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Your search keyword '"Kumagai, Shogo"' showing total 520 results
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520 results on '"Kumagai, Shogo"'

18. Complete response to definitive chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma

Author

Habu, Takumi, Kumanishi, Ryosuke, Ogata, Takatsugu, Fujisawa, Takeshi, Mishima, Saori, Kotani, Daisuke, Kadowaki, Shigenori, Nakamura, Masaki, Hojo, Hidehiro, Fujiwara, Hisashi, Kumagai, Shogo, Koyama, Shohei, Fujita, Takeo, Kinoshita, Takahiro, Nishikawa, Hiroyoshi, Yano, Tomonori, Tajika, Masahiro, Muro, Kei, Mitsunaga, Shuichi, Kojima, Takashi, and Bando, Hideaki

Published
2023
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33. Selective recovery of pyrolyzates of biodegradable (PLA, PHBH) and common plastics (HDPE, PP, PS) during co-pyrolysis under slow heating.

Author

Adachi, Wakana, Kumagai, Shogo, Shao, Zhuze, Saito, Yuko, and Yoshioka, Toshiaki

Subjects
*BIODEGRADABLE plastics, *PLASTICS, *POLYLACTIC acid, *HIGH density polyethylene, *PYROLYSIS gas chromatography, *TEMPERATURE control, *HEATING
Abstract

Pyrolytic synergistic interactions, in which the production of pyrolyzates is enhanced or inhibited, commonly occur during the co-pyrolysis of different polymeric materials, such as plastics and biomass. Although these interactions can increase the yield of desired pyrolysis products under controlled degradation conditions, the desired compounds must be separated from complex pyrolyzates and further purified. To balance these dual effects, this study was aimed at examining pyrolytic synergistic interactions during slow heating co-pyrolysis of biodegradable plastics including polylactic acid (PLA) and poly(3-hydroxybutyrate-co-3-hydroxyhexaoate) (PHBH) and petroleum-based plastics including high-density polyethylene (HDPE), polypropylene (PP), and polystyrene (PS). Comprehensive investigations based on thermogravimetric analysis, pyrolysis–gas chromatography/mass spectrometry, and evolved gas analysis-mass spectrometry revealed that PLA and PHBH decompose at lower temperatures (273–378 °C) than HDPE, PP, and PS (386–499 °C), with each polymer undergoing independent decomposition without any pyrolytic interactions. Thus, the independent pyrolysis of biodegradable plastics, such as PLA and PHBH, with common plastics, such as HDPE, PP, and PS, can theoretically be realized through temperature control, enabling the selective recovery of their pyrolyzates in different temperature ranges. Thus, pyrolytic approaches can facilitate the treatment of mixed biodegradable and common plastics. [ABSTRACT FROM AUTHOR]

Published
2024
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34. The CLIP1–LTK fusion is an oncogenic driver in non‐small‐cell lung cancer

Author

Izumi, Hiroki, Matsumoto, Shingo, Liu, Jie, Tanaka, Kosuke, Mori, Shunta, Hayashi, Kumiko, Kumagai, Shogo, Shibata, Yuji, Hayashida, Takuma, Watanabe, Kana, Fukuhara, Tatsuro, Ikeda, Takaya, Yoh, Kiyotaka, Kato, Terufumi, Nishino, Kazumi, Nakamura, Atsushi, Nakachi, Ichiro, Kuyama, Shoichi, Furuya, Naoki, Sakakibara-Konishi, Jun, Okamoto, Isamu, Taima, Kageaki, Ebi, Noriyuki, Daga, Haruko, Yamasaki, Akira, Kodani, Masahiro, Udagawa, Hibiki, Kirita, Keisuke, Zenke, Yoshitaka, Nosaki, Kaname, Sugiyama, Eri, Sakai, Tetsuya, Nakai, Tokiko, Ishii, Genichiro, Niho, Seiji, Ohtsu, Atsushi, Kobayashi, Susumu S., and Goto, Koichi

Published
2021
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50. LTK mutations responsible for resistance to lorlatinib in non-small cell lung cancer harboring CLIP1-LTK fusion.

Author

Mori, Shunta, Izumi, Hiroki, Araki, Mitsugu, Liu, Jie, Tanaka, Yu, Kagawa, Yosuke, Sagae, Yukari, Ma, Biao, Isaka, Yuta, Sasakura, Yoko, Kumagai, Shogo, Sakae, Yuta, Tanaka, Kosuke, Shibata, Yuji, Udagawa, Hibiki, Matsumoto, Shingo, Yoh, Kiyotaka, Okuno, Yasushi, Goto, Koichi, and Kobayashi, Susumu S.

Subjects
NON-small-cell lung carcinoma, EPIDERMAL growth factor receptors, PROTEIN-tyrosine kinase inhibitors, GENETIC mutation
Abstract

The CLIP1-LTK fusion was recently discovered as a novel oncogenic driver in non-small cell lung cancer (NSCLC). Lorlatinib, a third-generation ALK inhibitor, exhibited a dramatic clinical response in a NSCLC patient harboring CLIP1-LTK fusion. However, it is expected that acquired resistance will inevitably develop, particularly by LTK mutations, as observed in NSCLC induced by oncogenic tyrosine kinases treated with corresponding tyrosine kinase inhibitors (TKIs). In this study, we evaluate eight LTK mutations corresponding to ALK mutations that lead to on-target resistance to lorlatinib. All LTK mutations show resistance to lorlatinib with the L650F mutation being the highest. In vitro and in vivo analyses demonstrate that gilteritinib can overcome the L650F-mediated resistance to lorlatinib. In silico analysis suggests that introduction of the L650F mutation may attenuate lorlatinib-LTK binding. Our study provides preclinical evaluations of potential on-target resistance mutations to lorlatinib, and a novel strategy to overcome the resistance. A novel strategy using gilteritinib can overcome resistance to lorlatinib in non-small cell lung cancer with CLIP1-LTK-L650F mutation. [ABSTRACT FROM AUTHOR]

Published
2024
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