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Your search keyword '"Kværner, Ane S."' showing total 17 results
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17 results on '"Kværner, Ane S."'

3. Exploring the gut DNA virome in fecal immunochemical test stool samples reveals associations with lifestyle in a large population-based study

Author

Istvan, Paula, primary, Birkeland, Einar, additional, Avershina, Ekaterina, additional, Kværner, Ane S., additional, Bemanian, Vahid, additional, Pardini, Barbara, additional, Tarallo, Sonia, additional, de Vos, Willem M., additional, Rognes, Torbjørn, additional, Berstad, Paula, additional, and Rounge, Trine B., additional

Published
2024
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4. Exploring the gut DNA virome in fecal immunochemical test stool samples reveals associations with lifestyle in a large population-based study

Author

Istvan, Paula, Birkeland, Einar, Avershina, Ekaterina, Kværner, Ane S., Bemanian, Vahid, Pardini, Barbara, Tarallo, Sonia, de Vos, Willem M., Rognes, Torbjørn, Berstad, Paula, Rounge, Trine B., Istvan, Paula, Birkeland, Einar, Avershina, Ekaterina, Kværner, Ane S., Bemanian, Vahid, Pardini, Barbara, Tarallo, Sonia, de Vos, Willem M., Rognes, Torbjørn, Berstad, Paula, and Rounge, Trine B.

Abstract

Stool samples for fecal immunochemical tests (FIT) are collected in large numbers worldwide as part of colorectal cancer screening programs. Employing FIT samples from 1034 CRCbiome participants, recruited from a Norwegian colorectal cancer screening study, we identify, annotate and characterize more than 18000 DNA viruses, using shotgun metagenome sequencing. Only six percent of them are assigned to a known taxonomic family, with Microviridae being the most prevalent viral family. Linking individual profiles to comprehensive lifestyle and demographic data shows 17/25 of the variables to be associated with the gut virome. Physical activity, smoking, and dietary fiber consumption exhibit strong and consistent associations with both diversity and relative abundance of individual viruses, as well as with enrichment for auxiliary metabolic genes. We demonstrate the suitability of FIT samples for virome analysis, opening an opportunity for large-scale studies of this enigmatic part of the gut microbiome. The diverse viral populations and their connections to the individual lifestyle uncovered herein paves the way for further exploration of the role of the gut virome in health and disease.

Published
2024

5. DNA base oxidation in relation to TNM stages and chemotherapy treatment in colorectal cancer patients 2–9 months post-surgery

Author

Nordengen, Anne Lene, primary, Kværner, Ane S., additional, Krutto, Annika, additional, Alavi, Dena T., additional, Henriksen, Hege B., additional, Henriksen, Christine, additional, Raastad, Truls, additional, Smeland, Sigbjørn, additional, Bøhn, Siv K., additional, Shaposhnikov, Sergey, additional, Collins, Andrew R., additional, and Blomhoff, Rune, additional

Published
2023
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8. Characteristics of nonparticipants in a randomised colorectal cancer screening trial comparing sigmoidoscopy and faecal immunochemical testing

Author

Botteri, Edoardo, primary, Hoff, Geir, additional, Randel, Kristin R., additional, Holme, Øyvind, additional, de Lange, Thomas, additional, Bernklev, Tomm, additional, Aas, Eline, additional, Berthelsen, Mona, additional, Natvig, Erik, additional, Kirkøen, Benedicte, additional, Knudsen, Markus D., additional, Kværner, Ane S., additional, Schult, Anna L., additional, Ursin, Giske, additional, Jørgensen, Anita, additional, and Berstad, Paula, additional

Published
2022
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14. Associations between body shape across the life course and adulthood concentrations of sex hormones in men and pre- and postmenopausal women: a multicohort study.

Author

Chen, Ya-Wen, Hang, Dong, Kværner, Ane S., Giovannucci, Edward, and Song, Mingyang

Subjects
BODY weight, MEN'S health, HUMAN life cycle, REGRESSION analysis, SEX distribution, SEX hormones, DESCRIPTIVE statistics, BODY mass index, WOMEN'S health, ADIPOSE tissues, ADULTS
Abstract

The objective was to investigate associations between life-course adiposity and sex hormone concentrations: trajectory of adiposity from age 5 to 40 (premenopausal)/60 (postmenopausal women and men) in relation to levels of oestrone (E1), oestradiol (E2), sex hormone-binding globulins (SHBG), testosterone in 4801 premenopausal and 6019 postmenopausal women in the Nurses' Health Study (NHS) and NHS II, and 2431 men in the Health Professionals Follow-up Study. We used group-based trajectory models to identify groups within each cohort based on recalled somatotypes and reported BMI. Multivariate linear regression models were used to compare sex hormone concentration across different trajectory groups. The mean age at blood draw was 64·1 ± 8·1 years for men, 59·4 ± 6·0 for postmenopausal and 44·1 ± 4·6 for premenopausal women. In men, compared with the medium-stable group, lean-marked increase and medium increase groups had lower levels of SHBG (percentage difference: −17 and −9 %) and testosterone (−15 and −13 %). In postmenopausal women, compared with the medium-stable group, lean-marked increase and medium increase groups had higher levels of E1 (21 and 34 %) and E2 (45 and 68 %) but lower level of SHBG (–29 and −35 %). In premenopausal women, compared with the lean-moderate increase group, medium-stable/increase and heavy-stable/increase groups had lower levels of SHBG (–6 and −28 %). Attained adulthood adiposity and middle-life weight gain were associated with lower SHBG and testosterone in men, higher E1 and E2 and lower SHBG in postmenopausal women, and lower SHBG in premenopausal women. The study indicates the importance of maintaining a healthy body weight throughout life course for homoeostasis of sex hormones. [ABSTRACT FROM AUTHOR]

Published
2022
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Author

Svendsen, Karianne, primary, Arnesen, Erik, additional, and Kværner, Ane S., additional

Published
2018
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