234 results on '"Kurata, Y."'
Search Results
2. Numerical Simulation of Supersonic/Hypersonic Flow for TSTO’s Staging Separation
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Iwafuji, H., Kurata, Y., Kanazaki, M., Fujikawa, T., Yonemoto, K., Sasoh, Akihiro, editor, Aoki, Toshiyuki, editor, and Katayama, Masahide, editor
- Published
- 2019
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3. Ultrasonic Investigation of the Magnetic Ordering in Er3Ru4Al12 with a Distorted Kagome Lattice
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Ishii, I., Kurata, Y., Muneshige, H., Andreev, A. A., Gorbunov, D., Nohara, M., Suzuki, T., Ishii, I., Kurata, Y., Muneshige, H., Andreev, A. A., Gorbunov, D., Nohara, M., and Suzuki, T.
- Abstract
To investigate a phase transition around 2 K in Er3Ru4Al12 with a distorted kagome lattice, we conducted the specific heat, magnetic susceptibility, and ultrasonic measurements. At zero field a sharp peak of the specific heat is observed at TN = 2.2 K, implying a phase transition. The magnetic susceptibility in a field applied along [100], which is a magnetically easy direction, remains almost the same value below TN. The longitudinal elastic modulus, C11, shows an obvious hardening at TN, and TN decreases up to 0.4 T as the magnetic field applied along [100] increases, suggesting an antiferromagnetic ordering. In the magnetic field dependence of C11 at 0.5 K, we discovered two abrupt softenings at 0.25 T and around 0.47 T, proposing that the antiferromagnetic phase boundary closes around 0.47 T in the field applied along [100]. Other phase boundary exists around 0.25 T in the ordered state
- Published
- 2023
4. Factors Affecting Perceived Decision Making Among Filipinos in National Elections: An Integration of Theory of Planned Behavior and Behavioral Decision Theory
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Canares, X. J. G., primary, Estipular, L. L. C., additional, Protacio, T. M. A., additional, Ramos, B. D. P., additional, Kurata, Y. B., additional, and Ngo, J. K., additional
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- 2022
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5. Distinct field-induced ferroquadrupolar states for two different magnetic-field directions in DyNiAl
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Ishii, I., Suzuki, D., Umeno, T., Kurata, Y., Wada, Y., Suzuki, T., Andreev, A. V., Gorbunov, D., Miyata, A., (0000-0003-0320-6488) Zherlitsyn, S., Wosnitza, J., Ishii, I., Suzuki, D., Umeno, T., Kurata, Y., Wada, Y., Suzuki, T., Andreev, A. V., Gorbunov, D., Miyata, A., (0000-0003-0320-6488) Zherlitsyn, S., and Wosnitza, J.
- Abstract
The hexagonal Dy-based compound DyNiAl undergoes ferromagnetic and antiferromagnetic-type magnetic phase transitions at TC = 30 K and T1 = 15 K, respectively. To investigate the 4f -electronic state and quadrupole interactions in DyNiAl, we carried out ultrasonic measurements versus temperature and applied magnetic field. The transverse elastic moduli C44 and C66 show a prominent elastic softening originating from an interlevel ferroquadrupolar-type interaction between the ground state and excited Kramers doublets, clarified by a crystal field analysis. In magnetic fields applied along the [100] and [001] axes, we observed a field-induced phase transition. Because the quadrupole interaction is enhanced in high magnetic fields according to our calculations, we suggest a magnetic-field-induced ferroquadrupolar ordering of the electric quadrupoles Oxy and Oyz for fields applied along [100] and [001], respectively, with different quadrupolar order parameters depending on the field direction.
- Published
- 2021
6. Validity and reliability of the symptoms question in the Cold Intolerance Symptom Severity questionnaire in Japanese patients with hand injuries
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Echigo, A, Kurata, Y, Ibe, K, Osanami, Y, and Tsuji, H
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ddc: 610 ,macromolecular substances ,610 Medical sciences ,Medicine ,Cold intolerance ,CISS qustionnaire - Abstract
Objective: The Cold Intolerance Symptom Severity questionnaire (CISS) is a tool for measuring cold intolerance (CI) in patients with hand injuries. This consists of six questions (Q1-Q6); CI symptoms, frequency, duration, prevention measures, severity, and impact on daily activities. Q1 asks about the[for full text, please go to the a.m. URL], 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
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- 2020
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7. Is a replanted digit used in activities of daily living? A study on non-use rate of replanted digits
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Osanami, Y, Echigo, A, Ibe, K, Kurata, Y, and Tsuji, H
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Replanted digit ,ddc: 610 ,ADL ,Sensory disorder ,610 Medical sciences ,Medicine ,human activities - Abstract
Objective: After digital replantation, patients frequently stop using the replanted digit in their activities of daily living (ADL). The purpose of this study was to investigate the non-use rate of replanted digits in ADL. Materials and Methods: This study included 30 fingers in 28 patients treated[for full text, please go to the a.m. URL], 14th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT), 11th Triennial Congress of the International Federation of Societies for Hand Therapy (IFSHT)
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- 2020
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8. Magnetic transition due to the inter-singlet spin-exchange interaction and elastic softening by the interplay of electric quadrupoles in the distorted kagome lattice antiferromagnet Tb3Ru4Al12
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Ishii, I., Mizuno, T., Kumano, S., Umeno, T., Suzuki, D., Kurata, Y., Suzuki, T., Gorbunov, D., Henriques, M. S., and Andreev, A. V.
- Abstract
The distorted kagome lattice antiferromagnet Tb3Ru4Al12 with a hexagonal structure has the Néel temperature TN = 22 K. To clarify the 4 f -electronic state and an influence of electric quadrupoles in Tb3Ru4Al12, ultrasonic measurements on a single-crystalline sample at zero magnetic field and under fields were carried. A characteristic elastic softening of the transverse modulus C66 originating from a quadrupole interaction was found. The crystal electric field parameters were determined to reproduce C66, magnetic susceptibilities, and magnetization curves. The obtained level scheme is that the ground and first excited states are singlets, despite the existence of both the magnetic transition and the quadrupole interaction, indicating that Tb3Ru4Al12 is a curious compound. The positive sign of the quadrupole-quadrupole coupling constant for C66 indicates a ferroquadrupolar-type interaction of the electric quadrupole Oxy or O2. The anisotropic magnetic field dependencies of TN in the field along [100] and [001] were also clarified.
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- 2020
9. Crystal-field effects in Er3Ru<sub<4Al12with a distorted kagome lattice
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Gorbunov, D., Ishii, I., Kurata, Y., Andreev, A. V., Suzuki, T., Zherlitsyn, S., and Wosnitza, J.
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Condensed Matter::Strongly Correlated Electrons - Abstract
We report on the magnetic and elastic properties of Er3Ru4Al12 in static and pulsed magnetic fields up to 58 T. From the ultrasound results, we obtain evidence for a phase transition at 2 K related to magnetic ordering. Furthermore, in the paramagnetic state, Er3Ru4Al12 shows pronounced anomalies in the magnetization and elastic moduli as a function of temperature and magnetic field. We explain our findings using a crystal-electricfield (CEF) model that includes quadrupolar interactions and propose a CEF level scheme for this material. However, the CEF effects cannot explain all field-induced anomalies, which indicates that refined models are needed for explaining these.
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- 2020
10. Investigation of clinical utility of contrast-enhanced MRI in the diagnosis of ectopic pregnancy
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Nishio, N., primary, Kido, A., additional, Kurata, Y., additional, Minami, M., additional, Tokunaga, K., additional, Honda, M., additional, Mandai, M., additional, and Togashi, K., additional
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- 2020
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11. Crystal-field effects in Er3Ru4Al12 with a distorted kagome lattice
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Gorbunov, D. I., primary, Ishii, I., additional, Kurata, Y., additional, Andreev, A. V., additional, Suzuki, T., additional, Zherlitsyn, S., additional, and Wosnitza, J., additional
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- 2020
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12. Silicon Photonics Coherent Optical Subassembly with EO and OE Bandwidths of Over 50 GHz
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Yamanaka, S., primary, Ikuma, Y., additional, Itoh, T., additional, Kawamura, Y., additional, Kikuchi, K., additional, Kurata, Y., additional, Jizodo, M., additional, Jyo, T., additional, Soma, S., additional, Takahashi, M., additional, Tsuzuki, K., additional, Nagatani, M., additional, Nasu, Y., additional, Matsushita, A., additional, and Yamada, T., additional
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- 2020
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13. Postural Analysis Among Machinists Experiencing Work-related Musculoskeletal Disorders in the Philippines
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Necio, A. J. F., primary, Batac, N. E. C., additional, Odias, T. M. P., additional, Ricafort, J. L. B., additional, Salazar, R. R., additional, and Kurata, Y. B., additional
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- 2019
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14. MON-098 Losses of Amino Acid in the Pre- and Post-dilution of On-line HDF under the Same Reduction Rate of β2-microglobulin
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URABE, S., primary, Hyodo, T., additional, Kato, M., additional, Hiyama, E., additional, Kurii, A., additional, Kitamura, M., additional, Hida, M., additional, Kurata, Y., additional, Sakashita, K., additional, and Kokubo, K., additional
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- 2019
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15. EP07.02: First trimester ultrasound findings for detecting rare chromosomal aberrations
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Nakamura, Y., primary, Fujita, S., additional, Tajima, A., additional, Song, M., additional, Matsumoto-Runser, J., additional, Kurata, Y., additional, Arakawa, H., additional, and Tamura, C., additional
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- 2018
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16. Variation in Hemicellulose Structure and Assembly in the Cell Wall Associated with the Transition from Earlywood to Latewood in Cryptomeria japonica
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Kurata, Y., primary, Mori, Y., additional, Ishida, A., additional, Nakajima, M., additional, Ito, N., additional, Hamada, M., additional, Yamashita, K., additional, Fujiwara, T., additional, Tonosaki, M., additional, and Katayama, Y., additional
- Published
- 2018
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17. EP06.07: Sonographic features of Trisomy 13 at 11-13 weeks of gestation
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Nakamura, Y., primary, Song, M., additional, Fujita, S., additional, Kurata, Y., additional, Arakawa, H., additional, and Tamura, C., additional
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- 2017
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18. EP05.05: First trimester sonographic diagnosis of situs anomaly
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Nakamura, Y., primary, Fujita, S., additional, Song, M., additional, Kurata, Y., additional, Arakawa, H., additional, Tamura, C., additional, and Kawataki, M., additional
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- 2017
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19. Direct induction of molecular alignment in liquid crystal polymer network film by photopolymerization
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Hisano, K., additional, Aizawa, M., additional, Ishizu, M., additional, Kurata, Y., additional, and Shishido, A., additional
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- 2016
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20. Properties of irradiated LBE and Pb
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Neuhausen, J., Aerts, A., Glasbrenner, H., Heinitz, S., Jolkkonen, Mikael, Kurata, Y., Obara, T., David, J-C, Thiollière, N., Zanini, L., Neuhausen, J., Aerts, A., Glasbrenner, H., Heinitz, S., Jolkkonen, Mikael, Kurata, Y., Obara, T., David, J-C, Thiollière, N., and Zanini, L.
- Abstract
QC 20161214
- Published
- 2015
21. Direct induction of molecular alignment in liquid crystal polymer network film by photopolymerization
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Khoo, Iam Choon, Hisano, K., Aizawa, M., Ishizu, M., Kurata, Y., and Shishido, A.
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- 2016
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22. From Dibenzofurans to Triphenylenes.
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KURATA, Y., OTSUKA, S., FUKUI, N., NOGI, K., YORIMITSU, H., and OSUKA, A.
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- 2017
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23. Azelnidipine protects HL-1 cardiomyocytes from hypoxia/reoxygenation injury by enhancement of NO production independently of effects on gene expression.
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Minato H, Endo R, Kurata Y, Notsu T, Kinugasa Y, Wakimizu T, Tsuneto M, Shirayoshi Y, Ninomiya H, Yamamoto K, Hisatome I, and Otsuki A
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- Animals, Mice, Gene Expression Regulation drug effects, Nitric Oxide Synthase Type III metabolism, Action Potentials drug effects, Cell Hypoxia, Cell Line, Dihydropyridines pharmacology, Myocytes, Cardiac drug effects, Myocytes, Cardiac metabolism, Myocytes, Cardiac pathology, Nitric Oxide metabolism, Azetidinecarboxylic Acid pharmacology, Azetidinecarboxylic Acid analogs & derivatives, Calcium Channel Blockers pharmacology, Apoptosis drug effects, Myocardial Reperfusion Injury metabolism, Myocardial Reperfusion Injury prevention & control, Myocardial Reperfusion Injury genetics, Myocardial Reperfusion Injury pathology
- Abstract
It remains to be elucidated whether Ca
2+ antagonists induce pharmacological preconditioning to protect the heart against ischemia/reperfusion injury. The aim of this study was to determine whether and how pretreatment with a Ca2+ antagonist, azelnidipine, could protect cardiomyocytes against hypoxia/reoxygenation (H/R) injury in vitro. Using HL-1 cardiomyocytes, we studied effects of azelnidipine on NO synthase (NOS) expression, NO production, cell death and apoptosis during H/R. Action potential durations (APDs) were determined by the whole-cell patch-clamp technique. Azelnidipine enhanced endothelial NOS phosphorylation and NO production in HL-1 cells under normoxia, which was abolished by a heat shock protein 90 inhibitor, geldanamycin, and an antioxidant, N-acetylcysteine. Pretreatment with azelnidipine reduced cell death and shortened APDs during H/R. These effects of azelnidipine were diminished by a NOS inhibitor, L-NAME, but were influenced by neither a T-type Ca2+ channel inhibitor, NiCl2 , nor a N-type Ca2+ channel inhibitor, ω-conotoxin. The azelnidipine-induced reduction in cell death was not significantly enhanced by either additional azelnidipine treatment during H/R or increasing extracellular Ca2+ concentrations. RNA sequence (RNA-seq) data indicated that azelnidipine-induced attenuation of cell death, which depended on enhanced NO production, did not involve any significant modifications of gene expression responsible for the NO/cGMP/PKG pathway. We conclude that pretreatment with azelnidipine protects HL-1 cardiomyocytes against H/R injury via NO-dependent APD shortening and L-type Ca2+ channel blockade independently of effects on gene expression., (© 2024. Springer Nature Japan KK, part of Springer Nature.)- Published
- 2024
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24. Investigation of the clinical implications of anterior cervical invasion in locally advanced cervical squamous cell carcinoma.
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Tamura S, Yamanoi K, Inayama Y, Kurata Y, Himoto Y, Taki M, Murakami R, Horie A, Yamaguchi K, Hamanishi J, and Mandai M
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- Humans, Female, Middle Aged, Adult, Aged, Prognosis, Retrospective Studies, Magnetic Resonance Imaging, Neoadjuvant Therapy, Chemotherapy, Adjuvant, Uterine Cervical Neoplasms pathology, Uterine Cervical Neoplasms therapy, Uterine Cervical Neoplasms surgery, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell surgery, Carcinoma, Squamous Cell therapy, Neoplasm Invasiveness, Neoplasm Recurrence, Local
- Abstract
Purposes: This study investigates the clinical significance of the anterior parametrical invasion in surgically treated patients with cervical squamous cell carcinoma (SCC)., Methods: We included patients diagnosed with cervical SCC with local lesions classified as T2b, who were treated at our department between January 2006 and December 2020. We evaluated the degree of anterior invasion using pretreatment magnetic resonance imaging and divided patients into three groups: partial, equivocal, and full invasion. The frequency of recurrence within 3 years (early recurrence) and overall prognosis were assessed., Results: There were 12, 24, and 46 cases in the partial equivocal, and full invasion groups, respectively. Neoadjuvant chemotherapy followed by surgery and adjuvant chemotherapy was the mainstay of treatment across all groups (7, 17, and 27 cases, respectively). Although the frequency of early recurrence tended to be worse in the full group (partial; 2/7 cases, equivocal; 3/17 cases and full; 9/27 cases), all early local recurrence cases in the full group (four cases) responded well to the subsequent treatment. As for overall survival, the full invasion group had the best prognosis among the three groups., Conclusions: In surgical treatment, although full anterior invasion may increase the risk of early local recurrence, it was considered to have little prognostic impact., (© 2024 Japan Society of Obstetrics and Gynecology.)
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- 2024
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25. CT-derived skeletal muscle change before immunotherapy predicts survival of advanced gastric cancer: associations with inflammatory markers and liver lipid metabolism.
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Hayano K, Ohira G, Matsumoto Y, Kurata Y, Otsuka R, Hirata A, Toyozumi T, Murakami K, Uesato M, and Matsubara H
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- Humans, Male, Female, Middle Aged, Aged, Retrospective Studies, Muscle, Skeletal metabolism, Immune Checkpoint Inhibitors therapeutic use, Adult, Aged, 80 and over, Immunotherapy methods, Prognosis, Stomach Neoplasms pathology, Stomach Neoplasms mortality, Stomach Neoplasms metabolism, Tomography, X-Ray Computed, Lipid Metabolism, Liver metabolism, Liver pathology, Liver diagnostic imaging
- Abstract
Background: Skeletal muscle (SM) is a key factor in cancer treatment. However, it is unclear whether pretreatment SM change affects the outcome of immune checkpoint inhibitors (ICIs) therapy in gastric cancer (GC)., Methods: Advanced GCs treated with ICIs were retrospectively investigated. SM evaluated by psoas muscle area at the third lumbar vertebra was measured on CT acquired within 1 month from the start of ICIs therapy (CT-1), and on CT acquired 2.8 ± 0.84 months before CT-1. Monthly change rate of SM (MCR-SM) was defined as the change rate of SMs between those two CTs divided by the period between those CTs (month). Monthly change rate of body weight (MCR-BW) during the same period was also calculated. They were compared with disease-specific survival (DSS) and progression-free survival (PFS). MCR-SM was compared with pretreatment markers including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), C-reactive protein (CRP), and liver-to-spleen CT attenuation ratio (LSR) as a marker of liver lipid metabolism., Results: This study enrolled eighty-three GC patients. MCR-SM significantly correlated with DSS and PFS (P < 0.0001, 0.001, respectively), whereas MCR-BW did not. Kaplan-Meier analyses demonstrated that higher MCR-SM (MCR-SM ≥ -0.7185%) significantly associated with better DSS and PFS (P = 0.0002, 0.03, respectively). Patients with positive MCR-SM showed significantly lower NLR, MLR, and CRP than those with negative (P = 0.01, 0.006, 0.003, respectively). MCR-SM showed a significant positive correlation with LSR (P = 0.007, R = 0.30)., Conclusions: Pretreatment SM loss, associated with high systemic inflammation and hepatic fat accumulation, related to poor outcome of ICIs therapy in GC., (© 2024. The Author(s).)
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- 2024
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26. Development of deep learning model for diagnosing muscle-invasive bladder cancer on MRI with vision transformer.
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Kurata Y, Nishio M, Moribata Y, Otani S, Himoto Y, Takahashi S, Kusakabe J, Okura R, Shimizu M, Hidaka K, Nishio N, Furuta A, Kido A, Masui K, Onishi H, Segawa T, Kobayashi T, and Nakamoto Y
- Abstract
Rationale and Objectives: To develop and validate a deep learning (DL) model to automatically diagnose muscle-invasive bladder cancer (MIBC) on MRI with Vision Transformer (ViT)., Materials and Methods: This multicenter retrospective study included patients with BC who reported to two institutions between January 2016 and June 2020 (training dataset) and a third institution between May 2017 and May 2022 (test dataset). The diagnostic model for MIBC and the segmentation model for BC on MRI were developed using the training dataset with 5-fold cross-validation. ViT- and convolutional neural network (CNN)-based diagnostic models were developed and compared for diagnostic performance using the area under the curve (AUC). The performance of the diagnostic model with manual and auto-generated regions of interest (ROI
manual and ROIauto , respectively) was validated on the test dataset and compared to that of radiologists (three senior and three junior radiologists) using Vesical Imaging Reporting and Data System scoring., Results: The training and test datasets included 170 and 53 patients, respectively. Mean AUC of the top 10 ViT-based models with 5-fold cross-validation outperformed those of the CNN-based models (0.831 ± 0.003 vs. 0.713 ± 0.007-0.812 ± 0.006, p < .001). The diagnostic model with ROImanual achieved AUC of 0.872 (95 % CI: 0.777, 0.968), which was comparable to that of junior radiologists (AUC = 0.862, 0.873, and 0.930). Semi-automated diagnosis with the diagnostic model with ROIauto achieved AUC of 0.815 (95 % CI: 0.696, 0.935)., Conclusion: The DL model effectively diagnosed MIBC. The ViT-based model outperformed CNN-based models, highlighting its utility in medical image analysis., Competing Interests: The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yasuhisa Kurata reports financial support was provided by 10.13039/501100001691Japan Society for the Promotion of Science. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)- Published
- 2024
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27. Treatment outcomes in non-occlusive mesenteric ischemia and post-treatment return to social activities.
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Ohira G, Hayano K, Tochigi T, Maruyama T, Toyozumi T, Kurata Y, Maruyama M, Arai S, Nakada TA, and Matsubara H
- Abstract
Purpose: To investigate the treatment outcomes of patients with non-occlusive mesenteric ischemia (NOMI) at our institution, we focused on their post-treatment return to social activities., Methods: This study included patients with suspected NOMI who were referred to our department between 2011 and 2023. In-hospital mortality was also investigated as a prognostic factor. The Glasgow-Pittsburgh Outcome Categories (GPOC) score was used to evaluate the return to social activities. The relationship between in-hospital mortality and GPOC scores and patient background and treatment factors was examined., Results: Eighty-two patients were included in the study. Among them, 54 (65.9%) died during hospitalization. Only 9 patients (11%) returned to their social activities. In the multivariate analysis, non-surgical management was found to be the only independent factor for in-hospital mortality. Positive portal venous gas on computed tomography, no open abdomen, no pre-onset catecholamine administration, platelet count < 100,000/µL, lactate level < 5 mmol/L, APTT < 46 s, and Sequential Organ Failure Assessment score < 11 were factors significantly associated with an increased likelihood of return to social activities., Conclusion: This is the first study to assess the post-treatment return to social activities among patients with NOMI. Our findings highlight the concerning reality that survivors may face prolonged dependence on medical care., (© 2024. The Author(s).)
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- 2024
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28. Prognostic relevance of the most predominant and least differentiated grades of gastric adenocarcinoma after curative gastrectomy.
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Imai Y, Kurata Y, and Ichinose M
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- Humans, Male, Female, Prognosis, Middle Aged, Aged, Follow-Up Studies, Survival Rate, Neoplasm Grading, Lymphatic Metastasis, Retrospective Studies, Cell Differentiation, Neoplasm Invasiveness, Adult, Aged, 80 and over, Stomach Neoplasms pathology, Stomach Neoplasms surgery, Gastrectomy, Adenocarcinoma surgery, Adenocarcinoma pathology, Neoplasm Recurrence, Local pathology, Neoplasm Recurrence, Local surgery
- Abstract
Background: Prognostic relevance of differentiation grade has remained controversial in gastric adenocarcinoma (GAC) after curative resection., Methods: GAC patients who underwent curative gastrectomy were analyzed. Differentiation grade was evaluated according to either the most predominant or least differentiated component. Impacts of clinicopathologic parameters on postoperative recurrence and nodal metastasis were analyzed by the multivariate Cox regression analysis in pT1/2/3/4a and pT1b/2/3 GAC and by the logistic regression analysis in pT1b GAC, respectively., Results: 154 patients with GAC, consisting of 34 pT1a (recurrence rate 0%), 45 pT1b (4.4%), 18 pT2 (22.2%), 40 pT3 (35.0%), and 17 pT4a (76.5%), were included. In pT1/2/3/4a GAC, recurrence was significantly associated with only depth of invasion (pT) and grade of venous invasion (VI), although either mode of differentiation grade was significantly associated with pT by the Spearman's rank correlation test. Next, given no recurrence in pT1a and high-grade histopathology in nearly all pT4a, pT1b/2/3 GAC was analyzed, revealing that recurrence was significantly associated with only VI grade and nodal metastasis. Finally, nodal metastasis was not found in any pT1a GAC, of which 44.1% was predominantly high-grade. In pT1b GAC, nodal metastasis was irrelevant to either mode of differentiation grade, tumor size, and ulceration status but was only associated with lymphatic invasion, suggesting that endoscopic resection of pT1 GAC with negative margin can be curative even with high-grade histopathology., Conclusion: Either mode of differentiation grade revealed limited prognostic relevance after curative gastrectomy. Our results may warrant a controversy over current curability evaluation of endoscopic GAC resection., Competing Interests: Declaration of competing interest None of the authors declares any competing interests., (Copyright © 2024 Elsevier Ltd. All rights reserved.)
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- 2024
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29. Survival impact of the degree of parametrial invasion on MRI in locally advanced cervical cancer.
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Himoto Y, Yamanoi K, and Kurata Y
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- Humans, Female, Middle Aged, Adult, Aged, Neoplasm Staging, Prognosis, Uterine Cervical Neoplasms diagnostic imaging, Uterine Cervical Neoplasms pathology, Magnetic Resonance Imaging methods, Neoplasm Invasiveness
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- 2024
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30. [Chemotherapy Strategy in a Case of MSI-High Patients with Gastric Cancer-Case Report].
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Kinoshita K, Matsumoto Y, Hayano K, Kurata Y, Otsuka R, Hayashi H, Uesato M, Murakami K, Toyozumi T, Nakano A, and Matsubara H
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- Humans, Aged, Female, Stomach Neoplasms drug therapy, Stomach Neoplasms pathology, Stomach Neoplasms surgery, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Microsatellite Instability
- Abstract
A 73-year-old woman was referred to our hospital with a chief complaint of black stools and abdominal distention. She was diagnosed with advanced gastric cancer with pyloric stenosis and multiple lymph node metastasis(cT4aN3M0, cStage Ⅲ)and was administered preoperative chemotherapy after laparoscopy and gastric jejunal bypass surgery. The surgical diagnosis was sT4aN3M0P0CY0. After surgery, 2 courses of DS therapy were administered. However, a new liver metastatic lesion was found, and XELOX therapy was selected as the second-line of treatment. Subsequently, enlarged hepatic hilar lymph nodes were found; microsatellite instability testing confirmed MSI-High cancer. Nivolumab was selected as the third- line therapy. After 15 courses, a new liver metastatic lesion appeared. Although Ram+nab-PTX therapy was chosen as the fourth-line therapy, the patient developed myelosuppression after 3 courses. Two years and 4 months after the initial treatment, the patient was considered to have achieved CR. Because drug-induced liver injury had occurred, the Ram therapy was discontinued. The patient has remained in CR for 1 year without receiving any anticancer drugs. This case suggests that for MSI-high patients with gastric cancer, the consideration of treatment strategy should be based on the molecular biological background.
- Published
- 2024
31. Nodal infiltration in endometrial cancer: a prediction model using best subset regression.
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Matsumoto YK, Himoto Y, Nishio M, Kikkawa N, Otani S, Ito K, Yamanoi K, Kato T, Fujimoto K, Kurata Y, Moribata Y, Yoshida H, Minamiguchi S, Mandai M, Kido A, and Nakamoto Y
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- Humans, Female, Retrospective Studies, Middle Aged, Aged, Risk Factors, Adult, Neoplasm Invasiveness, CA-125 Antigen blood, Aged, 80 and over, Endometrial Neoplasms pathology, Endometrial Neoplasms diagnostic imaging, Lymphatic Metastasis diagnostic imaging, Magnetic Resonance Imaging methods, Lymph Nodes pathology, Lymph Nodes diagnostic imaging
- Abstract
Objectives: To build preoperative prediction models with and without MRI for regional lymph node metastasis (r-LNM, pelvic and/or para-aortic LNM (PENM/PANM)) and for PANM in endometrial cancer using established risk factors., Methods: In this retrospective two-center study, 364 patients with endometrial cancer were included: 253 in the model development and 111 in the external validation. For r-LNM and PANM, respectively, best subset regression with ten-time fivefold cross validation was conducted using ten established risk factors (4 clinical and 6 imaging factors). Models with the top 10 percentile of area under the curve (AUC) and with the fewest variables in the model development were subjected to the external validation (11 and 4 candidates, respectively, for r-LNM and PANM). Then, the models with the highest AUC were selected as the final models. Models without MRI findings were developed similarly, assuming the cases where MRI was not available., Results: The final r-LNM model consisted of pelvic lymph node (PEN) ≥ 6 mm, deep myometrial invasion (DMI) on MRI, CA125, para-aortic lymph node (PAN) ≥ 6 mm, and biopsy; PANM model consisted of DMI, PAN, PEN, and CA125 (in order of correlation coefficient β values). The AUCs were 0.85 (95%CI: 0.77-0.92) and 0.86 (0.75-0.94) for the external validation, respectively. The model without MRI for r-LNM and PANM showed AUC of 0.79 (0.68-0.89) and 0.87 (0.76-0.96), respectively., Conclusions: The prediction models created by best subset regression with cross validation showed high diagnostic performance for predicting LNM in endometrial cancer, which may avoid unnecessary lymphadenectomies., Clinical Relevance Statement: The prediction risks of lymph node metastasis (LNM) and para-aortic LNM can be easily obtained for all patients with endometrial cancer by inputting the conventional clinical information into our models. They help in the decision-making for optimal lymphadenectomy and personalized treatment., Key Points: •Diagnostic performance of lymph node metastases (LNM) in endometrial cancer is low based on size criteria and can be improved by combining with other clinical information. •The optimized logistic regression model for regional LNM consists of lymph node ≥ 6 mm, deep myometrial invasion, cancer antigen-125, and biopsy, showing high diagnostic performance. •Our model predicts the preoperative risk of LNM, which may avoid unnecessary lymphadenectomies., (© 2023. The Author(s), under exclusive licence to European Society of Radiology.)
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- 2024
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32. Reduction of adverse reactions and correlation between post-vaccination fever and specific antibody response across successive SARS-CoV-2 mRNA vaccinations.
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Tani N, Ikematsu H, Watanabe H, Goto T, Yanagihara Y, Kurata Y, Harada Y, Horiuchi T, Akashi K, Shimono N, and Chong Y
- Abstract
Background: SARS-CoV-2 mRNA vaccination, recognized for high immunogenicity, frequently induces adverse reactions, especially fever. We previously reported a correlation between post-vaccination fever and specific antibody responses to the primary series and first booster. We herein report changes in adverse reactions and the correlation between post-vaccination fever and antibody responses across successive vaccinations, from monovalent to bivalent mRNA vaccines., Methods: This cohort study was conducted at a Japanese hospital to investigate adverse reactions to the monovalent primary, first booster, and BA.4/5 bivalent BNT162b2 vaccinations. Local and systemic reactions were reported through a self-reporting diary after each dose. The spike-specific IgG titers were measured following each vaccination., Results: Across 727 vaccinations in the vaccine series, the bivalent booster induced fewer adverse reactions than earlier doses. Fever ≥ 38.0 °C was significantly less frequent in the bivalent booster (12.3 %) compared to the primary series and monovalent booster (22.0 %, 26.2 %, p < 0.001). Reaction severity was also reduced in the bivalent booster. In the analysis of 70 participants with complete data for all doses, post-vaccination fever ≥ 38.0 °C exhibited the highest relative risk (RR) among all solicited reactions throughout the vaccine series (RR: 5.24 [95 % CI: 2.40-11.42] for monovalent and 6.24 [95 % CI: 2.14-18.15] for bivalent). The frequency of fever ≥ 38.0 °C after all doses was 8.6 % (6/70), with no fever ≥ 39.0 °C across all vaccinations. A high-grade post-vaccination fever was correlated with higher IgG titers, with multivariate analyses confirming this correlation as independent for each dose and unaffected by previous post-vaccination fever., Conclusions: The bivalent mRNA vaccine booster showed fewer and milder adverse reactions than the monovalent doses. Although vaccinees with a history of post-vaccination fever were more likely to experience fever after a subsequent dose, such recurrences were infrequent. A correlation between post-vaccination fever and increased IgG titers was identified for each vaccination, irrespective of post-vaccination fever history., Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (© 2024 The Authors.)
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- 2024
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33. A case of laparoscopic revision surgery 30 years after vertical banded gastroplasty for morbid obesity.
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Matsumoto Y, Iida S, Kano M, Suito H, Hayashi H, Hayano K, Kurata Y, Otsuka R, Takahashi Y, and Matsubara H
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- Male, Humans, Reoperation, Gastroplasty adverse effects, Obesity, Morbid surgery, Laparoscopy, Bariatric Surgery
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As the number of bariatric and metabolic surgeries being performed is increasing, the importance of revision surgeries is escalating. In this report, we describe a case of revision surgery performed 30 years after vertical banded gastroplasty (VBG), including a review of the surgical techniques. The patient was a male in his 50s who had previously undergone VBG for morbid obesity (body mass index of 72.6 kg/m
2 ), resulting in gradual weight loss. Twenty-eight years later, reflux symptoms due to stenosis of the mesh area developed. Despite conservative treatment, the symptoms recurred, and aspiration pneumonia developed. Gastrojejunal and Y-anastomoses were performed laparoscopically. Postoperatively, the patient progressed well with no weight regain. In revision surgery, it is essential to accurately assess the patient's pathophysiology, as the surgical technique must consider improvement in symptoms, risk of weight regain, and the need for observation of the residual stomach., (© 2024 Asia Endosurgery Task Force and Japan Society of Endoscopic Surgery and John Wiley & Sons Australia, Ltd.)- Published
- 2024
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34. Intraoperative assessment of blood flow using transabdominal ultrasound during laparoscopic surgery of celiac artery compression syndrome.
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Hayano K, Kano M, Matsumoto Y, Kurata Y, Otsuka R, Hirata A, Nakano A, Toyozumi T, Murakami K, Uesato M, Ohira G, and Matsubara H
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- Female, Humans, Middle Aged, Celiac Artery diagnostic imaging, Celiac Artery surgery, Decompression, Surgical methods, Median Arcuate Ligament Syndrome diagnostic imaging, Median Arcuate Ligament Syndrome surgery, Arterial Occlusive Diseases diagnosis, Arterial Occlusive Diseases surgery, Laparoscopy methods
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Surgical treatment of celiac artery (CA) compression syndrome (CACS) is to release the median arcuate ligament (MAL) by removing the abdominal nerve plexus surrounding CA. In laparoscopic surgery of CACS, objective intraoperative assessment of blood flow in CA is highly desirable. We herein demonstrate a case of laparoscopic surgery of CACS with use of intraoperative transabdominal ultrasound. A 52-year-old woman was presented with epigastric pain and vomiting after eating. Contrast-enhanced computed tomography demonstrated significant stenosis at the origin of CA. Doppler study of CA was also performed, and she was diagnosed as CACS. Laparoscopic surgery was performed, and the MAL was divided. And then, Doppler study using intraoperative transabdominal ultrasound confirmed the successful decompression of CA. This patient was discharged on postoperative day 11, and her symptoms was improved. Intraoperative assessment of blood flow in CA using transabdominal ultrasound was a simple and useful method for laparoscopic surgery of CACS., (© 2024 Asia Endosurgery Task Force and Japan Society of Endoscopic Surgery and John Wiley & Sons Australia, Ltd.)
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- 2024
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35. Severe Atelectasis due to Aspirated Valproic Acid Tablet.
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Tanigaki T, Ogawa T, Nomura S, Ito K, Kurata Y, Matsukida A, Ishihara M, Yoshino A, Kawana A, and Kimizuka Y
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A 60-year-old man treated with valproic acid (VPA) for epilepsy developed atelectasis and respiratory failure after an accidentally aspirated VPA tablet-induced mucus hypersecretion. Following bronchoscopic removal of the aspirated tablet, his respiratory status improved and massive sputum production did not recur. We hypothesized that the aspirated VPA tablet increased the expression of mucin-related genes, thereby increasing mucus production. Our in vitro experiments using a human respiratory epithelial cell line revealed that VPA directly upregulates the airway mucin-related genes. We believe that this is the first case report of aspirated VPA-induced severe atelectasis and respiratory failure, which were successfully treated with the bronchoscopic removal of the VPA tablet., Competing Interests: The authors declare that there is no conflict of interest regarding the publication of this article., (Copyright © 2024 Tomomi Tanigaki et al.)
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- 2024
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36. Anterior Malreduction is Associated With Lag Screw Cutout After Internal Fixation of Intertrochanteric Fractures.
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Inui T, Watanabe Y, Suzuki T, Matsui K, Kurata Y, Ishii K, Kurozumi T, and Kawano H
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- Humans, Female, Aged, 80 and over, Aged, Male, Fracture Fixation, Internal adverse effects, Fracture Fixation, Internal methods, Bone Screws adverse effects, Retrospective Studies, Bone Nails, Treatment Outcome, Hip Fractures diagnostic imaging, Hip Fractures surgery, Surgeons, Fracture Fixation, Intramedullary methods
- Abstract
Background: Lag screw cutout is a devastating complication after internal fixation of an intertrochanteric fracture. Although the tip-apex distance (TAD) is known to be associated with this complication, another factor we thought was potentially important-fracture reduction on an oblique lateral view-has not, to our knowledge, been explored., Questions/purposes: (1) Is a well-reduced fracture position on an oblique lateral view after internal fixation of intertrochanteric fracture associated with a lower odds of postoperative cutout, independently of the TAD? (2) Is postoperative sliding of the lag screw after fixation associated with postoperative cutout?, Methods: Patients with intertrochanteric fractures who were at least 65 years old and who had been treated with internal fixation in one of six facilities between July 2011 and December 2017 were included. All patients in the study group had lag screw cutout, and controls were selected by risk-set sampling of age-matched and sex-matched patients using a ratio of 4:1 for patients from each hospital. Of the 2327 intertrochanteric fractures, there were 36 patients (0.02 per person-year), with a mean age of 85 years; 89% (32) were women. In the control group, there were 135 controls. There was no difference in age or sex between the two groups. Sagittal reduction was evaluated using an immediate postoperative oblique lateral radiograph (anterior malreduction versus anatomic reduction or posterior malreduction). The association between anterior malreduction and the odds of cutout was estimated by conditional logistic regression analysis with the TAD and interaction between the TAD and the reduced position as covariates. As a sensitivity analysis, we estimated whether sliding within 2 weeks postoperatively was associated with cutout., Results: After controlling for the potentially confounding variables of age and sex, we found that anterior malreduction was independently associated with a higher odds of cutout compared with anatomic reduction or posterior malreduction (adjusted OR 4.2 [95% CI 1.5 to 12]; p = 0.006). There was also an independent association between cutout and larger TAD (≥ 20 mm) (adjusted OR 4.4 [95% CI 1.4 to 14]; p = 0.01). However, the association between cutout and reduction was not modified by the TAD (adjusted OR of interaction term 0.6 [95% CI 0.08 to 4]; p = 0.54). Postoperative sliding ≥ 6 mm within 2 weeks was associated with higher odds of cutout after adjusting for age and sex (adjusted OR 11 [95% CI 3 to 40]; p < 0.001)., Conclusion: In patients older than 65 years with intertrochanteric fractures, anterior malreduction on a lateral oblique view was associated with much greater odds of postoperative cutout than anatomic reduction or posterior malreduction. Because anterior malreduction is within the surgeon's control, our findings may help surgeons focus on intraoperative reduction on an oblique lateral view to prevent cutouts. Although this factor is a reliable indicator, the results should be applied to cephalomedullary nails, because there was only one patient with cutout among those with sliding hip screws. Because this study was conducted in a homogenous Japanese population, future studies should focus on the association between anterior malreduction and cutout in people of different ethnicities, adjusting for confounding factors such as implant type and surgeon level., Level of Evidence: Level III, therapeutic study., Competing Interests: Each author certifies that there are no funding or commercial associations (consultancies, stock ownership, equity interest, patent/licensing arrangements, etc.) that might pose a conflict of interest in connection with the submitted article related to the author or any immediate family members. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research editors and board members are on file with the publication and can be viewed on request., (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Association of Bone and Joint Surgeons.)
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- 2024
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37. Peripherally inserted central catheter securement with cyanoacrylate glue and bloodstream infection: A retrospective cohort study.
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Kurata Y, Ohira G, Hayano K, Imanishi S, Tochigi T, Takahashi Y, Mamiya H, Iwata M, Uesato M, Murakami K, Toyozumi T, Matsumoto Y, Nakano A, Otsuka R, Hayashi H, and Matsubara H
- Subjects
- Adult, Humans, Catheters, Indwelling adverse effects, Cyanoacrylates therapeutic use, Retrospective Studies, Catheterization, Central Venous adverse effects, Catheterization, Central Venous methods, Central Venous Catheters adverse effects, Sepsis etiology, Catheterization, Peripheral adverse effects, Thrombosis etiology, Catheter-Related Infections prevention & control, Catheter-Related Infections etiology
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Background: Treatment via a peripherally inserted central venous catheter is important for anticancer treatment, perioperative management, and nutrition management. In this study, we aimed to investigate the usefulness of cyanoacrylate glue (CG) in managing peripherally inserted central venous catheters in adults., Methods: This retrospective cohort study enrolled 411 adults requiring a central venous catheter for treatment in the Chiba University Esophageal-Gastro-Intestinal Surgery department between January 2021 and October 2022. The preventive effect of CG in reducing adverse events, including infection, tip migration, and thrombus formation, was evaluated by reviewing electronic medical records, chest radiographs, and contrast-enhanced computed tomography scans., Results: CG and other dressings were used in 158 (CG group) and 253 (control group) patients, respectively. The incidence of catheter infection based on the clinical course was lower in the CG group (3.2%) than in the control group (9.1%; P = 0.03). However, cases of infection confirmed by blood or catheter cultures did not differ between the CG (1.3%) and control (1.9%) groups (P = 1.0). Chest radiographs revealed that catheter tip migration (mean ± SD) was lesser in the CG group (8.2 ± 6.7 mm) than in the control group (15.0 ± 15.8 mm; P < 0.01). There were two cases of venous thrombus formation in the control group., Conclusion: In a population dominated by esophago-gastroenterological malignancy, peripherally inserted central catheter securement via CG was associated with decreased catheter removal because of suspected catheter infection. Further research on larger cohorts is needed to determine if other adverse events decrease following peripherally inserted central catheter securement via CG., (© 2024 The Authors. Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition.)
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- 2024
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38. Regulation of long-term memory by a few clock neurons in Drosophila .
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Shirakawa R, Kurata Y, and Sakai T
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Identification of the neural circuits in the brain regulating animal behavior and physiology is critical for understanding brain functions and is one of the most challenging goals in neuroscience research. The fruitfly Drosophila melanogaster has often been used to identify the neural circuits involved in the regulation of specific behaviors because of the many neurogenetic tools available to express target genes in particular neurons. Neurons controlling sexual behavior, feeding behavior, and circadian rhythms have been identified, and the number of neurons responsible for controlling these phenomena is small. The search for a few neurons controlling a specific behavior is an important first step to clarify the overall picture of the neural circuits regulating that behavior. We previously found that the clock gene period ( per ), which is essential for circadian rhythms in Drosophila , is also essential for long-term memory (LTM). We have also found that a very limited number of per -expressing clock neurons in the adult brain are required for the consolidation and maintenance of LTM. In this review, we focus on LTM in Drosophila , introduce the concept of LTM regulation by a few clock neurons that we have recently discovered, and discuss how a few clock neurons regulate Drosophila LTM., Competing Interests: The author declares no conflicts of interest., (2024 THE BIOPHYSICAL SOCIETY OF JAPAN.)
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- 2024
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39. Stage IV and recurrent colorectal cancer cured following multimodal therapy: A case series.
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Kurata Y, Imai Y, Hirata A, and Ichinose M
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The treatment strategies for colorectal cancer (CRC) with distant metastasis or metastatic recurrence after resection of the primary tumor are controversial. In the present study, four cases of patients with advanced CRC with distant metastasis who achieved disease-free survival (DFS) for >5 years and were deemed potentially cured were reported. Case 1 was that of a 53-year-old male patient with rectal cancer and liver metastases (pT3N2bM1, pStage IV), and case 2 was that of a 58-year-old female patient with descending colon cancer (pT3N1M1, pStage IV) who had lung metastases at surgery and postoperatively. Both patients achieved DFS for >5 years after simultaneous or staged partial hepatectomy or pneumonectomy followed by chemotherapy. Case 3 was that of a 75-year-old male patient with transverse colon cancer (pT3N1M0, pStage IIIB) and case 4 was that of a 73-year-old male patient with sigmoid colon cancer (pT3N0M0, pStage IIA). These cases developed liver metastases after resection of the primary tumour and were subsequently treated with chemotherapy before or after partial hepatectomy. DFS for >5 years was achieved. All four patients were considered cured. The data revealed that even patients with CRC and distant metastases can potentially be cured following multidisciplinary treatment. In the present case report, the factors that enabled these patients to be considered cured were discussed and the aim was to improve the treatment strategy to cure CRC with distant metastasis or recurrence., Competing Interests: The authors declare that they have no competing interests., (Copyright © 2024, Spandidos Publications.)
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- 2024
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40. Endoscopic Diagnosis of Epithelial Subtypes of Superficial Non-Ampullary Duodenal Epithelial Tumors using Magnifying Narrow-Band Imaging.
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Kurata Y, Hirose T, Kakushima N, Nakaguro M, Okumura Y, Tanaka H, Fujishiro M, and Kawashima H
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- Humans, Male, Middle Aged, Female, Aged, Retrospective Studies, Adult, Aged, 80 and over, Adenoma pathology, Adenoma diagnostic imaging, Adenoma classification, Duodenal Neoplasms pathology, Duodenal Neoplasms diagnostic imaging, Narrow Band Imaging methods
- Abstract
Introduction: Superficial non-ampullary duodenal epithelial tumors (SNADETs) include low-grade adenoma (LGA) and high-grade adenoma or carcinoma (HGA/Ca) and are classified into two different epithelial subtypes, gastric-type (G-type) and intestinal-type (I-type). We attempted to distinguish them by endoscopic characteristics including magnifying endoscopy with narrow-band imaging (M-NBI)., Methods: Various endoscopic and M-NBI findings of 286 SNADETs were retrospectively reviewed and compared between G- and I-types and histological grades. M-NBI findings were divided into four patterns based on the following vascular patterns; absent, network, intrastructural vascular (ISV), and unclassified. Lesions displaying a single pattern were classified as mono-pattern and those displaying multiple patterns as mixed-pattern. Lesions showing CDX2 positivity were categorized as I-types and those showing MUC5AC or MUC6 positivity were categorized as G-types based on immunohistochemistry., Results: Among 286 lesions, 23 (8%) were G-type and 243 (85%) were I-type. More G-type lesions were located oral to papilla (91.3 vs. 45.6%, p < 0.001), and had protruding morphology compared to those of I-types (65.2 vs. 14.4%, p < 0.001). The major M-NBI pattern was ISV in G-type (78.2 vs. 26.3%, p < 0.001), and absent for I-type (0 vs. 34.5%, p = 0.003). Three endoscopic characteristics; location oral to papilla, protruding morphology, and major M-NBI pattern (ISV) were independent predictors for G-type. Mixed-pattern was more common in HGA/Ca than LGA for I-type (77.0 vs. 58.8%, p = 0.01); however, there was no difference for those in G-type., Conclusion: Endoscopic findings including M-NBI are useful to differentiate epithelial subtypes., (© 2024 The Author(s). Published by S. Karger AG, Basel.)
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- 2024
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41. Preoperative Imaging Evaluation of Endometrial Cancer in FIGO 2023.
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Kido A, Himoto Y, Kurata Y, Minamiguchi S, and Nakamoto Y
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The staging of endometrial cancer is based on the International Federation of Gynecology and Obstetrics (FIGO) staging system according to the examination of surgical specimens, and has revised in 2023, 14 years after its last revision in 2009. Molecular and histological classification has incorporated to new FIGO system reflecting the biological behavior and prognosis of endometrial cancer. Nonetheless, the basic role of imaging modalities including ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography, as a preoperative assessment of the tumor extension and also the evaluation points in CT and MRI imaging are not changed, other than several point of local tumor extension. In the field of radiology, it has also undergone remarkable advancement through the rapid progress of computational technology. The application of deep learning reconstruction techniques contributes the benefits of shorter acquisition time or higher quality. Radiomics, which extract various quantitative features from the images, is also expected to have the potential for the quantitative prediction of risk factors such as histological types and lymphovascular space invasion, which is newly included in the new FIGO system. This article reviews the preoperative imaging diagnosis in new FIGO system and recent advances in imaging analysis and their clinical contributions in endometrial cancer. EVIDENCE LEVEL: 4 TECHNICAL EFFICACY: Stage 3., (© 2023 International Society for Magnetic Resonance in Medicine.)
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- 2023
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42. Inflammatory and Nutritional Indices as Prognostic Markers in Elderly Patients With Gastric Cancer.
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Otsuka R, Hayashi H, Uesato M, Hayano K, Murakami K, Toyozumi T, Matsumoto Y, Kurata Y, Nakano A, Takahashi Y, Arasawa T, and Matsubara H
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- Aged, Humans, Male, Nutrition Assessment, Prognosis, Blood Platelets, Gastrectomy, Stomach Neoplasms surgery
- Abstract
Background/aim: Peripheral blood inflammatory and nutritional indices are independent prognostic factors for various cancers. However, as society's longevity and the demand for surgery in the elderly increase, it remains unclear whether these indices are valuable for patients aged ≥80 years. This study aimed to assess the utility of peripheral blood indices as prognostic markers in elderly patients with gastric cancer (GC)., Patients and Methods: This study included 103 elderly patients (aged ≥80 years) who underwent radical gastrectomy at our hospital between 2008 and 2020. Preoperative systemic inflammatory and nutritional indices, including the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), lymphocyte-monocyte ratio (LMR), and prognostic and nutritional index (PNI), were evaluated. Prognostic evaluation was performed using Kaplan-Meier analysis and Cox regression., Results: There were no statistically significant differences in NLR, PLR, and LMR regarding overall survival (OS) and relapse-free survival (RFS). However, patients with low PNI had a markedly worse prognosis (3-year OS: 63.9% vs. 81.2%, p=0.002; 3-year RFS: 55.3% vs. 77.6%, p=0.002). Multivariate analysis revealed that male sex and low PNI were independent predictors of OS (p=0.007p=0.003, respectively) and RFS, with only PNI showing significance (p=0.023)., Conclusion: Preoperative PNI is an independent prognostic factor for survival in elderly patients with GC who undergo radical gastrectomy., (Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
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- 2023
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43. Mechanisms for hypothermia during anaphylactic hypotension in awake rats.
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Shibamoto T, Ono M, Tanida M, Kuda Y, and Kurata Y
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- Rats, Animals, Histamine, Wakefulness, Platelet Activating Factor adverse effects, Anaphylaxis chemically induced, Hypothermia complications, Hypotension etiology
- Abstract
Hypothermia develops during systemic anaphylaxis in rodents. The aim of this study was to elucidate the mechanism for the hypothermia by assessing the roles of locomotor activity, tail heat dissipation, heat production in the brown adipose tissue (BAT) activity, and chemical mediators during ovalbumin-induced anaphylactic hypotension in awake rats. We measured the core body temperature (T
core ) and mean blood pressure (MBP), along with the surface temperature of the interscapular region (TiScap ), an indirect measure of BAT activity, and the tail (Ttail ). During anaphylaxis, MBP decreased to the nadir of 53 ± 2 mmHg at 8 min with recovery toward baseline. Tcore began to decrease at 7.5 min with the nadir of 36.1 ± 0.2°C at 30 min from the baseline of 38.0 ± 0.1°C. TiScap also significantly decreased, but its onset was preceded by that of Tcore . Ttail decreased after antigen, suggesting the absence of increased heat dissipation from the tail. The physical activity, as evaluated by moved distances, did not decrease until 20 min after antigen, followed by a progressive decrease. Reduced movement using a restraint maneuver not only reduced Tcore in nonsensitized rats but also augmented the anaphylactic hypothermia in the early phase (1.5-18 min) in sensitized rats. Combined antagonism against platelet-activating factor (PAF) and histamine H1 receptors abolished antigen-induced hypotension but only attenuated hypothermia. In conclusion, decreased locomotor activity, but not tail heat dissipation or decreased BAT activity, may at least in part contribute to this hypothermia. PAF and histamine are involved mainly in hypotension but only partly in hypothermia during rat anaphylaxis. NEW & NOTEWORTHY Anaphylactic shock is a life-threatening systemic hypotension. Hypothermia is observed during systemic anaphylaxis of rats. We determined the mechanism as follows: decreased locomotor activity, but not tail heat dissipation or decreased BAT activity, may at least in part contribute to this hypothermia. PAF and histamine are involved mainly in hypotension, but only partly in hypothermia during rat anaphylaxis.- Published
- 2023
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44. Small bowel adenocarcinomas with favorable prognoses by radical resection and adjuvant chemotherapy: a case series of five cases.
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Nishioka Y, Matsumoto Y, Imanishi S, Endo S, Toyozumi T, Kurata Y, Sasaki T, Ohira G, Hayano K, and Matsubara H
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Background: Small bowel cancer is very rare, accounting for less than 5% of all gastrointestinal cancers, and small bowel adenocarcinoma accounts for approximately 40% of all small bowel cancers. Small bowel adenocarcinoma is often found in advanced stages, with only 40-65% of cases being curatively resectable. The prognosis is poor, with a 5-year survival rate of 14-33% for all patients and 40-60% for those who are curatively resectable. In Japan, practice guidelines for duodenal cancer were instituted in 2021. However, evidence-based standard treatments have not been established for jejunal and ileal cancers. In particular, chemotherapeutic options are limited, and there are only a few reports on multidisciplinary treatments, including adjuvant chemotherapy., Case Presentation: We report five cases of jejunal or ileal lesions that were treated with adjuvant chemotherapy after radical resection. Three patients were male and two were female, with a median age of 67 years. Tumor localization was observed in the jejunum in all cases. Clinical staging was as follows: stage IIIA in two cases and stage IIIB in three cases. Laparotomy was then performed in all cases, employing partial resection with lymph node dissection. Pathological staging in all cases was as follows: stage IIB in two cases, stage IIIA in one case, and stage IIIB in two cases. In all cases, the regimen for adjuvant chemotherapy was selected based on the colorectal cancer guidelines. No serious complications arose from adjuvant therapy; however, adverse events occurred in patients receiving multi-agent chemotherapy. No recurrence was observed in any of the cases, and all the patients survived, with a median survival time of 32 months. As a representative case, we present a case of adjuvant chemotherapy for jejunal adenocarcinoma staged as pT3N2M0, pStage IIIB, with no recurrence at 32 months postoperatively., Conclusions: In general, favorable outcomes were achieved with adjuvant therapy applied in accordance with the criteria for colorectal cancer. These favorable outcomes suggest that it is necessary to identify the risk factors and indications for adjuvant therapy, specifically for small bowel adenocarcinoma., (© 2023. The Author(s).)
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- 2023
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45. Corrigendum to "Quality of clinical practice guidelines in Japan remains low: a cross-sectional meta-epidemiological study" [Journal of Clinical Epidemiology 138 (2021) 10550].
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Kataoka Y, Anan K, Taito S, Tsujimoto Y, Kurata Y, Wada Y, Maruta M, Kanaoka K, Oide S, Takahashi S, and Nango E
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- 2023
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46. Inhibition of the uric acid efflux transporter ABCG2 enhances stimulating effect of soluble uric acid on IL-1β production in murine macrophage-like J774.1 cells.
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Notsu T, Kurata Y, Ninomiya H, Taufiq F, Komatsu K, Miake J, Sawano T, Tsuneto M, Shirayoshi Y, and Hisatome I
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- Mice, Animals, NLR Family, Pyrin Domain-Containing 3 Protein metabolism, Lipopolysaccharides pharmacology, Macrophages metabolism, Interleukin-1beta genetics, Interleukin-1beta metabolism, Interleukin-1beta pharmacology, RNA, Small Interfering pharmacology, RNA, Messenger pharmacology, Caspases pharmacology, Uric Acid pharmacology, Inflammasomes metabolism, Inflammasomes pharmacology
- Abstract
Soluble uric acid (UA) absorbed by cells through UA transporters (UATs) accumulates intracellularly, activates the NLRP3 inflammasome and thereby increases IL-1β secretion. ABCG2 transporter excludes intracellular UA. However, it remains unknown whether ABCG2 inhibition leads to intracellular accumulation of UA and increases IL-1β production. In this study, we examined whether genetic and pharmacological inhibition of ABCG2 could increase IL-1β production in mouse macrophage-like J774.1 cells especially under hyperuricemic conditions. We determined mRNA and protein levels of pro-IL-1β, mature IL-1β, caspase-1 and several UATs in culture supernatants and lysates of J774.1 cells with or without soluble UA pretreatment. Knockdown experiments using an shRNA against ABCG2 and pharmacological experiments with an ABCG2 inhibitor were conducted. Extracellularly applied soluble UA increased protein levels of pro-IL-1β, mature IL-1β and caspase-1 in the culture supernatant from lipopolysaccharide (LPS)-primed and monosodium urate crystal (MSU)-stimulated J774.1 cells. J774.1 cells expressed UATs of ABCG2, GLUT9 and MRP4, and shRNA knockdown of ABCG2 increased protein levels of pro-IL-1β and mature IL-1β in the culture supernatant. Soluble UA increased mRNA and protein levels of ABCG2 in J774.1 cells without either LPS or MSU treatment. An ABCG2 inhibitor, febuxostat, but not a urate reabsorption inhibitor, dotinurad, enhanced IL-1β production in cells pretreated with soluble UA. In conclusion, genetic and pharmacological inhibition of ABCG2 enhanced IL-1β production especially under hyperuricemic conditions by increasing intracellularly accumulated soluble UA that activates the NLRP3 inflammasome and pro-IL-1β transcription in macrophage-like J774.1 cells., (© 2023. The Author(s), under exclusive licence to The Japanese Society of Hypertension.)
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- 2023
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47. Theoretical prediction of early afterdepolarization-evoked triggered activity formation initiating ventricular reentrant arrhythmias.
- Author
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Tsumoto K, Shimamoto T, Aoji Y, Himeno Y, Kuda Y, Tanida M, Amano A, and Kurata Y
- Subjects
- Humans, Arrhythmias, Cardiac, Heart Ventricles, Electrocardiography, Action Potentials, Tachycardia, Ventricular, Long QT Syndrome diagnosis, Long QT Syndrome metabolism, Torsades de Pointes
- Abstract
Background and Objective: Excessive prolongation of QT interval on ECGs in patients with congenital/acquired long QT syndrome and heart failure is a sign suggesting the development of early afterdepolarization (EAD), an abnormal repolarization in the action potential of ventricular cardiomyocytes. The development of EAD has been believed to be a trigger for fatal tachyarrhythmia, which can be a risk for sudden cardiac death. The role of EAD in triggering ventricular tachycardia (VT) remains unclear. The aim of this study was to elucidate the mechanism of EAD-induced triggered activity formation that leads to the VT such as Torsades de Pointes., Methods: We investigated the relationship between EAD and tachyarrhythmia initiation by constructing homogeneous myocardial sheet models consisting of the mid-myocardial cell version of a human ventricular myocyte model and performing simulations of excitation propagation., Results: A solitary island-like (clustering) occurrence of EADs in the homogeneous myocardial sheet could induce a focal excitation wave. However, reentrant excitation, an entity of tachyarrhythmia, was not able to be triggered regardless of the EAD cluster size when the focal excitation wave formed a repolarization potential difference boundary consisting of only a convex surface. The discontinuous distribution of multiple EAD clusters in the ventricular tissue formed a specific repolarization heterogeneity due to the repolarization potential difference, the shape of which depended on EAD cluster size and placed intervals. We found that the triggered activity was formed in such a manner that the repolarization potential difference boundary included a concave surface., Conclusions: The formation of triggered activity that led to tachyarrhythmia required not only the occurrence of EAD onset-mediated focal excitation wave but also a repolarization heterogeneity-based specific repolarization potential difference boundary shape formed within the tissue., Competing Interests: Declaration of Competing Interest The authors declare no competing interests., (Copyright © 2023. Published by Elsevier B.V.)
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- 2023
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48. Use of inducible and limiting fluorescence in laparoscopic endoscopic cooperative surgery.
- Author
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Uesato M, Kurata Y, Matsumoto Y, Kainuma S, Hirosuna T, Otsuka R, Hayano K, and Matsubara H
- Abstract
Video 1Demonstration of the special use of the near-infrared fluorescent clip in laparoscopic endoscopic cooperative surgery., Competing Interests: The authors did not disclose any financial relationships., (© 2024 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc.)
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- 2023
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49. Dznep, a histone modification inhibitor, inhibits HIF1α binding to TIMP2 gene and suppresses TIMP2 expression under hypoxia.
- Author
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Yamazaki T, Mimura I, Kurata Y, Tanaka T, and Nangaku M
- Subjects
- Animals, Mice, Humans, Histone Code, Adenosine, Disease Models, Animal, Tissue Inhibitor of Metalloproteinase-2 genetics, Epigenesis, Genetic, Acute Kidney Injury
- Abstract
Epidemiological studies have shown that patients who recovered from acute kidney injury (AKI) may subsequently develop chronic kidney disease (CKD). AKI is primarily caused by renal hypoxia, and it causes epigenetic alterations, known as hypoxic memory. 3-Deazaneplanocin A (Dznep), an inhibitor of histone modification, suppresses renal fibrosis and the expression of tissue inhibitor of metalloproteinases-2 (TIMP2), a profibrotic factor, in mouse ischemia-reperfusion models. The current study investigated the epigenetic regulation of TIMP2 in human kidney 2 (HK-2) cells. The expression of TIMP2 was upregulated in HK-2 cells under hypoxic conditions and was suppressed by Dznep. ChIP-qPCR showed that Dznep reduced the amount of H3K4me3 at the promoter region of the TIMP2 gene under hypoxic condition. Formaldehyde-assisted isolation of regulatory elements-qPCR of the TIMP2 gene showed that Dznep reduced open chromatin area. In addition, based on ChIP-qPCR of hypoxia-inducible factor 1 alpha (HIF1α), Dznep inhibited the binding of HIF1α to the TIMP2 gene under hypoxic conditions. The reporter assays for the binding region of HIF1α showed enhanced transcriptional activity by hypoxia. Dznep suppresses the expression of TIMP2 under hypoxic conditions by inhibiting the binding of HIF1α to the TIMP2 gene., (© 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
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- 2023
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50. Use of antibiotics as a therapeutic approach to prevent AKI-to-CKD progression.
- Author
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Kurata Y and Nangaku M
- Subjects
- Humans, Anti-Bacterial Agents adverse effects, Amoxicillin, Acute Kidney Injury prevention & control, Gastrointestinal Microbiome, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic drug therapy
- Abstract
The microbiota plays important roles in the health and diseases of its host. Gharaie et al. demonstrated that antibiotic treatment, especially amoxicillin, facilitated the repair process from ischemic acute kidney injury despite postinjury administration through microbiota modulation. This commentary discusses the implications and limitations of the study's findings for utilizing gut microbiota modification with antibiotics as a novel therapeutic approach to prevent acute kidney injury-to-chronic kidney disease progression., (Copyright © 2023 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2023
- Full Text
- View/download PDF
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