fish, and Paule V. Joseph
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β-cell ,diabetes ,extracellular vesicle ,exosome ,insulin secretion ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Extracellular vesicles (EVs) released by cells throughout the body have been implicated in diabetes pathogenesis. Understanding the role of EVs in regulation of β-cell function and viability may provide insights into diabetes etiology and may lead to the development of more effective screening and diagnostic tools to detect diabetes earlier and prevent disease progression. This review was conducted to determine what is known from the literature about the effect of EV crosstalk on pancreatic β-cell function and viability in the pathogenesis of diabetes mellitus, to perform a gap analysis for future research directions, and to discuss implications of available evidence for diabetes care. The literature search yielded 380 studies from which 31 studies were determined to meet eligibility criteria. The majority of studies had the disease context of autoimmunity in T1DM. The most commonly studied EV crosstalk dynamics involved localized EV-mediated communication between β-cells and other islet cells, or between β-cells and immune cells. Other organs and tissues secreting EVs that affect β-cells include skeletal muscle, hepatocytes, adipocytes, immune cells, bone marrow, vascular endothelium, and mesenchymal stem cells. Characterization of EV cargo molecules with regulatory effects in β-cells was conducted in 24 studies, with primary focus on microRNA cargo. Gaps identified included scarcity of evidence for the effect on β-cell function and viability of EVs from major metabolic organs/tissues such as muscle, liver, and adipose depots. Future research should address these gaps as well as characterize a broader range of EV cargo molecules and their activity in β-cells.
- Published
- 2020
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29. Influenza seasonality goes south in the Yucatan Peninsula: The case for a different influenza vaccine calendar in this Mexican region
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Ayora-Talavera, Guadalupe, Flores, Gerardo Montalvo-Zurbia, Gómez-Carballo, Jesus, González-Losa, Refugio, Conde-Ferraez, Laura, Puerto-Solís, Marylin, López-Martínez, Irma, Díaz-Quiñonez, Alberto, Barrera-Badillo, Gisela, Acuna-Soto, Rodolfo, Livinski, Alicia A., and Alonso, Wladimir J.
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- 2017
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30. A Panoply of Rheumatological Manifestations in Patients with GATA2 Deficiency
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Amarnani, Abhimanyu A., Poladian, Katlin R., Marciano, Beatriz E., Daub, Janine R., Williams, Sandra G., Livinski, Alicia A., Hsu, Amy P., Palmer, Cindy L., Kenney, Cara M., Avila, Daniele N., Holland, Steven M., and Katz, James D.
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- 2020
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31. Implementation Science for the Prevention and Treatment of HIV among Adolescents and Young Adults in Sub-Saharan Africa: A Scoping Review
- Author
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Susan Vorkoper, Kadija M. Tahlil, Nadia A. Sam-Agudu, Joseph D. Tucker, Alicia A. Livinski, Frances Fernando, and Rachel Sturke
- Subjects
Infectious Diseases ,Social Psychology ,Public Health, Environmental and Occupational Health - Abstract
Despite many evidence-based adolescent and young adult (AYA) HIV interventions, few are implemented at scale in sub-Saharan Africa (SSA). A growing implementation science literature provides important context for scaling up AYA HIV interventions in this high HIV-burden region. This scoping review examined the use of implementation research in AYA HIV studies conducted in SSA. We searched five databases and included articles which focused on AYA (10–24 years old), addressed HIV prevention or treatment, were conducted exclusively in SSA countries, and included an implementation science outcome. We included 44 articles in 13 SSA countries. Most were in East (52.3%) and South Africa (27.3%), and half focused exclusively on HIV prevention components of the care continuum. Acceptability and feasibility were the most cited implementation science outcomes. Only four articles used an established implementation science framework. The findings informed our recommendations to guide the design, implementation, and dissemination of further studies and health policymaking.
- Published
- 2022
32. A scoping review of methods used in musculoskeletal soft tissue and nerve shear wave elastography studies
- Author
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Kevin J, Cipriano, Jordan, Wickstrom, Michael, Glicksman, Lauren, Hirth, Michael, Farrell, Alicia A, Livinski, Sogol Attaripour, Esfahani, Robert J, Maldonado, Jared, Astrow, William A, Berrigan, Antonia M H, Piergies, Lisa D, Hobson-Webb, and Katharine E, Alter
- Subjects
Tendons ,Neurology ,Electromyography ,Physiology (medical) ,Elasticity Imaging Techniques ,Humans ,Neurology (clinical) ,Muscle, Skeletal ,Sensory Systems ,Ultrasonography - Abstract
This scoping review of shear wave elastography (SWE) articles in musculoskeletal soft tissue and nerve research demonstrates methodological heterogeneity resulting from a lack of standardized data collection and reporting requirements. Seven literature databases were searched for original articles published in English from 2004-2020 that examine human skeletal muscles, tendons, and nerves in vivo. Although 5,868 records were initially identified, only 375 reports met inclusion criteria. Of the 375 articles, 260 examined 89 unique muscles, 94 examined 14 unique tendons, and 43 examined 8 unique nerves. Cohorts were often small (n = 11-20) and young (mean = 20-29 years), and participants were typically tested in the prone position. Regarding equipment, a variety of ultrasound systems (n = 11), ultrasound models (n = 18), and transducers (n = 19) were identified. Only 11% of articles contained information on the use of electromyography to confirm absence of muscle activity, and only 8% reported measurement depth. Since musculoskeletal soft tissue and nerve stiffness can vary significantly based on data collection methods, it is essential to standardize SWE collection and reporting procedures. This will allow SWE to serve as a valid and reproducible tool for assessing tissue pathology, disease progression, and response to intervention within a variety of musculoskeletal and nerve-related disorders.
- Published
- 2022
33. The National Cancer Institute's Cancer Disparities Research Partnership Program: a unique funding model 20 years later.
- Author
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Coleman, C Norman, Wong, Rosemary, Petereit, Daniel G, Maguire, Patrick D, Heron, Dwight E, Steinberg, Michael, Bains, Yadvindera, Vikram, Bhadrasain, Angelis, Patricia, Livinski, Alicia A, Roach, Mack, and Govern, Frank S
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BUSINESS partnerships ,MEDICALLY underserved persons ,CANCER research ,MEDICALLY underserved areas ,LIKERT scale ,HEALTH care industry - Abstract
The burden of cancer and access to effective treatment are not experienced equally by all in the United States. For underserved populations that often access the health-care system when their cancers are in advanced disease stages, radiation oncology services are essential. In 2001, the National Cancer Institute's (NCI's) Radiation Research Program created and implemented the Cancer Disparities Research Partnership Program (CDRP). CDRP was a pioneering funding model whose goal was to increase participation of medically underserved populations in NCI clinical trials. CDRP's Cooperative Agreement funding supported for awardees the planning, development, and conduct of radiation oncology clinical research in institutions not traditionally involved in NCI-sponsored research and cared for a disproportionate number of medically underserved, health-disparities populations. The awardee secured and provided support for mentorship from 1 of 2 NCI comprehensive cancer centers named in its application. Six CDRP awards were made over two 5-year funding periods ending in 2013, with the end-of-program accomplishments previously reported. With the current focus on addressing equity, diversity, and inclusion, the 6 principal investigators were surveyed, 5 of whom responded about the impact of CDRP on their institutions, communities, and personal career paths. The survey that was emailed included 10 questions on a 5-point Likert scale. It was not possible to collect patient data this long after completion of the program. This article provides a 20-year retrospective of the experiences and observations from those principal investigators that can inform those now planning, building, and implementing equity, diversity, and inclusion programs. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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34. Ionising radiation and cardiovascular disease : systematic review and meta-analysis
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Little, Mark P., Azizova, Tamara, V, Richardson, David B., Tapio, Soile, Bernier, Marie-Odile, Kreuzer, Michaela, Cucinotta, Francis A., Bazyka, Dimitry, Chumak, Vadim, Ivanov, Victor K., Veiga, Lene H. S., Livinski, Alicia, Abalo, Kossi, Zablotska, Lydia B., Einstein, Andrew J., Hamada, Nobuyuki, Little, Mark P., Azizova, Tamara, V, Richardson, David B., Tapio, Soile, Bernier, Marie-Odile, Kreuzer, Michaela, Cucinotta, Francis A., Bazyka, Dimitry, Chumak, Vadim, Ivanov, Victor K., Veiga, Lene H. S., Livinski, Alicia, Abalo, Kossi, Zablotska, Lydia B., Einstein, Andrew J., and Hamada, Nobuyuki
- Abstract
OBJECTIVE: To systematically review and perform a meta-analysis of radiation associated risks of cardiovascular disease in all groups exposed to radiation with individual radiation dose estimates. DESIGN: Systematic review and meta-analysis. MAIN OUTCOME MEASURES: Excess relative risk per unit dose (Gy), estimated by restricted maximum likelihood methods. DATA SOURCES: PubMed and Medline, Embase, Scopus, Web of Science Core collection databases. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Databases were searched on 6 October 2022, with no limits on date of publication or language. Animal studies and studies without an abstract were excluded. RESULTS: The meta-analysis yielded 93 relevant studies. Relative risk per Gy increased for all cardiovascular disease (excess relative risk per Gy of 0.11 (95% confidence interval 0.08 to 0.14)) and for the four major subtypes of cardiovascular disease (ischaemic heart disease, other heart disease, cerebrovascular disease, all other cardiovascular disease). However, interstudy heterogeneity was noted (P<0.05 for all endpoints except for other heart disease), possibly resulting from interstudy variation in unmeasured confounders or effect modifiers, which is markedly reduced if attention is restricted to higher quality studies or those at moderate doses (<0.5 Gy) or low dose rates (<5 mGy/h). For ischaemic heart disease and all cardiovascular disease, risks were larger per unit dose for lower dose (inverse dose effect) and for fractionated exposures (inverse dose fractionation effect). Population based excess absolute risks are estimated for a number of national populations (Canada, England and Wales, France, Germany, Japan, USA) and range from 2.33% per Gy (95% confidence interval 1.69% to 2.98%) for England and Wales to 3.66% per Gy (2.65% to 4.68%) for Germany, largely reflecting the underlying rates of cardiovascular disease mortality in these populations. Estimated risk of mortality from cardiovascular disease are g
- Published
- 2023
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35. The catalytic role of a research university and international partnerships in building research capacity in Peru: A bibliometric analysis.
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Christopher W Belter, Patricia J Garcia, Alicia A Livinski, Fabiola Leon-Velarde, Kristen H Weymouth, and Roger I Glass
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Arctic medicine. Tropical medicine ,RC955-962 ,Public aspects of medicine ,RA1-1270 - Abstract
ObjectiveIn Peru, the past three decades have witnessed impressive growth in biomedical research catalyzed from a single research university and its investigators who secured international partnerships and funding. We conducted a bibliometric analysis of publications by Peruvian authors to understand the roots of this growth and the spread of research networks within the country.MethodsFor 1997-2016, publications from Web of Science with at least one author affiliated with a Peruvian institution were examined by year, author affiliations, funding agencies, co-authorship linkages, and research topics.ResultsFrom 1997-2016, the annual number of publications from Peru increased 9-fold from 75 to 672 totaling 6032. Of these, 56% of the articles had co-authors from the US, 13% from the UK, 12% from Brazil, and 10% from Spain. Universidad Peruana Cayetano Heredia (UPCH) was clearly the lead research institution noted on one-third of publications. Of the 20 most published authors, 15 were Peruvians, 14 trained at some point at UPCH, and 13 received advanced training abroad. Plotting co-authorships documented the growth of institutional collaborations, the robust links between investigators and some lineages of mentorship.ConclusionsThis analysis suggests that international training of Peruvian physician-scientists who built and sustained longstanding international partnerships with funding accelerated quality research on diseases of local importance. The role of a single research university, UPCH, was critical to advance a culture of biomedical research. Increased funding from the Peruvian Government and its Council for Science, Technology and Innovation will be needed to sustain this growth in the future. Middle-income countries might consider the Peruvian experience where long-term research and training partnerships yielded impressive advances to address key health priorities of the country.
- Published
- 2019
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36. COVID-19 exposed pre-existing roadblocks for cancer control in Africa: strategies, lessons and recommendations from the 2019–2020 Africa Cancer Research and Control ECHO
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Annet Nakaganda, Nwamaka Lasebikan, Elise M Garton, Benda Kithaka, Eunice Garanganga, Alicia A Livinski, and Mishka K Cira
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Cancer Research ,Oncology - Published
- 2023
37. Characteristics of Cancer Epidemiology Studies That Employ Metabolomics: A Scoping Review.
- Author
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Yu, Catherine T., Farhat, Zeinab, Livinski, Alicia A., Loftfield, Erikka, and Zanetti, Krista A.
- Abstract
An increasing number of cancer epidemiology studies use metabolomics assays. This scoping review characterizes trends in the literature in terms of study design, population characteristics, and metabolomics approaches and identifies opportunities for future growth and improvement. We searched PubMed/MEDLINE, Embase, Scopus, and Web of Science: Core Collection databases and included research articles that used metabolomics to primarily study cancer, contained a minimum of 100 cases in each main analysis stratum, used an epidemiologic study design, and were published in English from 1998 to June 2021. A total of 2,048 articles were screened, of which 314 full texts were further assessed resulting in 77 included articles. The most well-studied cancers were colorectal (19.5%), prostate (19.5%), and breast (19.5%). Most studies used a nested case-control design to estimate associations between individual metabolites and cancer risk and a liquid chromatography-tandem mass spectrometry untargeted or semi-targeted approach to measure metabolites in blood. Studies were geographically diverse, including countries in Asia, Europe, and North America; 27.3% of studies reported on participant race, the majority reporting White participants. Most studies (70.2%) included fewer than 300 cancer cases in their main analysis. This scoping review identified key areas for improvement, including needs for standardized race and ethnicity reporting, more diverse study populations, and larger studies. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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38. Ionising radiation and cardiovascular disease : systematic review and meta-analysis
- Author
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Mark P Little, Tamara V Azizova, David B Richardson, Soile Tapio, Marie-Odile Bernier, Michaela Kreuzer, Francis A Cucinotta, Dimitry Bazyka, Vadim Chumak, Victor K Ivanov, Lene H S Veiga, Alicia Livinski, Kossi Abalo, Lydia B Zablotska, Andrew J Einstein, and Nobuyuki Hamada
- Subjects
Arbetsmedicin och miljömedicin ,General Medicine ,Occupational Health and Environmental Health - Abstract
Objective To systematically review and perform a meta-analysis of radiation associated risks of cardiovascular disease in all groups exposed to radiation with individual radiation dose estimates. Design Systematic review and meta-analysis. Main outcome measures Excess relative risk per unit dose (Gy), estimated by restricted maximum likelihood methods. Data sources PubMed and Medline, Embase, Scopus, Web of Science Core collection databases. Eligibility criteria for selecting studies Databases were searched on 6 October 2022, with no limits on date of publication or language. Animal studies and studies without an abstract were excluded. Results The meta-analysis yielded 93 relevant studies. Relative risk per Gy increased for all cardiovascular disease (excess relative risk per Gy of 0.11 (95% confidence interval 0.08 to 0.14)) and for the four major subtypes of cardiovascular disease (ischaemic heart disease, other heart disease, cerebrovascular disease, all other cardiovascular disease). However, interstudy heterogeneity was noted (P Conclusions Results provide evidence supporting a causal association between radiation exposure and cardiovascular disease at high dose, and to a lesser extent at low dose, with some indications of differences in risk between acute and chronic exposures, which require further investigation. The observed heterogeneity complicates a causal interpretation of these findings, although this heterogeneity is much reduced if only higher quality studies or those at moderate doses or low dose rates are considered. Studies are needed to assess in more detail modifications of radiation effect by lifestyle and medical risk factors. Systematic review registration PROSPERO CRD42020202036
- Published
- 2023
39. The effect of music on response to ketamine: A scoping review protocol
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Price, Rebecca B., Jamalabadi, Hamidreza, Neely, Lucinda, Yavi, Mani, Shahaboddin Dabaghi Varnosfaderani, Livinski, Alicia, Kheirkhah, Mina, Zarate, Carlos A., Johnson, Sara C., Walter, Martin, and Nugent, Allison C
- Subjects
Neurology ,ketamine ,Mental and Social Health ,Other Mental and Social Health ,Medicine and Health Sciences ,Medical Specialties ,music ,protocol ,scoping review - Abstract
Few studies have investigated the co-administration of music and ketamine, which could lead to different therapeutic outcomes than administration of ketamine alone. This scoping review will describe the existing literature on the joint use of ketamine and music in humans and seeks to determine how ketamine and music may interact. Five databases (PubMed, Embase, PsycNet, Scopus, Web of Science: Core) and Google Scholar will be searched; articles of interest will be limited to the English language but not to any publication year. Two reviewers will independently screen each record using Covidence, a screening and data extraction tool, and resolve disagreements via consensus. All studies in English that address the effects of co-administration of ketamine (any dose or administration route) and music in healthy volunteers or patients (any age group for any treatment) will be included. Articles about recreational use of ketamine will be excluded. Two reviewers will extract the identified data items using Covidence. This scoping review will be the first on the topic of music and ketamine and will help researchers who wish to design future studies investigating ketamine and music.
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- 2023
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40. How to write a scoping review protocol: Guidance and template
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Wickstrom, Jordan, Butera, Gisela, Lely, Justine, Livinski, Alicia A., Morris, Hailey C., Camarillo, Nathan D., and Sasson, Noa
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Medicine and Health Sciences ,Life Sciences ,evidence synthesis ,protocol ,scoping review ,Other Medicine and Health Sciences - Abstract
A scoping review provides a comprehensive overview of a particular topic by synthesizing the breadth of evidence currently available. It has become an increasingly common approach to summarize the literature since its inception in 2005, and detailed approaches have since been developed to provide methodological and reporting guidance. Scoping reviews are intended to provide readers with key concepts and definitions, important insights regarding the topic of interest, knowledge gaps in the field, and a summary of how research has been conducted. They may serve as a precursor to systematic reviews conducted on larger, more homogeneous bodies of evidence, which often include more specific research questions, methodological appraisals, risk of bias assessments, and meta-analyses. This Scoping Review Protocol Guidance is intended to serve as an educational tool for those developing or reviewing scoping review protocols including novice, intermediate, and experienced researchers and clinicians. This document provides information for each core protocol component (see color-coded headings) consisting of overarching goals, core requirements, helpful tips, and published protocol examples. Please note these examples may not include all recommendations provided herein. When writing your protocol, this guidance is intended to be used in tandem with the Scoping Review Protocol Template, which includes headings and subheadings to insert relevant protocol information. Please refer to our bibliography for the list of resources used to create these documents.
- Published
- 2023
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41. Team-Based Care for Cancer Survivors With Comorbidities: A Systematic Review
- Author
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Michelle Doose, Dana Verhoeven, Janeth I. Sanchez, Alicia A. Livinski, Michelle Mollica, Veronica Chollette, and Sallie J. Weaver
- Subjects
Adult ,Cancer Survivors ,Health Policy ,Communication ,Neoplasms ,Public Health, Environmental and Occupational Health ,Humans ,Comorbidity ,Delivery of Health Care ,Article ,Quality of Health Care - Abstract
Coordination of quality care for the growing population of cancer survivors with comorbidities remains poorly understood, especially among health disparity populations who are more likely to have comorbidities at the time of cancer diagnosis. This systematic review synthesized the literature from 2000 to 2022 on team-based care for cancer survivors with comorbidities and assessed team-based care conceptualization, teamwork processes, and outcomes. Six databases were searched for original articles on adults with cancer and comorbidity, which defined care team composition and comparison group, and assessed clinical or teamwork processes or outcomes. We identified 1,821 articles of which 13 met the inclusion criteria. Most studies occurred during active cancer treatment and nine focused on depression management. Four studies focused on Hispanic or Black cancer survivors and one recruited rural residents. The conceptualization of team-based care varied across articles. Teamwork processes were not explicitly measured, but teamwork concepts such as communication and mental models were mentioned. Despite team-based care being a cornerstone of quality cancer care, studies that simultaneously assessed care delivery and outcomes for cancer and comorbidities were largely absent. Improving care coordination will be key to addressing disparities and promoting health equity for cancer survivors with comorbidities.
- Published
- 2023
42. The Reporting of Social Determinants of Health in Pediatric Dermatology Clinical Trials: A Systematic Review Protocol
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Castelo-Soccio, Leslie, Candrice Heath, Livinski, Alicia, and Nwankwo, Christy
- Subjects
dermatology ,Skin and Connective Tissue Diseases ,clinical trials ,pediatrics ,social determinants of health ,Medical Specialties ,Medicine and Health Sciences ,Diseases ,Other Medicine and Health Sciences ,Translational Medical Research - Abstract
Rationale: By 2044, 50% of the United States will be of minority status [1]. Given the changing US population, it is important to reconsider traditional ways of understanding diversity. Diversity in research allows for the examination of drivers of health disparities as evidenced by prior research finding differences in health outcomes dependent on patient race [2]. However, most scholars now agree that markers such as race and ethnicity are imperfect measures of variation as there is more genetic heterogeneity between people of the same race than those of different races [3]. Due to the known impact of social determinants on health disparities, these may serve as better tools to use in research analysis for understanding diversity and differences in health outcomes [4]. In this systematic review, we will discuss the current practice for using race in pediatric clinical trial research and provide a review of the use of social determinants of health in pediatric clinical trial research. Objective: The objective of this systematic review is to assess if there is reporting of social determinants of health in pediatric dermatology clinical trial research (specifically income, location, education, healthcare, and social support) and the conditions and setting this reporting occurs.
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- 2023
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43. Global Health Reciprocal Innovation: A Scoping Review Protocol
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Jepchirchir Kiplagat, Kupfer, Linda, Knowlton, Arina, Livinski, Alicia, and Ishimwe, Sage M.C.
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International Public Health ,reciprocal innovation ,public health ,Medicine and Health Sciences ,global health ,reverse innovation - Abstract
This scoping review seeks to highlight how health innovations researched, developed, and implemented in low- and middle-income countries (LMICs) can be adapted and adopted to address similar challenges in high-income country (HIC) settings utilizing various scientific methods. By understanding the range of research and programs already conducted under reciprocal innovation , we hope by conducting this review to identify knowledge gaps in the evidence base and determine which methods work best to encourage health researchers and funders to conduct and support reciprocal innovations in the future.
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- 2023
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44. A scoping review on sex and gender differences in sickle cell trait and adverse health outcomes
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Phillips, Angela, Livinski, Alicia, Bevans, Margaret, Segovia, Laura, Shet, Arun, and Wilson, Candy
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Medicine and Health Sciences - Abstract
In SCT individuals (population) with adverse health outcomes (context), what is known about sex and gender differences (concepts)?
- Published
- 2023
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45. Identifying Approaches to Process Actigraphy Data: A Scoping Review Protocol
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Gonsalves, Stephen, Steele, Michael, Fuss, Timothy, Ross, Alexander, Kwiat, Catherine, Nguyen, Christopher, Livinski, Alicia, and Saligan, Leorey
- Subjects
Medicine and Health Sciences ,accelerometry ,physical activity ,Sports Sciences ,Nursing ,human physical activity ,FOS: Health sciences ,data cleaning ,actigraphy ,data preparation - Abstract
Background: Wearable actigraphy monitors have seen rapid growth in both clinical and physical activity (PA) research. For research studies that utilize human participants, these portable devices provide a means to objectively quantify symptom burden and therapy effectiveness. The highly detailed data gathered from actigraphy devices allows researchers to identify even the subtlest changes in rest, sleep, and activity patterns that occur with other therapeutics. Compared to participant self-report, the data collection automation by a passive activity monitor improves the quality and reliability of the data. However, there is no consensus in how the data from these monitors are processed, different actigraphy brands and models used, and inconsistent reporting making comparisons difficult. There are several actigraphy data processing methods, but no consensus on definitions for PA values or cleaning guidelines to facilitate comparison across studies. PA research could be advanced with globally acceptable standardization in the processing of PA data. We will conduct a scoping review to identify common cleaning and pre-processing techniques of raw PA counts collected from commercially available actigraphy devices. Methods: We will use the Joanna Briggs Institute’s methodology to guide the conduct of this review and the PRISMA extension for scoping reviews checklist for reporting. A librarian will search PubMed (NLM), Scopus (Elsevier), and Web of Science: Core Collection (Clarivate Analytics) using keywords and controlled vocabulary. The reference lists of included articles and consultation with experts will be used to identify additional records. Two authors will first screen the titles and abstracts and then full-text using Covidence. Studies describing the cleaning or preparation of PA data collected from actigraphy monitors for human movement will be included. Two authors will independently extract from each included article the type of PA analyzed, criteria and descriptions used to categorize PA, accelerometry data collection methods, actigraphy cleaning method, actigraphy algorithms, and PA variables. Results will be presented through a descriptive numerical summary of studies, PRISMA flow diagram, and tables showing the cleaning methods and algorithms used and PA variables. Discussion: The findings of this scoping review will identify common actigraphy data cleaning procedures to fill the existing gap in PA research.
- Published
- 2022
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46. The role of race in self-reported psychoneurophysical symptom reporting in patients with chronic disease: a protocol for a scoping review
- Author
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Rio, Carielle, Blumborst, Cathy, Kwiat, Catherine, Nguyen, Christopher, Livinski, Alicia, and Saligan, Leorey
- Subjects
diabetes ,cardiovascular disease ,racial disparities ,Medicine and Health Sciences ,psychoneurophysical symptoms ,cancer ,self-reporting ,Nursing ,scoping review ,FOS: Health sciences ,patient reported outcomes ,respiratory disease - Abstract
This scoping review will explore the effects of race in the self-reporting of psychoneurophysical (PNP) symptoms in adult patients with four chronic diseases (cardiovascular diseases, respiratory diseases, cancers, and diabetes. The PNP symptoms of interest include depressive symptoms, fatigue, anxiety, pain, cognitive impairment, sleep impairment, mood impairment, irritability, and shortness of breath.
- Published
- 2022
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47. The State of Preclinical Modeling for Early Phase Cancer Trials Using Molecularly Targeted Agents with Radiation
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Julie A. Hong, Bhadrasian Vikram, Jeffrey Buchsbaum, Jacek Capala, Alicia Livinski, Beverly Teicher, Pataje Prasanna, Mansoor M. Ahmed, Ceferino Obcemea, C. Norman Coleman, and Michael Graham Espey
- Subjects
Radiation ,Biophysics ,Radiology, Nuclear Medicine and imaging ,Article - Abstract
Preclinical studies inform and guide the development of novel treatment combination strategies that bridge the laboratory with the clinic. We aimed to evaluate approaches cancer researchers used to justify advancing new combinations of molecularly targeted agents and radiation treatment into early-phase human clinical trials. Unsolicited early phase clinical trial proposals submitted to the National Cancer Institute's Cancer Therapy Evaluation Program between January 2016 and July 2020 were curated to quantify key characteristics and proportion of preclinical data provided by trialists seeking to conduct molecularly targeted agent-radiation combination studies in cancer patients. These data elucidate the current landscape for how the rationale for a molecularly targeted agent-radiation combination therapy is supported by preclinical research and illustrate unique challenges faced in translation at the intersection of precision medicine and radiation oncology.
- Published
- 2022
48. A systematic review of the biological mediators of fat taste and smell
- Author
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Rosario B. Jaime-Lara, Brianna E. Brooks, Carlotta Vizioli, Mari Chiles, Nafisa Nawal, Rodrigo S. E. Ortiz-Figueroa, Alicia A. Livinski, Khushbu Agarwal, Claudia Colina-Prisco, Natalia Iannarino, Aliya Hilmi, Hugo A. Tejeda, and Paule V. Joseph
- Subjects
Smell ,Physiology ,Physiology (medical) ,Taste ,Animals ,Humans ,General Medicine ,Feeding Behavior ,Obesity ,Taste Buds ,Molecular Biology - Abstract
Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is growing interest in the study of the biological mediators of fat taste and associated olfaction as potential targets for pharmacologic and nutritional interventions in the context of obesity and health. The number of studies examining mechanisms underlying fat taste and smell has grown rapidly in the last 5 years. Therefore, the purpose of this systematic review is to summarize emerging evidence examining the biological mechanisms of fat taste and smell. A literature search was conducted of studies published in English between 2014 and 2021 in adult humans and animal models. Database searches were conducted using PubMed, EMBASE, Scopus, and Web of Science for key terms including fat/lipid, taste, and olfaction. Initially, 4,062 articles were identified through database searches, and a total of 84 relevant articles met inclusion and exclusion criteria and are included in this review. Existing literature suggests that there are several proteins integral to fat chemosensation, including cluster of differentiation 36 (CD36) and G protein-coupled receptor 120 (GPR120). This systematic review will discuss these proteins and the signal transduction pathways involved in fat detection. We also review neural circuits, key brain regions, ingestive cues, postingestive signals, and genetic polymorphism that play a role in fat perception and consumption. Finally, we discuss the role of fat taste and smell in the context of eating behavior and obesity.
- Published
- 2022
49. Cancer incidence and surveillance strategies in individuals with RASopathies
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Gina Ney, Andrea Gross, Alicia Livinski, Christian P. Kratz, and Douglas R. Stewart
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Genetics ,Genetics (clinical) - Abstract
RASopathies are a set of clinical syndromes that have molecular and clinical overlap. Genetically, these syndromes are defined by germline pathogenic variants in RAS/MAPK pathway genes resulting in activation of this pathway. Clinically, their common molecular signature leads to comparable phenotypes, including cardiac anomalies, neurologic disorders and notably, elevated cancer risk. Cancer risk in individuals with RASopathies has been estimated from retrospective reviews and cohort studies. For example, in Costello syndrome, cancer incidence is significantly elevated over the general population, largely due to solid tumors. In some forms of Noonan syndrome, cancer risk is also elevated over the general population and is enriched for hematologic malignancies. Thus, cancer surveillance guidelines have been developed to monitor for the occurrence of such cancers in individuals with some RASopathies. These include abdominal ultrasound and urinalyses for individuals with Costello syndrome, while complete blood counts and splenic examination are recommended in Noonan syndrome. Improved cancer risk estimates and refinement of surveillance recommendations will improve the care of individuals with RASopathies.
- Published
- 2022
50. Data sharing in PLOS ONE: An analysis of Data Availability Statements.
- Author
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Lisa M Federer, Christopher W Belter, Douglas J Joubert, Alicia Livinski, Ya-Ling Lu, Lissa N Snyders, and Holly Thompson
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Medicine ,Science - Abstract
A number of publishers and funders, including PLOS, have recently adopted policies requiring researchers to share the data underlying their results and publications. Such policies help increase the reproducibility of the published literature, as well as make a larger body of data available for reuse and re-analysis. In this study, we evaluate the extent to which authors have complied with this policy by analyzing Data Availability Statements from 47,593 papers published in PLOS ONE between March 2014 (when the policy went into effect) and May 2016. Our analysis shows that compliance with the policy has increased, with a significant decline over time in papers that did not include a Data Availability Statement. However, only about 20% of statements indicate that data are deposited in a repository, which the PLOS policy states is the preferred method. More commonly, authors state that their data are in the paper itself or in the supplemental information, though it is unclear whether these data meet the level of sharing required in the PLOS policy. These findings suggest that additional review of Data Availability Statements or more stringent policies may be needed to increase data sharing.
- Published
- 2018
- Full Text
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