Search

Your search keyword '"Kojima, Kazuhiro"' showing total 148 results
Start Over Author "Kojima, Kazuhiro" Publication Year Range Last 10 years
148 results on '"Kojima, Kazuhiro"'

5. Pro-inflammatory cytokine expression and the STAT1/3 pathway in canine chronic enteropathy and intestinal T-cell lymphoma.

Author

Kojima, Kazuhiro, Chambers, James K., Nakashima, Ko, and Uchida, Kazuyuki

Subjects
T-cell lymphoma, INTESTINAL diseases, T cells, POLYMERASE chain reaction, INFLAMMATORY bowel diseases, INTESTINES
Abstract

The accumulation of intraepithelial lymphocytes (IELs) is a histopathological feature of canine chronic enteropathy (CE), and IELs are considered the cells of origin of intestinal T-cell lymphoma (ITCL). However, the pathogenic mechanism of IEL activation in CE remains unclear. This study hypothesized that the expression of proinflammatory cytokines, associated with cytotoxic T/NK-cell activation, is upregulated in CE and ITCL, and examined the expression of IFN-γ, IL-2, IL-12p35, IL-12p40, IL-15, and IL-21 and the downstream signal transducers and activators of transcription (STAT) pathway in the duodenal mucosa of dogs without lesions (n = 11; NC), with IEL–CE (n = 19; CE without intraepithelial lymphocytosis), IEL+CE (n = 29; CE with intraepithelial lymphocytosis), and with ITCL (n = 60). Quantitative polymerase chain reaction (PCR) revealed that IFN-γ and IL-21 were higher in IEL+CE than in IEL–CE or NC. Western blot revealed upregulation of STAT1 and STAT3 in IEL+CE. Double-labeling immunohistochemistry revealed a positive correlation between the Ki67 index of CD3+ T-cells and IFN-γ expression levels. Immunohistochemistry revealed a higher ratio of p-STAT1-positive villi in IEL+CE and ITCL than IEL–CE and NC, which positively correlated with IFN-γ expression levels. Among the 60 ITCL cases, neoplastic lymphocytes were immunopositive for p-STAT1 in 28 cases and p-STAT3 in 29 cases. These results suggest that IFN-γ and IL-21 contribute to the pathogenesis of IEL+CE, and IFN-γ may be involved in T-cell activation and mucosal injury in CE. STAT1 and STAT3 activation in ITCL cells suggests a role for the upregulation of the STAT pathway in the pathogenesis of ITCL. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

8. Different expression patterns of p63 and p73 in Felis catus papillomavirus type 2-associated feline Merkel cell carcinomas and other epidermal carcinomas.

Author

SUMI, Ayumi, CHAMBERS, James K., ITO, Soma, KOJIMA, Kazuhiro, OMACHI, Tetsuo, DOI, Masaki, and UCHIDA, Kazuyuki

Subjects
MERKEL cell carcinoma, CATS, MERKEL cells, LIFE cycles (Biology), BASAL cell carcinoma, CAT diseases, SKIN cancer
Abstract

Merkel cell carcinoma (MCC) is a cutaneous neuroendocrine tumor, and more than 90% of feline MCC cases test positive for Felis catus papillomavirus type 2 (FcaPV2). In the present study, basal cell markers p40, p63, and p73 and the stem cell marker SOX2 and cytokeratin 14 (CK14) were immunohistochemically examined in normal fetal, infant, and adult feline skin tissues. The expression of these proteins was examined in tumors positive for FcaPV2, including MCC, basal cell carcinoma (BCC), Bowenoid in situ carcinoma (BISC), and squamous cell carcinoma (SCC). Infant and adult feline skin tissues had mature Merkel cells, which were CK14-, CK18+, CK20+, SOX2+, synaptophysin+ and CD56+, while fetal skin tissue had no mature Merkel cells. MCC was immunopositive for p73, CK18, and SOX2 in 32/32 cases, and immunonegative for CK14 in 31/32 cases and for p40 and p63 in 32/32 cases. These results indicate that MCC exhibits different immunophenotypes from Merkel cells (p73-) and basal cells (p40+, p63+, and SOX2-). In contrast, all 3 BCCs, 1 BISC, and 2 SCCs were immunopositive for the basal cell markers p40, p63, and p73. The life cycle of papillomavirus is closely associated with the differentiation of infected basal cells, which requires the transcription factor p63. Changes in p63 expression in FcaPV2-positive MCC may be associated with unique cytokeratin expression patterns (CK14-, CK18+, and CK20+). Furthermore, SOX2 appears to be involved in Merkel cell differentiation in cats, similar to humans and mice. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

13. Malignant transformation of central neurocytoma with dissemination 17 years after initial treatment: illustrative case

Author

20378649, 50716602, 10252462, Kojima, Kazuhiro, Arakawa, Yoshiki, Takeuchi, Yasuhide, Terada, Yukinori, Tanji, Masahiro, Mineharu, Yohei, Haga, Hironori, Miyamoto, Susumu, 20378649, 50716602, 10252462, Kojima, Kazuhiro, Arakawa, Yoshiki, Takeuchi, Yasuhide, Terada, Yukinori, Tanji, Masahiro, Mineharu, Yohei, Haga, Hironori, and Miyamoto, Susumu

Abstract

BACKGROUND: Central neurocytomas usually have a favorable clinical course, and gross total resection (GTR) results in long-term survival. Recurrences of central neurocytomas are usually local, and dissemination is extremely rare. OBSERVATIONS: A 24-year-old man who presented with vomiting was found to have a mass in the right lateral ventricle. After GTR, he received whole-brain irradiation and chemotherapy and had remained disease-free on follow-up for years. The review of the initial tumor revealed central neurocytoma. Seventeen years later, he presented with deterioration of memory, and magnetic resonance imaging showed an enhanced lesion in the left hippocampus. The enhanced lesion was resected, and the histological examination revealed that the tumor was a disseminated atypical central neurocytoma with frequent mitoses. Although he was treated with chemotherapy, the disseminated tumor slowly grew and invaded the brain. Massive brain invasion occurred without enhanced lesions, and he died 27 months after the tumor recurrence. LESSONS: In this patient, a central neurocytoma disseminated after an extremely long period of time. Once neurocytomas disseminate and show aggressive behavior, patients usually follow a poor course. Patients with central neurocytomas should be followed up for a long time.

Published
2022

15. sj-pdf-1-vet-10.1177_03009858221102599 – Supplemental material for Nodal T-zone lymphoma and T-zone hyperplasia in dogs

Author

Kojima, Kazuhiro, Chambers, James K., Mizuno, Takuya, and Uchida, Kazuyuki

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, fungi, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental material, sj-pdf-1-vet-10.1177_03009858221102599 for Nodal T-zone lymphoma and T-zone hyperplasia in dogs by Kazuhiro Kojima, James K. Chambers, Takuya Mizuno and Kazuyuki Uchida in Veterinary Pathology

Published
2022
Full Text
View/download PDF

17. Cancer Rehabilitation Provided by Designated Cancer Hospitals in Japan: The Current State of Outpatient Setting and Coordination after Discharge

Author

Fukushima, Takuya, primary, Tsuji, Tetsuya, additional, Watanabe, Noriko, additional, Sakurai, Takuro, additional, Matsuoka, Aiko, additional, Kojima, Kazuhiro, additional, Yahiro, Sachiko, additional, Oki, Mami, additional, Okita, Yusuke, additional, Yokota, Shota, additional, Nakano, Jiro, additional, Sugihara, Shinsuke, additional, Sato, Hiroshi, additional, Kawakami, Juichi, additional, Kagaya, Hitoshi, additional, Tanuma, Akira, additional, Sekine, Ryuichi, additional, Mori, Keita, additional, Zenda, Sadamoto, additional, and Kawai, Akira, additional

Published
2022
Full Text
View/download PDF

21. Supplemental Material, sj-pdf-1-vet-10.1177_03009858211030523 - Histopathological features and immunophenotyping of canine transmural gastrointestinal lymphoma using full-thickness biopsy samples

Author

Kojima, Kazuhiro, Chambers, James K., Ii, Tatsuhito, Nibe, Kazumi, Mizuno, Takuya, and Uchida, Kazuyuki

Subjects
70706 Veterinary Medicine, FOS: Clinical medicine, FOS: Veterinary sciences, fungi, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Abstract

Supplemental Material, sj-pdf-1-vet-10.1177_03009858211030523 for Histopathological features and immunophenotyping of canine transmural gastrointestinal lymphoma using full-thickness biopsy samples by Kazuhiro Kojima, James K. Chambers, Tatsuhito Ii, Kazumi Nibe, Takuya Mizuno and Kazuyuki Uchida in Veterinary Pathology

Published
2021
Full Text
View/download PDF

22. The current status of inpatient cancer rehabilitation provided by designated cancer hospitals in Japan

Author

Fukushima, Takuya, primary, Tsuji, Tetsuya, additional, Watanabe, Noriko, additional, Sakurai, Takuro, additional, Matsuoka, Aiko, additional, Kojima, Kazuhiro, additional, Yahiro, Sachiko, additional, Oki, Mami, additional, Okita, Yusuke, additional, Yokota, Shota, additional, Nakano, Jiro, additional, Sugihara, Shinsuke, additional, Sato, Hiroshi, additional, Kawakami, Juichi, additional, Kagaya, Hitoshi, additional, Tanuma, Akira, additional, Sekine, Ryuichi, additional, Mori, Keita, additional, Zenda, Sadamoto, additional, and Kawai, Akira, additional

Published
2021
Full Text
View/download PDF

31. Immunophenotyping of intraepithelial lymphocytes in canine chronic enteropathy and intestinal T-cell lymphoma using endoscopic samples.

Author

Kojima, Kazuhiro, Chambers, James K., Nakashima, Ko, Goto-Koshino, Yuko, and Uchida, Kazuyuki

Subjects
T-cell lymphoma, IMMUNOPHENOTYPING, INTESTINAL physiology, INTESTINAL diseases, INTESTINAL mucosa, INTESTINES, GENE rearrangement, T cells
Abstract

Human enteropathy-associated T-cell lymphoma (EATL) is considered to be derived from intraepithelial lymphocytes (IELs); however, the origin of canine intestinal T-cell lymphoma (ITCL) remains unclear. Histological, immunohistochemical, and clonality examinations were performed using endoscopically collected canine duodenum samples of mucosal lesions of chronic enteropathy (CE; 73 cases) and ITCL without transmural neoplastic mass lesions (64 cases). Histopathological examinations revealed the intraepithelial accumulation of lymphocytes (called "intraepithelial lymphocytosis") in 54/73 CE cases (74%) and the epitheliotropism of neoplastic lymphocytes in 63/64 ITCL cases (98%). Immunohistochemically, IELs in CE with intraepithelial lymphocytosis (IEL+CE) were diffusely immunopositive for CD3, with scattered immunopositivity for CD5, CD8, CD20, and granzyme B (GRB). The percentage of CD8+ in CD3+ IELs was significantly lower in IEL+CE than in CE without intraepithelial lymphocytosis (IEL−CE). Double-labeling immunohistochemistry revealed a high percentage of GRB expression in CD8− IEL among IEL+CE. Among 64 ITCL cases, CD3 was immunopositive in 64 (100%), CD5 in 22 (34%), CD8 in 8 (13%), CD20 in 12 (19%), CD30 in 13 (20%), and GRB in 49 (77%). In CD3+ cells, Ki67 immunopositivity was highest in ITCL, intermediate in IEL+CE, and lower in IEL−CE. A clonal TCR gene rearrangement was detected in 1/19 IEL−CE cases (5%), 15/54 IEL+CE (28%), and 38/58 ITCL (66%). These results indicate that the immunophenotype of canine ITCL (CD8−GRB+) is similar to that of the increased IELs in CE. The high proliferative activity and clonality of T cells in IEL+CE suggest that canine ITCL originates from these IELs, similar to human EATL. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

46. Reasoning by a Bipolar Argumentation Framework for PROLEG

Author

Kawasaki, Tatsuki, Moriguchi, Sosuke, Takahashi, Kazuko, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Kojima, Kazuhiro, editor, Sakamoto, Maki, editor, Mineshima, Koji, editor, and Satoh, Ken, editor

Published
2019
Full Text
View/download PDF

47. Detecting Freezing-of-Gait Symptom in Parkinson’s Disease by Analyzing Vertical Motion from Force Plate

Author

Le, Dinh-Khiet, Torii, Takuma, Fujinami, Tsutomu, Buated, Wannipat, Lolekha, Praween, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Kojima, Kazuhiro, editor, Sakamoto, Maki, editor, Mineshima, Koji, editor, and Satoh, Ken, editor

Published
2019
Full Text
View/download PDF

48. A Vision Sensor Network to Study Viewers’ Visible Behavior of Art Appreciation

Author

Wu, Yilang, Huang, Luyi, Wei, Zhongyu, Cheng, Zixue, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Kojima, Kazuhiro, editor, Sakamoto, Maki, editor, Mineshima, Koji, editor, and Satoh, Ken, editor

Published
2019
Full Text
View/download PDF

49. Effects of Casual Computer Game on Cognitive Performance Through Hemodynamic Signals

Author

Ouankhamchan, Phetnidda, Fujinami, Tsutomu, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Kojima, Kazuhiro, editor, Sakamoto, Maki, editor, Mineshima, Koji, editor, and Satoh, Ken, editor

Published
2019
Full Text
View/download PDF

50. Constraints on Joint Degrees of Freedom Affect Human Postural Dynamics: A Pilot Study

Author

Kodama, Kentaro, Yasuda, Kazuhiro, Yamagiwa, Hideo, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Kojima, Kazuhiro, editor, Sakamoto, Maki, editor, Mineshima, Koji, editor, and Satoh, Ken, editor

Published
2019
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results