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2,651 results on '"Liang, Rui"'

1. Saving Private WAN: Using Internet Paths to Offload WAN Traffic in Conferencing Services

Author

Kataria, Bhaskar, LNU, Palak, Bothra, Rahul, Gandhi, Rohan, Bhattacherjee, Debopam, Padmanabhan, Venkata N., Atov, Irena, Ramakrishnan, Sriraam, Chaturmohta, Somesh, Kotipalli, Chakri, Liang, Rui, Sueda, Ken, He, Xin, and Hinton, Kevin

Subjects
Computer Science - Networking and Internet Architecture
Abstract

Large-scale video conferencing services incur significant network cost while serving surging global demands. Our work systematically explores the opportunity to offload a fraction of this traffic to the Internet, a cheaper routing option offered already by cloud providers, from WAN without drop in application performance. First, with a large-scale latency measurement study with 3.5 million data points per day spanning 241K source cities and 21 data centers across the globe, we demonstrate that Internet paths perform comparable to or better than the private WAN for parts of the world (e.g., Europe and North America). Next, we present Titan, a live (12+ months) production system that carefully moves a fraction of the conferencing traffic to the Internet using the above observation. Finally, we propose Titan-Next, a research prototype that jointly assigns the conferencing server and routing option (Internet or WAN) for individual calls. With 5 weeks of production data, we show Titan-Next reduces the sum of peak bandwidth on WAN links that defines the operational network cost by up to 61% compared to state-of-the-art baselines. We will open-source parts of the measurement data.

Published
2024

2. Robust single divacancy defects near stacking faults in 4H-SiC under resonant excitation

Author

He, Zhen-Xuan, Zhou, Ji-Yang, Lin, Wu-Xi, Li, Qiang, Liang, Rui-Jian, Wang, Jun-Feng, Wen, Xiao-Lei, Hao, Zhi-He, Liu, Wei, Ren, Shuo, Li, Hao, You, Li-Xing, Tang, Jian-Shun, Xu, Jin-Shi, Li, Chuan-Feng, and Guo, Guang-Can

Subjects
Quantum Physics
Abstract

Color centers in silicon carbide (SiC) have demonstrated significant promise for quantum information processing. However, the undesirable ionization process that occurs during optical manipulation frequently causes fluctuations in the charge state and performance of these defects, thereby restricting the effectiveness of spin-photon interfaces. Recent predictions indicate that divacancy defects near stacking faults possess the capability to stabilize their neutral charge states, thereby providing robustness against photoionization effects. In this work, we present a comprehensive protocol for the scalable and targeted fabrication of single divacancy arrays in 4H-SiC using a high-resolution focused helium ion beam. Through photoluminescence emission (PLE) experiments, we demonstrate long-term emission stability with minimal linewidth shift ($\sim$ 50 MHz over 3 hours) for the single c-axis divacancies within stacking faults. By measuring the ionization rate for different polytypes of divacancies, we found that the divacancies within stacking faults are more robust against resonant excitation. Additionally, angle-resolved PLE spectra reveal their two resonant-transition lines with mutually orthogonal polarizations. Notably, the PLE linewidths are approximately 7 times narrower and the spin-coherent times are 6 times longer compared to divacancies generated via carbon-ion implantation. These findings highlight the immense potential of SiC divacancies for on-chip quantum photonics and the construction of efficient spin-to-photon interfaces, indicating a significant step forward in the development of quantum technologies., Comment: 11 pages, 4 figures

Published
2024

6. Optimal divergence rate of the focusing Gibbs measure

Author

Li, Guopeng, Liang, Rui, and Wang, Yuzhao

Subjects
Mathematics - Probability, Mathematical Physics, Mathematics - Analysis of PDEs, 60H30, 81T08, 35Q55, 60H40
Abstract

We study the focusing Gibbs measure with critical/supercritical potentials. In particular, we prove asymptotic formulae for the frequency approximation of the partition function, which captures the optimal divergence rate of the partition function as the frequency truncation is removed., Comment: 15 pages

Published
2023

13. Gibbs dynamics for fractional nonlinear Schr\'odinger equations with weak dispersion

Author

Liang, Rui and Wang, Yuzhao

Subjects
Mathematics - Analysis of PDEs, 35Q55, 37K99
Abstract

We consider the Cauchy problem for the one-dimensional periodic cubic nonlinear fractional Schr{\"o}dinger equation (FNLS) with initial data distributed via its associated Gibbs measure. We construct global strong solutions with the flow property for the FNLS on the support of the Gibbs measure in the full dispersive range, thus resolving a question proposed by Sun-Tzvetkov (2021). As a byproduct, we prove the invariance of the Gibbs measure and almost sure global well-posedness for FNLS., Comment: 65 pages. Minor modifications. To appear in Comm. Math. Phys

Published
2023

14. Plasmonic-enhanced bright single spin defects in silicon carbide membranes

Author

Zhou, Ji-Yang, Li, Qiang, Hao, Zhi-He, Lin, Wu-Xi, He, Zhen-Xuan, Liang, Rui-Jian, Guo, Liping, Li, Hao, You, Lixing, Tang, Jian-Shun, Xu, Jin-Shi, Li, Chuan-Feng, and Guo, Guang-Can

Subjects
Physics - Optics, Quantum Physics
Abstract

Optically addressable spin defects in silicon carbide (SiC) have emerged as attractable platforms for various quantum technologies. However, the low photon count rate significantly limits their applications. We strongly enhanced the brightness by 7 times and spin-control strength by 14 times of single divacancy defects in 4H-SiC membranes using surface plasmon generated by gold film coplanar waveguides. The mechanism of the plasmonic-enhanced effect is further studied by tuning the distance between single defects and the surface of the gold film. A three-energy-level model is used to determine the corresponding transition rates consistent with the enhanced brightness of single defects. Lifetime measurements also verified the coupling between defects and surface plasmons. Our scheme is low-cost, without complicated microfabrication and delicate structures, which is applicable for other spin defects in different materials. This work would promote developing spin defect-based quantum applications in mature SiC materials.

Published
2023
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16. Review of Progress in Proactive Health Research

Author

Zou, Lin, Cao, Licong, Li, Weiping, Pan, Yichen, Liang, Rui, Chen, Jianxiong, Striełkowski, Wadim, Editor-in-Chief, Black, Jessica M., Series Editor, Butterfield, Stephen A., Series Editor, Chang, Chi-Cheng, Series Editor, Cheng, Jiuqing, Series Editor, Dumanig, Francisco Perlas, Series Editor, Al-Mabuk, Radhi, Series Editor, Scheper-Hughes, Nancy, Series Editor, Urban, Mathias, Series Editor, Webb, Stephen, Series Editor, Rad, Dana, editor, Chew, Fong Peng, editor, Hutagalung, Fonny Dameaty, editor, and Birkök, Cüneyt, editor

Published
2024
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17. The Concept and Framework Construction of Proactive Health

Author

Zou, Lin, Cao, Licong, Li, Weiping, Pan, Yichen, Liang, Rui, Chen, Jianxiong, Striełkowski, Wadim, Editor-in-Chief, Black, Jessica M., Series Editor, Butterfield, Stephen A., Series Editor, Chang, Chi-Cheng, Series Editor, Cheng, Jiuqing, Series Editor, Dumanig, Francisco Perlas, Series Editor, Al-Mabuk, Radhi, Series Editor, Scheper-Hughes, Nancy, Series Editor, Urban, Mathias, Series Editor, Webb, Stephen, Series Editor, Rad, Dana, editor, Chew, Fong Peng, editor, Hutagalung, Fonny Dameaty, editor, and Birkök, Cüneyt, editor

Published
2024
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18. Multi-objective Optimization Scheduling of Photovoltaic Thermal Power Units Based on Electric Vehicles: An Improved NSGA-II Algorithm

Author

Li, Pengfei, Yang, Zhile, Guo, Yuanjun, Zhu, Xiaodong, Zhang, Linxin, Liang, Rui, Angrisani, Leopoldo, Series Editor, Arteaga, Marco, Series Editor, Chakraborty, Samarjit, Series Editor, Chen, Shanben, Series Editor, Chen, Tan Kay, Series Editor, Dillmann, Rüdiger, Series Editor, Duan, Haibin, Series Editor, Ferrari, Gianluigi, Series Editor, Ferre, Manuel, Series Editor, Hirche, Sandra, Series Editor, Jabbari, Faryar, Series Editor, Jia, Limin, Series Editor, Kacprzyk, Janusz, Series Editor, Khamis, Alaa, Series Editor, Kroeger, Torsten, Series Editor, Li, Yong, Series Editor, Liang, Qilian, Series Editor, Martín, Ferran, Series Editor, Ming, Tan Cher, Series Editor, Minker, Wolfgang, Series Editor, Misra, Pradeep, Series Editor, Mukhopadhyay, Subhas, Series Editor, Ning, Cun-Zheng, Series Editor, Nishida, Toyoaki, Series Editor, Oneto, Luca, Series Editor, Panigrahi, Bijaya Ketan, Series Editor, Pascucci, Federica, Series Editor, Qin, Yong, Series Editor, Seng, Gan Woon, Series Editor, Speidel, Joachim, Series Editor, Veiga, Germano, Series Editor, Wu, Haitao, Series Editor, Zamboni, Walter, Series Editor, Tan, Kay Chen, Series Editor, Hu, Cungang, editor, and Cao, Wenping, editor

Published
2024
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19. FEDSET: Federated Random Forest Based on Differential Privacy

Author

Tao, Fuqiang, Sun, Zhe, Liang, Rui, Shao, Rundong, Chai, Yuhan, Wang, Yangyang, Ceccarelli, Marco, Series Editor, Agrawal, Sunil K., Advisory Editor, Corves, Burkhard, Advisory Editor, Glazunov, Victor, Advisory Editor, Hernández, Alfonso, Advisory Editor, Huang, Tian, Advisory Editor, Jauregui Correa, Juan Carlos, Advisory Editor, Takeda, Yukio, Advisory Editor, and Li, Shaofan, editor

Published
2024
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24. Identification of fatty acids synthesis and metabolism-related gene signature and prediction of prognostic model in hepatocellular carcinoma

Author

Ai Zhengdong, Xing Xiaoying, Fu Shuhui, Liang Rui, Tang Zehui, Song Guanbin, Yang Li, Tang Xi, and Liu Wanqian

Subjects
Fatty acids, Immune microenvironment, Hepatocellular carcinoma, Acetyl-CoA carboxylase1, Cancer stemness, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671
Abstract

Abstract Background Fatty acids synthesis and metabolism (FASM)-driven lipid mobilization is essential for energy production during nutrient shortages. However, the molecular characteristics, physiological function and clinical prognosis value of FASM-associated gene signatures in hepatocellular carcinoma (HCC) remain elusive. Methods The Gene Expression Omnibus database (GEO), the Cancer Genome Atlas (TCGA), and International Cancer Genome Consortium (ICGC) database were utilized to acquire transcriptome data and clinical information of HCC patients. The ConsensusClusterPlus was employed for unsupervised clustering. Subsequently, immune cell infiltration, stemness index and therapeutic response among distinct clusters were decoded. The tumor immune dysfunction and exclusion (TIDE) algorithm was utilized to anticipate the response of patients towards immunotherapy, and the genomics of drug sensitivity in cancer (GDSC) tool was employed to predict their response to antineoplastic medications. Least absolute shrinkage and selection operator (LASSO) regression analysis and protein–protein interaction (PPI) network were employed to construct prognostic model and identity hub gene. Single cell RNA sequencing (scRNA-seq) and CellChat were used to analyze cellular interactions. The hub gene of FASM effect on promoting tumor progression was confirmed through a series of functional experiments. Results Twenty-six FASM-related genes showed differential expression in HCC. Based on these FASM-related differential genes, two molecular subtypes were established, including Cluster1 and Cluster2 subtype. Compared with cluster2, Cluster1 subtype exhibited a worse prognosis, higher risk, higher immunosuppressive cells infiltrations, higher immune escape, higher cancer stemness and enhanced treatment-resistant. PPI network identified Acetyl-CoA carboxylase1 (ACACA) as central gene of FASM and predicted a poor prognosis. A strong interaction between cancer stem cells (CSCs) with high expression of ACACA and macrophages through CD74 molecule (CD74) and integrin subunit beta 1 (ITGB1) signaling was identified. Finally, increased ACACA expression was observed in HCC cells and patients, whereas depleted ACACA inhibited the stemness straits and drug resistance of HCC cells. Conclusions This study provides a resource for understanding FASM heterogeneity in HCC. Evaluating the FASM patterns can help predict the prognosis and provide new insights into treatment response in HCC patients.

Published
2024
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25. Human germline heterozygous gain-of-function STAT6 variants cause severe allergic disease

Author

Sharma, Mehul, Leung, Daniel, Momenilandi, Mana, Jones, Lauren CW, Pacillo, Lucia, James, Alyssa E, Murrell, Jill R, Delafontaine, Selket, Maimaris, Jesmeen, Vaseghi-Shanjani, Maryam, Del Bel, Kate L, Lu, Henry Y, Chua, Gilbert T, Di Cesare, Silvia, Fornes, Oriol, Liu, Zhongyi, Di Matteo, Gigliola, Fu, Maggie P, Amodio, Donato, San Tam, Issan Yee, Chan, Gavin Shueng Wai, Sharma, Ashish A, Dalmann, Joshua, van der Lee, Robin, Blanchard-Rohner, Géraldine, Lin, Susan, Philippot, Quentin, Richmond, Phillip A, Lee, Jessica J, Matthews, Allison, Seear, Michael, Turvey, Alexandra K, Philips, Rachael L, Brown-Whitehorn, Terri F, Gray, Christopher J, Izumi, Kosuke, Treat, James R, Wood, Kathleen H, Lack, Justin, Khleborodova, Asya, Niemela, Julie E, Yang, Xingtian, Liang, Rui, Kui, Lin, Wong, Christina Sze Man, Poon, Grace Wing Kit, Hoischen, Alexander, van der Made, Caspar I, Yang, Jing, Chan, Koon Wing, Da Rosa Duque, Jaime Sou, Lee, Pamela Pui Wah, Ho, Marco Hok Kung, Chung, Brian Hon Yin, Le, Huong Thi Minh, Yang, Wanling, Rohani, Pejman, Fouladvand, Ali, Rokni-Zadeh, Hassan, Changi-Ashtiani, Majid, Miryounesi, Mohammad, Puel, Anne, Shahrooei, Mohammad, Finocchi, Andrea, Rossi, Paolo, Rivalta, Beatrice, Cifaldi, Cristina, Novelli, Antonio, Passarelli, Chiara, Arasi, Stefania, Bullens, Dominique, Sauer, Kate, Claeys, Tania, Biggs, Catherine M, Morris, Emma C, Rosenzweig, Sergio D, O’Shea, John J, Wasserman, Wyeth W, Bedford, H Melanie, van Karnebeek, Clara DM, Palma, Paolo, Burns, Siobhan O, Meyts, Isabelle, Casanova, Jean-Laurent, Lyons, Jonathan J, Parvaneh, Nima, Van Nguyen, Anh Thi, Cancrini, Caterina, Heimall, Jennifer, Ahmed, Hanan, McKinnon, Margaret L, Lau, Yu Lung, Béziat, Vivien, and Turvey, Stuart E

Subjects
Genetics, Rare Diseases, Clinical Research, 2.1 Biological and endogenous factors, Aetiology, Inflammatory and immune system, Humans, STAT6 Transcription Factor, Gain of Function Mutation, Asthma, Food Hypersensitivity, Immunoglobulin E, Medical and Health Sciences, Immunology
Abstract

STAT6 (signal transducer and activator of transcription 6) is a transcription factor that plays a central role in the pathophysiology of allergic inflammation. We have identified 16 patients from 10 families spanning three continents with a profound phenotype of early-life onset allergic immune dysregulation, widespread treatment-resistant atopic dermatitis, hypereosinophilia with esosinophilic gastrointestinal disease, asthma, elevated serum IgE, IgE-mediated food allergies, and anaphylaxis. The cases were either sporadic (seven kindreds) or followed an autosomal dominant inheritance pattern (three kindreds). All patients carried monoallelic rare variants in STAT6 and functional studies established their gain-of-function (GOF) phenotype with sustained STAT6 phosphorylation, increased STAT6 target gene expression, and TH2 skewing. Precision treatment with the anti-IL-4Rα antibody, dupilumab, was highly effective improving both clinical manifestations and immunological biomarkers. This study identifies heterozygous GOF variants in STAT6 as a novel autosomal dominant allergic disorder. We anticipate that our discovery of multiple kindreds with germline STAT6 GOF variants will facilitate the recognition of more affected individuals and the full definition of this new primary atopic disorder.

Published
2023

26. Study on the response of the winding direction of multi-layer CORC cable to its electromagnetic characteristics.

Author

Jia, Rongli, Zhou, Wenhai, Liang, Rui, Su, Bingxu, and Hu, Zongwu

Subjects
HIGH temperature superconductors, CABLES, STRAINS & stresses (Mechanics), ELECTROMAGNETIC fields, ADHESIVE tape, MAGNETIC fields, ATHLETIC tape
Abstract

A Conductor on Round Core (CORC) cable wound with a high-temperature superconductor is an important cable concept for high-current density applications. It is widely used in large power systems because of its advantages of good flexibility and high engineering current density. However, the complex design structure of CORC cable makes it very difficult to understand its electromagnetic properties (such as AC loss). In particular, the different winding directions of each layer in multi-layer cable have a great influence on its electromagnetic characteristics. In this paper, the H-method is used to solve the electromagnetism and mechanics equations. The influence of the winding direction of CORC cable on its electromagnetic field distribution characteristics, AC loss, and mechanical variation under the action of external magnetic field is investigated. The AC loss study of single-layer cable reveals that when the applied magnetic field is increased from 0.01 to 0.02 and 0.03 T, the AC loss peak of the cable increases by 107 and 103 orders of magnitude, respectively, indicating that the effect of low applied magnetic field on the AC loss of the cable is more significant. For multi-layer cables, cables with opposite winding directions have a greater depth of current density penetration than cables with the same winding direction. In addition, the mechanical variations of multi-layer cables with different winding orientations are explored. The results show that the Mises stress in the cable with the same winding direction is about 32% higher than that of the cable with the opposite winding direction, which indicates that the method of winding the cable in the opposite direction between adjacent layers of tape can avoid excessive mechanical stress. [ABSTRACT FROM AUTHOR]

Published
2024
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