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Since the traditional semi-supervised multi-view algorithms seldom take into account the diversity of information contained in different views and neglect the consistency of spatial structure between different views, they hardly achieve promising performance when dealing with multi-view data with noise and outlying entries. Although some researchers have proposed semi-supervised multi-view methods,these methods do not make full use of sample discriminant information and subspace structure information under different metric learning,which leads to the unsatisfactory classification results. To deal with the above problems,this paper proposes a semi-supervised multi-view classification via consistency constraint (SMCC) for multi-view data analysis. Firstly, the consistency constraints between different views are enhanced based on the Hilbert-Schmidt independence criteria (HSIC). Then, the dimensionality reduction is performed by feature projection to preserve the local manifold structure, which is integrated with Frobenius norm constraint to improve the robustness of the algorithm. Furthermore, the corresponding weights are adaptively assigned to different views to reduce the influence of feature information and noise pollution in different views. Finally, the proposed model can be solved efficiently using the linear alternative direction method with adaptive penalty and eigen-decomposition. The experimental results on four benchmark datasets show that the proposed algorithm can discover more effective discriminant information from multi-view data and its accuracy is improved.

Cannabis sativa has been used for improving sleep for long history. Cannabidiol (CBD) has drown much attention as a non-addictive psychoactive component in Cannabis sativa extract. However, the effects of CBD on sleep architecture and it's acting mechanism remains unclear. In the present study, we evaluated the sedative-hypnotic effect of cannabidiol (CBD), assessed the effects of CBD on sleep using a wireless physiological telemetry system. We further explored the therapeutic effects of CBD using 4-chloro-dl-phenylalanine (PCPA) induced insomnia model and changes in sleep latency, sleep duration and intestinal flora were evaluated. CBD shortened sleep latency and increases sleep duration in both normal and insomnia mice, and those effects were blocked by 5-HT1A receptor antagonist WAY100635. We determined that CBD increases 5-HT1A receptors expression and 5-HT content in the hypothalamus of PCPA-pretreated mice and affects tryptophan metabolism in the intestinal flora. These results showed that activation of 5-HT1A receptors is one of the potential mechanisms underlying the sedative-hypnotic effect of CBD. This study validated the effects of CBD on sleep and evaluated its potential therapeutic effects on insomnia. [ABSTRACT FROM AUTHOR]

Quantum computing is expected to break the computing power bottleneck with the help of quantum superposition and quantum entanglement. In order to fabricate fault-tolerant quantum computers for encoding quantum information, it is important to improve the cryogenic mobility of silicon-based metal oxide semiconductor field effect transistors (MOSFETs) with a thin gate dielectric layer as much as possible. Based on a thin SiO2/HfO2 stacked dielectric, we investigate the effect of post-deposition annealing (PDA) temperature on the MOSFET cryogenic transport properties. The results show that silicon atoms will diffuse into the HfO2 to form silicates during PDA, leading to the HfO2 dielectric constant decrease. As the PDA temperature increases, the proportion of monoclinic hafnium oxide decreases and the tetragonal phase increases gradually. The oxygen vacancy content increases gradually, resulting in fixed charge density increases and the mobility decreases. The contribution of the forming gas annealing (FGA) to the mobility enhancement is clarified and the HfO2 recrystallization process is revealed from the perspective of long-time annealing. Finally, the mobility peak of silicon MOSFETs with thin SiO2/HfO2 dielectrics is enhanced to 1387 cm2(V·s)−1 at 1.6 K, which provides a technical pathway for the development of silicon-based quantum computation. [ABSTRACT FROM AUTHOR]

This study aimed to investigate the effects of caprylic acid (C8:0) on lipid metabolism and inflammation, and examine the mechanisms underlying these effects in mice and cells. Fifty-six 6-week-old male C57BL/6J mice were randomly allocated to four groups fed a high-fat diet (HFD) without or with 2% C8:0, palmitic acid (C16:0) or eicosapentaenoic acid (EPA). RAW246.7 cells were randomly divided into five groups: normal, lipopolysaccharide (LPS), LPS+C8:0, LPS+EPA and LPS+cAMP. The serum lipid profiles, inflammatory biomolecules, and ABCA1 and JAK2/STAT3 mRNA and protein expression were measured. C8:0 decreased TC and LDL-C, and increased the HDL-C/LDL-C ratio after injection of LPS. Without LPS, it decreased TC in mice (P < 0.05). Moreover, C8:0 decreased the inflammatory response after LPS treatment in both mice and cells (P < 0.05). Mechanistic investigations in C57BL/6J mouse aortas after injection of LPS indicated that C8:0 resulted in higher ABCA1 and JAK2/STAT3 expression than that with HFD, C16:0 and EPA, and resulted in lower TNF-α, NF-κB mRNA expression than that with HFD (P < 0.05). In RAW 264.7 cells, C8:0 resulted in lower expression of pNF-κBP65 than that in the LPS group, and higher protein expression of ABCA1, p-JAK2 and p-STAT3 than that in the LPS and LPS+cAMP groups (P < 0.05). Our studies demonstrated that C8:0 may play an important role in lipid metabolism and the inflammatory response, and the mechanism may be associated with ABCA1 and the p-JAK2/p-STAT3 signaling pathway. [ABSTRACT FROM AUTHOR]

Objective: To study the ultrasound real-time tissue elastography technique used in the evaluation of cervical maturity during pregnancy. Methods: 145 pregnant women were divided into 3 groups according to the gestational weeks. All pregnant women in the routine obstetric ultrasound examination were voluntary to take transvaginal ultrasound cervical evaluation. Cervical length was measured based on two-dimensional ultrasound image, followed by real-time tissue elastography, and then strain rate in the cervical region of interest was gotten during early, mid and late pregnancy. Results: Cervical length and cervical defined region of interest differ at each pregnancy group had statistical significance (P<0.05), and the early and mid pregnancy group of cervical length is longer than the third trimester group, cervical defined region of interest differ is less than the late pregnancy group, the difference was statistically significant (P<0.05), while there was no statistically significant difference between the early and mid pregnancy group (P>0.05). The cervical length was negatively correlation with the strain rate (r=-0.95, P=0.032). Conclusions: Ultrasound real-time tissue elastography technology during pregnancy plays an important role in cervical maturity evaluation, and it provides accurate index about the cervical maturity. Also, it offers a new examination way to predict premature. [ABSTRACT FROM AUTHOR]

Hyperplasia of mammary glands is a benign breast disease with disordered breast structure. Nowadays, the incidence rate of breast hyperplasia in women is increasing year by year, and the etiology is related to the imbalance of estrogen and progesterone in the body. The symptoms include breast pain, breast nodules, or nipple discharge, which can develop into breast cancer in the context of psychological pressure. Therefore, it is timely and effectively necessary for people to treat the symptoms. At present, traditional Chinese medicine(TCM) often treats breast hyperplasia by oral drug, external application, acupuncture, moxibustion, and massage, while western medicine often uses hormone therapy or surgery. TCM can regulate hormone levels to treat breast hyperplasia. Acupuncture, moxibustion, and other methods can stimulate acupoints to reduce breast lumps. However, since TCM is easy to produce hepatorenal toxicity after long-term use and simple external treatment is slow to take effect, rapid and effective treatment is difficult to be achieved. Although western medicine can inhibit the disease, it is easy to produce toxic and side effects if taken for a long time. In addition, surgery can only remove the focus and the recurrence rate is high. Some studies have found that the combination of oral and external use of TCM compounds has a significant effect, with mild toxic and side effects, few adverse reactions, and a low recurrence rate. Based on the relevant literature in recent years, this article reviewed the combination of oral and external treatment of TCM in the treatment of hyperplasia of mammary glands, discussed the effectiveness, clinical evaluation indexes, and mechanism, and pointed out the existing shortcomings to explore a comprehensive therapy worthy of clinical application.

Hypertension plays an important role in the pathogenesis of stroke,which,however,is only known at the blood pressure level.The relationship between circadian rhythm of blood pressure(especially the circadian rhythm disorder of blood pressure)and stroke has been a hot research topic.This article reviews the concept of circadian rhythm of blood pressure,classification of circadian rhythm disorder of blood pressure,and the relationship of circadian rhythm disorder of blood pressure with ischemic stroke.

Background: In this multi-institutional prospective study, we aimed to assess the safety and efficacy of nedaplatin plus S-1 (NS) chemotherapy for patients with recurrent and metastatic nasopharyngeal carcinoma (NPC) when platinum-containing regimens failed., Methods: A total of 52 recurrent and metastatic NPC patients who previously received, but failed with platinum-containing chemotherapy, had oral S-1 chemotherapy (twice daily from the first day to the fourteenth day) and nedaplatin (80 mg/ m 2 , day 1) every 3 weeks. The body surface area (BSA) decided the dose of S-1: 40 mg twice a day when BSA < 1.25 m 2 ; 50 mg twice daily when 1.25 m 2 ⩽ BSA < 1.5 m 2 ; and 60 mg twice daily when BSA ⩾ 1.5 m 2 ., Results: Treatment was well tolerated. The main hematological adverse event was neutropenia. Five patients (9.6%) had grade 3 neutropenia. Three patients were found with grade 3 anemia (5.8%). One patient was found with grade 3 thrombocytopenia (1.9%). No patient was found with grade 3 or 4 nonhematological toxicity. The rates of complete response, partial response and overall response were 3.8%, 38.5% and 42.3%, respectively. Median time to progression was 6.2 months and median survival was 14.6 months. The rates of 1-year survival and 2-year survival were 63% and 27%, respectively., Conclusions: NS chemotherapy provides a satisfactory and safe clinical activity for patients with recurrent and metastatic NPC after platinum-containing chemotherapy failed., Competing Interests: Conflict of interest statement: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.