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109 results on '"Kwon, Hyeong Ju"'

4. Supplementary Methods and Materials, Figures S1-S3, Tables S1-S5 from Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck

Author

Kim, Han Sang, primary, Kwon, Hyeong Ju, primary, Jung, Inkyung, primary, Yun, Mi Ran, primary, Ahn, Myung-Ju, primary, Kang, Byung Woog, primary, Sun, Jong-Mu, primary, Kim, Sung Bae, primary, Yoon, Dok-Hyun, primary, Park, Keon Uk, primary, Lee, Se-Hoon, primary, Koh, Yoon Woo, primary, Kim, Se Hun, primary, Choi, Eun Chang, primary, Koo, Dong Hoe, primary, Sohn, Jin Hee, primary, Kim, Bomi, primary, Kwon, Nak-Jung, primary, Yun, Hwan Jung, primary, Lee, Min Goo, primary, Lee, Ji Hyun, primary, Kim, Tae-Min, primary, Kim, Hye Ryun, primary, Kim, Joo Hang, primary, Paik, Soonmyung, primary, and Cho, Byoung Chul, primary

Published
2023
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14. Optimal cutoff values of primary tumour size to better predict long‐term outcomes in patients with papillary thyroid carcinoma undergoing total thyroidectomy: A preliminary study using restricted cubic spline analysis.

Author

Jang, Sung Woo, Park, Jae Hyun, Kwon, Hyeong Ju, and Yoon, Jong Ho

Subjects
REFERENCE values, THYROIDECTOMY, PAPILLARY carcinoma, THYROID cancer, TREATMENT effectiveness, SPLINES
Abstract

Objective: Primary tumour size (PTS) is known to be a significant prognostic factor in patients with papillary thyroid carcinoma (PTC) undergoing thyroidectomy. Although cutoff values of 2 and 4 cm are widely used in surgical extent decision and long‐term outcomes predictions, the effectiveness of arbitrary cutoff values in stratifying patients for target outcomes is questionable. This study aimed to determine new optimal cutoffs of PTS. Design, Patient And Measurements: Patients (n = 529) with PTC who underwent total thyroidectomy were retrospectively reviewed. After risk factor analysis for structural recurrence, the optimal cutoffs of PTS were automatically calculated using restricted cubic spline analysis and X‐tile software. Subgroups were classified based on the newly determined cutoff values. Both the recurrence‐free survival (RFS) and the proportion of patients in each response‐to‐therapy category, using the dynamic risk stratification system (DRS), were compared between the subgroups. Results: PTS was confirmed as an independent risk factor for structural recurrence. The optimal cutoff values were calculated as 1.4 and 3.0 cm. The subgroups stratified using these newly determined cutoffs showed significantly different RFS and DRS based on the response to initial therapy, but the subgroups classified using the cutoffs of 2 and 4 cm did not. Conclusions: The newly determined cutoff values of PTS may be useful in better stratifying patients with PTC undergoing thyroidectomy for target outcomes and can be considered as a new definition in staging and risk stratification systems. [ABSTRACT FROM AUTHOR]

Published
2022
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17. Primary Bone Marrow B-Cell Lymphoma Undetected by Multiple Imaging Modalities That Initially Presented with Hypercalcemia

Author

Yoo, Jin Sae, Kim, Juwon, Kwon, Hyeong Ju, and Lim, Jung Soo

Subjects
Article Subject
Abstract

Purpose. We report a rare case of severe hypercalcemia that was ultimately diagnosed as primary bone marrow diffuse large B-cell lymphoma (BCL). Case Report. A 74-year-old male patient visited our hospital complaining of tenderness and swelling of the left knee caused by supracondylar fracture of the left distal femur. His initial blood tests showed a serum calcium level of 13.9 mg/dL, inorganic phosphorus of 4.34 mg/dL, and a serum creatinine level of 1.54 mg/dL. A serum assay of intact parathyroid hormone showed 5.24 pg/mL, and the patient’s serum 25(OH)D level was 22.33 ng/mL. To exclude malignancy, we performed imaging studies, including abdomen or chest computed tomography and positron emission tomography-computed tomography; however, no suspicious lesion was found, although the serum PTH-related peptide level was elevated at 4.0 pmol/L. A bone marrow biopsy was performed to identify any hidden hematologic malignancy. As a result, the pathology of bone marrow confirmed the presence of atypical lymphocytes that stained positive for the CD20 marker, which is consistent with BCL involving the bone marrow. Conclusion. This case highlights the importance of pursuing a thorough workup for rare underlying causes of hypercalcemia when parathyroid-related etiologies can be excluded.

Published
2018
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21. The prevalence and surgical outcomes of Hürthle cell lesions in FNAs of the thyroid: A multi‐institutional study in 6 Asian countries

Author

Agarwal, Shipra, primary, Bychkov, Andrey, additional, Jung, Chan Kwon, additional, Hirokawa, Mitsuyoshi, additional, Lai, Chiung‐Ru, additional, Hong, SoonWon, additional, Kwon, Hyeong Ju, additional, Rangdaeng, Samreung, additional, Liu, Zhiyan, additional, Su, Peng, additional, Kakudo, Kennichi, additional, and Jain, Deepali, additional

Published
2019
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23. Thyroid Fine-Needle Aspiration Cytology Practice in Korea

Author

Cha, Yoon Jin, primary, Pyo, Ju Yeon, additional, Hong, SoonWon, additional, Seok, Jae Yeon, additional, Kim, Kyung-Ju, additional, Han, Jee-Young, additional, Bae, Jeong Mo, additional, Kwon, Hyeong Ju, additional, Kim, Yeejeong, additional, Min, Kyueng-Whan, additional, Oak, Soonae, additional, and Chang, Sunhee, additional

Published
2017
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25. The Use of the Bethesda System for Reporting Thyroid Cytopathology in Korea: A Nationwide Multicenter Survey by the Korean Society of Endocrine Pathologists

Author

Kim, Mimi, primary, Park, Hyo Jin, additional, Min, Hye Sook, additional, Kwon, Hyeong Ju, additional, Jung, Chan Kwon, additional, Chae, Seoung Wan, additional, Yoo, Hyun Ju, additional, Choi, Yoo Duk, additional, Lee, Mi Ja, additional, Kwak, Jeong Ja, additional, Song, Dong Eun, additional, Kim, Dong Hoon, additional, Lee, Hye Kyung, additional, Kim, Ji Yeon, additional, Hong, Sook Hee, additional, Sohn, Jang Sihn, additional, Lee, Hyun Seung, additional, Park, So Yeon, additional, Hong, Soon Won, additional, and Shin, Mi Kyung, additional

Published
2017
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28. Predictive biomarkers to ramucirumab in Asian metastatic gastric cancer patients: Circulating angiogenic factors of VEGFR2 and neurophilin as predictive to ramucirumab efficacy in Asain recurrent/metatatic gastric cancer patients.

Author

Lim, Seungtaek, primary, Rha, Sun Young, additional, Kim, Tae Soo, additional, Kim, Hyo Song, additional, Beom, Seung Hoon, additional, Chung, Hyun Cheol, additional, Jung, Minkyu, additional, Kwon, Hyeong Ju, additional, Kim, Jee Hung, additional, and Heo, Su Jin, additional

Published
2016
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32. Exome sequencing reveals recurrent REV3L mutations in cisplatin-resistant squamous cell carcinoma of head and neck

Author

Huang, Kie Kyon, primary, Jang, Kang Won, additional, Kim, Sangwoo, additional, Kim, Han Sang, additional, Kim, Sung-Moo, additional, Kwon, Hyeong Ju, additional, Kim, Hye Ryun, additional, Yun, Hwan Jung, additional, Ahn, Myung Ju, additional, Park, Keon Uk, additional, Ramnarayanan, Kalpana, additional, McPherson, John R., additional, Zhang, Shenli, additional, Rhee, Je-Keun, additional, Vettore, André L., additional, Das, Kakoli, additional, Ishimoto, Takatsugu, additional, Kim, Joo Hang, additional, Koh, Yoon Woo, additional, Kim, Se Hun, additional, Choi, Eun Chang, additional, Teh, Bin Tean, additional, Rozen, Steven G., additional, Kim, Tae-Min, additional, Tan, Patrick, additional, and Cho, Byoung Chul, additional

Published
2016
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35. c-Met-mediated reactivation of PI3K/AKT signaling contributes to insensitivity of BRAF(V600E) mutant thyroid cancer to BRAF inhibition

Author

Byeon, Hyung Kwon, primary, Na, Hwi Jung, additional, Yang, Yeon Ju, additional, Kwon, Hyeong Ju, additional, Chang, Jae Won, additional, Ban, Myung Jin, additional, Kim, Won Shik, additional, Shin, Dong Yeob, additional, Lee, Eun Jig, additional, Koh, Yoon Woo, additional, Yoon, Joo-Heon, additional, and Choi, Eun Chang, additional

Published
2015
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39. RAS Mutations in AUS/FLUS Cytology

Author

Yoon, Jung Hyun, primary, Kwon, Hyeong Ju, additional, Lee, Hye Sun, additional, Kim, Eun-Kyung, additional, Moon, Hee Jung, additional, and Kwak, Jin Young, additional

Published
2015
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40. Phase II Clinical and Exploratory Biomarker Study of Dacomitinib in Patients with Recurrent and/or Metastatic Squamous Cell Carcinoma of Head and Neck

Author

Kim, Han Sang, primary, Kwon, Hyeong Ju, additional, Jung, Inkyung, additional, Yun, Mi Ran, additional, Ahn, Myung-Ju, additional, Kang, Byung Woog, additional, Sun, Jong-Mu, additional, Kim, Sung Bae, additional, Yoon, Dok-Hyun, additional, Park, Keon Uk, additional, Lee, Se-Hoon, additional, Koh, Yoon Woo, additional, Kim, Se Hun, additional, Choi, Eun Chang, additional, Koo, Dong Hoe, additional, Sohn, Jin Hee, additional, Kim, Bomi, additional, Kwon, Nak-Jung, additional, Yun, Hwan Jung, additional, Lee, Min Goo, additional, Lee, Ji Hyun, additional, Kim, Tae-Min, additional, Kim, Hye Ryun, additional, Kim, Joo Hang, additional, Paik, Soonmyung, additional, and Cho, Byoung Chul, additional

Published
2015
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41. KSR1 is coordinately regulated with Notch signaling and oxidative phosphorylation in thyroid cancer

Author

Lee, Jandee, primary, Seol, Mi-Youn, additional, Jeong, Seonhyang, additional, Kwon, Hyeong Ju, additional, Lee, Cho Rok, additional, Ku, Cheol Ryong, additional, Kang, Sang-Wook, additional, Jeong, Jong Ju, additional, Shin, Dong Yeob, additional, Nam, Kee-Hyun, additional, Lee, Eun Jig, additional, Chung, Woong Youn, additional, and Jo, Young Suk, additional

Published
2015
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43. Hypoxia Induces Epithelial-Mesenchymal Transition in Follicular Thyroid Cancer: Involvement of Regulation of Twist by Hypoxia Inducible Factor-1α

Author

Yang, Yeon Ju, primary, Na, Hwi Jung, additional, Suh, Michelle J., additional, Ban, Myung Jin, additional, Byeon, Hyung Kwon, additional, Kim, Won Shik, additional, Kim, Jae Wook, additional, Choi, Eun Chang, additional, Kwon, Hyeong Ju, additional, Chang, Jae Won, additional, and Koh, Yoon Woo, additional

Published
2015
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46. Subcategorization of atypia of undetermined significance/follicular lesion of undetermined significance ( AUS/ FLUS): a study applying Thyroid Imaging Reporting and Data System ( TIRADS).

Author

Yoon, Jung Hyun, Kwon, Hyeong Ju, Kim, Eun‐Kyung, Moon, Hee Jung, and Kwak, Jin Young

Subjects
*NEEDLE biopsy, *THYROID cancer treatment, *THYROID gland, *FOLLICULAR dendritic cells, *CYTOLOGY, *MAGNETIC resonance imaging
Abstract

Objective To evaluate the clinical significance and compare the imaging features according to the Thyroid Image Reporting and Data System ( TIRADS) between atypia of undetermined significance/follicular lesion of undetermined significance ( AUS/ FLUS) subcategories. Design & patients A total of 192 thyroid nodules in 188 patients (mean age: 50·2 ± 11·8 years) that had been initially diagnosed as AUS/ FLUS on US-guided fine needle aspiration ( US- FNA) were included. One cytopathologist retrospectively reviewed the cytology slides, subcategorizing cytology results into AUS and FLUS. A TIRADS category was assigned to each thyroid nodule according to the number of suspicious US features. Clinical, US features and malignancy rates were compared between the two subcategories. Results Of the 192 AUS/ FLUS lesions, 149 (77·6%) were subcategorized as AUS and 43 (22·4%) as FLUS. Of the 192 AUS/ FLUS nodules, 82 (42·7%) were malignant. The malignancy rates between AUS and FLUS subcategories were not significantly different, 45·6% to 32·6%, respectively ( P = 0·127). When applying TIRADS, significant differences were seen in TIRADS category between benign and malignant nodules in the AUS subcategory ( P < 0·001), but not in the FLUS subcategory ( P = 0·414). The malignancy rates in TIRADS categories 3, 4a, 4b, 4c and 5 were 15·4%, 22·2%, 33·3%, 57·1% and 80·0% ( P < 0·001) in AUS nodules and 40·0%, 50·0%, 23·5%, 22·2% and 0·0% ( P = 0·414) in FLUS nodules, respectively. Conclusion Suspicious US features are useful in predicting malignancy among AUS subcategories but not in FLUS subcategories. Subcategorization into AUS and FLUS cytology may be helpful in deciding upon treatment or management of thyroid nodules. [ABSTRACT FROM AUTHOR]

Published
2016
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48. Fine Needle Aspiration Cytology vs. Core Needle Biopsy for Thyroid Nodules: A Prospective, Experimental Study Using Surgical Specimen.

Author

Kwon H, Lee J, Hong SW, Kwon HJ, Kwak JY, and Yoon JH

Abstract

Purpose: To evaluate and compare the diagnostic outcomes of ultrasonography (US)-guided fine needle aspiration (FNA) and core needle biopsy (CNB) performed on the same thyroid nodule using a surgical specimen for direct comparison., Materials and Methods: We included 89 thyroid nodules from 88 patients from February 2015 to January 2016. The inclusion criterion was thyroid nodules measuring ≥ 20 mm (mean size: 40.0 ± 15.3 mm). Immediately after surgical resection, FNA and subsequent CNB were performed on the surgical specimen under US guidance. FNA and CNB cytopathologic results on the specimen were compared with the surgical diagnosis., Results: Among the 89 nodules, 30 were malignant and 59 were benign. Significantly higher inconclusive rates were seen in FNA for malignant than benign nodules (80.0% vs. 39.0%, p < 0.001). For CNB, conclusive and inconclusive rates did not differ between benign and malignant nodules ( p = 0.796). Higher inconclusive rates were seen for FNA among cancers regardless of US features, and in the subgroup of size ≥ 40 mm (62.5% vs. 22.9%, p = 0.028). Eleven cancers were diagnosed with CNB (36.7%, 11/30), while none was diagnosed using FNA., Conclusion: In this experimental study using surgical specimens, CNB showed a potential to provide improved diagnostic sensitivity for thyroid cancer, especially when a conclusive diagnosis is limited with FNA., Competing Interests: Conflicts of Interest: The authors have no potential conflicts of interest to disclose., (Copyrights © 2022 The Korean Society of Radiology.)

Published
2022
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49. Value of additional von Kossa staining in thyroid nodules with echogenic spots on ultrasound.

Author

Chae IH, Kwon HJ, Kim EK, Moon HJ, Yoon JH, Lee HS, and Kwak JY

Subjects
Adult, Aged, Aged, 80 and over, Carcinoma, Papillary diagnostic imaging, Cytodiagnosis, Female, Humans, Male, Middle Aged, Sensitivity and Specificity, Staining and Labeling, Thyroid Gland diagnostic imaging, Thyroid Neoplasms diagnostic imaging, Thyroid Nodule diagnostic imaging, Young Adult, Carcinoma, Papillary pathology, Thyroid Gland pathology, Thyroid Neoplasms pathology, Thyroid Nodule pathology, Ultrasonography
Abstract

Purpose: To evaluate the clinical value of additional von Kossa staining on cytology in thyroid nodules with echogenic spots on ultrasound (US)., Materials and Methods: 342 thyroid nodules were analyzed for cytology and von Kossa staining was performed to detect microcalcifications. We compared diagnostic performances and accuracies of FNA and FNA with von Kossa staining to detect malignancy. We evaluated associations of aggressive pathologic features and von Kossa positivity in the surgically confirmed papillary thyroid carcinoma (PTC) group., Results: Two hundred and thirty two (67.8%) nodules were malignant and 110 (32.2%) were benign on cytopathology. Compared to cytology alone, additional von Kossa staining slightly improved sensitivity from 89.7% to 90.9% (P=0.081). In 207 cases of surgically confirmed PTC, von Kossa positivity was an independent predictor of central lymph node metastasis in PTCs by multivariate analysis (odds ratio, 2.218; P=0.021)., Conclusions: Adding von Kossa staining to cytology improved the sensitivity of thyroid nodules with echogenic spots on US. Positive von Kossa stains in PTCs may also be useful in predicting central lymph node metastasis., (Copyright © 2016 Elsevier GmbH. All rights reserved.)

Published
2016
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50. Human Papillomavirus and Epidermal Growth Factor Receptor in Oral Cavity and Oropharyngeal Squamous Cell Carcinoma: Correlation With Dynamic Contrast-Enhanced MRI Parameters.

Author

Choi YS, Park M, Kwon HJ, Koh YW, Lee SK, and Kim J

Subjects
Aged, Biomarkers, Tumor analysis, Biomarkers, Tumor isolation & purification, Biomarkers, Tumor metabolism, Contrast Media, Female, Humans, Immunohistochemistry, Magnetic Resonance Imaging, Male, Middle Aged, Mouth chemistry, Mouth pathology, Mouth virology, Retrospective Studies, Carcinoma, Squamous Cell chemistry, Carcinoma, Squamous Cell metabolism, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell virology, ErbB Receptors metabolism, Mouth Neoplasms chemistry, Mouth Neoplasms metabolism, Mouth Neoplasms pathology, Mouth Neoplasms virology, Oropharyngeal Neoplasms chemistry, Oropharyngeal Neoplasms metabolism, Oropharyngeal Neoplasms pathology, Oropharyngeal Neoplasms virology, Papillomaviridae isolation & purification
Abstract

Objective: The objective of this study was to investigate differences in dynamic contrast-enhanced MRI (DCE-MRI) parameters on the basis of the status of human papillomavirus (HPV) and epidermal growth factor receptor (EGFR) biomarkers in patients with squamous cell carcinoma (SCC) of the oral cavity and oropharynx by use of histogram analysis., Materials and Methods: A total of 22 consecutive patients with oral cavity and oropharyngeal SCC underwent DCE-MRI before receiving treatment. DCE parameter maps of the volume transfer constant (K(trans)), the flux rate constant (kep), and the extravascular extracellular volume fraction (ve) were obtained. The histogram parameters were calculated using the entire enhancing tumor volume and were compared between the patient subgroups on the basis of HPV and EGFR biomarker statuses., Results: The cumulative histogram parameters of K(trans) and kep showed lower values in the HPV-negative and EFGR-overexpression group than in the HPV-positive EGFR-negative group. These differences were statistically significant for the mean (p = 0.009), 25th, 50th, and 75th percentile values of K(trans) and for the 25th percentile value of kep when correlated with HPV status in addition to the mean K(trans) value (p = 0.047) and kep value (p = 0.004) when correlated with EGFR status. No statistically significant difference in ve was found on the basis of HPV and EGFR status., Conclusion: DCE-MRI is useful for the assessment of the tumor microenvironment associated with HPV and EGFR biomarkers before treatment of patients with oral cavity and oropharyngeal SCC.

Published
2016
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