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35 results on '"Laham, Roger J."'

7. Preventing Coronary Obstruction During Transcatheter Aortic Valve Replacement: Results From the Multicenter International BASILICA Registry

Author

Khan, Jaffar M., Babaliaros, Vasilis C., Greenbaum, Adam B., Spies, Christian, Daniels, David, Depta, Jeremiah P., Oldemeyer, J. Bradley, Whisenant, Brian, McCabe, James M., Muhammad, Kamran I., George, Isaac, Mahoney, Paul, Lanz, Jonas, Laham, Roger J., Shah, Pinak B., Chhatriwalla, Adnan, Yazdani, Shahram, Hanzel, George, Pershad, Ashish, Leonardi, Robert A., Khalil, Ramzi, Tang, Gilbert H.L., Herrmann, Howard C., Agarwal, Shikhar, Fail, Peter S., Zhang, Ming, Pop, Andrei, Lisko, John, Perdoncin, Emily, Koch, Rachel L., Ben-Dor, Itsik, Satler, Lowell F., Zhang, Cheng, Cohen, Jeffrey E., Lederman, Robert J., Waksman, Ron, and Rogers, Toby

Published
2021
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14. Functional Status After Transcatheter and Surgical Aortic Valve Replacement

Author

Tuttle, Mark K., primary, Kiaii, Bob, additional, Van Mieghem, Nicolas M., additional, Laham, Roger J., additional, Deeb, G. Michael, additional, Windecker, Stephan, additional, Chetcuti, Stanley, additional, Yakubov, Steven J., additional, Chawla, Atul, additional, Hockmuth, David, additional, Teefy, Patrick, additional, Li, Shuzhen, additional, and Reardon, Michael J., additional

Published
2022
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16. Contributors

Author

Abbott, Brian G., primary, Abbott, J. Dawn, additional, Adams, David H., additional, Al-Atassi, Talal, additional, Al-Dameh, Ali, additional, Allen, Mark S., additional, Altorki, Nasser K., additional, Anand, Jatin, additional, Anderson, Robert H., additional, Anraku, Masaki, additional, Anyanwu, Anelechi C., additional, Arora, Amit, additional, Austin, Erle H., additional, Awtry, Eric H., additional, Bacha, Emile A., additional, Backhus, Leah M., additional, Bagai, Jayant, additional, Baillot, Richard, additional, Baird, Christopher W., additional, Barron, David J., additional, Bavaria, Joseph E., additional, Bernal, Jose M., additional, Bianco, Valentino J., additional, Bichell, David P., additional, Birgisson, Sigurbjorn, additional, Blackburn, Nick J.R., additional, Bonatti, Johannes, additional, Boodhwani, Munir, additional, Bove, Edward L., additional, Brawn, William J., additional, Brizard, Christian P., additional, Brothers, Julie A., additional, Brown, Lisa M., additional, Bryant, Ayesha S., additional, Burkhart, Harold M., additional, Caldarone, Christopher A., additional, Cannon, Jeremy W., additional, Carr, Justine M., additional, Castelvecchio, Serenella, additional, Castillo, Javier G., additional, Cecchin, Frank, additional, Cerfolio, Robert J., additional, Chahine, A. Alfred, additional, Chaikof, Elliot L., additional, Chan, Vincent, additional, Chaudhry, Sunit-Preet, additional, Chen, Frederick Y., additional, Chen, Stuart H., additional, Cheng, Aaron M., additional, Chien, Victor, additional, Chin, Alvin J., additional, Chin, Cynthia S., additional, Chiu, Peter, additional, Cleveland, Joseph C., additional, Cohn, Lawrence H., additional, Cohn, William E., additional, Colson, Yolonda L., additional, Colucci, Wilson S., additional, Cook, Andrew C., additional, Coselli, Joseph S., additional, Crawford, Todd C., additional, Culligan, Melissa, additional, Dagenais, François, additional, Damiano, Ralph J., additional, D'Amico, Thomas A., additional, Dartevelle, Philippe G., additional, David, Tirone E., additional, D'Cunha, Jonathan, additional, de la Cruz, Kim I., additional, Dearani, Joseph A., additional, DeArmond, Daniel T., additional, del Nido, Pedro J., additional, DeMeester, Tom R., additional, Demers, Philippe, additional, Demmy, Todd L., additional, Dexter, Elisabeth U., additional, Dhupar, Rajeev, additional, DiNardo, James A., additional, Doyle, Thomas P., additional, Ehsan, Afshin, additional, Khoury, Gebrine El, additional, Ellis, Ethan R., additional, Elmadhun, Nassrene Y., additional, Emani, Sitaram M., additional, Erasmus, Jeremy J., additional, Fauza, Dario O., additional, Fein, Adam S., additional, Fiedler, Amy G., additional, Foppa, Murilo, additional, Freeman, Rosario V., additional, Friedberg, Joseph, additional, Friscia, Michael, additional, Fynn-Thompson, Francis, additional, Gaynor, J. William, additional, Ge, Liang, additional, Geva, Tal, additional, Gheewala, Neil M., additional, Gillinov, A. Marc, additional, Glower, Donald D., additional, Goldstone, Andrew B., additional, Groth, Shawn S., additional, Grover, Frederick L., additional, Guccione, Julius, additional, Ha, Richard, additional, Hammon, John W., additional, Hanna, Jennifer M., additional, Harrison, David G., additional, Hauser, Thomas H., additional, Henn, Matthew C., additional, Hirsch-Romano, Jennifer C., additional, Hoang, Chuong D., additional, Hofstetter, Wayne L., additional, Honjo, Osami, additional, Huynh, Tam T., additional, Bravo, Carlos E., additional, Iturra, Sebastian, additional, Jacobs, Jeffrey P., additional, Jacobs, Marshall L., additional, Jaklitsch, Michael T., additional, Jamieson, Stuart W., additional, Jarrar, Doraid, additional, Jarrett, Craig M., additional, Jones, David R., additional, Josephson, Mark E., additional, Joventino, Lilian P., additional, Juraszek, Amy L., additional, Kachala, Stefan S., additional, Kaiser, Larry R., additional, Kanter, Kirk R., additional, Karamichalis, John M., additional, Kaza, Aditya K., additional, Kemp, Clinton D., additional, Kernstine, Kemp H., additional, Keshavamurthy, Suresh, additional, Keshavjee, Shaf, additional, Kozik, Deborah J., additional, Laham, Roger J., additional, Landzberg, Michael J., additional, Lawrance, Christopher P., additional, Lee, Lawrence S., additional, LeMaire, Scott A., additional, Levitsky, Sidney, additional, Levy, Jerrold H., additional, Linden, Philip A., additional, Liptay, Michael J., additional, Litle, Virginia R., additional, Rito, Mauro Lo, additional, Luketich, James D., additional, Lytle, Bruce W., additional, Madani, Michael, additional, Mahmood, Feroze, additional, Mallidi, Hari R., additional, Mangi, Abeel A., additional, Manning, Warren J., additional, Marom, Edith M., additional, Marshall, Audrey C., additional, Martinez, Mauricio Perez, additional, Mascio, Christopher E., additional, Mason, David P., additional, Mathisen, Douglas J., additional, Mattox, Kenneth L., additional, Matyal, Robina, additional, McCully, James D., additional, McKenna, Robert J., additional, McNamee, Ciaran, additional, McNeil, Jeffrey D., additional, Menicanti, Lorenzo, additional, Mestres, Carlos A., additional, Mettler, Bret A., additional, Meyers, Bryan Fitch, additional, Mick, Stephanie, additional, Mihaljevic, Tomislav, additional, Milano, Carmelo A., additional, Miller, D. Craig, additional, Miller, Daniel L., additional, Miller, Meagan M., additional, Mitchell, John D., additional, Montealegre-Gallegos, Mario, additional, Moores, Neal G., additional, Murphy, Charles E., additional, Murthy, Raghav A., additional, Murthy, Sudish C., additional, Mussot, Sacha, additional, Naka, Yoshifumi, additional, Nathan, Meena, additional, Newman, Kurt D., additional, Nwogu, Chukwumere, additional, Odegard, Kirsten C., additional, Oh, Daniel S., additional, Ohye, Richard G., additional, Onaitis, Mark W., additional, Ostojic, Aleksandra, additional, Ott, Harald C., additional, Ouzounian, Maral, additional, Owais, Khurram, additional, Padalino, Massimo, additional, Papadakis, Konstantinos, additional, Patterson, G.A., additional, Patz, Edward F., additional, Paul, Subroto, additional, Pennathur, Arjun, additional, Perry, Yaron, additional, Piana, Robert N., additional, Pigula, Frank A., additional, Pinto, Duane S., additional, Pomar, Jose L., additional, Preventza, Ourania, additional, Pua, Bradley, additional, Puri, Varun, additional, Quinonez, Luis, additional, Raja, Siva, additional, Ratcliffe, Mark, additional, Reardon, Michael J., additional, Reilly, John J., additional, Reyes, Karl G., additional, Rice, Thomas W., additional, Robbins, Robert C., additional, Rocco, Gaetano, additional, Rubens, Fraser D., additional, Ruel, Marc, additional, Rusch, Valerie W., additional, Sabe, Ashraf A., additional, Said, Sameh M., additional, Samson, Pamela P., additional, Sanders, Stephen P., additional, Sarin, Eric L., additional, Schaff, Hartzell V., additional, Schaheen, Lara W., additional, Seder, Christopher W., additional, Sellke, Frank W., additional, Sepesi, Boris, additional, Shahani, Rohit, additional, Shamberger, Robert C., additional, Shapira, Oz M., additional, Shay, Steven S., additional, Shrager, Joseph B., additional, Si, Ming-Sing, additional, Singh, Steve K., additional, Smith, Peter K., additional, Sodha, Neel R., additional, Solaro, R. John, additional, Soukiasian, Harmik J., additional, Spurlock, David, additional, Stellin, Giovanni, additional, Stiles, Brendon M., additional, Straznicka, Michaela, additional, Stump, David A., additional, Sugarbaker, David J., additional, Suuronen, Erik J., additional, Svensson, Lars G., additional, Swanson, Scott J., additional, Szeto, Wilson Y., additional, Taghavi, Sharven, additional, Takayama, Hiroo, additional, Takeda, Koji, additional, Thiagarajan, Ravi R., additional, Thistlethwaite, Patricia A., additional, Thourani, Vinod H., additional, Toeg, Hadi D., additional, Tong, Michael Z., additional, Truesdell, Alexander G., additional, Tsai, Peter I., additional, Urschel, Harold C., additional, Valente, Anne Marie, additional, Vallabhajosyula, Prashanth, additional, Velotta, Jeffrey B., additional, Vida, Vladimiro, additional, Vlahakes, Gus J., additional, Voisine, Pierre, additional, Wall, Matthew J., additional, Walsh, Garrett L., additional, Walters, Dustin M., additional, Wei, Benjamin, additional, Welsby, Ian J., additional, Westfall, Margaret V., additional, Wiener, Daniel C., additional, Wilcox, Benson R., additional, Williams, Judson B., additional, Wilson, Jay M., additional, Woo, Y. Joseph, additional, Wood, Douglas E., additional, Wylie, John V., additional, Yang, Stephen C., additional, Yendamuri, Sai, additional, Yeon, Susan B., additional, and Zimetbaum, Peter J., additional

Published
2016
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17. Physical Performance and Risk of Postoperative Delirium in Older Adults Undergoing Aortic Valve Replacement

Author

Rao, Aarti, Shi, Sandra M, Afilalo, Jonathan, Popma, Jeffrey J, Khabbaz, Kamal R, Laham, Roger J, Guibone, Kimberly, Marcantonio, Edward R, and Kim, Dae Hyun

Subjects
Aged, 80 and over, Male, Delirium, physical performance, prediction, Physical Functional Performance, Cohort Studies, Transcatheter Aortic Valve Replacement, Logistic Models, Treatment Outcome, Risk Factors, Clinical Interventions in Aging, Aortic Valve, Heart Valve Prosthesis, mental disorders, Humans, aortic valve replacement, Female, Prospective Studies, Original Research, Aged
Abstract

Aarti Rao,1 Sandra M Shi,2,3 Jonathan Afilalo,4 Jeffrey J Popma,5 Kamal R Khabbaz,6 Roger J Laham,5 Kimberly Guibone,5 Edward R Marcantonio,2,7,* Dae Hyun Kim2,3,* 1Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; 3Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; 4Division of Cardiology and Centre for Clinical Epidemiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; 5Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; 6Division of Cardiac Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA; 7Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA*These authors contributed equally to this workCorrespondence: Dae Hyun KimHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USATel +1 617-971-8320Fax +1 617-971-5339Email daehyunkim@hsl.harvard.eduBackground: Delirium is a major risk factor for poor recovery after surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). It is unclear whether preoperative physical performance tests improve delirium prediction.Objective: To examine whether physical performance tests can predict delirium after SAVR and TAVR, and adapt an existing delirium prediction rule for cardiac surgery, which includes Mini-Mental State Examination (MMSE), depression, prior stroke, and albumin level.Design: Prospective cohort, 2014– 2017.Setting: Single academic center.Subjects: A total of 187 patients undergoing SAVR (n=77) or TAVR (n=110).Methods: The Short Physical Performance Battery (SPPB) score was calculated based on gait speed, balance, and chair stands (range: 0– 12 points, lower scores indicate poor performance). Delirium was assessed using the Confusion Assessment Method. We fitted logistic regression to predict delirium using SPPB components and risk factors of delirium.Results: Delirium occurred in 35.8% (50.7% in SAVR and 25.5% in TAVR). The risk of delirium increased for lower SPPB scores: 10– 12 (28.2%), 7– 9 (34.5%), 4– 6 (37.5%) and 0– 3 (44.1%) (p-for-trend=0.001). A model that included gait speed < 0.46 meter/second (OR, 2.7; 95% CI, 1.2– 6.4), chair stands time ≥ 11.2 seconds (OR, 3.5; 95% CI, 1.0– 12.4), MMSE < 24 points (OR, 2.9; 95% CI, 1.3– 6.4), isolated SAVR (OR, 5.4; 95% CI, 2.1– 13.8), and SAVR and coronary artery bypass grafting (OR, 15.8; 95% CI, 5.5– 45.7) predicted delirium better than the existing prediction rule (C statistics: 0.71 vs 0.61; p=0.035).Conclusion: Assessing physical performance, in addition to cognitive function, can help identify high-risk patients for delirium after SAVR and TAVR.Keywords: delirium, physical performance, aortic valve replacement, prediction

Published
2020

19. Abstract 11037: Procedural Success, Valve Hemodynamics and Outcomes in Patients with Moderate Aortic Stenosis Undergoing Supra-Annular Transcatheter Aortic Valve Replacement

Author

Sharma, Ravi, primary, Laham, Roger J, additional, Sorajja, Paul, additional, Shah, Binita, additional, Garcia, Santiago, additional, Jain, Renuka, additional, Fender, Eric, additional, Philip, Femi, additional, Eisenberg, Ruth, additional, and Chetcuti, Stanley, additional

Published
2021
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21. Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia: the CORE320 multicenter study

Author

Kishi, Satoru, Magalhaes, Tiago A., George, Richard T., Dewey, Marc, Laham, Roger J., Niinuma, Hiroyuki, Friedman, Lisa Aronson, Cox, Christopher, Tanami, Yutaka, Schuijf, Joanne D., Vavere, Andrea L., Kitagawa, Kakuya, Chen, Marcus Y., Nomura, Cesar H., Brinker, Jeffrey A., Rybicki, Frank J., Di Carli, Marcelo F., Arbab-Zadeh, Armin, and Lima, Joao A.C.

Published
2015
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23. Physical Performance and Risk of Postoperative Delirium in Older Adults Undergoing Aortic Valve Replacement

Author

Rao,Aarti, Shi,Sandra M, Afilalo,Jonathan, Popma,Jeffrey J, Khabbaz,Kamal R, Laham,Roger J, Guibone,Kimberly, Marcantonio,Edward R, Kim,Dae Hyun, Rao,Aarti, Shi,Sandra M, Afilalo,Jonathan, Popma,Jeffrey J, Khabbaz,Kamal R, Laham,Roger J, Guibone,Kimberly, Marcantonio,Edward R, and Kim,Dae Hyun

Abstract

Aarti Rao,1 Sandra M Shi,2,3 Jonathan Afilalo,4 Jeffrey J Popma,5 Kamal R Khabbaz,6 Roger J Laham,5 Kimberly Guibone,5 Edward R Marcantonio,2,7,* Dae Hyun Kim2,3,* 1Icahn School of Medicine at Mount Sinai, New York, NY, USA; 2Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; 3Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA; 4Division of Cardiology and Centre for Clinical Epidemiology, Jewish General Hospital, McGill University, Montreal, Quebec, Canada; 5Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; 6Division of Cardiac Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, USA; 7Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA*These authors contributed equally to this workCorrespondence: Dae Hyun KimHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, 1200 Centre Street, Boston, MA 02131, USATel +1 617-971-8320Fax +1 617-971-5339Email daehyunkim@hsl.harvard.eduBackground: Delirium is a major risk factor for poor recovery after surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR). It is unclear whether preoperative physical performance tests improve delirium prediction.Objective: To examine whether physical performance tests can predict delirium after SAVR and TAVR, and adapt an existing delirium prediction rule for cardiac surgery, which includes Mini-Mental State Examination (MMSE), depression, prior stroke, and albumin level.Design: Prospective cohort, 2014– 2017.Setting: Single academic center.Subjects: A total of 187 patients undergoing SAVR (n=77) or TAVR (n=110).Methods: The Short Physical Performance Battery (SPPB) score was calculated based on gait speed, balance, and chair stands (range: 0– 12 points, lower scores indicate poor performance). Deli

Published
2020

27. Delirium Incidence and Functional Outcomes After Transcatheter and Surgical Aortic Valve Replacement

Author

Shi, Sandra M., primary, Sung, Minhee, additional, Afilalo, Jonathan, additional, Lipsitz, Lewis A., additional, Kim, Caroline A., additional, Popma, Jeffrey J., additional, Khabbaz, Kamal R., additional, Laham, Roger J., additional, Guibone, Kimberly, additional, Lee, Jung, additional, Marcantonio, Edward R., additional, and Kim, Dae Hyun, additional

Published
2019
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31. Frailty Phenotype and Deficit Accumulation Frailty Index in Predicting Recovery After Transcatheter and Surgical Aortic Valve Replacement.

Author

Shi, Sandra, Afilalo, Jonathan, Lipsitz, Lewis A, Popma, Jeffrey J, Khabbaz, Kamal R, Laham, Roger J, Guibone, Kim, Grodstein, Francine, Lux, Eliah, and Kim, Dae Hyun

Subjects
AORTIC valve, ACADEMIC medical centers, DEATH forecasting, PHENOTYPES, OLDER patients
Abstract

Background: Frailty phenotype and deficit-accumulation frailty index (FI) are widely used measures of frailty. Their performance in predicting recovery after surgical aortic valve replacement (SAVR) and transcatheter aortic valve replacement (TAVR) has not been compared.Methods: Patients undergoing SAVR (n = 91) or TAVR (n = 137) at an academic medical center were prospectively assessed for frailty phenotype and FI. Outcomes were death or poor recovery, defined as a decline in ability to perform 22 daily activities and New York Heart Association class 3 or 4 at 6 months after surgery. The predictive ability of frailty phenotype versus FI and their additive value to a traditional surgical risk model were evaluated using C-statistics, net reclassification improvement (NRI), and integrated discrimination improvement.Results: TAVR patients had higher prevalence of phenotypic frailty (85% vs 38%, p < .001) and greater mean FI (0.37 vs 0.24, p < .001) than SAVR patients. In the overall cohort, FI had a higher C-statistic than frailty phenotype (0.74 vs 0.63, p = .01) for predicting death or poor recovery. Adding FI to the traditional model improved prediction (NRI, 26.4%, p = .02; integrated discrimination improvement, 7.7%, p < .001), while adding phenotypic frailty did not (NRI, 4.0%, p = .70; integrated discrimination improvement, 1.6%, p = .08). The additive value of FI was evident in TAVR patients (NRI, 42.8%, p < .01) but not in SAVR patients (NRI, 25.0%, p = .29). Phenotypic frailty did not add significantly in either TAVR (NRI, 6.8%, p = .26) or SAVR patients (NRI, 25.0%, p = .29).Conclusions: Deficit-accumulation FI provides better prediction of death or poor recovery than frailty phenotype in older patients undergoing SAVR and TAVR. [ABSTRACT FROM AUTHOR]

Published
2019
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33. Mechanical Discordance between Left Atrium and Left Atrial Appendage.

Author

Khamooshian, Arash, Jeganthan, Jelliffe, Amador, Yannis, Laham, Roger J., Mahmood, Feroze, and Matyal, Robina

Subjects
TRANSESOPHAGEAL echocardiography, ATRIAL arrhythmias, HEART failure, CARDIOVASCULAR diseases, ECHOCARDIOGRAPHY, CARDIAC arrest
Abstract

During standard transesophageal echocardiographic examinations in sinus rhythm (SR) patients, the left atrial appendage (LAA) is not routinely assessed with Doppler. Despite having a SR, it is still possible to have irregular activity in the LAA. This situation is even more important for SR patients where assessment of the left atrium is often foregone. We describe a case where we encountered this situation and briefly review how to assess the left atrium and its appendage in such a case scenario. [ABSTRACT FROM AUTHOR]

Published
2018
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34. Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia: the CORE320 multicenter study.

Author

Satoru Kishi, Magalhaes, Tiago A., George, Richard T., Dewey, Marc, Laham, Roger J., Hiroyuki Niinuma, Aronson Friedman, Lisa, Cox, Christopher, Tanami, Yutaka, Schuijf, Joanne D., Vavere, Andrea L., Kitagawa, Kakuya, Chen, Marcus Y., Nomura, Cesar H., Brinker, Jeffrey A., Rybicki, Frank J., Di Carli, Marcelo F., Arbab-Zadeh, Armin, and Lima, Joao A. C.

Subjects
DIAGNOSIS, BLOOD vessels, COMPUTED tomography, CONFIDENCE intervals, CORONARY disease, MULTIVARIATE analysis, MYOCARDIAL infarction, REGRESSION analysis, LOGISTIC regression analysis, CARDIAC-gated SPECT, ODDS ratio, LEFT ventricular hypertrophy
Abstract

Aims The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI). Methods and results Patients (n = 338) underwent 320 x 0.5 mm detector row coronary computed tomography (CT) angiography, invasive coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysed to reflect quantitative total atheroma volume. LVM was measured on myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50% diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0% of enrolled patients. LVMi was independently associated with abnormal summed rest score [SRS; odds ratio (OR), 1.07; 95% confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95% CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95% CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95% CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI. Conclusions LVM was independently associated with the presence of coronary artery atherosclerosis and MI. [ABSTRACT FROM AUTHOR]

Published
2015
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35. Relationship of left ventricular mass to coronary atherosclerosis and myocardial ischaemia: the CORE320 multicenter study.

Author

Kishi S, Magalhaes TA, George RT, Dewey M, Laham RJ, Niinuma H, Friedman LA, Cox C, Tanami Y, Schuijf JD, Vavere AL, Kitagawa K, Chen MY, Nomura CH, Brinker JA, Rybicki FJ, Di Carli MF, Arbab-Zadeh A, and Lima JA

Subjects
Aged, Algorithms, Coronary Artery Disease physiopathology, Female, Humans, Hypertrophy, Left Ventricular physiopathology, Male, Middle Aged, Myocardial Ischemia physiopathology, Prospective Studies, Cardiac Imaging Techniques, Coronary Artery Disease diagnosis, Hypertrophy, Left Ventricular diagnosis, Myocardial Ischemia diagnosis
Abstract

Aims: The aim of this study was to investigate the association of left ventricular mass (LVM) with coronary atherosclerosis and myocardial infarction (MI)., Methods and Results: Patients (n = 338) underwent 320 × 0.5 mm detector row coronary computed tomography (CT) angiography, invasive coronary angiography (ICA), and single-photon emission CT (SPECT) myocardial perfusion imaging. Quantitative coronary atheroma volume was obtained from the CT images for the entire coronary tree (19-segment model) with an arterial contour detection algorithm. Normalized total atheroma volume (NormTAV) was analysed to reflect quantitative total atheroma volume. LVM was measured on myocardial CT images and indexed to height to the power of 2.7 (LVMi). Patients with obstructive coronary artery disease (CAD) were defined as those with ≥50% diameter stenosis by quantitative ICA. Abnormal perfusion defect was defined as ≥1 abnormal myocardial segment by SPECT. The association of LVMi with coronary atherosclerosis and myocardial perfusion defect on SPECT at the patient level was determined with uni- and multivariable linear and logistic regression analyses. Obstructive CAD was present in 60.0% of enrolled patients. LVMi was independently associated with abnormal summed rest score [SRS; odds ratio (OR), 1.07; 95% confidence interval (CI), 1.03-1.09] and summed stress score (OR, 1.04; 95% CI, 1.01-1.07). An increase in LVMi was also independently associated with that in NormTAV (coefficient, 10.44; 95% CI, 1.50-19.39) and SRS ≥1 (OR, 1.05; 95% CI, 1.01-1.10), even after adjusting for cardiovascular risk factors in patients without previous MI., Conclusions: LVM was independently associated with the presence of coronary artery atherosclerosis and MI., (Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2014. For permissions please email: journals.permissions@oup.com.)

Published
2015
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