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3. The Society of Laboratory Diagnostics Working Grouprecommendations for serum protein electrophoresis. 2023

Author

Ciepiela, Olga, primary, Cofta, Justyna, additional, Drożdż, Ryszard, additional, Korpysz, Maciej, additional, Kruk, Barbara, additional, Ludziejewska, Aleksandra, additional, Materski, Jarosław, additional, Rodziewicz-Lurzyńska, Anna, additional, Słowikowska, Iwona, additional, Tarasiewicz, Barbara, additional, and Ząbek-Adamska, Anna, additional

Published
2023
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4. Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor

Author

Zhuang, Linghang, Tice, Colin M., Xu, Zhenrong, Zhao, Wei, Cacatian, Salvacion, Ye, Yuan-Jie, Singh, Suresh B., Lindblom, Peter, McKeever, Brian M., Krosky, Paula M., Zhao, Yi, Lala, Deepak, Kruk, Barbara A., Meng, Shi, Howard, Lamont, Johnson, Judith A., Bukhtiyarov, Yuri, Panemangalore, Reshma, Guo, Joan, Guo, Rong, Himmelsbach, Frank, Hamilton, Bradford, Schuler-Metz, Annette, Schauerte, Heike, Gregg, Richard, McGeehan, Gerard M., Leftheris, Katerina, and Claremon, David A.

Published
2017
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8. Discovery of Potent Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 Using a Novel Growth-Based Protocol of in Silico Screening and Optimization in CONTOUR

Author

Liu, Zhijie, primary, Singh, Suresh B., additional, Zheng, Yajun, additional, Lindblom, Peter, additional, Tice, Colin, additional, Dong, Chengguo, additional, Zhuang, Linghang, additional, Zhao, Yi, additional, Kruk, Barbara A., additional, Lala, Deepak, additional, Claremon, David A., additional, McGeehan, Gerard M., additional, Gregg, Richard D., additional, and Cain, Robert, additional

Published
2019
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9. The role of Mig1, Mig2, Tup1 and Hap4 transcription factors in regulation of xylose and glucose fermentation in the thermotolerant yeast Ogataea polymorpha.

Author

Kurylenko, Olena, Ruchala, Justyna, Kruk, Barbara, Vasylyshyn, Roksolana, Szczepaniak, Justyna, Dmytruk, Kostyantyn, and Sibirny, Andriy

Subjects
XYLOSE, TRANSCRIPTION factors, LIGNOCELLULOSE, METABOLIC regulation, GLUCOSE, FERMENTATION
Abstract

Glucose is a preferred carbon source for most living organisms. The metabolism and regulation of glucose utilization are well studied mostly for Saccharomyces cerevisiae. Xylose is the main pentose sugar released from the lignocellulosic biomass, which has a high potential as a renewable feedstock for bioethanol production. The thermotolerant yeast Ogataea (Hansenula) polymorpha , in contrast to S. cerevisiae , is able to metabolize and ferment not only glucose but also xylose. However, in non-conventional yeasts, the regulation of glucose and xylose metabolism remains poorly understood. In this study, we characterize the role of transcriptional factors Mig1, Mig2, Tup1 and Hap4 in the natural xylose-fermenting yeast O. polymorpha. The deletion of MIG1 had no significant influence on ethanol production either from xylose or glucose, however the deletion of both MIG1 and MIG2 reduced the amount of ethanol produced from these sugars. The deletion of HAP4-A and TUP1 genes resulted in increased ethanol production from xylose. Inversely, the overexpression of HAP4-A and TUP1 genes reduced ethanol production during xylose alcoholic fermentation. Thus, HAP4-A and TUP1 are involved in repression of xylose metabolism and fermentation in yeast O. polymorpha and their deletion could be a viable strategy to improve ethanol production from this pentose. [ABSTRACT FROM AUTHOR]

Published
2021
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10. Light Chain Escape in 3 Cases: Evidence of Intraclonal Heterogeneity in Multiple Myeloma from a Single Institution in Poland

Author

Kraj, Maria, Kruk, Barbara, Endean, Kelly, Warzocha, Krzysztof, Budziszewska, Katarzyna, and Dąbrowska, Monika

Subjects
Article Subject
Abstract

We report three cases of light chain escape (LCE) at a single institution in Poland, including an interesting case of biclonal monoclonal gammopathy of undetermined significance (MGUS) that satisfied the criteria for progression to light chain multiple myeloma (LCMM) with a rapid rise in serum free light chain (FLC) levels, following steroidal treatment for simultaneous temporal artery inflammation and polymyalgia rheumatica (PMR). In the three cases discussed, progression of the disease by light chain escape was associated with rapid and severe renal impairment, highlighting the necessity for prompt detection of such free light chain-only producing clones in order to prevent the possible development of irreversible end-organ damage. Interestingly, monitoring of these three patients by serum free light chain assay (sFLC) and retrospective heavy/light chain analysis (HLC) detected this clonal evolution prior to clinical relapse and suggests that these assays represent important additional tools for more accurate monitoring of multiple myeloma patients.

Published
2015
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11. Discovery of Potent Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 Using a Novel Growth-Based Protocol of in SilicoScreening and Optimization in CONTOUR

Author

Liu, Zhijie, Singh, Suresh B., Zheng, Yajun, Lindblom, Peter, Tice, Colin, Dong, Chengguo, Zhuang, Linghang, Zhao, Yi, Kruk, Barbara A., Lala, Deepak, Claremon, David A., McGeehan, Gerard M., Gregg, Richard D., and Cain, Robert

Abstract

With the continuous progress in ultralarge virtual libraries which are readily accessible, it is of great interest to explore this large chemical space for hit identification and lead optimization using reliable structure-based approaches. In this work, a novel growth-based screening protocol has been designed and implemented in the structure-based design platform CONTOUR. The protocol was used to screen the ZINC database in silicoand optimize hits to discover 11β-HSD1 inhibitors. In contrast to molecular docking, the virtual screening process makes significant improvements in computational efficiency without losing chemical equities through partitioning 1.8 million ZINC compounds into fragments, docking fragments to form key hydrogen bonds with anchor residues, reorganizing molecules into molecular fragment trees using matched fragments and common substructures, and then regrowing molecules with the help of developed intelligent growth features inside the protein binding site to find hits. The growth-base screening approach is validated by the high hit rate. A total of 50 compounds have been selected for testing; of these, 15 hits having diverse scaffolds are found to inhibit 11β-HSD1 with IC50values of less than 1 μM in a biochemical enzyme assay. The best hit which exhibits an enzyme IC50of 33 nM is further developed to a novel series of bicyclic 11β-HSD1 inhibitors with the best inhibition of enzyme IC50of 3.1 nM. The final lead candidate exhibits IC50values of 7.2 and 21 nM in enzyme and adipocyte assays, respectively, displayed greater than 1000-fold of selectivity over 11β-HSD2 and two other related hydroxysteroid dehydrogenases, and can serve as good starting points for further optimization to develop clinical candidates.

Published
2019
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12. P1-314: Pharmacological characterization of the new bace1 inhibitor bi 1181181

Author

Dorner-Ciossek, Cornelia, primary, Hobson, Scott, additional, Fuchs, Klaus, additional, Sauer, Achim, additional, Bauer, Margit, additional, Morales-Ramos, Angel, additional, Venkatraman, Shankar, additional, Dillard, Lawrence W., additional, Kruk, Barbara, additional, Howard, Lamont, additional, Bukhtiyarov, Yuri, additional, Zhao, Yi, additional, and Lala, Deepak S., additional

Published
2015
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14. VTP-43742 is a potent and selective RORγt blocker that demonstrates oral efficacy in a mouse model of autoimmunity through suppression of IL-17A production (THER7P.945)

Author

McGeehan, Gerard, primary, Bukhtiyarov, Yuri, additional, Zhao, Yi, additional, Meng, Shi, additional, Noto, Paul, additional, Stadanlick, Jason, additional, Kruk, Barbara, additional, Hardy, Andrew, additional, Lipinski, Kerri, additional, Kandpal, Geeta, additional, Algayer, Bethany, additional, Guo, Joan, additional, Guo, Rong, additional, Marcus, Andrew, additional, Lotesta, Stephen, additional, Dong, Chengguo, additional, Fan, Kristi, additional, Jia, Lanqi, additional, Yuan, Jing, additional, Zheng, Yajun, additional, Zhuang, Linghang, additional, Dillard, Lawrence, additional, Claremon, David, additional, Gregg, Richard, additional, and Lala, Deepak, additional

Published
2015
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16. Zajęcie ośrodkowego układu nerwowego w przebiegu szpiczaka plazmocytowego ― opis przypadku.

Author

Kruk, Barbara, Końska, Agnieszka, and Hus, Iwona

Abstract

Copyright of Acta Haematologica Polonica is the property of VM Medica-VM Group (Via Medica) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2022

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