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1. Opioid Utilization and Management in the Setting of Stewardship During Inpatient Rehab Care

Author

Murphy L, Leblanc K, Badr S, Ching E, Mao L, Steenhof N, Hamandi B, Rubin B, Seto A, and Furlan AD

Subjects
opioid, pain management, medication reconciliation, pharmacy practice, medication safety, discharge prescription., Medicine (General), R5-920
Abstract

Laura Murphy,1– 3 Kori Leblanc,1,2,4 Souzi Badr,1,2 Emily Ching,1 Lynda Mao,1,2 Naomi Steenhof,1,2 Bassem Hamandi,1,2,4 Bonita Rubin,1,2 Ada Seto,1 Andrea D Furlan3,5,6 1Department of Pharmacy, University Health Network, Toronto, ON, Canada; 2Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada; 3KITE Research Institute, University Health Network, Toronto, ON, Canada; 4Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada; 5Department of Medicine, University of Toronto, Toronto, ON, Canada; 6Institute for Work & Health, Toronto, ON, CanadaCorrespondence: Laura Murphy, Department of Pharmacy, University Health Network, 550 University Ave, Toronto, ON, M5G 2A2, Canada, Tel +1 416-597-3422 x 3657, Fax +1 416-260-2658, Email laura.murphy@uhn.caBackground: Opioid utilization and management in an inpatient rehabilitation setting have not been widely described, despite the unique opportunities that exist in this setting to support opioid stewardship across transitions in care. We aimed to characterize opioid utilization and management by interprofessional teams across a large, inpatient rehabilitation setting after incorporation of opioid stewardship principles by pharmacists as part of their daily practice.Patients and methods: This was a retrospective chart review at Toronto Rehab, University Health Network, Toronto, Canada. Patients with admission orders for any opioid from November 2017 to February 2018 were included. Complex continuing care and palliative care patients were excluded. Descriptive statistics were primarily used to describe the data as well as univariate linear regression to compare associations with milligram morphine equivalent (MME) reduction.Results: A total of 448 patients were included. A reduction in total daily MME was seen in 49% (n=219) of the patients during their inpatient stay, with 73% (n=159) of these patients having a reduction of ≥ 50%. Sixty-nine percent (n=311) of the patients received an opioid prescription at discharge, with most scheduled (90%, n=98) with a supply of less than 30 days. Rehabilitation length of stay was correlated with a MME decrease during rehab (p< 0.01), suggesting that longer lengths of stay contributed to a greater reduction in MME. Patients with chronic opioid use prior to acute care admission (p=0.01), and those who started extended-release opioids during acute care (p=0.02) were significantly less likely to discontinue opioids during rehab stay.Conclusion: Opioid utilization and management in the setting of opioid stewardship across inpatient rehab and transitions of care were characterized. Opportunities exist for further quality improvement initiatives within inpatient rehabilitation and acute care settings to identify and support patients with complex pain management needs.Keywords: opioid, pain management, medication reconciliation, pharmacy practice, medication safety, discharge prescription

Published
2022

2. Performance of Antenna-based and Rydberg Quantum RF Sensors in the Electrically Small Regime

Author

Backes, K. M., Elgee, P. K., LeBlanc, K. -J., Fancher, C. T., Meyer, D. H., Kunz, P. D., Malvania, N., Nicolich, K. M., Hill, J. C., Marlow, B. L. Schmittberger, and Cox, K. C.

Subjects
Physics - Atomic Physics, Quantum Physics
Abstract

Rydberg atom electric field sensors are tunable quantum sensors that can perform sensitive radio frequency (RF) measurements. Their qualities have piqued interest at longer wavelengths where their small size compares favorably to impedance-matched antennas. Here, we compare the signal detection sensitivity of cm-scale Rydberg sensors to similarly sized room-temperature electrically small antennas with active and passive receiver backends. We present and analyze effective circuit models for each sensor type, facilitating a fair sensitivity comparison for cm-scale sensors. We calculate that contemporary Rydberg sensor implementations are less sensitive than unmatched antennas with active amplification. However, we find that idealized Rydberg sensors operating with a maximized atom number and at the standard quantum limit may perform well beyond the capabilities of antenna-based sensors at room temperature, the sensitivities of both lying below typical atmospheric background noise., Comment: 6 pages, 3 figures

Published
2024

3. A multicenter prospective study of patients undergoing open ventral hernia repair with intraperitoneal positioning using themonofilament polyester composite ventral patch: interim results of the PANACEA study

Author

Berrevoet F, Doerhoff C, Muysoms F, Hopson S, Muzi MG, Nienhuijs S, Kullman E, Tollens T, Schwartz MR, LeBlanc K, Velanovich V, and Jørgensen LN

Subjects
intraperitoneal mesh, epigastric hernia, umbilical hernia, pain, Medical technology, R855-855.5
Abstract

Frederik Berrevoet,1 Carl Doerhoff,2 Filip Muysoms,3 Steven Hopson,4 Marco Gallinella Muzi,5 Simon Nienhuijs,6 Eric Kullman,7 Tim Tollens,8 Mark R Schwartz,9 Karl LeBlanc,10 Vic Velanovich,11 Lars Nannestad Jørgensen12 1Department of General and Hepatopancreaticobiliary Surgery, Ghent University Hospital, Ghent, Belgium; 2General Surgery, Surgicare of Missouri, Jefferson City, MO, USA; 3Department of Surgery, AZ Maria Middelares Ghent, Ghent, Belgium; 4Bon Secours Hernia Center, Mary Immaculate Hospital, Newport News, VA, USA; 5University Hospital Tor Vergata, Rome, Italy; 6Catharina Hospital, Eindhoven, the Netherlands; 7Medicinskt Centrum Linköping, Linköping, Sweden; 8Imelda Hospital-General Surgery Imelda Hospital, Bonheiden, Belgium; 9Monmouth Medical Center, Long Branch, NJ, 10Our Lady of Lakes Regional Medical Center, Baton Rouge, LA, 11Tampa General Hospital, University of South Florida, Tampa, FL, USA; 12Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark Purpose: This study assessed the recurrence rate and other safety and efficacy parameters following ventral hernia repair with a polyester composite prosthesis (Parietex™ Composite Ventral Patch [PCO-VP]).Patients and methods: A single-arm, multicenter prospective study of 126 patients undergoing open ventral hernia repair with the PCO-VP was performed. Patient outcomes were assessed at discharge and at 10 days, 1, 6, 12, and 24 months postoperative.Results: All patients had hernioplasty for umbilical (n = 110, 87.3%) or epigastric hernia (n = 16, 12.7%). Mean hernia diameter was 1.8 ± 0.8 cm. Mean operative time was 36.2 ±15.6 minutes, with a mean mesh positioning time of 8.1 ± 3.4 minutes. Surgeons reported satisfaction with mesh ease of use in 95% of surgeries. The cumulative hernia recurrence rate at 1 year was 2.8% (3/106). Numeric Rating Scale (NRS) pain scores showed improvement from 2.1 ± 2.0 at preoperative baseline to 0.5 ± 0.7 at 1 month postoperative (P < 0.001), and this low pain level was maintained at 12 months postsurgery (P < 0.001). The mean global Carolina’s Comfort Scale® (CCS) score improved postoperatively from 3.8 ± 6.2 at 1 month to 1.6 ± 3.5 at 6 months (P < 0.001). One patient was unsatisfied with the procedure.Conclusion: This 1-year interim analysis using PCO-VP for primary umbilical and epigastric defects shows promising results in terms of mesh ease of use, postoperative pain, and patient satisfaction. Recurrence rate is low, but, as laparoscopic evaluation shows a need for patch repositioning in some cases, an accurate surgical technique remains of utmost importance. Keywords: intraperitoneal mesh, epigastric hernia, umbilical hernia, pain

Published
2017

10. META Score: An International Consensus Scoring System on Mesh-Tissue Adhesions

Author

van den Hil, L. C. L., Mommers, E. H. H., Bosmans, J. W. A. M., Morales-Conde, S., Gómez-Gil, V., LeBlanc, K., Vanlander, A., Reynvoet, E., Berrevoet, F., Gruber-Blum, S., Altinli, E., Deeken, C. R., Fortelny, R. H., Greve, J. W., Chiers, K., Kaufmann, R., Lange, J. F., Klinge, U., Miserez, M., Petter-Puchner, A. H., Schreinemacher, M. H. F., and Bouvy, N. D.

Published
2020
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12. Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS)): Part B

Author

Bittner, R., Bain, K., Bansal, V. K., Berrevoet, F., Bingener-Casey, J., Chen, D., Chen, J., Chowbey, P., Dietz, U. A., de Beaux, A., Ferzli, G., Fortelny, R., Hoffmann, H., Iskander, M., Ji, Z., Jorgensen, L. N., Khullar, R., Kirchhoff, P., Köckerling, F., Kukleta, J., LeBlanc, K., Li, J., Lomanto, D., Mayer, F., Meytes, V., Misra, M., Morales-Conde, S., Niebuhr, H., Radvinsky, D., Ramshaw, B., Ranev, D., Reinpold, W., Sharma, A., Schrittwieser, R., Stechemesser, B., Sutedja, B., Tang, J., Warren, J., Weyhe, D., Wiegering, A., Woeste, G., and Yao, Q.

Published
2019
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13. Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS))—Part A

Author

Bittner, R., Bain, K., Bansal, V. K., Berrevoet, F., Bingener-Casey, J., Chen, D., Chen, J., Chowbey, P., Dietz, U. A., de Beaux, A., Ferzli, G., Fortelny, R., Hoffmann, H., Iskander, M., Ji, Z., Jorgensen, L. N., Khullar, R., Kirchhoff, P., Köckerling, F., Kukleta, J., LeBlanc, K., Li, J., Lomanto, D., Mayer, F., Meytes, V., Misra, M., Morales-Conde, S., Niebuhr, H., Radvinsky, D., Ramshaw, B., Ranev, D., Reinpold, W., Sharma, A., Schrittwieser, R., Stechemesser, B., Sutedja, B., Tang, J., Warren, J., Weyhe, D., Wiegering, A., Woeste, G., and Yao, Q.

Published
2019
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14. Correction to: Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS))—Part A

Author

Bittner, R., Bain, K., Bansal, V. K., Berrevoet, F., Bingener-Casey, J., Chen, D., Chen, J., Chowbey, P., Dietz, U. A., de Beaux, A., Ferzli, G., Fortelny, R., Hoffmann, H., Iskander, M., Ji, Z., Jorgensen, L. N., Khullar, R., Kirchhoff, P., Köckerling, F., Kukleta, J., LeBlanc, K., Li, J., Lomanto, D., Mayer, F., Meytes, V., Misra, M., Morales-Conde, S., Niebuhr, H., Radvinsky, D., Ramshaw, B., Ranev, D., Reinpold, W., Sharma, A., Schrittwieser, R., Stechemesser, B., Sutedja, B., Tang, J., Warren, J., Weyhe, D., Wiegering, A., Woeste, G., and Yao, Q.

Published
2019
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18. Incisional Hernia: Daily Cases

Author

LeBlanc, K., Jensen, K., Krarup, P.-M., Jorgensen, L., Mynster, T., Zappa, B., Begolli, L., Quazi, S., Bhargava, A., Luque, J. Bellido, Suarez gráu, J. M., Menchero, J. Gomez, Moreno, J. García, Juraro, J. Guadalajra, Ferreras, I. Durán, Nardi, M., Millo, P., Usai, A., Lorusso, R., Grivon, M., Persico, F., Allieta, R., Christoffersen, M., Brandt, E., Helgstrand, F., Westen, M., Rosenberg, J., Kehlet, H., Strandfeit, P., Bisgaard, T., Vanini, P., Kabbara, S., Elia, E., Piancastelli, A., Guglielminetti, D., Katsumoto, F., Ahlqvist, S., Björk, D., Jänes, A., Weisby-Enbom, L., Israelsson, L., Cengiz, Y., Ndungu, B., Kiragu, P., Odende, K., Jovanovic, S., Pejcic, V., Filipovic, N., Trenkic, M., Pavlovic, A., Jovanovc, B., Tatic, M., Jovanovic, A., Misra, M. C., Bansal, V. K., Subodh, H., Krishna, A., Bansal, D., Ray, S., Rajeshwari, S., Björklund, I., Burman, A., Riccio, P. A., Vetrone, G., Linguerri, R., Liotta, S., Antor, M., Scottá, M., Khalil, H., Ichihara, K., Takuo, H., Ogawa, M., Hidaka, S., Hara, K., Taki, T., Ohashi, S., Yoshida, K., Galimov, O., Shkundin, A., Khanov, V., Sarik, J., Basta, M., Bauder, A., Kovach, S., Fischer, J., Tang, L., Fei, X., and Xu, M.

Published
2015
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19. Trial & Guidelines

Author

Roumen, R., Boelens, O., Van Assen, T., Scheltinga, M., Wijerathne, S., Agarwal, N., Ramzi, A., Liem, D., Lomanto, D., Simon, T., Buechler, M. W., Koeckerling, F., Siawash, M., de Jager-Kieviet, J. W. A., Roumen, R. M., Scheltinga, M. R., Lincourt, A., Augenstein, V., Kercher, K., Heniford, B., Andresen, K., Burcharth, J., Hupfeld, L., Fonnes, S., Rothman, J. P., Winther, D., Deigaard, S. L., Sørensen, F. S., Bjerg, J., Therkildsen, R., Errebo, M., Hauge, D., Rosenberg, J., Fischer, J., Fox, J., Basta, M., Kovach, S., East, B., Krejci, T., Hoch, J., Jorgensen, L. N., Kullman, E., Tollens, T., Nienhuijs, S., Doerhoff, C., Muzi, M. G., Hopson, S., Velanovich, V., Muysoms, F., Leblanc, K., Schwartz, M., Berrevoet, F., Holihan, J., Nguyen, D. H., Flores-Gonzalez, J. R., Alawadi, Z. M., Nguyen, M. T., Kao, L. S., Liang, M. K., Hassan, S., Raslan, C., Henley, N., Van Veenendaal, N., Poelman, M. M., Van den Heuvel, B., Schreurs, H., Dwars, B., Bonjer, H. J., Kaufmann, R., Halm, J. A., Nieuwenhuizen, J., Klitsie, P., Eker, H. H., van Geldere, D., Simons, M. P., van’t Riet, M., Jeekel, J., Lange, J. F., and Pathania, B.

Published
2015
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20. Quality of Life after Hernia Surgery

Author

LeBlanc, K., Misra, D., Zacherl, J., Petrella, G., Khan, F., Negro, P., Roll, S., Hope, W., Campanelli, G., Van Lander, A., Muysoms, F., Kyle-Leinhase, I., Ceulemans, R., Pletinckx, P., Jacobs, I., Michiels, M., Berrevoet, F., Blair, L., Huntington, C., Cox, T., Ross, S., Prasad, T., Lincourt, A., Matthews, B., Kercher, K., Heniford, B. T., Augenstein, V., El Khatib, M., Pandian, T. K., Abdelsattar, J., Farley, D., Halmerbauer, G., Arthofer, K., Ausch, C., Ehrenmüller, M., Hangl, C., Hubatka, K., Kamptner, N., Königswieser, T., Rieger, R., Magnusson, J., Nygren, J., Thorell, A., Huang, C., Tai, F. C., Chou, T. H., Huang, C. S., Latham, L., Cadinu, I., Livraghi, L., Berselli, M., Agrusti, S., Borghi, F., Ambrosoli, A., Crespi, A., Pagano, G., Galvanin, J., Raveglia, V., Cocozza, E., Olory-Togbe, J., Hounnou, G. M., Dossou, F., Gbessi, D. G., Idossou, V., Gnangnon, F., and Elegbede, A.

Published
2015
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25. Development and psychometric property testing of a skin tear knowledge assessment instrument (OASES) in 37 countries

Author

Karadağ, Ayişe (ORCID 0000-0001-6436-1647 & YÖK ID 3549), Van Tiggelen, H.; Alves, P.; Ayello, E.; Baath, C.; Baranoski, S.; Campbell, K.; Dunk, A.M.; Gloeckner, M.; Hevia, H.; Holloway, S.; Idensohn, P.; Langemo, D.; LeBlanc, K.; Ousey, K.; Pokorna, A.; Romanelli, M.; Santos, V.L.C.D.G.; Smet, S.; Williams, A.; Woo, K.; Van Hecke, A.; Verhaeghe, S.; Beeckman D., School of Nursing, Karadağ, Ayişe (ORCID 0000-0001-6436-1647 & YÖK ID 3549), Van Tiggelen, H.; Alves, P.; Ayello, E.; Baath, C.; Baranoski, S.; Campbell, K.; Dunk, A.M.; Gloeckner, M.; Hevia, H.; Holloway, S.; Idensohn, P.; Langemo, D.; LeBlanc, K.; Ousey, K.; Pokorna, A.; Romanelli, M.; Santos, V.L.C.D.G.; Smet, S.; Williams, A.; Woo, K.; Van Hecke, A.; Verhaeghe, S.; Beeckman D., and School of Nursing

Abstract

Aim: to develop and psychometrically evaluate a skin tear knowledge assessment instrument (OASES). Design: Prospective psychometric instrument validation study. Method: the skin tear knowledge assessment instrument was developed based on a literature review and expert input (N = 19). Face and content validity were assessed in a two-round Delphi procedure by 10 international experts affiliated with the International Skin Tear Advisory Panel (ISTAP). The instrument was psychometrically tested in a convenience sample of 387 nurses in 37 countries (April–May 2020). Validity of the multiple-choice test items (item difficulty, discriminating index, quality of the response alternatives), construct validity, and test–retest reliability (stability) were analysed and evaluated in light of international reference standards. Results: a 20-item instrument, covering six knowledge domains most relevant to skin tears, was designed. Content validity was established (CVI = 0.90–1.00). Item difficulty varied between 0.24 and 0.94 and the quality of the response alternatives between 0.01–0.52. The discriminating index was acceptable (0.19–0.77). Participants with a theoretically expected higher knowledge level had a significantly higher total score than participants with theoretically expected lower knowledge (p <.001). The 1-week test-retest intraclass correlation coefficient (ICC) was 0.83 (95% CI = 0.78–0.86) for the full instrument and varied between 0.72 (95% CI = 0.64–0.79) and 0.85 (95% CI = 0.81–0.89) for the domains. Cohen's Kappa coefficients of the individual items ranged between 0.21 and 0.74. Conclusion: the skin tear knowledge assessment instrument is supported by acceptable psychometric properties and can be applied in nursing education, research, and practice to assess knowledge of healthcare professionals about skin tears. Impact: Prevention and treatment of skin tears are a challenge for healthcare professionals. The provision of adequate care is based on profound and, NA

Published
2021

26. META Score: An International Consensus Scoring System on Mesh-Tissue Adhesions

Author

Hil, L.C.L. (Leontine) van den, Mommers, E.H.H. (E. H.H.), Bosmans, J.W.A.M. (J. W.A.M.), Morales Conde, S. (S.), Gómez-Gil, V. (V.), LeBlanc, K. (K.), Vanlander, A. (A.), Reynvoet, E. (E.), Berrevoet, F., Gruber-Blum, S. (S.), Altinli, E. (E.), Deeken, C.R. (C. R.), Fortelny, R.H. (Rene), Greve, J.W. (J. W.), Chiers, K. (K.), Posthuma-Kaufmann, R. (Ruth), Lange, J.F. (Johan), Klinge, U., Miserez, M., Petter-Puchner, A.H. (A. H.), Schreinemacher, M.H.F. (Marc H.F.), Kannekens-Bouvy, N.D. (Nicole), Hil, L.C.L. (Leontine) van den, Mommers, E.H.H. (E. H.H.), Bosmans, J.W.A.M. (J. W.A.M.), Morales Conde, S. (S.), Gómez-Gil, V. (V.), LeBlanc, K. (K.), Vanlander, A. (A.), Reynvoet, E. (E.), Berrevoet, F., Gruber-Blum, S. (S.), Altinli, E. (E.), Deeken, C.R. (C. R.), Fortelny, R.H. (Rene), Greve, J.W. (J. W.), Chiers, K. (K.), Posthuma-Kaufmann, R. (Ruth), Lange, J.F. (Johan), Klinge, U., Miserez, M., Petter-Puchner, A.H. (A. H.), Schreinemacher, M.H.F. (Marc H.F.), and Kannekens-Bouvy, N.D. (Nicole)

Abstract

Background: Currently, the lack of consensus on postoperative mesh-tissue adhesion scoring leads to incomparable scientific results. The aim of this study was to develop an adhesion score recognized by experts in the field of hernia surgery. Methods: Authors of three or more previously published articles on both mesh-tissue adhesion scores and postoperative adhesions were marked as experts. They were queried on seven items using a modified Delphi method. The items concerned the utility of adhesion scoring models, the appropriateness of macroscopic and microscopic variables, the range and use of composite scores or subscores, adhesion-related complications and follow-up length. This study comprised two questionnaire-based rounds and one consensus meeting. Results: The first round was completed by 23 experts (82%), the second round by 18 experts (64%). Of those 18 experts, ten were able to participate in the final consensus meeting and all approved the final proposal. From a total of 158 items, consensus was reached on 90 items. The amount of mesh surface covered with adhesions, tenacity and thickness of adhesions and organ involvement was concluded to be a minimal set of variables to be communicated separately in each future study on mesh adhesions. Conclusion: The MEsh Tissue Adhesion scoring system is the first consensus-based scoring system with a wide backing of renowned experts and can be used to assess mesh-related adhesions. By including this minimal set of variables in future research interstudy comparability and objectivity can be increased and eventually linked to clinically relevant outcomes.

Published
2020
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27. Standardizing the classification of skin tears: validity and reliability testing of the International Skin Tear Advisory Panel Classification System in 44 countries

Author

Van Tiggelen, H., LeBlanc, K., Campbell, K., Woo, K., Baranoski, S., Chang, Y. Y., Dunk, A. M., Gloeckner, M., Hevia, H., Holloway, S., Idensohn, P., Karadağ, A., Koren, E., Kottner, J., Langemo, D., Ousey, K., Pokorná, A., Romanelli, M., Santos, V. L.C.G., Smet, S., Tariq, G., Van den Bussche, K., Van Hecke, A., Verhaeghe, S., Vuagnat, H., Williams, A., Beeckman, D., Van Tiggelen, H., LeBlanc, K., Campbell, K., Woo, K., Baranoski, S., Chang, Y. Y., Dunk, A. M., Gloeckner, M., Hevia, H., Holloway, S., Idensohn, P., Karadağ, A., Koren, E., Kottner, J., Langemo, D., Ousey, K., Pokorná, A., Romanelli, M., Santos, V. L.C.G., Smet, S., Tariq, G., Van den Bussche, K., Van Hecke, A., Verhaeghe, S., Vuagnat, H., Williams, A., and Beeckman, D.

Abstract

Background: Skin tears are acute wounds that are frequently misdiagnosed and under-reported. A standardized and globally adopted skin tear classification system with supporting evidence for diagnostic validity and reliability is required to allow assessment and reporting in a consistent way. Objectives: To measure the validity and reliability of the International Skin Tear Advisory Panel (ISTAP) Classification System internationally. Methods: A multicountry study was set up to validate the content of the ISTAP Classification System through expert consultation in a two-round Delphi procedure involving 17 experts from 11 countries. An online survey including 24 skin tear photographs was conducted in a convenience sample of 1601 healthcare professionals from 44 countries to measure diagnostic accuracy, agreement, inter-rater reliability and intrarater reliability of the instrument. Results: A definition for the concept of a ‘skin flap’ in the area of skin tears was developed and added to the initial ISTAP Classification System consisting of three skin tear types. The overall agreement with the reference standard was 0·79 [95% confidence interval (CI) 0·79–0·80] and sensitivity ranged from 0·74 (95% CI 0·73–0·75) to 0·88 (95% CI 0·87–0·88). The inter-rater reliability was 0·57 (95% CI 0·57–0·57). The Cohen's Kappa measuring intrarater reliability was 0·74 (95% CI 0·73–0·75). Conclusions: The ISTAP Classification System is supported by evidence for validity and reliability. The ISTAP Classification System should be used for systematic assessment and reporting of skin tears in clinical practice and research globally. What's already known about this topic?. Skin tears are common acute wounds that are misdiagnosed and under-reported too often. A skin tear classification system is needed to standardize documentation and description for clinical practice, audit and research. What does this study add?. The International Skin Tear Advisory Panel Classification System was psy

Published
2020

28. META Score: An International Consensus Scoring System on Mesh-Tissue Adhesions

Author

Hil, LCL, Mommers, EH, Bosmans, JWAM, Morales-Conde, S, Gómez-Gil, V, LeBlanc, K, Vanlander, A, Reynvoet, E, Berrevoet, F, Gruber-Blum, S, Altinli, E, Deeken, CR, Fortelny, R H, Greve, JW, Chiers, K, Kaufmann, Ruth, Lange, Johan, Klinge, U, Miserez, M, Petter-Puchner, AH, Schreinemacher, MHF, Bouvy, ND, Hil, LCL, Mommers, EH, Bosmans, JWAM, Morales-Conde, S, Gómez-Gil, V, LeBlanc, K, Vanlander, A, Reynvoet, E, Berrevoet, F, Gruber-Blum, S, Altinli, E, Deeken, CR, Fortelny, R H, Greve, JW, Chiers, K, Kaufmann, Ruth, Lange, Johan, Klinge, U, Miserez, M, Petter-Puchner, AH, Schreinemacher, MHF, and Bouvy, ND

Published
2020

29. Standardising the classification of skin tears : validity and reliability testing of the International Skin Tear Advisory Panel (ISTAP) Classification System in 44 countries

Author

Van Tiggelen, H., LeBlanc, K., Campbell, K., Woo, K., Baranoski, S., Chang, Y. Y., Dunk, A. M., Gloeckner, M., Hevia, H., Holloway, S., Idensohn, P., Karadağ, A., Koren, E., Kottner, J., Langemo, D., Ousey, K., Pokorná, A., Romanelli, M., Santos, V. L. C. G., Smet, S., Tariq, G., Van den Bussche, K., Van Hecke, A., Verhaeghe, S., Vuagnat, H., Williams, A., Beeckman, Dimitri, Van Tiggelen, H., LeBlanc, K., Campbell, K., Woo, K., Baranoski, S., Chang, Y. Y., Dunk, A. M., Gloeckner, M., Hevia, H., Holloway, S., Idensohn, P., Karadağ, A., Koren, E., Kottner, J., Langemo, D., Ousey, K., Pokorná, A., Romanelli, M., Santos, V. L. C. G., Smet, S., Tariq, G., Van den Bussche, K., Van Hecke, A., Verhaeghe, S., Vuagnat, H., Williams, A., and Beeckman, Dimitri

Abstract

BACKGROUND: Skin tears are acute wounds that are frequently misdiagnosed and underreported. A standardised and globally adopted skin tear classification system with supporting evidence for diagnostic validity and reliability is required to allow assessment and reporting in a consistent way. OBJECTIVES: To measure the validity and reliability of the International Skin Tear Advisory Panel (ISTAP) Classification System internationally. METHODS: A multi-country study was set up to validate the content of the ISTAP Classification System through expert consultation in a two-round Delphi procedure involving 17 experts from 11 countries. An online survey including 24 skin tear photographs was conducted in a convenience sample of 1601 healthcare professionals from 44 countries to measure diagnostic accuracy, agreement, inter-rater reliability, and intra-rater reliability of the instrument. RESULTS: A definition for the concept of a "skin flap" in the area of skin tears was developed and added to the initial ISTAP Classification System consisting of three skin tear types. The overall agreement with the reference standard was 0.79 (95% CI 0.79-0.80) and sensitivity ranged from 0.74 (95% CI 0.73-0.75) to 0.88 (95% CI 0.87-0.88). The inter-rater reliability was 0.57 (95% CI 0.57-0.57). The Cohen's Kappa measuring intra-rater reliability was 0.74 (95% CI 0.73-0.75). CONCLUSIONS: The ISTAP Classification System is supported by evidence for validity and reliability. The ISTAP Classification System should be used for a systematic assessment and reporting of skin tears in clinical practice and research globally., Funding Agency:International Skin Tear Advisory Panel (ISTAP)

Published
2020
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33. Ultraspecific live imaging of the dynamics of zebrafish neutrophil granules by a histopermeable fluorogenic benzochalcone probe

Author

Colucci-Guyon, E., Batista, A. S., Oliveira, S. D. S., Blaud, M., Bellettini, I. C., Marteyn, B. S., Leblanc, K., Herbomel, P., and Duval, Romain

Abstract

Neutrophil granules (NGs) are key components of the innate immune response and mark the development of neutrophilic granulocytes in mammals. However, there has been no specific fluorescent vital stain up to now to monitor their dynamics within a whole live organism. We rationally designed a benzochalcone fluorescent probe (HAB) featuring high tissue permeability and optimal photophysics such as elevated quantum yield, pronounced solvatochromism and target-induced fluorogenesis. Phenotypic screening identified HAB as the first cell- and organelle-specific small-molecule fluorescent tracer of NGs in live zebrafish larvae, with no labeling of other cell types or organelles. HAB staining was independent of the state of neutrophil activation, labeling NGs of both resting and phagocytically active neutrophils with equal specificity. By high-resolution live imaging, we documented the dynamics of HAB-stained NGs during phagocytosis. Upon zymosan injection, labeled NGs were rapidly recruited to the forming phagosomes. Despite being a reversible ligand, HAB could not be displaced by high concentrations of pharmacologically relevant competing chalcones, indicating that this specific labeling was the result of the HAB's precise physicochemical signature rather than a general feature of chalcones. However, one of the competitors was discovered as a promising interstitial fluorescent tracer illuminating zebrafish histology, similarly to BODIPY-ceramide. As a yellow-emitting histopermeable vital stain, HAB functionally and spectrally complements most genetically incorporated fluorescent tags commonly used in live zebrafish biology, holding promise for the study of neutrophil-dependent responses relevant to human physiopathology such as developmental defects, inflammation and infection. Furthermore, HAB intensely labeled isolated live human neutrophils at the level of granulated subcellular structures consistent with human NGs, suggesting that the labeling of NGs by HAB is not restricted to the zebrafish model but also relevant to mammalian systems.

Published
2019

34. Open ventral hernia repair with a composite ventral patch:final results of a multicenter prospective study

Author

Berrevoet, F, Doerhoff, C, Muysoms, F, Hopson, S, Muzi, M G, Nienhuijs, S, Kullman, E, Tollens, T, Schwartz, M, Leblanc, K, Velanovich, V, Jørgensen, L N, Berrevoet, F, Doerhoff, C, Muysoms, F, Hopson, S, Muzi, M G, Nienhuijs, S, Kullman, E, Tollens, T, Schwartz, M, Leblanc, K, Velanovich, V, and Jørgensen, L N

Abstract

BACKGROUND: This study assessed clinical outcomes, including safety and recurrence, from the two-year follow-up of patients who underwent open ventral primary hernia repair with the use of the Parietex™ Composite Ventral Patch (PCO-VP).METHODS: A prospective single-arm, multicenter study of 126 patients undergoing open ventral hernia repair for umbilical and epigastric hernias with the PCO-VP was performed.RESULTS: One hundred twenty-six subjects (110 with umbilical hernia and 16 with epigastric hernia) with a mean hernia diameter of 1.8 cm (0.4-4.0) were treated with PCO-VP. One hundred subjects completed the two-year study. Cumulative hernia recurrence was 3.0% (3/101; 95%CI: 0.0-6.3%) within 24 months. Median Numeric Rating Scale pain scores improved from 2 [0-10] at baseline to 0 [0-3] at 1 month (P < 0.001) and remained low at 24 months 0 [0-6] (P < 0.001). 99% (102/103) of the patients were satisfied with their repair at 24 months postoperative.CONCLUSIONS: The use of PCO-VP to repair primary umbilical and epigastric defects yielded a low recurrence rate, low postoperative and chronic pain, and high satisfaction ratings, confirming that PCO-VP is effective for small ventral hernia repair in the two-year term after implantation.TRIAL REGISTRATION: The study was registered publically at clinicaltrials.gov ( NCT01848184 registered May 7, 2013).

Published
2019

35. Spectrum of neurodevelopmental disease associated with the GNAO1 guanosine triphosphate-binding region

Author

Kelly, M, Park, M, Mihalek, I, Rochtus, A, Gramm, M, Perez-Palma, E, Axeen, ET, Hung, CY, Olson, H, Swanson, L, Anselm, I, Briere, LC, High, FA, Sweetser, DA, Kayani, S, Snyder, M, Calvert, S, Scheffer, IE, Yang, E, Waugh, JL, Lal, D, Bodamer, O, Poduri, A, Adams, DR, Aday, A, Alejandro, ME, Allard, P, Ashley, EA, Azamian, MS, Bacino, CA, Baker, E, Balasubramanyam, A, Barseghyan, H, Batzli, GF, Beggs, AH, Behnam, B, Bellen, HJ, Bernstein, JA, Bican, A, Bick, DP, Birch, CL, Bonner, D, Boone, BE, Bostwick, BL, Brokamp, E, Brown, DM, Brush, M, Burke, EA, Burrage, LC, Butte, MJ, Chen, S, Clark, GD, Coakley, TR, Cogan, JD, Colley, HA, Cooper, CM, Cope, H, Craigen, WJ, D'Souza, P, Davids, M, Davidson, JM, Dayal, JG, Dell'Angelica, EC, Dhar, SU, Dipple, KM, Donnell-Fink, LA, Dorrani, N, Dorset, DC, Douine, ED, Draper, DD, Dries, AM, Eckstein, DJ, Emrick, LT, Eng, CM, Enns, G-GM, Eskin, A, Esteves, C, Estwick, T, Fairbrother, L, Fernandez, L, Ferreira, C, Fieg, EL, Fisher, PG, Fogel, BL, Friedman, ND, Gahl, WA, Glanton, E, Godfrey, RA, Goldman, AM, Goldstein, DB, Gould, SE, Gourdine, J-PF, Groden, CA, Gropman, AL, Haendel, M, Hamid, R, Hanchard, NA, High, F, Holm, IA, Horn, J, Howerton, EM, Huang, Y, Jamal, F, Jiang, Y-H, Johnston, JM, Jones, AL, Karaviti, L, Koeller, DM, Kohane, IS, Kohler, JN, Konick, S, Koziura, M, Krasnewich, DM, Krier, JB, Kyle, JE, Lalani, SR, Lau, CC, Lazar, J, LeBlanc, K, Lee, BH, Lee, H, Levy, SE, Lewis, RA, Lincoln, SA, Loo, SK, Loscalzo, J, Maas, RL, Macnamara, EF, MacRae, CA, Maduro, VV, Majch-erska, MM, Malicdan, MC, Mamounas, LA, Manolio, TA, Markello, TC, Marom, R, Martin, MG, Martinez-Agosto, JA, Mar-waha, S, May, T, McConkie-Rosell, A, McCormack, CE, McCray, AF, Merker, JD, Metz, TO, Might, M, Moretti, PM, Morimoto, M, Mulvihill, JJ, Murdock, DR, Murphy, JL, Muzny, DM, Nehrebecky, ME, Nelson, SF, Newberry, JS, Newman, JH, Nicholas, SK, Novacic, D, Orange, JS, Orengo, JP, Pallais, JC, Palmer, CGS, Papp, JC, Parker, NH, Pena, LDM, Phillips, JA, Posey, JE, Postlethwait, JH, Potocki, L, Pusey, BN, Reuter, CM, Rives, L, Robertson, AK, Rodan, LH, Rosenfeld, JA, Sampson, JB, Samson, SL, Schoch, K, Scott, DA, Shakachite, L, Sharma, P, Shashi, V, Signer, R, Silverman, EK, Sinsheimer, JS, Smith, KS, Spillmann, RC, Stoler, JM, Stong, N, Sullivan, JA, Tan, QK-G, Tifft, CJ, Toro, C, Tran, AA, Urv, TK, Vilain, E, Vogel, TP, Waggott, DM, Wahl, CE, Walker, M, Walley, NM, Walsh, CA, Wan, J, Wangler, MF, Ward, PA, Waters, KM, Webb-Robertson, B-JM, Westerfield, M, Wheeler, MT, Wise, AL, Wolfe, LA, Worthey, EA, Yamamoto, S, Yang, Y, Yoon, AJ, Yu, G, Zastrow, DB, Zhao, C, Zheng, A, Kelly, M, Park, M, Mihalek, I, Rochtus, A, Gramm, M, Perez-Palma, E, Axeen, ET, Hung, CY, Olson, H, Swanson, L, Anselm, I, Briere, LC, High, FA, Sweetser, DA, Kayani, S, Snyder, M, Calvert, S, Scheffer, IE, Yang, E, Waugh, JL, Lal, D, Bodamer, O, Poduri, A, Adams, DR, Aday, A, Alejandro, ME, Allard, P, Ashley, EA, Azamian, MS, Bacino, CA, Baker, E, Balasubramanyam, A, Barseghyan, H, Batzli, GF, Beggs, AH, Behnam, B, Bellen, HJ, Bernstein, JA, Bican, A, Bick, DP, Birch, CL, Bonner, D, Boone, BE, Bostwick, BL, Brokamp, E, Brown, DM, Brush, M, Burke, EA, Burrage, LC, Butte, MJ, Chen, S, Clark, GD, Coakley, TR, Cogan, JD, Colley, HA, Cooper, CM, Cope, H, Craigen, WJ, D'Souza, P, Davids, M, Davidson, JM, Dayal, JG, Dell'Angelica, EC, Dhar, SU, Dipple, KM, Donnell-Fink, LA, Dorrani, N, Dorset, DC, Douine, ED, Draper, DD, Dries, AM, Eckstein, DJ, Emrick, LT, Eng, CM, Enns, G-GM, Eskin, A, Esteves, C, Estwick, T, Fairbrother, L, Fernandez, L, Ferreira, C, Fieg, EL, Fisher, PG, Fogel, BL, Friedman, ND, Gahl, WA, Glanton, E, Godfrey, RA, Goldman, AM, Goldstein, DB, Gould, SE, Gourdine, J-PF, Groden, CA, Gropman, AL, Haendel, M, Hamid, R, Hanchard, NA, High, F, Holm, IA, Horn, J, Howerton, EM, Huang, Y, Jamal, F, Jiang, Y-H, Johnston, JM, Jones, AL, Karaviti, L, Koeller, DM, Kohane, IS, Kohler, JN, Konick, S, Koziura, M, Krasnewich, DM, Krier, JB, Kyle, JE, Lalani, SR, Lau, CC, Lazar, J, LeBlanc, K, Lee, BH, Lee, H, Levy, SE, Lewis, RA, Lincoln, SA, Loo, SK, Loscalzo, J, Maas, RL, Macnamara, EF, MacRae, CA, Maduro, VV, Majch-erska, MM, Malicdan, MC, Mamounas, LA, Manolio, TA, Markello, TC, Marom, R, Martin, MG, Martinez-Agosto, JA, Mar-waha, S, May, T, McConkie-Rosell, A, McCormack, CE, McCray, AF, Merker, JD, Metz, TO, Might, M, Moretti, PM, Morimoto, M, Mulvihill, JJ, Murdock, DR, Murphy, JL, Muzny, DM, Nehrebecky, ME, Nelson, SF, Newberry, JS, Newman, JH, Nicholas, SK, Novacic, D, Orange, JS, Orengo, JP, Pallais, JC, Palmer, CGS, Papp, JC, Parker, NH, Pena, LDM, Phillips, JA, Posey, JE, Postlethwait, JH, Potocki, L, Pusey, BN, Reuter, CM, Rives, L, Robertson, AK, Rodan, LH, Rosenfeld, JA, Sampson, JB, Samson, SL, Schoch, K, Scott, DA, Shakachite, L, Sharma, P, Shashi, V, Signer, R, Silverman, EK, Sinsheimer, JS, Smith, KS, Spillmann, RC, Stoler, JM, Stong, N, Sullivan, JA, Tan, QK-G, Tifft, CJ, Toro, C, Tran, AA, Urv, TK, Vilain, E, Vogel, TP, Waggott, DM, Wahl, CE, Walker, M, Walley, NM, Walsh, CA, Wan, J, Wangler, MF, Ward, PA, Waters, KM, Webb-Robertson, B-JM, Westerfield, M, Wheeler, MT, Wise, AL, Wolfe, LA, Worthey, EA, Yamamoto, S, Yang, Y, Yoon, AJ, Yu, G, Zastrow, DB, Zhao, C, and Zheng, A

Abstract

OBJECTIVE: To characterize the phenotypic spectrum associated with GNAO1 variants and establish genotype-protein structure-phenotype relationships. METHODS: We evaluated the phenotypes of 14 patients with GNAO1 variants, analyzed their variants for potential pathogenicity, and mapped them, along with those in the literature, on a three-dimensional structural protein model. RESULTS: The 14 patients in our cohort, including one sibling pair, had 13 distinct, heterozygous GNAO1 variants classified as pathogenic or likely pathogenic. We attributed the same variant in two siblings to parental mosaicism. Patients initially presented with seizures beginning in the first 3 months of life (8/14), developmental delay (4/14), hypotonia (1/14), or movement disorder (1/14). All patients had hypotonia and developmental delay ranging from mild to severe. Nine had epilepsy, and nine had movement disorders, including dystonia, ataxia, chorea, and dyskinesia. The 13 GNAO1 variants in our patients are predicted to result in amino acid substitutions or deletions in the GNAO1 guanosine triphosphate (GTP)-binding region, analogous to those in previous publications. Patients with variants affecting amino acids 207-221 had only movement disorder and hypotonia. Patients with variants affecting the C-terminal region had the mildest phenotypes. SIGNIFICANCE: GNAO1 encephalopathy most frequently presents with seizures beginning in the first 3 months of life. Concurrent movement disorders are also a prominent feature in the spectrum of GNAO1 encephalopathy. All variants affected the GTP-binding domain of GNAO1, highlighting the importance of this region for G-protein signaling and neurodevelopment.

Published
2019

36. Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS)) - Part A

Author

Bittner, R, Bain, K, Bansal, V K, Berrevoet, F, Bingener-Casey, J, Chen, D., Chen, J., Chowbey, P, Dietz, U A, de Beaux, A, Ferzli, G, Fortelny, R, Hoffmann, H., Iskander, M, Ji, Z, Jørgensen, L N, Khullar, R, Kirchhoff, P, Köckerling, F, Kukleta, J, LeBlanc, K, Li, J, Lomanto, D, Mayer, F, Meytes, V, Misra, M, Morales-Conde, S, Niebuhr, H, Radvinsky, D, Ramshaw, B, Ranev, D, Reinpold, W, Sharma, A., Schrittwieser, R, Stechemesser, B, Sutedja, B, Tang, J., Warren, J., Weyhe, D, Wiegering, A, Woeste, G, Yao, Q., Bittner, R, Bain, K, Bansal, V K, Berrevoet, F, Bingener-Casey, J, Chen, D., Chen, J., Chowbey, P, Dietz, U A, de Beaux, A, Ferzli, G, Fortelny, R, Hoffmann, H., Iskander, M, Ji, Z, Jørgensen, L N, Khullar, R, Kirchhoff, P, Köckerling, F, Kukleta, J, LeBlanc, K, Li, J, Lomanto, D, Mayer, F, Meytes, V, Misra, M, Morales-Conde, S, Niebuhr, H, Radvinsky, D, Ramshaw, B, Ranev, D, Reinpold, W, Sharma, A., Schrittwieser, R, Stechemesser, B, Sutedja, B, Tang, J., Warren, J., Weyhe, D, Wiegering, A, Woeste, G, and Yao, Q.

Abstract

In 2014, the International Endohernia Society (IEHS) published the first international "Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias." Guidelines reflect the currently best available evidence in diagnostics and therapy and give recommendations to help surgeons to standardize their techniques and to improve their results. However, science is a dynamic field which is continuously developing. Therefore, guidelines require regular updates to keep pace with the evolving literature.METHODS: For the development of the original guidelines, all relevant literature published up to year 2012 was analyzed using the ranking of the Oxford Centre for Evidence-Based Medicine. For the present update, all of the previous authors were asked to evaluate the literature published during the recent years from 2012 to 2017 and revise their statements and recommendations given in the initial guidelines accordingly. In two Consensus Conferences (October 2017 Beijing, March 2018 Cologne), the updates were presented, discussed, and confirmed. To avoid redundancy, only new statements or recommendations are included in this paper. Therefore, for full understanding both of the guidelines, the original and the current, must be read. In addition, the new developments in repair of abdominal wall hernias like surgical techniques within the abdominal wall, release operations (transversus muscle release, component separation), Botox application, and robot-assisted repair methods were included.RESULTS: Due to an increase of the number of patients and further development of surgical techniques, repair of primary and secondary abdominal wall hernias attracts increasing interests of many surgeons. Whereas up to three decades ago hernia-related publications did not exceed 20 per year, currently this number is about 10-fold higher. Recent years are characterized by the advent of new techniques-minimal invasive techniques using robotics and laparoscop

Published
2019

37. Update of Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias (International Endohernia Society (IEHS)):Part B

Author

Bittner, R, Bain, K, Bansal, V K, Berrevoet, F, Bingener-Casey, J, Chen, D., Chen, J., Chowbey, P, Dietz, U A, de Beaux, A, Ferzli, G, Fortelny, R, Hoffmann, H., Iskander, M, Ji, Z, Jørgensen, L N, Khullar, R, Kirchhoff, P, Köckerling, F, Kukleta, J, LeBlanc, K, Li, J, Lomanto, D, Mayer, F, Meytes, V, Misra, M, Morales-Conde, S, Niebuhr, H, Radvinsky, D, Ramshaw, B, Ranev, D, Reinpold, W, Sharma, A, Schrittwieser, R, Stechemesser, B, Sutedja, B, Tang, J., Warren, J., Weyhe, D, Wiegering, A, Woeste, G, Yao, Q., Bittner, R, Bain, K, Bansal, V K, Berrevoet, F, Bingener-Casey, J, Chen, D., Chen, J., Chowbey, P, Dietz, U A, de Beaux, A, Ferzli, G, Fortelny, R, Hoffmann, H., Iskander, M, Ji, Z, Jørgensen, L N, Khullar, R, Kirchhoff, P, Köckerling, F, Kukleta, J, LeBlanc, K, Li, J, Lomanto, D, Mayer, F, Meytes, V, Misra, M, Morales-Conde, S, Niebuhr, H, Radvinsky, D, Ramshaw, B, Ranev, D, Reinpold, W, Sharma, A, Schrittwieser, R, Stechemesser, B, Sutedja, B, Tang, J., Warren, J., Weyhe, D, Wiegering, A, Woeste, G, and Yao, Q.

Abstract

In 2014 the International Endohernia Society (IEHS) published the first international "Guidelines for laparoscopic treatment of ventral and incisional abdominal wall hernias". Guidelines reflect the currently best available evidence in diagnostics and therapy and give recommendations to help surgeons to standardize their techniques and to improve their results. However, science is a dynamic field which is continuously developing. Therefore, guidelines require regular updates to keep pace with the evolving literature.METHODS: For the development of the original guidelines all relevant literature published up to year 2012 was analyzed using the ranking of the Oxford Centre for Evidence-Based-Medicine. For the present update all of the previous authors were asked to evaluate the literature published during the recent years from 2012 to 2017 and revise their statements and recommendations given in the initial guidelines accordingly. In two Consensus Conferences (October 2017 Beijing, March 2018 Cologne) the updates were presented, discussed, and confirmed. To avoid redundancy, only new statements or recommendations are included in this paper. Therefore, for full understanding both of the guidelines, the original and the current, must be read. In addition, the new developments in repair of abdominal wall hernias like surgical techniques within the abdominal wall, release operations (transversus muscle release, component separation), Botox application, and robot-assisted repair methods were included.RESULTS: Due to an increase of the number of patients and further development of surgical techniques, repair of primary and secondary abdominal wall hernias attracts increasing interests of many surgeons. Whereas up to three decades ago hernia-related publications did not exceed 20 per year, currently this number is about 10-fold higher. Recent years are characterized by the advent of new techniques-minimal invasive techniques using robotics and laparoscopy, t

Published
2019

38. Standardizing the classification of skin tears: validity and reliability testing of the International Skin Tear Advisory Panel Classification System in 44 countries

Author

Karadağ, Ayişe (ORCID 0000-0001-6436-1647 & YÖK ID 3549), Van Tiggelen, H.; LeBlanc, K.; Campbell, K.; Woo, K.; Baranoski, S.; Chang, Y. Y.;Dunk, A. M.; Gloeckner, M.; Hevia, H.; Holloway, S.; Idensohn, P.; Koren, E.; Kottner, J.; Langemo, D.; Ousey, K.; Pokorna, A.; Pokorna, A.; Santos, V. L. C. G.; Smet, S.; Tariq, G.; Van den Bussche, K.; Van Hecke, A.; Verhaeghe, S.; Vuagnat, H.; Williams, A.; Beeckman, D., School of Nursing, Karadağ, Ayişe (ORCID 0000-0001-6436-1647 & YÖK ID 3549), Van Tiggelen, H.; LeBlanc, K.; Campbell, K.; Woo, K.; Baranoski, S.; Chang, Y. Y.;Dunk, A. M.; Gloeckner, M.; Hevia, H.; Holloway, S.; Idensohn, P.; Koren, E.; Kottner, J.; Langemo, D.; Ousey, K.; Pokorna, A.; Pokorna, A.; Santos, V. L. C. G.; Smet, S.; Tariq, G.; Van den Bussche, K.; Van Hecke, A.; Verhaeghe, S.; Vuagnat, H.; Williams, A.; Beeckman, D., and School of Nursing

Abstract

Background: skin tears are acute wounds that are frequently misdiagnosed and under-reported. A standardized and globally adopted skin tear classification system with supporting evidence for diagnostic validity and reliability is required to allow assessment and reporting in a consistent way. Objectives To measure the validity and reliability of the International Skin Tear Advisory Panel (ISTAP) Classification System internationally. Methods: a multicountry study was set up to validate the content of the ISTAP Classification System through expert consultation in a two-round Delphi procedure involving 17 experts from 11 countries. An online survey including 24 skin tear photographs was conducted in a convenience sample of 1601 healthcare professionals from 44 countries to measure diagnostic accuracy, agreement, inter-rater reliability and intrarater reliability of the instrument. Results: a definition for the concept of a 'skin flap' in the area of skin tears was developed and added to the initial ISTAP Classification System consisting of three skin tear types. The overall agreement with the reference standard was 0 center dot 79 [95% confidence interval (CI) 0 center dot 79-0 center dot 80] and sensitivity ranged from 0 center dot 74 (95% CI 0 center dot 73-0 center dot 75) to 0 center dot 88 (95% CI 0 center dot 87-0 center dot 88). The inter-rater reliability was 0 center dot 57 (95% CI 0 center dot 57-0 center dot 57). The Cohen's Kappa measuring intrarater reliability was 0 center dot 74 (95% CI 0 center dot 73-0 center dot 75). Conclusions: the ISTAP Classification System is supported by evidence for validity and reliability. The ISTAP Classification System should be used for systematic assessment and reporting of skin tears in clinical practice and research globally. What's already known about this topic? Skin tears are common acute wounds that are misdiagnosed and under-reported too often. A skin tear classification system is needed to standardize documentatio, International Skin Tear Advisory Panel (ISTAP)

Published
2019

39. Robotic-assisted, laparoscopic, and open incisional hernia repair: early outcomes from the Prospective Hernia Study.

Author

LeBlanc, K. A., Gonzalez, A., Dickens, E., Olsofka, J., Ortiz-Ortiz, C., Verdeja, J.-C., and Pierce, R.

Subjects
*LAPAROSCOPIC surgery, *TREATMENT effectiveness, *HERNIA, *MYOFASCIAL release, *VENTRAL hernia, *INAPPROPRIATE prescribing (Medicine)
Abstract

Purpose: To provide a comparative analysis of short-term outcomes after open, laparoscopic, and robotic-assisted (RAS) ventral incisional hernia (VIH) repairs that include subject-reported pain medication usage and hernia-related quality of life (QOL). Methods: Subjects were ≥ 18 years old and underwent elective open, laparoscopic or RAS VIH repair without myofascial release. Perioperative clinical outcomes through 30 days were analyzed as were prescription pain medication use and subject-reported responses to the HerQLes Abdominal QOL questionnaire. Observed differences in baseline characteristics were controlled using a weighted propensity score analysis to obviate potential selection bias (inverse probability of treatment weighting, IPTW). A p value < 0.05 was considered statistically significant. Results: Three hundred and seventy-one subjects (RAS, n = 159; open, n = 130; laparoscopic, n = 82) were enrolled in the study across 17 medical institutions within the United States. Operative times were significantly different between the RAS and laparoscopic groups (126.2 vs 57.2, respectively; p < 0.001). Mean length of stay was comparable for RAS vs laparoscopic (1.4 ± 1.0 vs 1.4 ± 1.1, respectively; p = 0.623) and differed for the RAS vs open groups (1.4 ± 1.0 vs 2.0 ± 1.9, respectively; p < 0.001). Conversion rates differed between RAS and laparoscopic groups (0.6% vs 4.9%; p = 0.004). The number of subjects reporting the need to take prescription pain medication through the 2–4 weeks visit differed between RAS vs open (65.2% vs 79.8%; p < 0.001) and RAS vs laparoscopic (65.2% vs 78.75%; p < 0.001). For those taking prescription pain medication, the mean number of pills taken was comparable for RAS vs open (23.3 vs 20.4; p = 0.079) and RAS vs laparoscopic (23.3 vs 23.3; p = 0.786). Times to return to normal activities and to work, complication rates and HerQLes QOL scores were comparable for the RAS vs open and RAS vs laparoscopic groups. The reoperation rate within 30 days post-procedure was comparable for RAS vs laparoscopic (0.6% vs 0%; p = 0.296) and differed for RAS vs open (0.6% vs 3.1%; p = 0.038). Conclusions: Short-term outcomes indicate that open, laparoscopic, and robotic-assisted approaches are effective surgical approaches to VIH repair; however, each repair technique may demonstrate advantages in terms of clinical outcomes. Observed differences in the RAS vs laparoscopic comparison are longer operative time and lower conversion rate in the RAS group. Observed differences in the RAS vs open comparison are shorter LOS and lower reoperation rate through 30 days in the RAS group. The operative time in the RAS vs open comparison is similar. The number of subjects requiring the use of prescription pain medication favored the RAS group in both comparisons; however, among subjects reporting a need for pain medication, there was no difference in the number of prescription pain medication pills taken. While the study adds to the body of evidence evaluating the open, laparoscopic, and RAS approaches, future controlled studies are needed to better understand pain and QOL outcomes related to incisional hernia repair. Trial registration: ClinicalTrials.gov identifier: NCT02715622. [ABSTRACT FROM AUTHOR]

Published
2021
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40. Understanding Adult Participant and Parent Empowerment Prior to Evaluation in the Undiagnosed Diseases Network

Author

Palmer, CGS, McConkie-Rosell, A, Holm, IA, LeBlanc, K, Sinsheimer, JS, Briere, LC, Dorrani, N, Herzog, MR, Lincoln, S, Schoch, K, Spillmann, RC, Brokamp, E, and Network, UD

Subjects
Parents, Adult, Male, Decision Making, Clinical Sciences, Pilot Projects, Genetic Counseling, Clinical Research, Surveys and Questionnaires, Diagnosis, Humans, Patient Reported Outcome Measures, Adaptation, Child, Genetics & Heredity, Undiagnosed condition, Uncertainty, Reproducibility of Results, Infant, Disease Management, Undiagnosed Diseases Network, Support groups, Power, Psychological, Female, Empowerment, Undiagnosed disease
Abstract

The burden of living with an undiagnosed condition is high and includes physical and emotional suffering, frustrations, and uncertainty. For patients and families experiencing these stressors, higher levels of empowerment may be associated with better outcomes. Thus, it is important to understand the experiences of patients with undiagnosed conditions and their families affected by undiagnosed conditions in order to identify strategies for fostering empowerment. In this study, we used the Genetic Counseling Outcome Scale (GCOS-24) to assess levels of empowerment and support group participation in 35 adult participants and 67 parents of child participants in the Undiagnosed Diseases Network (UDN) prior to their UDN in-person evaluation. Our results revealed significantly lower empowerment scores on the GCOS-24 in adult participants compared to parents of child participants [t(100) = - 3.01, p = 0.003, average difference = - 11.12, 95% CI (- 3.78, - 18.46)] and no significant association between support group participation and empowerment scores. The majority of participants (84.3%, 86/102) are not currently participating in any support groups, and participation rates were not significantly different for adult participants and parents of child participants (11.4 vs. 19.7%, respectively, FE p = 0.40). Open-ended responses provided additional insight into support group participation, the challenges of living with undiagnosed conditions, and positive coping strategies. Future research will evaluate the extent to which empowerment scores change as participation in the UDN unfolds.

Published
2018

41. Standardizing the classification of skin tears: validity and reliability testing of the International Skin Tear Advisory Panel Classification System in 44 countries

Author

Van Tiggelen, H., primary, LeBlanc, K., additional, Campbell, K., additional, Woo, K., additional, Baranoski, S., additional, Chang, Y.Y., additional, Dunk, A.M., additional, Gloeckner, M., additional, Hevia, H., additional, Holloway, S., additional, Idensohn, P., additional, Karadağ, A., additional, Koren, E., additional, Kottner, J., additional, Langemo, D., additional, Ousey, K., additional, Pokorná, A., additional, Romanelli, M., additional, Santos, V.L.C.G., additional, Smet, S., additional, Tariq, G., additional, Van den Bussche, K., additional, Van Hecke, A., additional, Verhaeghe, S., additional, Vuagnat, H., additional, Williams, A., additional, and Beeckman, D., additional

Published
2019
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42. Cardiopoietic cell therapy for advanced ischemic heart failure : results at 39 weeks of the prospective, randomized, double blind, sham-controlled CHART-1 clinical trial

Author

Bartunek, Jozef, Terzic, Andre, Davison, Beth A, Filippatos, Gerasimos S, Radovanovic, Slavica, Beleslin, Branko, Merkely, Bela, Musialek, Piotr, Wojakowski, Wojciech, Andreka, Peter, Horvath, Ivan G, Katz, Amos, Dolatabadi, Dariouch, El Nakadi, Badih, Arandjelovic, Aleksandra, Edes, Istvan, Seferovic, Petar M, Obradovic, Slobodan, Vanderheyden, Marc, Jagic, Nikola, Petrov, Ivo, Atar, Shaul, Halabi, Majdi, Gelev, Valeri L, Shochat, Michael K, Kasprzak, Jaroslaw D, Sanz Ruiz, Ricardo, Heyndrickx, Guy R, Nyolczas, Noémi, Legrand, Victor, Guédès, Antoine, Heyse, Alex, Moccetti, Tiziano, Fernandez Aviles, Francisco, Jimenez Quevedo, Pilar, Bayes Genis, Antoni, Hernandez Garcia, Jose Maria, Ribichini, Flavio, Gruchala, Marcin, Waldman, Scott A, Teerlink, John R, Gersh, Bernard J, Povsic, Thomas J, Henry, Timothy D, Metra, Marco, Hajjar, Roger J, Tendera, Michal, Behfar, Atta, Alexandre, Bertrand, Seron, Aymeric, Stough, Wendy Gattis, Sherman, Warren, Cotter, Gad, Wijns, W. i. l. l. i. a. m. Collaborators Clinical investigators, Dens, sites Belgium: Ziekenhuis Oost Limburg: J., Dupont, M., Mullens, W., Janssens, M., Dolatabadi, Hoˆpital Civil de Charleroi: D., De Bruyne, Y., Lalmand, J., Dubois, P., El Nakadi, B., Aminian, A., De Vuyst, E., Gurnet, P., Gujic, M., Blankoff, I., Guedes, CHU Mont Godinne UCL: A., Gabriel, L., Seldrum, S., Doyen, C., Andre´, M., Heyse, AZ Glorieux: A., Van Durme, F., Verschuere, J., Legrand, Domaine Universitaire du Sart Tilman: V., Gach, O., D’Orio, V., Davin, L., Lancellotti, P., Baudoux, E., Ancion, A., Dulgheru, R., Vanderheyden, OLV Ziekenhuis Aalst – Cardiologie: M., Bartunek, J., Wijns, W., Verstreken, S., Penicka, . M., Gelev, P. Meeus Bulgaria: Tokuda Hospital Sofia: V., Zheleva Kichukova, I., Parapunova, R., Melamed, R., Sardovski, S., Radev, O., Yordanov, A., Radinov, A., Nenov, D., Amine, I., Petrov, City Hospital Clinic Cardiology Center: I., Kichukov, K., Nikitasov, L., Stankov, Z., Stoyanov, H., Tasheva Dimitrova, I., Angelova, M., Dimitrov, E., Minchev, M., Garvanski, I., Botev, C., Polomski, P., Alexandrovska University Hospital, Vassilev, Sofia: D., Karamfiloff, K., Tarnovska Kadreva, R., Vladimirova, L., Dimitrov, G., Hadzhiev, E., Tzvetkova, G., Andreka, . M. Atanasova Hungary: Gottsegen Gyo¨ rgy Orszagos Kardiologiai Inte´zet: P., Fontos, G., Fabian, J., Csepregi, A., Uzonyi, G., Gelei, A., Edes, Debreceni Egyetem Orvos e´s Ege´szse´gtudomanyi Centrum Altalanos Orvostudomanyi Kar Kardiologia Inte´zet: I., Balogh, L., Vajda, G., Darago, A., Gergely, S., Fulop, T., Jenei, C., Horvath, Pe´csi Tudomanyegyetem Klinikai Ko¨zpont Szıvgyogyaszati Klinika: I., Magyari, B., Nagy, A., Cziraki, A., Faludi, R., Kittka, B., Alizadeh, H., Merkely, Semmelweis Egyetem Varosmajori Szıv e´s Ergyogyaszati Klinika: B., Geller, L., Farkas, P., Szombath, G., Foldes, G., Skopal, J., Kovacs, A., Kosztin, A., Gara, E., Sydo, N., Nyolczas, MH Ege´szse´gu¨gyi Ko¨zpont Kardiologiai Osztaly: N., Kerecsen, G., Korda, A., Kiss, . M., Borsanyi, T., Polgar, B., Muk, B., Sharif, Z. Bari Ireland: HRB Clinical Research Facility: F., Atar, Y. M. Smyth Israel:Western Galilee Hospital: S., Shturman, A., Akria, L., Kilimnik, M., Brezins, M., Halabi, Ziv Medical Center: M., Dally, N., Goldberg, A., Aehab, K., Rosenfeld, I., Levinas, T., Saleem, D., Katz, Barzilai Medical Center: A., Plaev, T., Drogenikov, T., Nemetz, A., Barshay, Y., Jafari, J., Orlov, I., Nazareth Hospital EMMS: M. Omory, N. Kogan Nielsen, Shochat, Hillel Yaffe Medical Center: M., Shotan, A., Frimerman, A., Meisel, S., Asif, A., Sofer, O., Blondheim, D. S., Vazan, A., Metra, L. Arobov Italy: A. O. Spedali Civili di Brescia: M., Bonadei, I., Inama, L., Chiari, E., Lombardi, C., Magatelli, M., Russo, D., Lazzarini, V., Carubelli, V., Vassanelli, AOUI Verona – Borgo Trento Hospital: C., Ribichini, Flavio Luciano, Bergamini, C., Krampera, Mauro, Cicoria, M. A., Zanolla, L., Dalla Mura, D., Gambaro, A., Rossi, A., Pesarini Poland: Jagiellonian University Department of Cardiac, G., Musialek, Vascular Diseases at John Paul II Hospital in Krakow: P., Mazurek, A., Drabik, L., Ka˛dzielski, A., Walter, Z., Dzieciuch Rojek, M., Rubis, P., Plazak, . W., Tekieli, L., Podolec, J., Orczyk, W., Sutor, U., Zmudka, K., Olszowska, M., Podolec, P., Gruchala, Uniwersyteckie Centrum Kliniczne: M., Ciecwierz, D., Mielczarek, M., Burakowski, S., Chmielecki, M., Zielinska, M., Frankiewicz, A., Wdowczyk, J., Stopczynska, I., Bellwon, J., Mosakowska, K., Nadolna, R., Wroblewska, J., Rozmyslowska, M., Rynkiewicz, M., Marciniak, I., Raczak, G., Tarnawska, M., Taszner, M., Kasprzak, Bieganski Hospital: J., Plewka, M., Fiutowska, D., Rechcinski, T., Lipiec, P., Sobczak, M., Weijner Mik, P., Wraga, M., Krecki, R., Markiewicz, M., Haval Qawoq, D., Wojakowski, Gornosla˛skie Centrum Medyczne Sla˛skie j. Akademii Medycznej: W., Ciosek, J., Dworowy, S., Gaszewska Zurek, E., Ochala, A., Cybulski, W., Jadczyk, T., Wanha, W., Parma, Z., Kozlowski, M., Dzierzak, M., Markiewicz Serbia: Clinical Hospital Center Zvezdara, M., Arandjelovic, Cardiology Clinic: A., Sekularac, N., Boljevic, D., Bogdanovic, A., Zivkovic, S., Cvetinovic, N., Loncar, G., Clinical Centre of Serbia, Beleslin, Cardiology Clinic: B., Nedeljkovic, M., Trifunovic, D., Giga, V., Banovic, M., Nedeljkovic, I., Stepanovic, J., Vukcevic, V., Djordjevic Dikic, A., Dobric, M., Obrenovic Kircanski, B., Seferovic, Cardiology Clinic: P., Orlic, D., Tesic, M., Petrovic, O., Milinkovic, I., Simeunovic, D., Jagic, Clinical Center of Kragujevac: N., Tasic, M., Nikolic, D., Miloradovic, V., Djurdjevic, P., Sreckovic, M., Zornic, N., Clinical Hospital Center Bezanijska Kosa, Radovanovic, Cardiology Department: S., Saric, J., Hinic, S., Djokovic, A., Ðordevic, S., Bisenic, V., Markovic, O., Stamenkovic, S., Malenkovic, V., Tresnjak, J., Misic, G., Cotra, D., Tomovic, L., Vuckovic, V., Clinic of Emergency Internal Medicine, Obradovic, Military Medical Academy: S., Jovic, Z., Vukotic, S., Markovic, D., Djenic, N., Ristic Andjelkov, A., Bayes Genis, D. Ljubinka Spain: Hospital Universitario Germans Trias I. Pujol: A., Rodriguez Leor, O., Labata, C., Vallejo, N., Ferrer, E., Batlle, M., Fernandez Aviles, Hospital General Universitario Gregorio Mara~non: F., Sanz Ruiz, R., Casado, A., Loughlin, G., Zatarain, E., Anguita, J., Ferna ndez Santos, M. E., Pascual, C., Bermejo, J., Hernandez Garcia, Hospital Clinico Universitario Virgen de la Victoria: J. M., Jimenez Navarro, M., Dominguez, A., Carrasco, F., Mu~noz, A., Garcia Pinilla, J. M., Ruiz, J., Queipo de Llano, M. P., Hernandez, A., Fernandez, A., Jimenez Quevedo, Hospital Clinico San Carlos: P., Guerra, R., Biagioni, C., Gonzalez, R. A., Gomez deDiego, J. J., Mansson Broberg, L. Perez de Isla Sweden: Karolinska University Hospital: A., Sylve´n, C., Leblanc, K., Winter, R., Blomberg, P., Gunyeli, E., Ruck, A., Silva, C., Fo¨rstedt Switzerland: CardioCentro Ticino, J., Moccetti, Switzerland: T., Rossi, M., Pasotti, E., Petrova, I., Crljenica, C., Monti, C., Murzilli, R., Su¨rder, D., Moccetti, M., Turchetto, L., Locicero, V., Chiumiento, L., Maspoli, S., Mombelli, M., Anesini, A., Biggiogero, M., Ponti, G., Camporini, C., Polledri, S., Hill, G. Dolci United Kingdom: Kings College Hospital: J., Plymen, C., Amin Youssef, G., Mcdonagh, T., Drasar, E., Mijovic, A., Jouhra, F., Mcloman, D., Dworakowski, R., Webb, I., Byrne, J., and Potter, V.

Subjects
0301 basic medicine, Male, Cardiopoiesis, Cardiovascular disease, Disease severity, Marker, Precision medicine, Regenerative medicine, Stem cell, Target population, Adult, Aged, Double-Blind Method, Female, Heart Failure, Humans, Mesenchymal Stem Cell Transplantation, Middle Aged, Myocardial Ischemia, Prospective Studies, Treatment Outcome, Young Adult, Cardiology and Cardiovascular Medicine, Cell- and Tissue-Based Therapy, mesenchymal stem-cells, 030204 cardiovascular system & hematology, Cardiorespiratory Medicine and Haematology, outcomes, Fast-Track Clinical Research, Sudden cardiac death, 0302 clinical medicine, Ischemia, cardiovascular disease, Clinical endpoint, target population, CHART Program, Ejection fraction, bone-marrow, Heart Failure/Cardiomyopathy, 3. Good health, Cohort, Cardiology, Fast Track, disease severity, delivery, medicine.medical_specialty, precision medicine, Clinical Sciences, regenerative medicine, 03 medical and health sciences, cardiopoiesis, Internal medicine, medicine, Adverse effect, marker, disease, business.industry, medicine.disease, mortality, Confidence interval, Clinical trial, stem cell, Editor's Choice, 030104 developmental biology, predictors, Cardiovascular System & Hematology, Heart failure, business
Abstract

Altres ajuts: This work was supported by Celyad, SA (Mont-Saint-Guibert, Belgium). Celyad has received research grants from the Walloon Region (Belgium, DG06 funding). Cardiopoietic cells, produced through cardiogenic conditioning of patients' mesenchymal stem cells, have shown preliminary efficacy. The Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial aimed to validate cardiopoiesis-based biotherapy in a larger heart failure cohort. This multinational, randomized, double-blind, sham-controlled study was conducted in 39 hospitals. Patients with symptomatic ischaemic heart failure on guideline-directed therapy (n = 484) were screened; n = 348 underwent bone marrow harvest and mesenchymal stem cell expansion. Those achieving > 24 million mesenchymal stem cells (n = 315) were randomized to cardiopoietic cells delivered endomyocardially with a retention-enhanced catheter (n = 157) or sham procedure (n = 158). Procedures were performed as randomized in 271 patients (n = 120 cardiopoietic cells, n = 151 sham). The primary efficacy endpoint was a Finkelstein–Schoenfeld hierarchical composite (all-cause mortality, worsening heart failure, Minnesota Living with Heart Failure Questionnaire score, 6-min walk distance, left ventricular end-systolic volume, and ejection fraction) at 39 weeks. The primary outcome was neutral (Mann–Whitney estimator 0.54, 95% confidence interval [CI] 0.47–0.61 [value > 0.5 favours cell treatment], P = 0.27). Exploratory analyses suggested a benefit of cell treatment on the primary composite in patients with baseline left ventricular end-diastolic volume 200–370 mL (60% of patients) (Mann–Whitney estimator 0.61, 95% CI 0.52–0.70, P = 0.015). No difference was observed in serious adverse events. One (0.9%) cardiopoietic cell patient and 9 (5.4%) sham patients experienced aborted or sudden cardiac death. The primary endpoint was neutral, with safety demonstrated across the cohort. Further evaluation of cardiopoietic cell therapy in patients with elevated end-diastolic volume is warranted.

Published
2017

43. Baseline brain function in the preadolescents of the ABCD Study

Author

Chaarani, B., Hahn, S., Allgaier, N., Adise, S., Owens, M. M., Juliano, A. C., Yuan, D. K., Loso, H., Ivanciu, A., Albaugh, M. D., Dumas, J., Mackey, S., Laurent, J., Ivanova, M., Hagler, D. J., Cornejo, M. D., Hatton, S., Agrawal, A., Aguinaldo, L., Ahonen, L., Aklin, W., Anokhin, A. P., Arroyo, J., Avenevoli, S., Babcock, D., Bagot, K., Baker, F. C., Banich, M. T., Barch, D. M., Bartsch, H., Baskin-Sommers, A., Bjork, J. M., Blachman-Demner, D., Bloch, M., Bogdan, R., Bookheimer, S. Y., Breslin, F., Brown, S., Calabro, F. J., Calhoun, V., Casey, B. J., Chang, L., Clark, D. B., Cloak, C., Constable, R. T., Constable, K., Corley, R., Cottler, L. B., Coxe, S., Dagher, R. K., Dale, A. M., Dapretto, M., Delcarmen-Wiggins, R., Dick, A. S., Do, E. K., Dosenbach, N. U. F., Dowling, G. J., Edwards, S., Ernst, T. M., Fair, D. A., Fan, C. C., Feczko, E., Feldstein-Ewing, S. W., Florsheim, P., Foxe, J. J., Freedman, E. G., Friedman, N. P., Friedman-Hill, S., Fuemmeler, B. F., Galvan, A., Gee, D. G., Giedd, J., Glantz, M., Glaser, P., Godino, J., Gonzalez, M., Gonzalez, R., Grant, S., Gray, K. M., Haist, F., Harms, M. P., Hawes, S., Heath, A. C., Heeringa, S., Heitzeg, M. M., Hermosillo, R., Herting, M. M., Hettema, J. M., Hewitt, J. K., Heyser, C., Hoffman, E., Howlett, K., Huber, R. S., Huestis, M. A., Hyde, L. W., Iacono, W. G., Infante, M. A., Irfanoglu, O., Isaiah, A., Iyengar, S., Jacobus, J., James, R., Jean-Francois, B., Jernigan, T., Karcher, N. R., Kaufman, A., Kelley, B., Kit, B., Ksinan, A., Kuperman, J., Laird, A. R., Larson, C., LeBlanc, K., Lessov-Schlagger, C., Lever, N., Lewis, D. A., Lisdahl, K., Little, A. R., Lopez, M., Luciana, M., Luna, B., Madden, P. A., Maes, H. H., Makowski, C., Marshall, A. T., Mason, M. J., Matochik, J., McCandliss, B. D., McGlade, E., Montoya, I., Morgan, G., Morris, A., Mulford, C., Murray, P., Nagel, B. J., Neale, M. C., Neigh, G., Nencka, A., Noronha, A., Nixon, S. J., Palmer, C. E., Pariyadath, V., Paulus, M. P., Pelham, W. E., Pfefferbaum, D., Pierpaoli, C., Prescot, A., Prouty, D., Puttler, L. I., Rajapaske, N., Rapuano, K. M., Reeves, G., Renshaw, P. F., Riedel, M. C., Rojas, P., de la Rosa, M., Rosenberg, M. D., Ross, M. J., Sanchez, M., Schirda, C., Schloesser, D., Schulenberg, J., Sher, K. J., Sheth, C., Shilling, P. D., Simmons, W. K., Sowell, E. R., Speer, N., Spittel, M., Squeglia, L. M., Sripada, C., Steinberg, J., Striley, C., Sutherland, M. T., Tanabe, J., Tapert, S. F., Thompson, W., Tomko, R. L., Uban, K. A., Vrieze, S., Wade, N. E., Watts, R., Weiss, S., Wiens, B. A., Williams, O. D., Wilbur, A., Wing, D., Wolff-Hughes, D., Yang, R., Yurgelun-Todd, D. A., Zucker, R. A., Potter, A., and Garavan, H. P.

Abstract

The Adolescent Brain Cognitive Development (ABCD) Study®is a 10-year longitudinal study of children recruited at ages 9 and 10. A battery of neuroimaging tasks are administered biennially to track neurodevelopment and identify individual differences in brain function. This study reports activation patterns from functional MRI (fMRI) tasks completed at baseline, which were designed to measure cognitive impulse control with a stop signal task (SST; N= 5,547), reward anticipation and receipt with a monetary incentive delay (MID) task (N= 6,657) and working memory and emotion reactivity with an emotional N-back (EN-back) task (N= 6,009). Further, we report the spatial reproducibility of activation patterns by assessing between-group vertex/voxelwise correlations of blood oxygen level-dependent (BOLD) activation. Analyses reveal robust brain activations that are consistent with the published literature, vary across fMRI tasks/contrasts and slightly correlate with individual behavioral performance on the tasks. These results establish the preadolescent brain function baseline, guide interpretation of cross-sectional analyses and will enable the investigation of longitudinal changes during adolescent development.

Published
2021
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44. SCT for severe autoimmune diseases: consensus guidelines of the European Society for Blood and Marrow Transplantation for immune monitoring and biobanking

Author

Alexander, T., Bondanza, A., Muraro, P.A., Greco, R., Saccardi, R., Daikeler, T., Kazmi, M., Hawkey, C., Simoes, P., Leblanc, K., Fibbe, W.E., Moore, J., Snarski, E., Martin, T., Hiepe, F., Velardi, A., Toubert, A., Snowden, J.A., Farge, D., EBMT Autoimmune Dis Working Party, Immunobiology Working Party, Alexander, T, Bondanza, Attilio, Muraro, Pa, Greco, R, Saccardi, R, Daikeler, T, Kazmi, M, Hawkey, C, Simoes, Bp, Leblanc, K, Fibbe, We, Moore, J, Snarski, E, Martin, T, Hiepe, F, Velardi, A, Toubert, A, Snowden, Ja, and Farge, D.

Subjects
medicine.medical_specialty, medicine.medical_treatment, Preservation, Biological, Hematopoietic stem cell transplantation, medicine.disease_cause, Severity of Illness Index, Autoimmunity, Autoimmune Diseases, Immune system, Medical, Severity of illness, medicine, Humans, Intensive care medicine, Special Report, Societies, Medical, Biological Specimen Banks, Congresses as Topic, Practice Guidelines as Topic, Hematopoietic Stem Cell Transplantation, Transplantation, business.industry, Hematology, medicine.disease, Biological, Biobank, Preservation, 3. Good health, Graft-versus-host disease, Immunology, Cohort, business, Societies
Abstract

Over the past 15 years, SCT has emerged as a promising treatment option for patients with severe autoimmune diseases (ADs). Mechanistic studies recently provided the proof-of-concept that restoration of immunological tolerance can be achieved by haematopoietic SCT in chronic autoimmunity through eradication of the pathologic, immunologic memory and profound reconfiguration of the immune system, that is, immune ‘resetting’. Nevertheless, a number of areas remain unresolved and warrant further investigation to refine our understanding of the underlying mechanisms of action and to optimize clinical SCT protocols. Due to the low number of patients transplanted in each centre, it is essential to adequately collect and analyse biological samples in a larger cohort of patients under standardized conditions. The European society for blood and marrow transplantation Autoimmune Diseases and Immunobiology Working Parties have, therefore, undertaken a joint initiative to develop and implement guidelines for ‘good laboratory practice’ in relation to procurement, processing, storage and analysis of biological specimens for immune reconstitution studies in AD patients before, during and after SCT. The aim of this document is to provide practical recommendations for biobanking of samples and laboratory immune monitoring in patients with ADs undergoing SCT, both for routine supportive care purposes and investigational studies.

Published
2015

45. Prospective, multicenter, pairwise analysis of robotic-assisted inguinal hernia repair with open and laparoscopic inguinal hernia repair: early results from the Prospective Hernia Study.

Author

LeBlanc, K., Dickens, E., Gonzalez, A., Gamagami, R., Pierce, R., Balentine, C., and Voeller, G.

Subjects
*INGUINAL hernia, *PROPENSITY score matching, *LONGITUDINAL method, *SURGICAL complications
Abstract

Purpose: To evaluate and compare peri-operative outcomes through 30 days, including pain and quality of life (QOL) through 3 months across three cohorts of inguinal hernia repair (IHR) patients (robotic-assisted, laparoscopic, and open IHR). Methods: The Prospective Hernia Study is an ongoing, multicenter, comparative, open-label analysis of clinical and patient-reported outcomes from robotic-assisted surgery (RAS) versus open and RAS versus laparoscopic IHR procedures. Patient responses to the Carolinas Comfort Scale (CCS) questionnaire provided QOL outcomes. Results: 504 enrolled patients underwent unilateral or bilateral IHR (RAS, n = 159; open, n = 190; laparoscopic, n = 155) at 17 medical institutions from May 2016 through December 2018. Propensity score matching provided a balanced comparison: RAS versus open (n = 112 each) and RAS versus laparoscopic (n = 80 each). Overall, operative times were significantly different between the RAS and laparoscopic cases (83 vs. 65 min; p < 0.001). Fewer RAS patients required prescription pain medication than either open (49.5% vs. 80.0%; p < 0.001) or laparoscopic patients (45.3% vs. 65.4%; p = 0.013). Median number of prescription pain pills taken differed for RAS vs. open (0.5 vs. 15.5; p = 0.001) and were comparable for RAS vs laparoscopic (7.0 vs. 6.0; p = 0.482) among patients taking prescribed pain medication. Time to return to normal activities differed for RAS vs. open (3 vs. 4 days; p = 0.005) and were comparable for RAS vs. laparoscopic (4 vs. 4 days; p = 0.657). Median CCS scores through 3 months were comparable for the three approaches. Postoperative complication rates for the three groups also were comparable. One laparoscopic case was converted to open. Conclusion: This study demonstrates that IHR can be performed effectively with the robotic-assisted, laparoscopic, or open approaches. There was no difference in the median number of prescription pain medication pills taken between the RAS and laparoscopic groups. A difference was observed in the overall number of patients reporting the need to take prescription pain medication. Comparable operative times were observed for RAS unilateral IHR patients compared to open unilateral IHR patients; however, operative times for RAS overall and bilateral subjects were longer than for open patients. Operative times were longer overall for RAS patients compared to laparoscopic patients; however, there was no difference in conversion and complication rate in the RAS vs. laparoscopic groups or the complication rate in the RAS vs. open group. Time to return to normal activities for RAS IHR patients was comparable to that of laparoscopically repaired patients and significantly sooner compared to open IHR patients. [ABSTRACT FROM AUTHOR]

Published
2020
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46. NON-VITAMIN K ANTAGONIST ORAL ANTICOAGULANT (NOAC) USE AND DOSING IN CANADIAN PRACTICE: INSIGHTS FROM THE OPTIMIZING PHARMACOTHERAPY IN THE MANAGEMENT APPROACH TO LOWERING RISK IN ATRIAL FIBRILLATION (OPTIMAL-AF) PROGRAM

Author

Bell, A., primary, Ezekowitz, J., additional, Tan, M., additional, Laflamme, D., additional, Goldin, L., additional, Leblanc, K., additional, Habert, J., additional, Lin, P., additional, Saunders, K., additional, Ngui, D., additional, Ng, A., additional, Desroches, J., additional, and Goodman, S., additional

Published
2018
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