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8. Risk factors of long-term postoperative renal function after partial nephrectomy in a solitary kidney

Author

Zhu Jie, Kuru Timur, Wei Yingqi, Hatiboglu Gencay, Popeneciu Valentin, Schöenberg Gita, Simpfendörfer Tobias, Zeier Martin, Xin Ma, Zhang Xu, Hohenfellner Markus, and Pahernik Sascha

Subjects
renal function, partial nephrectomy, solitary kidney, warm ischemia time, risk factors, Biology (General), QH301-705.5
Abstract

The effect of warm ischemia time (WIT) on longterm renal function after partial nephrectomy remains controversial. In this retrospectively cohort study, 75 solitary kidney patients were included and the effects of warm ischemia time, preoperative renal function and resected normal parenchyma volume on long-term renal function were evaluated. Multivariable analysis showed that the preoperative renal function baseline was significantly associated with renal function 12 months postoperation (P=0.01), adjusting for age and comorbidities factors. Meanwhile, perioperative acute renal failure (ARF) events significantly affected postoperative renal function at postoperative time points of 12 months (P=0.001) and 60 months (P=0.03), as well as renal function change at postoperative 12 months (P

Published
2017
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13. Comparative Analysis of Transperineal Template Saturation Prostate Biopsy Versus Magnetic Resonance Imaging Targeted Biopsy with Magnetic Resonance Imaging-Ultrasound Fusion Guidance

Author

Radtke, Jan P., Kuru, Timur H., Boxler, Silvan, Alt, Celine D., Popeneciu, Ionel V., Huettenbrink, Clemens, Klein, Tilman, Steinemann, Sarah, Bergstraesser, Claudia, Roethke, Matthias, Roth, Wilfried, Schlemmer, Heinz-Peter, Hohenfellner, Markus, and Hadaschik, Boris A.

Published
2015
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14. Die transperineale Biopsie der Prostata ohne Antibiotikaprophylaxe - eine sichere Alternative zur transrektalen Biopsie

Author

Achtelik, Katharina, Kohl, Tobias, Siegle, August, Kuru, Timur H., Salem, Johannes, Rolfs, Hanjo, Kowalke, Tobias, Jilg, Cordula A., Grabbert, Markus, Gratzke, Christian, and Porres, Daniel

Subjects
ddc: 610, Medicine and health
Abstract

Einleitung: Die transperineale Biopsie der Prostata (TPB) verspricht selbst ohne Antibiotikaprophylaxe eine sichere Alternative, zu der mit steigenden Infektkomplikationen in Verruf geratenen herk��mmlichen transrektalen Biopsie der Prostata, zu sein. Insbesondere die Rate der postoperativen Sepsis [zum vollst��ndigen Text gelangen Sie ��ber die oben angegebene URL]

Published
2022
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17. FURTHER REDUCTION OF DISQUALIFICATION RATES BY ADDITIONAL MRI-TARGETED BIOPSY WITH TRANSPERINEAL SATURATION BIOPSY COMPARED TO STANDARD 12-CORE SYSTEMATIC BIOPSIES FOR SELECTION OF PROSTATE CANCER PATIENTS FOR ACTIVE SURVEILLANCE.: PD08-10

Author

Radtke, Jan Philipp, Kuru, Timur Hasan, Bonekamp, David, Freitag, Martin, Kesch, Claudia Verena, Wolf, Maya, Alt, Celine, Hatiboglu, Gencay, Boxler, Silvan, Pahernik, Sascha, Roth, Wilfried, Roethke, Matthias Claudius, Schlemmer, Heinz-Peter, Hohenfellner, Markus, and Hadaschik, Boris

Published
2016
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20. Comprehensive analysis of complications after transperineal prostate biopsy without antibiotic prophylaxis: results of a multicenter trial with 30 days’ follow-up

Author

Kohl, Tobias, primary, Sigle, August, additional, Kuru, Timur, additional, Salem, Johannes, additional, Rolfs, Hanjo, additional, Kowalke, Tobias, additional, Suarez-Ibarrola, Rodrigo, additional, Michaelis, Jakob, additional, Binder, Nadine, additional, Jilg, Cordula A., additional, Miernik, Arkadiusz, additional, Grabbert, Markus T., additional, Schultze-Seemann, W., additional, Gratzke, Christian, additional, and Porres, Daniel, additional

Published
2021
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21. Triggers and oncologic outcome of salvage radical prostatectomy, salvage radiotherapy and active surveillance after focal therapy of prostate cancer

Author

von Hardenberg, Jost, Cash, Hannes, Koch, Daniel, Borkowetz, Angelika, Bruendl, Johannes, Leyh-Bannurah, Sami-Ramzi, Kuru, Timur H., Kowalewski, Karl-Friedrich, Schindele, Daniel, Mala, Katharina S., Westhoff, Niklas, Blana, Andreas, Schostak, Martin, von Hardenberg, Jost, Cash, Hannes, Koch, Daniel, Borkowetz, Angelika, Bruendl, Johannes, Leyh-Bannurah, Sami-Ramzi, Kuru, Timur H., Kowalewski, Karl-Friedrich, Schindele, Daniel, Mala, Katharina S., Westhoff, Niklas, Blana, Andreas, and Schostak, Martin

Abstract

Purpose Due to the tissue preserving approach of focal therapy (FT), local cancer relapse can occur. Uncertainty exists regarding triggers and outcome of salvage strategies. Methods Patients with biopsy-proven prostate cancer (PCa) after FT for localized PCa from 2011 to 2020 at eight tertiary referral hospitals in Germany that underwent salvage radical prostatectomy (S-RP), salvage radiotherapy (S-RT) or active surveillance (AS) were reported. Prostate specific antigen (PSA) changes, suspicious lesions on mpMRI and histopathological findings on biopsy were analyzed. A multivariable regression model was created for adverse pathological findings (APF) at S-RP specimen. Kaplan-Meier curves were generated to determine oncological outcomes. Results A total of 90 men were included. Cancer relapse after FT was detected at a median of 12 months (IQR 9-16). Of 50 men initially under AS 13 received S-RP or S-RT. In total, 44 men underwent S-RP and 13 S-RT. At cancer relapse 17 men (38.6%) in the S-RP group [S-RT n = 4 (30.8%); AS n = 3 (6%)] had ISUP > 2. APF (pT >= 3, ISUP >= 3, pN + or R1) were observed in 23 men (52.3%). A higher ISUP on biopsy was associated with APF [p = 0.006 (HR 2.32, 97.5% CI 1.35-4.59)] on univariable analysis. Progression-free survival was 80.4% after S-RP and 100% after S-RT at 3 years. Secondary therapy-free survival was 41.7% at 3 years in men undergoing AS. Metastasis-free survival was 80% at 5 years for the whole cohort. Conclusion With early detection of cancer relapse after FT S-RP and S-RT provide sufficient oncologic control at short to intermediate follow-up. After AS, a high secondary-therapy rate was observed.

Published
2021

22. Evaluation of the Ginsburg Scheme: Where Is Significant Prostate Cancer Missed?

Author

Sigle, August, primary, Jilg, Cordula A., additional, Kuru, Timur H., additional, Binder, Nadine, additional, Michaelis, Jakob, additional, Grabbert, Markus, additional, Schultze-Seemann, Wolfgang, additional, Miernik, Arkadiusz, additional, Gratzke, Christian, additional, Benndorf, Matthias, additional, and Suarez-Ibarrola, Rodrigo, additional

Published
2021
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24. Vimentin 3 and endothelin in prostate cancer.

Author

Kohl, Tobias, von Brandenstein, Melanie, Stog, Andreas, Schlosser, Monika, Kuru, Timur H., Pfister, David, Fries, Jochen, Heidenreich, Axel, Kohl, Tobias, von Brandenstein, Melanie, Stog, Andreas, Schlosser, Monika, Kuru, Timur H., Pfister, David, Fries, Jochen, and Heidenreich, Axel

Published
2018

26. Genomic features of renal cell carcinoma with venous tumor thrombus

Author

Warsow, Gregor, Huebschmann, Daniel, Kleinheinz, Kortine, Nientiedt, Cathleen, Heller, Martina, Van Coile, Laura, Tolstov, Yanis, Trennheuser, Lukas, Wieczorek, Kathrin, Pecqueux, Carine, Gasch, Claudia, Kuru, Timur, Nyarangi-Dix, Joanne, Hatiboglu, Gencay, Teber, Dogu, Perner, Sven, Stenzinger, Albrecht, Roth, Wilfried, Hadaschik, Boris, Pahernik, Sascha, Jaeger, Dirk, Gruellich, Carsten, Duensing, Anette, Eils, Roland, Schlesner, Matthias, Sueltmann, Holger, Hohenfellner, Markus, Duensing, Stefan, Warsow, Gregor, Huebschmann, Daniel, Kleinheinz, Kortine, Nientiedt, Cathleen, Heller, Martina, Van Coile, Laura, Tolstov, Yanis, Trennheuser, Lukas, Wieczorek, Kathrin, Pecqueux, Carine, Gasch, Claudia, Kuru, Timur, Nyarangi-Dix, Joanne, Hatiboglu, Gencay, Teber, Dogu, Perner, Sven, Stenzinger, Albrecht, Roth, Wilfried, Hadaschik, Boris, Pahernik, Sascha, Jaeger, Dirk, Gruellich, Carsten, Duensing, Anette, Eils, Roland, Schlesner, Matthias, Sueltmann, Holger, Hohenfellner, Markus, and Duensing, Stefan

Abstract

A venous tumor thrombus (VTT) is a potentially lethal complication of renal cell carcinoma (RCC) but virtually nothing is known about the underlying natural history. Based on our observation that venous thrombi contain significant numbers of viable tumor cells, we applied multiregion whole exome sequencing to a total of 37 primary tumor and VTT samples including normal tissue specimens from five consecutive patients. Our findings demonstrate mutational heterogeneity between primary tumor and VTT with 106 of 483 genes (22%) harboring functional SNVs and/or indels altered in either primary tumor or thrombus. Reconstruction of the clonal phylogeny showed clustering of tumor samples and VTT samples, respectively, in the majority of tumors. However, no new subclones were detected suggesting that pre-existing subclones of the primary tumor drive VTT formation. Importantly, we found several lines of evidence for BRCAness in a subset of tumors. These included mutations in genes that confer BRCAness, a mutational signature and an increase of small indels. Re-analysis of SNV calls from the TCGA KIRC-US cohort confirmed a high frequency of the BRCAness mutational signature AC3 in clear cell RCC. Our findings warrant further pre-clinical experiments and may lead to novel personalized therapies for RCC patients.

Published
2018

28. Genomic features of renal cell carcinoma with venous tumor thrombus

Author

Warsow, Gregor, primary, Hübschmann, Daniel, additional, Kleinheinz, Kortine, additional, Nientiedt, Cathleen, additional, Heller, Martina, additional, Van Coile, Laura, additional, Tolstov, Yanis, additional, Trennheuser, Lukas, additional, Wieczorek, Kathrin, additional, Pecqueux, Carine, additional, Gasch, Claudia, additional, Kuru, Timur, additional, Nyarangi-Dix, Joanne, additional, Hatiboglu, Gencay, additional, Teber, Dogu, additional, Perner, Sven, additional, Stenzinger, Albrecht, additional, Roth, Wilfried, additional, Hadaschik, Boris, additional, Pahernik, Sascha, additional, Jäger, Dirk, additional, Grüllich, Carsten, additional, Duensing, Anette, additional, Eils, Roland, additional, Schlesner, Matthias, additional, Sültmann, Holger, additional, Hohenfellner, Markus, additional, and Duensing, Stefan, additional

Published
2018
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29. MP30-03 MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION IN PATIENTS WITH LOCALIZED PROSTATE CANCER: 3-YEAR OUTCOMES OF A PROSPECTIVE PHASE I STUDY

Author

Chin, Joseph L., primary, Relle, James, additional, Dewar, Malcolm, additional, Hetou, Khalil, additional, Kuru, Timur, additional, Hatiboglu, Gencay, additional, Popeneciu, Ionel Valentin, additional, Hafron, Jason, additional, Roethke, Matthias, additional, Mueller-Wolf, Maya, additional, Kassam, Zahra, additional, Staruch, Robert, additional, Burtnyk, Mathieu, additional, Bonekamp, David, additional, Schlemmer, Heinz-Peter, additional, and Pahernik, Sascha, additional

Published
2018
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30. Vimentin 3 and endothelin in prostate cancer.

Author

Kohl, Tobias, primary, von Brandenstein, Melanie, additional, Stog, Andreas, additional, Schlosser, Monika, additional, Kuru, Timur H., additional, Pfister, David, additional, Fries, Jochen, additional, and Heidenreich, Axel, additional

Published
2018
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32. Websites on Bladder Cancer: an Appropriate Source of Patient Information?

Author

Salem, Johannes, primary, Paffenholz, Pia, additional, Bolenz, Christian, additional, von Brandenstein, Melanie, additional, Cebulla, Angelika, additional, Haferkamp, Axel, additional, Kuru, Timur, additional, Lee, Cheryl T., additional, Pfister, David, additional, Tsaur, Igor, additional, Borgmann, Hendrik, additional, and Heidenreich, Axel, additional

Published
2018
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33. V4-11 MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION IN PATIENTS WITH LOCALIZED PROSTATE CANCER: PRIMARY OUTCOMES OF A PROSPECTIVE PHASE I STUDY

Author

Chin, Joseph, primary, Relle, James, additional, Billia, Michele, additional, Popeneciu, Valentin, additional, Kuru, Timur, additional, Hafron, Jason, additional, Roethke, Matthias, additional, Mueller-Wolf, Maya, additional, Kassam, Zahra, additional, Kibria, Fayruz, additional, Burtnyk, Mathieu, additional, Schlemmer, Heinz-Peter, additional, and Pahernik, Sascha, additional

Published
2017
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34. Transperineal prostate biopsies for diagnosis of prostate cancer are well tolerated: a prospective study using patient-reported outcome measures

Author

Wadhwa, Karan, primary, Carmona-Echeveria, Lina, additional, Kuru, Timur, additional, Gaziev, Gabriele, additional, Serrao, Eva, additional, Parashar, Deepak, additional, Frey, Julia, additional, Dimov, Ivailo, additional, Seidenader, Jonas, additional, Acher, Pete, additional, Muir, Gordon, additional, Doble, Andrew, additional, Gnanapragasam, Vincent, additional, Hadaschik, Boris, additional, and Kastner, Christof, additional

Published
2017
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36. Evaluation of an Automated Analysis Tool for Prostate Cancer Prediction Using Multiparametric Magnetic Resonance Imaging

Author

Roethke, Matthias C., Kuru, Timur H., Mueller-Wolf, Maya B., Agterhuis, Erik, Edler, Christopher, Hohenfellner, Markus, Schlemmer, Heinz-Peter, Hadaschik, Boris A., Roethke, Matthias C., Kuru, Timur H., Mueller-Wolf, Maya B., Agterhuis, Erik, Edler, Christopher, Hohenfellner, Markus, Schlemmer, Heinz-Peter, and Hadaschik, Boris A.

Abstract

Objective To evaluate the diagnostic performance of an automated analysis tool for the assessment of prostate cancer based on multiparametric magnetic resonance imaging (mpMRI) of the prostate. Methods A fully automated analysis tool was used for a retrospective analysis of mpMRI sets (T2-weighted, T1-weighted dynamic contrast-enhanced, and diffusion-weighted sequences). The software provided a malignancy prediction value for each image pixel, defined as Malignancy Attention Index (MAI) that can be depicted as a colour map overlay on the original images. The malignancy maps were compared to histopathology derived from a combination of MRI-targeted and systematic transperineal MRI/TRUS-fusion biopsies. Results In total, mpMRI data of 45 patients were evaluated. With a sensitivity of 85.7% (with 95% CI of 65.4-95.0), a specificity of 87.5%(with 95% CI of 69.0-95.7) and a diagnostic accuracy of 86.7% (with 95% CI of 73.8-93.8) for detection of prostate cancer, the automated analysis results corresponded well with the reported diagnostic accuracies by human readers based on the PI-RADS system in the current literature. Conclusion The study revealed comparable diagnostic accuracies for the detection of prostate cancer of a user-independent MAI-based automated analysis tool and PI-RADS-scoring-based human reader analysis of mpMRI. Thus, the analysis tool could serve as a detection support system for less experienced readers. The results of the study also suggest the potential of MAI-based analysis for advanced lesion assessments, such as cancer extent and staging prediction.

Published
2016

37. Untitled

Author

Kuru, Timur H., Schlemmer, Heinz-Peter, Roethke, Matthias A., Kuru, Timur H., Schlemmer, Heinz-Peter, and Roethke, Matthias A.

Published
2016

38. Magnetic Resonance Imaging–Guided Transurethral Ultrasound Ablation of Prostate Tissue in Patients with Localized Prostate Cancer: A Prospective Phase 1 Clinical Trial

Author

Chin, Joseph L., primary, Billia, Michele, additional, Relle, James, additional, Roethke, Matthias C., additional, Popeneciu, Ionel V., additional, Kuru, Timur H., additional, Hatiboglu, Gencay, additional, Mueller-Wolf, Maya B., additional, Motsch, Johann, additional, Romagnoli, Cesare, additional, Kassam, Zahra, additional, Harle, Christopher C., additional, Hafron, Jason, additional, Nandalur, Kiran R., additional, Chronik, Blaine A., additional, Burtnyk, Mathieu, additional, Schlemmer, Heinz-Peter, additional, and Pahernik, Sascha, additional

Published
2016
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41. Therapieerfolg nur durch präzise Tumorlokalisation möglich

Author

Ganzer, Roman, primary, Baumunk, Daniel, additional, Blana, Andreas, additional, Franiel, Tobias, additional, Hadaschik, Boris, additional, Henkel, Thomas, additional, Köhrmann, Kai-Uwe, additional, Köllermann, Jens, additional, Kuru, Timur, additional, Liehr, Uwe-Bernd, additional, Machtens, Stefan, additional, Roosen, Alexander, additional, Salomon, Georg, additional, Schlemmer, Heinz-Peter, additional, Sentker, Ludger, additional, Witzsch, Ulrich, additional, and Schostak, Martin, additional

Published
2016
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43. PD08-10 FURTHER REDUCTION OF DISQUALIFICATION RATES BY ADDITIONAL MRI-TARGETED BIOPSY WITH TRANSPERINEAL SATURATION BIOPSY COMPARED TO STANDARD 12-CORE SYSTEMATIC BIOPSIES FOR SELECTION OF PROSTATE CANCER PATIENTS FOR ACTIVE SURVEILLANCE.

Author

Radtke, Jan Philipp, primary, Kuru, Timur Hasan, additional, Bonekamp, David, additional, Freitag, Martin, additional, Kesch, Claudia Verena, additional, Wolf, Maya, additional, Alt, Celine, additional, Hatiboglu, Gencay, additional, Boxler, Silvan, additional, Pahernik, Sascha, additional, Roth, Wilfried, additional, Roethke, Matthias Claudius, additional, Schlemmer, Heinz-Peter, additional, Hohenfellner, Markus, additional, and Hadaschik, Boris, additional

Published
2016
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44. MP18-18 MAGNETIC RESONANCE IMAGING-GUIDED TRANSURETHRAL ULTRASOUND PROSTATE ABLATION IN PATIENTS WITH LOCALIZED PROSTATE CANCER: 18-MONTH OUTCOMES OF A PROSPECTIVE PHASE I STUDY

Author

Chin, Joseph, primary, Relle, James, additional, Hafron, Jason, additional, Popeneciu, Lonel, additional, Kuru, Timur, additional, Billia, Michele, additional, Siddiqui, Khurram, additional, Roethke, Matthias, additional, Romagnoli, Cesare, additional, Burtnyk, Mathieu, additional, Schlemmer, Heinz-Peter, additional, and Pahernik, Sascha, additional

Published
2016
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47. Role of Focal Therapy with High-Intensity Focused Ultrasound in the Management of Clinically Localized Prostate Cancer

Author

Kuru, Timur H., van Essen, Julius, Pfister, David, Porres, Daniel, Kuru, Timur H., van Essen, Julius, Pfister, David, and Porres, Daniel

Abstract

Overtreatment of prostate cancer (PC) remains one of the main burdens in uro-oncology. Focal therapy may be a reasonable alternative with less side effects and morbidity. Application of high-intensity focused ultrasound (HIFU) induces immediate and irreversible coagulation. The treatment leads to consecutive necrosis with sharply delineated margins, making HIFU a promising tool for the focal therapy of localized PC. Unlike radiation, the treatment leaves no collateral damage outside of the heated tissue, allowing repeated use of HIFU, if necessary. In case of non-organ-confined relapse, additional radical salvage therapy can be performed. This review gives an overview of the existing evidence on focal HIFU. Today, 3 HIFU devices are approved for the treatment of localized PC: Sonablate (TM), AblathermTM and the FocalOne (TM) device. In summary, the first published results of focal HIFU are promising. The quality of life and potency of the patients are well preserved. Therefore, HIFU treatment, and especially focal ablation of tumor foci, seems to be a safe alternative to standard treatment, with low side effects. The oncologic results seem satisfactory but need further follow-up to validate this practice of PC control. (C) 2015 S. Karger GmbH, Freiburg

Published
2015

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