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141 results on '"Legnani, Cristina"'

1. More early bleeds associated with high baseline direct oral anticoagulant levels in atrial fibrillation: the MAS study

Author

Testa, Sophie, Dellanoce, Claudia, Paoletti, Oriana, Morandini, Rossella, Tala, Maurizio, Ciampa, Antonio, Gaeta, Martina, Chiarugi, Paolo, Casini, Monica, Guerri, Valentina, Santoro, Rita Carlotta, Iannaccaro, Piergiorgio, Iannone, Angela Maria, Campagna, Maddalena, De Candia, Erica, Alberelli, Maria Adele, Basso, Maria, De Cristofaro, Raimondo, Di Gennaro, Leonardo, Ferretti, Antonietta, Sorrentino, Silvia, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Saliola, Mirella, Faioni, Elena Maria, Avarello, Ilaria, Razzari, Cristina, Chistolini, Antonio, Aprile, Simona Michela, Santoro, Cristina, Serrao, Alessandra, Esteban, Maria del Pilar, Ricca, Sergio, Marietta, Marco, Arletti, Laura, Coluccio, Valeria, Debbia, Giulia, Grisolia, Deborah, Serra, Domizio, Orselli, Alberto, Pescarollo, Alessandra, Verna, Sandra, Di Gregorio, Patrizia, Cassetti, Giuseppina, Molteni, Mauro, Monelli, Mauro, Paparo, Carmelo, Resani, Guido, Di Gregorio, Nicoletta, Grassi, Davide, Lodigiani, Corrado, Banfi, Elena, Ferrazzi, Paola, Librè, Luca, Pacetti, Veronica, Sacco, Clara, Bucciarelli, Paolo, Martinelli, Ida, Abbattista, Maria, Artoni, Andrea, Capecchi, Marco, Gianniello, Francesca, Scimeca, Barbara, Turrini, Anna, Moretta, Francesca, Parise, Giorgio, Zeccardo, Ciro, Fregoni, Vittorio, Balboni, Massimo, Leggio, Federico, Poli, Daniela, Ria, Luigi, Spagnolo, Marina, Dirienzo, Giovanni, Dirienzo, Lavinia, Fuzio, Diana, Donadini, Marco Paolo, Squizzato, Alessandro, Ageno, Walter, Colombo, Giovanna, Galliazzo, Silvia, Gallo, Andrea, Tamborini Permunian, Eleonora, Virano, Alexandra, Falanga, Anna, Barcella, Luca, Gamba, Sara, Lerede, Teresa, Maggioni, Anna, Russo, Laura, Schieppati, Francesca, Zunino, Federica, Barillari, Giovanni, Bertone, Antonella, Poz, Alessandra, Venturelli, Ugo, Serricchio, Giuseppina, Brevi, Francesca, Palareti, Gualtiero, Legnani, Cristina, Cini, Michela, Antonucci, Emilia, Tripodi, Armando, and Tosetto, Alberto

Published
2024
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4. Thrombotic events associated with low baseline direct oral anticoagulant levels in atrial fibrillation: the MAS study

Author

Testa, Sophie, Dellanoce, Claudia, Paoletti, Oriana, Morandini, Rossella, Tala, Maurizio, Ciampa, Antonio, Gaeta, Martina, Chiarugi, Paolo, Casini, Monica, Guerri, Valentina, Santoro, Rita Carlotta, Iannaccaro, Piergiorgio, Iannone, Angela Maria, Campagna, Maddalena, De Candia, Erica, Alberelli, Maria Adele, Basso, Maria, De Cristofaro, Raimondo, Di Gennaro, Leonardo, Ferretti, Antonietta, Sorrentino, Silvia, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Saliola, Mirella, Faioni, Elena Maria, Avarello, Ilaria, Razzari, Cristina, Chistolini, Antonio, Aprile, Simona Michela, Santoro, Cristina, Serrao, Alessandra, Esteban, Maria del Pilar, Ricca, Sergio, Marietta, Marco, Arletti, Laura, Coluccio, Valeria, Debbia, Giulia, Grisolia, Deborah, Serra, Domizio, Orselli, Alberto, Pescarollo, Alessandra, Verna, Sandra, Di Gregorio, Patrizia, Cassetti, Giuseppina, Molteni, Mauro, Monelli, Mauro, Paparo, Carmelo, Resani, Guido, Di Gregorio, Nicoletta, Grassi, Davide, Lodigiani, Corrado, Banfi, Elena, Ferrazzi, Paola, Librè, Luca, Pacetti, Veronica, Sacco, Clara, Bucciarelli, Paolo, Martinelli, Ida, Abbattista, Maria, Artoni, Andrea, Capecchi, Marco, Gianniello, Francesca, Scimeca, Barbara, Turrini, Anna, Moretta, Francesca, Parise, Giorgio, Zeccardo, Ciro, Fregoni, Vittorio, Balboni, Massimo, Leggio, Federico, Poli, Daniela, Ria, Luigi, Spagnolo, Marina, Dirienzo, Giovanni, Dirienzo, Lavinia, Fuzio, Diana, Donadini, Marco Paolo, Squizzato, Alessandro, Ageno, Walter, Colombo, Giovanna, Galliazzo, Silvia, Gallo, Andrea, Permunian, Eleonora Tamborini, Virano, Alexandra, Falanga, Anna, Barcella, Luca, Gamba, Sara, Lerede, Teresa, Maggioni, Anna, Russo, Laura, Schieppati, Francesca, Zunino, Federica, Barillari, Giovanni, Bertone, Antonella, Poz, Alessandra, Venturelli, Ugo, Serricchio, Giuseppina, Brevi, Francesca, Palareti, Gualtiero, Legnani, Cristina, Cini, Michela, Antonucci, Emilia, Tripodi, Armando, and Tosetto, Alberto

Published
2024
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6. MORE EARLY BLEEDS ASSOCIATED WITH HIGH BASELINE DIRECT ORAL ANTICOAGULANT LEVELS IN ATRIAL FIBRILLATION: THE MAS STUDY

Author

Palareti, Gualtiero, primary, Testa, Sophie, additional, Legnani, Cristina, additional, Dellanoce, Claudia, additional, Cini, Michela, additional, Paoletti, Oriana, additional, Ciampa, Antonio, additional, Antonucci, Emilia, additional, Poli, Daniela, additional, Morandini, Rossella, additional, Tala, Maurizio, additional, Chiarugi, Paolo, additional, Santoro, Rita Carlotta, additional, Iannone, Angela Maria, additional, De Candia, Erica, additional, Pignatelli, Pasquale, additional, Faioni, Elena Maria, additional, Chistolini, Antonio, additional, Esteban, Maria del Pilar, additional, Marietta, Marco, additional, Tripodi, Armando, additional, and Tosetto, Alberto, additional

Published
2024
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7. D-dimer and reduced-dose apixaban for extended treatment after unprovoked venous thromboembolism: the Apidulcis study

Author

Palareti, Gualtiero, Poli, Daniela, Ageno, Walter, Legnani, Cristina, Antonucci, Emilia, Bucherini, Eugenio, Testa, Sophie, Paoletti, Oriana, Chistolini, Antonio, Serrao, Alessandra, Martinelli, Ida, Bucciarelli, Paolo, Falanga, Anna, Tosetto, Alberto, Sarti, Luca, Mastroiacovo, Daniela, Cosmi, Benilde, Visonà, Adriana, Santoro, Rita Carlotta, Zanatta, Nello, Grandone, Elvira, Bertù, Lorenza, Pengo, Vittorio, Caiano, Lucia, and Prandoni, Paolo

Published
2022
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8. Long‐term risk of recurrent venous thromboembolism among patients receiving extended oral anticoagulant therapy for first unprovoked venous thromboembolism: A systematic review and meta‐analysis

Author

Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S., Kearon, Clive, Weitz, Jeffrey I., Büller, Harry R., Raskob, Gary E., Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A., Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, Geersing, Geert‐Jan, Takada, Toshihiko, Cosmi, Benilde, Aujesky, Drahomir, Marconi, Letizia, Palla, Antonio, Siragusa, Sergio, Bradbury, Charlotte A., Parpia, Sameer, Mallick, Ranjeeta, Lensing, Anthonie W.A., Gebel, Martin, Grosso, Michael A., Shi, Minggao, Thavorn, Kednapa, Hutton, Brian, Le Gal, Gregoire, Rodger, Marc, and Fergusson, Dean

Published
2021
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10. Sex Differences in Clinical Presentation of Lower Extremity Deep Vein Thrombosis.

Author

Cosmi, Benilde, Borgese, Laura, Legnani, Cristina, Sartori, Michelangelo, and Palareti, Gualtiero

Subjects
LEG, OUTPATIENT services in hospitals, VENOUS thrombosis, SEX distribution, FIBRIN fibrinogen degradation products, RETROSPECTIVE studies, HOSPITAL emergency services, DESCRIPTIVE statistics, COMPARATIVE studies, ALGORITHMS, SYMPTOMS
Abstract

Background: Differences between men and women in the clinical features and extent of lower limb deep vein thrombosis (DVT) may influence DVT diagnostic algorithms involving pretest clinical probability (PTP) assessment, D-dimer, and compression ultrasonography (CUS). Aims: To assess differences in DVT clinical presentation between men and women and their effect on PTP and D-dimer. Methods: We conducted a retrospective study in outpatients referred for suspected DVT of the lower limbs to our vascular emergency department from January 2005 to December 2019. Patients underwent PTP assessment with the Wells score, D-dimer testing, and CUS. Results: More women were referred for suspected DVT than men (M/F: 1,785/2,821; F: 61.4%; p < 0.0001). Women were older than men (median age: 71 vs. 67 years; p = 0.0001), DVT was diagnosed in 436 patients (9.4%) but in more men than women (M: 210 [11.8%] vs. F: 226 [8%]; p = 0.0002), with more proximal DVT in men than women (M: 131 7.3% vs. F: 124 [4.4%]; p = 0.00021). PTP was more likely in men (355 [19.9%]) than women (455 [16.2%]) (p = 0.0011); more men had swelling in the entire limb, increased calf circumference by >3 cm compared with the contralateral limb, and pitting edema, than women. D-dimer levels (available in 65% of patients) were more frequently positive in women with DVT than in men (94.6% vs. 85.7%; p = 0.016). However, a positive D-dimer and/or likely PTP was similarly frequent in men (92%) and women (96%) with DVT. Conclusions: More women than men are referred for suspected DVT, and men have a higher prevalence of proximal DVT. However, current algorithms for DVT diagnosis perform similarly in men and in women. [ABSTRACT FROM AUTHOR]

Published
2024
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11. LOW LEVELS OF DIRECT ORAL ANTICOAGULANTS AT STEADY STATE IN ATRIAL FIBRILLATION PATIENTS WHO LATER DEVELOP THROMBOTIC COMPLICATIONS; THE PROSPECTIVE MAS (MEASURE AND SEE) STUDY

Author

Testa, Sophie, primary, Palareti, Gualtiero, additional, LEGNANI, CRISTINA, additional, Dellanoce, Claudia, additional, Cini, Michela, additional, Paoletti, Oriana, additional, Ciampa, Antonio, additional, Antonucci, Emilia, additional, Poli, Daniela, additional, Morandini, Rossella, additional, Tala, Maurizio, additional, Chiarugi, Paolo, additional, Santoro, Rita Carlotta, additional, Iannone, Angela Maria, additional, De Candia, Erica, additional, Pignatelli, Pasquale, additional, Faioni, Elena, additional, Chistolini, Antonio, additional, Esteban, Maria Del Pilar, additional, Marietta, Marco, additional, Tripodi, Armando, additional, and Tosetto, Alberto, additional

Published
2023
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17. COVID-19 pandemic affects the ability of negative D-dimer to identify venous thromboembolism patients at low risk of recurrence: insights from the Apidulcis study

Author

Palareti, Gualtiero, Legnani, Cristina, Poli, Daniela, Ageno, Walter, Pengo, Vittorio, Testa, Sophie, Tosetto, Alberto, Prandoni, Paolo, De Candia, Erica, De Candia E (ORCID:0000-0003-0942-2819), Palareti, Gualtiero, Legnani, Cristina, Poli, Daniela, Ageno, Walter, Pengo, Vittorio, Testa, Sophie, Tosetto, Alberto, Prandoni, Paolo, De Candia, Erica, and De Candia E (ORCID:0000-0003-0942-2819)

Abstract

N/A

Published
2023

19. Evaluation of Coaguchek®Pro II coagulation testing device performance to assess direct oral anticoagulant action. The DOAC-CHECK study

Author

Legnani, Cristina, primary, Cini, Michela, additional, Testa, Sophie, additional, Tosetto, Alberto, additional, Dellanoce, Claudia, additional, Bellesso, Stefania, additional, Carli, Giuseppe, additional, Nichele, Ilaria, additional, Lissandrini, Laura, additional, Zorzi, Serena, additional, Antonucci, Emilia, additional, and Palareti, Gualtiero, additional

Published
2022
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23. Rationale and design of a study on D-dimer use to stratify patients after a first unprovoked venous thromboembolism for their risk of recurrence: extended low-dose Apixaban given only to patients with positive D-dimer results

Author

Palareti, Gualtiero, primary, Prandoni, Paolo, additional, Legnani, Cristina, additional, Antonucci, Emilia, additional, Zorzi, Serena, additional, Tosetto, Alberto, additional, Bertù, Lorenza, additional, Testa, Sophie, additional, Pengo, Vittorio, additional, Ageno, Walter, additional, Martinelli, Ida, additional, Cosmi, Benilde, additional, Bucherini, Eugenio, additional, and Poli, Daniela, additional

Published
2022
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24. Long-term Risk of Recurrent Venous Thromboembolism Among Patients Receiving Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism

Author

Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S, Kearon, Clive, Weitz, Jeffrey I, Büller, Harry R, Raskob, Gary E, Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A, Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, Geersing, Geert-Jan, Takada, Toshihiko, Cosmi, Benilde, Aujesky, Drahomir, Marconi, Letizia, Palla, Antonio, Siragusa, Sergio, Bradbury, Charlotte A, Parpia, Sameer, Mallick, Ranjeeta, Lensing, Anthonie W A, Gebel, Martin, Grosso, Michael A, Shi, Minggao, Thavorn, Kednapa, Hutton, Brian, Le Gal, Gregoire, Rodger, Marc, and Fergusson, Dean

Subjects
cardiovascular diseases, equipment and supplies
Abstract

BACKGROUND The long-term risk for recurrent venous thromboembolism (VTE) during extended anticoagulation for a first unprovoked VTE is uncertain. OBJECTIVES To determine the incidence of recurrent VTE during extended anticoagulation up to 5 years in patients with a first unprovoked VTE. METHODS MEDLINE, EMBASE, and the Cochrane CENTRAL were searched to identify randomized trials and prospective cohort studies reporting recurrent VTE among patients with a first unprovoked VTE who were to receive anticoagulation for a minimum of 6 additional months after completing ≥ 3 months of initial treatment. Unpublished data on number of recurrent VTE and person-years, obtained from authors of included studies, were used to calculate study-level incidence rate, and random-effects meta-analysis was used to pool results. RESULTS Twenty-six studies and 15, 603 patients were included in the analysis. During 11, 631 person-years of follow-up, the incidence of recurrent VTE and fatal pulmonary embolism per 100 person-years was 1.41 (95% CI, 1.03-1.84) and 0.09 (0.04-0.16), with 5-year cumulative incidences of 7.1% (3.0%-13.2%) and 1.2% (0.4%-4.6%), respectively. The incidence of recurrent VTE was 1.08 (95% CI, 0.77-1.44) with direct oral anticoagulants and 1.55 (1.01-2.20) with vitamin K antagonists. The case-fatality rate of recurrent VTE was 4.9% (95% CI, 2.2%-8.7%). CONCLUSIONS In patients with a first unprovoked VTE, the long-term risk of recurrent VTE during extended anticoagulation is low but not negligible. Thus, clinicians and patients should be aware of this risk and take appropriate and timely action in case of suspicion of recurrent VTE. Estimates from this study can be used to advise patients on what to expect while receiving extended anticoagulation, and estimate the net clinical benefit of extended treatment to guide long-term management of unprovoked VTE.

Published
2021

28. Thrombophilia testing in the real-world clinical setting of thrombosis centres taking part in the Italian Start 2-Register

Author

Legnani, Cristina, Palareti, Gualtiero, Antonucci, Emilia, Poli, Daniela, Cosmi, Benilde, Falanga, Anna, Mastroiacovo, Daniela, Testa, Sophie, Paoletti, Oriana, Morandini, Rossella, Marcucci, Rossella, Maggini, Niccolò, Guazzaloca, Giuliana, Lerede, Teresa, Barcella, Luca, Bucherini, Eugenio, Chiarugi, Paolo, Grandone, Elvira, Colaizzo, Donatella, Pengo, Vittorio, Pignatelli, Pasquale, Pastori, Daniele, Piana, Antonietta, Cibecchini, Francesco, Martini, Giuliana, Bradamante, Salvatore, Masciocco, Lucilla, Paparo, Carmelo, Ageno, Walter, Colombo, Giovanna, Vasselli, Claudio, Toma, Andrea, Visonà, Adriana, Tonello, Diego, Legnani, C., Palareti, G., Antonucci, E., Poli, D., Cosmi, B., Falanga, A., Mastroiacovo, D., and Testa, S.

Subjects
Haemostasis And Thrombosis, Recurrent event, Incidence, anticoagulant, Bleeding, Thrombosis, Venous Thromboembolism, Italy, thrombofilia, Humans, Thrombophilia, VTE, thrombosis, Prospective Studies, Anticoagulant therapy, Factor Xa Inhibitors, Follow-Up Studies
Abstract

Background - Even though it rarely influences venous thromboembolism (VTE) treatment and the fact that it is generally discouraged, thrombophilia testing is still largely prescribed. We assessed: 1) whether/how frequently Italian thrombosis centres requested thrombophilia testing; 2) what results were obtained; and 3) if the results affected treatment and clinical results. Materials and methods - We examined data from 4,826 VTE patients enrolled by 19 clinical centres participating in the START 2-Register. Results - 57.2% of patients were tested. Numbers varied widely among centres (2.9-99.7%). Thrombophilic alterations were recorded in 18.2% of patients and the percentage of positive results was inversely correlated with that of patients tested. Significantly less patients with deep vein thrombosis (DVT) were tested, whereas more were tested when the event was idiopathic, presenting as isolated pulmonary embolism (PE), or in unusual sites. Patients with thrombophilic alterations were younger, more frequently treated with direct oral anticoagulants (DOACs), with lower mortality and less frequently discontinued anticoagulation. DOACs were more frequently prescribed in patients with heterozygous Factor V (FV) Leiden or prothrombin mutations, whereas vitamin K antagonists were preferred in patients with inhibitor deficiencies, combined alterations or antiphospholipid syndrome (APLS). There was no difference in duration of treatment among those with or without alterations, though more APLS patients received an extended treatment course. Bleeding and thrombotic complications occurred with a similar and fairly low incidence in patients with or without thrombophilic alterations. Discussion - Although general testing for thrombophilia in VTE patients is currently discouraged, more than half of the VTE patients included in the START2-Register were tested. However, there were marked differences in practice between Italian thrombosis centres. About 60% of all patients with alterations were treated with DOACs, confirming that DOACs can be a useful option for treatment of thrombophilic VTE patients, with the exclusion of those with APLS. IMTIPRO Sr © SIMTIPRO Srl

Published
2021

29. Management and Outcomes of Isolated Distal Deep Vein Thromboses: A Questionable Trend toward Long-Lasting Anticoagulation Treatment. Results from the START-Register

Author

Palareti, Gualtiero, additional, Legnani, Cristina, additional, Antonucci, Emilia, additional, Testa, Sophie, additional, Mastroiacovo, Daniela, additional, Cosmi, Benilde, additional, Poli, Daniela, additional, Bucherini, Eugenio, additional, Dentali, Francesco, additional, Fontanella, Andrea, additional, Mumoli, Nicola, additional, Imberti, Davide, additional, Falanga, Anna, additional, Ageno, Walter, additional, and Pomero, Fulvio, additional

Published
2021
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30. Long-term risk of recurrent venous thromboembolism among patients receiving extended oral anticoagulant therapy for first unprovoked venous thromboembolism: A systematic review and meta-analysis

Author

HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S, Kearon, Clive, Weitz, Jeffrey I, Büller, Harry R, Raskob, Gary E, Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A, Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, Geersing, Geert-Jan, Takada, Toshihiko, Cosmi, Benilde, Aujesky, Drahomir, Marconi, Letizia, Palla, Antonio, Siragusa, Sergio, Bradbury, Charlotte A, Parpia, Sameer, Mallick, Ranjeeta, Lensing, Anthonie W A, Gebel, Martin, Grosso, Michael A, Shi, Minggao, Thavorn, Kednapa, Hutton, Brian, Le Gal, Gregoire, Rodger, Marc, Fergusson, Dean, HAG Trombose, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S, Kearon, Clive, Weitz, Jeffrey I, Büller, Harry R, Raskob, Gary E, Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A, Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, Geersing, Geert-Jan, Takada, Toshihiko, Cosmi, Benilde, Aujesky, Drahomir, Marconi, Letizia, Palla, Antonio, Siragusa, Sergio, Bradbury, Charlotte A, Parpia, Sameer, Mallick, Ranjeeta, Lensing, Anthonie W A, Gebel, Martin, Grosso, Michael A, Shi, Minggao, Thavorn, Kednapa, Hutton, Brian, Le Gal, Gregoire, Rodger, Marc, and Fergusson, Dean

Published
2021

32. Bleeding and thrombotic complications during treatment with direct oral anticoagulants or vitamin K antagonists in venous thromboembolic patients included in the prospective, observational START2-register

Author

Palareti, Gualtiero, primary, Antonucci, Emilia, additional, Legnani, Cristina, additional, Mastroiacovo, Daniela, additional, Poli, Daniela, additional, Prandoni, Paolo, additional, Tosetto, Alberto, additional, Pengo, Vittorio, additional, Testa, Sophie, additional, and Ageno, Walter, additional

Published
2020
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33. Design and rationale of a randomized, placebo-controlled trial on the efficacy and safety of sulodexide for extended treatment in elderly patients after a first venous thromboembolism

Author

Palareti, Gualtiero, primary, Legnani, Cristina, additional, Antonucci, Emilia, additional, Zorzi, Serena, additional, Bignamini, Angelo A., additional, Lodigiani, Corrado, additional, Tosetto, Alberto, additional, Bertù, Lorenza, additional, Pengo, Vittorio, additional, Testa, Sophie, additional, Ageno, Walter, additional, Prisco, Domenico, additional, Prandoni, Paolo, additional, and Poli, Daniela, additional

Published
2020
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34. DOAC plasma levels measured by chromogenic anti‐Xa assays and HPLC‐UV in apixaban‐ and rivaroxaban‐treated patients from the START‐Register

Author

Cini, Michela, primary, Legnani, Cristina, additional, Padrini, Roberto, additional, Cosmi, Benilde, additional, Dellanoce, Claudia, additional, De Rosa, Giovanni, additional, Marcucci, Rossella, additional, Pengo, Vittorio, additional, Poli, Daniela, additional, Testa, Sophie, additional, and Palareti, Gualtiero, additional

Published
2020
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35. Position paper on laboratory testing for patients on direct oral anticoagulants. A Consensus Document from the SISET, FCSA, SIBioC and SIPMeL

Author

Tripodi, Armando, Ageno, Walter, Ciaccio, Marcello, Legnani, Cristina, Lippi, Giuseppe, Manotti, Cesare, Marcucci, Rossella, Moia, Marco, Morelli, Benedetto, Poli, Daniela, Steffan, Agostino, Testa, Sophie, Tripodi, Armando, Ageno, Walter, Ciaccio, Marcello, Legnani, Cristina, Lippi, Giuseppe, Manotti, Cesare, Marcucci, Rossella, Moia, Marco, Morelli, Benedetto, Poli, Daniela, Steffan, Agostino, and Testa, Sophie

Subjects
Societies, Scientific, Oral, Consensus, DOAC, Anticoagulant, Anticoagulation, Thrombosis, Administration, Oral, Anticoagulants, Drug Monitoring, Humans, Italy, Immunology and Allergy, Hematology, Consensu, Scientific, Long-Term Care, Settore BIO/12 - Biochimica Clinica E Biologia Molecolare Clinica, Thrombosi, Administration, Position Paper, anticoagulation, thrombosis, consensus, Societies, Human
Abstract

Although direct oral anticoagulants (DOAC) do not require dose-adjustment on the basis of laboratory test results, the measurement of their anticoagulant effect is useful in special situations. This position paper issued by the Italian Scientific Societies that are mainly involved in the management of patients on DOAC is aimed at providing guidance to care-givers on which tests should be used and the situations in which testing is useful. The guidance is based on the data from the literature so far available and/or on consensus among experts.

Published
2018

36. Long-Term Risk for Major Bleeding During Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism : A Systematic Review and Meta-analysis.

Author

Khan, Faizan, Tritschler, Tobias, Kimpton, Miriam, Wells, Philip S., Kearon, Clive, Weitz, Jeffrey I., Büller, Harry R., Raskob, Gary E., Ageno, Walter, Couturaud, Francis, Prandoni, Paolo, Palareti, Gualtiero, Legnani, Cristina, Kyrle, Paul A., Eichinger, Sabine, Eischer, Lisbeth, Becattini, Cecilia, Agnelli, Giancarlo, Vedovati, Maria Cristina, and Geersing, Geert-Jan

Subjects
THROMBOEMBOLISM, ANTICOAGULANTS, HEMORRHAGE, RANDOMIZED controlled trials, PROGNOSIS, THROMBOEMBOLISM prevention, RESEARCH, VEINS, META-analysis, AGE distribution, ORAL drug administration, RESEARCH methodology, SYSTEMATIC reviews, MEDICAL cooperation, EVALUATION research, COMPARATIVE studies
Abstract

Background: The long-term risk for major bleeding in patients receiving extended (beyond the initial 3 to 6 months) anticoagulant therapy for a first unprovoked venous thromboembolism (VTE) is uncertain.Purpose: To determine the incidence of major bleeding during extended anticoagulation of up to 5 years among patients with a first unprovoked VTE, overall, and in clinically important subgroups.Data Sources: MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials from inception to 23 July 2021.Study Selection: Randomized controlled trials (RCTs) and prospective cohort studies reporting major bleeding among patients with a first unprovoked VTE who were to receive oral anticoagulation for a minimum of 6 additional months after completing at least 3 months of initial anticoagulant treatment.Data Extraction: Two reviewers independently abstracted data and assessed study quality. Unpublished data required for analyses were obtained from authors of included studies.Data Synthesis: Among the 14 RCTs and 13 cohort studies included in the analysis, 9982 patients received a vitamin K antagonist (VKA) and 7220 received a direct oral anticoagulant (DOAC). The incidence of major bleeding per 100 person-years was 1.74 events (95% CI, 1.34 to 2.20 events) with VKAs and 1.12 events (CI, 0.72 to 1.62 events) with DOACs. The 5-year cumulative incidence of major bleeding with VKAs was 6.3% (CI, 3.6% to 10.0%). Among patients receiving either a VKA or a DOAC, the incidence of major bleeding was statistically significantly higher among those who were older than 65 years or had creatinine clearance less than 50 mL/min, a history of bleeding, concomitant use of antiplatelet therapy, or a hemoglobin level less than 100 g/L. The case-fatality rate of major bleeding was 8.3% (CI, 5.1% to 12.2%) with VKAs and 9.7% (CI, 3.2% to 19.2%) with DOACs.Limitation: Data were insufficient to estimate incidence of major bleeding beyond 1 year of extended anticoagulation with DOACs.Conclusion: In patients with a first unprovoked VTE, the long-term risks and consequences of anticoagulant-related major bleeding are considerable. This information will help inform patient prognosis and guide decision making about treatment duration for unprovoked VTE.Primary Funding Source: Canadian Institutes of Health Research. (PROSPERO: CRD42019128597). [ABSTRACT FROM AUTHOR]

Published
2021
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37. D-dimer levels during and after anticoagulation withdrawal in patients with venous thromboembolism treated with non-vitamin K anticoagulants

Author

Legnani, Cristina, primary, Martinelli, Ida, additional, Palareti, Gualtiero, additional, Ciavarella, Alessandro, additional, Poli, Daniela, additional, Ageno, Walter, additional, Testa, Sophie, additional, Mastroiacovo, Daniela, additional, Ciammaichella, Maurizio, additional, Bucherini, Eugenio, additional, Mumoli, Nicola, additional, and Cosmi, Benilde, additional

Published
2019
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38. Consenso sulla diagnostica di laboratorio per i pazienti in trattamento con farmaci anticoagulanti ad azione diretta. Sottoscritto dalla Società Italiana per lo Studio dell'Emostasi e della Trombosi (SISET), dalla Federazione Centri per la diagnosi della trombosi e la Sorveglianza delle terapie Antitrombotiche (FCSA), dalla Società Italiana di Biochimica Clinica e Biologia Molecolare Clinica (SIBioC) e dalla Società Italiana di Patologia Clinica e Medicina di Laboratorio (SIPMeL)

Author

Paoletti, Oriana, primary, Legnani, Cristina, additional, Martini, Giuliana, additional, Bertini, Michele, additional, Agostini, Pierfrancesco, additional, Bondanini, Francesco, additional, Cozzi, Maria R., additional, Demicheli, Marta S.A., additional, Di Felice, Giovina, additional, Novembrino, Cristina, additional, Pedrini, Simona, additional, Ruocco, Lucia, additional, Steffan, Agostino, additional, Terzuoli, Lucia, additional, and Testa, Sophie, additional

Published
2019
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42. D-dimer testing, with gender-specific cutoff levels, is of value to assess the individual risk of venous thromboembolic recurrence in non-elderly patients of both genders: a post hoc analysis of the DULCIS study.

Author

Palareti, Gualtiero, Legnani, Cristina, Antonucci, Emilia, Cosmi, Benilde, Poli, Daniela, Testa, Sophie, Tosetto, Alberto, Ageno, Walter, Falanga, Anna, Ferrini, Piera Maria, Pengo, Vittorio, Prandoni, Paolo, for the DULCIS (D-dimer and ULtrasonography in Combination Italian Study) Investigators, Prisco, Domenico, Ghirarduzzi, Angelo, Veropalumbo, Maria Rosaria, Ugolotti, Maria Chiara, Erba, Nicoletta, De Micheli, Valeria, and Paoletti, Oriana

Abstract

Male patients, especially the young, are at a higher risk of recurrent venous thromboembolism (RVTE) than females. Recent scientific reports show the use of D-dimer does not help predict RVTE risk in males. In the present report, we reviewed the data obtained in the DULCIS study (main report published in Blood 2014), focusing on D-dimer results recorded in non-elderly patients of both genders included in the study, and their relationship with RVTE events occurring during follow-up. Using specifically designed cutoff values for positive/negative interpretation, serial D-dimer measurements (performed during warfarin treatment and up to 3 months after discontinuation of anticoagulation) in 475 patients (males 57.3%) aged ≤ 65 years were obtained. D-dimer resulted positive in 46.3% and 30.5% of males and females, respectively (p = 0.001). Following management procedure, anticoagulation was stopped in 53.7% of males and 69.5% of females, who had persistently negative D-dimer results. The rate of subsequent recurrent events was 1.7% (95% CI 0.5-4.5%) and 0.4% (95% CI 0-2.5%) patient-years in males and females, respectively, with upper limits of confidence intervals always below the level of risk considered acceptable by international scientific societies for stopping anticoagulation (< 5%). In conclusion, using sensitive quantitative assays with specifically designed cutoff values and serial measurements during and after discontinuation of anticoagulation, D-dimer testing is useful to predict the risk of RVTE and is of help in deciding the duration of anticoagulation in both male and female adult patients aged up to 65 years. [ABSTRACT FROM AUTHOR]

Published
2020
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43. Il laboratorio nella terapia anticoagulante orale

Author

Tosetto, Alberto, Testa, Sophie, Ageno, Walter, Legnani, Cristina, Paoletti, Oriana, Plebani, Mario, Poli, Daniela, and Giavarina, Davide

Subjects
Medical Laboratory Technology, Clinical Biochemistry, Biochemistry (medical)
Published
2016

46. D-dimer levels during and after anticoagulation withdrawal in patients with venous thromboembolism treated with nonvitamin K anticoagulants.

Author

Legnani, Cristina, Martinelli, Ida, Palareti, Gualtiero, Ciavarella, Alessandro, Poli, Daniela, Ageno, Walter, Testa, Sophie, Mastroiacovo, Daniela, Ciammaichella, Maurizio, Bucherini, Eugenio, Mumoli, Nicola, and Cosmi, Benilde

Abstract

Background D-dimer levels measured during and after vitamin K antagonist withdrawal may be used in clinical practice to assess the individual risk of recurrent venous thromboembolism. Currently, direct oral anticoagulants (DOACs) are frequently used in venous thromboembolism treatment; however, their pharmacokinetics and pharmacodynamics characteristics are completely different than vitamin K antagonists. The present study aimed at comparing the results of D-dimer levels during and after anticoagulation withdrawal in patients with venous thromboembolism treated with DOACs or warfarin. Material and methods D-dimer levels were measured in 527 patients (“cases”) during DOACs treatment (T0) and after 15 (T15), 30 (T30), 60 (T60) and 90 (T90) days after their discontinuation and in 527 patients (“controls”) enrolled in the DULCIS study (all treated with warfarin), matched for sex, age (+/-3 y), type of D-dimer assay and site of venous thromboembolism. Both cases and controls received anticoagulant treatment after a first venous thromboembolism event that was unprovoked or associated with weak risk factors. Results The rate of positive D-dimer results was significantly higher in cases than in controls at T0 (10.8% vs 5.1%, p = 0.002) and at T30 (18.8% vs 11.8%, p = 0.019), as well as at the other time-points, though not statistically significant. Conclusion D-dimer levels during and after stopping an anticoagulant treatment for a venous thromboembolism episode differ between patients treated with a DOAC than in those treated with warfarin. Specifically designed prospective studies are warranted to reassess the use of Ddimer as predictor of the risk of recurrent venous thromboembolism in patients treated with DOACs. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Duration of anticoagulation after isolated pulmonary embolism

Author

Palareti, Gualtiero, primary, Cosmi, Benilde, additional, Antonucci, Emilia, additional, Legnani, Cristina, additional, Erba, Nicoletta, additional, Ghirarduzzi, Angelo, additional, Poli, Daniela, additional, Testa, Sophie, additional, Tosetto, Alberto, additional, Pengo, Vittorio, additional, and Prandoni, Paolo, additional

Published
2016
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50. Plasma levels of direct oral anticoagulants in real life patients with atrial fibrillation: Results observed in four anticoagulation clinics

Author

Testa, Sophie, primary, Tripodi, Armando, additional, Legnani, Cristina, additional, Pengo, Vittorio, additional, Abbate, Rosanna, additional, Dellanoce, Claudia, additional, Carraro, Paolo, additional, Salomone, Luisa, additional, Paniccia, Rita, additional, Paoletti, Oriana, additional, Poli, Daniela, additional, and Palareti, Gualtiero, additional

Published
2016
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