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Your search keyword '"Koegelenberg, Coenraad F.N."' showing total 48 results
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48 results on '"Koegelenberg, Coenraad F.N."'

1. Lung Cancer Screening Considerations During Respiratory Infection Outbreaks, Epidemics or Pandemics: An International Association for the Study of Lung Cancer Early Detection and Screening Committee Report

Author

Huber, Rudolf M., Cavic, Milena, Kerpel-Fronius, Anna, Viola, Lucia, Field, John, Jiang, Long, Kazerooni, Ella A., Koegelenberg, Coenraad F.N., Mohan, Anant, Sales dos Santos, Ricardo, Ventura, Luigi, Wynes, Murry, Yang, Dawei, Zulueta, Javier, Lee, Choon-Taek, Tammemägi, Martin C., Henschke, Claudia I., and Lam, Stephen

Published
2022
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4. The utility of high-flow nasal oxygen for severe COVID-19 pneumonia in a resource-constrained setting: A multi-centre prospective observational study

Author

Calligaro, Gregory L., Lalla, Usha, Audley, Gordon, Gina, Phindile, Miller, Malcolm G., Mendelson, Marc, Dlamini, Sipho, Wasserman, Sean, Meintjes, Graeme, Peter, Jonathan, Levin, Dion, Dave, Joel A., Ntusi, Ntobeko, Meier, Stuart, Little, Francesca, Moodley, Desiree L., Louw, Elizabeth H., Nortje, Andre, Parker, Arifa, Taljaard, Jantjie J., Allwood, Brian W., Dheda, Keertan, and Koegelenberg, Coenraad F.N.

Published
2020
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6. Lung Cancer Presents at a Younger Age and Is Less Likely to be Curable in People Living with HIV.

Author

Bhikoo, Raisa, Allwood, Brian W., Irusen, Elvis M., and Koegelenberg, Coenraad F.N.

Subjects
LUNG cancer, FUNCTIONAL status, AGE distribution, LUNG tumors, TUMOR classification, BODY movement, DESCRIPTIVE statistics, CELL lines, SOCIODEMOGRAPHIC factors, DATA analysis software, PSYCHOLOGY of HIV-positive persons, LONGITUDINAL method
Abstract

Introduction: Globally, lung cancer remains the leading cause of malignancy-related death in men and women. There is increasing evidence that the risk for lung cancer in people living with human immunodeficiency virus (PLHIV) is higher than that of the general population. Given the high burden of PLHIV and lung cancer in Southern Africa, we aimed to compare the characteristics of PLHIV and HIV-negative lung cancer patients with regards to demographics, cell type, performance status, and tumour stage at presentation. Methods: All patients who presented to a large tertiary hospital over a 7-year period with a confirmed tissue diagnosis of primary lung cancer were included in a prospective registry. The patient demographics, HIV status, as well as the patients' performance status according to the Eastern Cooperative Oncology Group (ECOG) were documented. Results: The cohort consisted of 1,805 patients (mean age 60.0 years) of which 1,129 were male. In total, 133 were PLHIV and 1,292 were confirmed HIV-negative, while the remaining were categorised as HIV-unknown. PLHIV with lung cancer were found to be younger than the HIV-negative group (mean [±SD] 54.6 [9.3] versus 60.3 [10.1], p < 0.001). Notably, not a single PLHIV was diagnosed with resectable non-small cell lung cancer (NSCLC), and only 7 of 133 (6.5%) had potentially curable disease NSCLC (up to stage IIIB) compared to 240 of 1292 HIV-negative patients (27.7%, p < 0.001). Conclusion: PLHIV with lung cancer were diagnosed at a significantly younger age and were significantly less likely to have curable NSCLC at presentation. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Clinical characteristics of chylothorax: results from the International Collaborative Effusion database

Author

Porcel, José M., primary, Bielsa, Silvia, additional, Civit, Carmen, additional, Aujayeb, Avinash, additional, Janssen, Julius, additional, Bodtger, Uffe, additional, Fjaellegaard, Katrine, additional, Petersen, Jesper Koefod, additional, Welch, Hugh, additional, Symonds, Jenny, additional, Mitchell, Michael A., additional, Grabczak, Elżbieta Magdalena, additional, Ellayeh, Mohamed, additional, Addala, Dinesh, additional, Wrightson, John M., additional, Rahman, Najib M., additional, Munavvar, Mohammed, additional, Koegelenberg, Coenraad F.N., additional, Labarca, Gonzalo, additional, Mei, Federico, additional, Maskell, Nick, additional, and Bhatnagar, Rahul, additional

Published
2023
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11. Investigation and outcomes in patients with non-specific pleuritis: Results from the International Collaborative Effusion (ICE) database

Author

Sundaralingam, Anand, primary, Aujayeb, Avinash, additional, Jackson, Karl A., additional, Pellas, Emilia I., additional, Khan, Irfan I., additional, Chohan, Muhammad T., additional, Joosten, Roos, additional, Boersma, Anton, additional, Kerkhoff, Jordy, additional, Bielsa, Silvia, additional, Porcel, Jose M., additional, Rozman, Ales, additional, Marc-Malovrh, Mateja, additional, Welch, Hugh, additional, Symonds, Jenny, additional, Anevlavis, Stavros, additional, Froudrakis, Marios, additional, Mei, Federico, additional, Zuccatosta, Lina, additional, Gasparini, Stefano, additional, Gonnelli, Francesca, additional, Dhaliwal, Inderdeep, additional, Mitchell, Michael A., additional, Fjaellegaard, Katrine, additional, Petersen, Jesper K., additional, Ellayeh, Mohamed, additional, Rahman, Najib M., additional, Burden, Tom, additional, Bodtger, Uffe, additional, Koegelenberg, Coenraad F.N., additional, Maskell, Nick A., additional, Janssen, Julius, additional, and Bhatnagar, Rahul, additional

Published
2023
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22. Autologous Blood Patch Pleurodesis for the Management of a Persistent Air Leak after Secondary Spontaneous Pneumothorax.

Author

Shaw, Jane A., Wilken, Elisma, Allwood, Brian W., Irusen, Elvis M., and Koegelenberg, Coenraad F.N.

Subjects
AUTOTRANSFUSION of blood, PLEURODESIS, BRONCHIAL fistula, BIOTHERAPY, TREATMENT effectiveness, DESCRIPTIVE statistics, EMPYEMA, PNEUMOTHORAX
Abstract

Patients with secondary spontaneous pneumothorax (SSP) complicated by persistent air leak (PAL) and who are poor surgical candidates have limited treatment options. This case series explored autologous blood patch pleurodesis as a possible cost-effective management option. A total of 46 episodes of SSP with PAL were included. The procedure was successful in 33 (71.7%). Of these, 17 (51.5%) resolved within 1 day. The mean duration of intercostal drainage prior to the blood patch was 22 days in the successful group. Pneumothoraces with incomplete lung re-expansion at the time of procedure were successful in 20 of 30 (66.7%). Only human immunodeficiency virus infection was associated with failure (p = 0.03). Adverse events included transient fever (n = 3) that resolved spontaneously, and empyema (n = 3) which were successfully managed with antibiotics and pigtail drainage. We conclude that a large proportion of patients with SSP complicated by PAL who are unfit for surgery may be liberated from intercostal drainage by an autologous blood patch pleurodesis, with minimal adverse effects. [ABSTRACT FROM AUTHOR]

Published
2022
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27. The Utility of High-Flow Nasal Oxygen for Severe COVID-19 Pneumonia in a Resource-Constrained Setting: A Multi-Centre Prospective Observational Study

Author

Calligaro, Gregory L., primary, Lalla, Usha, additional, Audley, Gordon, additional, Gina, Phindile, additional, Miller, Malcolm Gregory, additional, Mendelson, Marc, additional, Dlamini, Sipho, additional, Wasserman, Sean, additional, Meintjes, Graeme, additional, Peter, Jonathan, additional, Levin, Dion, additional, Dave, Joel A., additional, Ntusi, Ntobeko, additional, Meier, Stuart, additional, Little, Francesca, additional, Moodley, Desiree L., additional, Louw, Elizabeth H., additional, Nortje, Andre, additional, Parker, Arifa, additional, Taljaard, Jantjie J., additional, Allwood, Brian W., additional, Dheda, Keertan, additional, and Koegelenberg, Coenraad F.N., additional

Published
2020
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34. The Utility of Pleural Fluid Lactate Dehydrogenase to Adenosine Deaminase Ratio in Pleural Tuberculosis.

Author

Beukes, Amanda, Shaw, Jane Alexandra, Diacon, Andreas H., Irusen, Elvis M., and Koegelenberg, Coenraad F.N.

Subjects
TUBERCULOSIS diagnosis, EXUDATES & transudates, HYDROLASES, LACTATE dehydrogenase, LONGITUDINAL method, PLEURAL effusions, RECEIVER operating characteristic curves, DESCRIPTIVE statistics, LYMPHOCYTE count
Abstract

In high-burden settings, the diagnosis of pleural tuberculosis (TB) is frequently inferred in patients who present with lymphocyte predominant exudative effusions and high adenosine deaminase (ADA) levels. Two recent small retrospective studies suggested that the lactate dehydrogenase (LDH)/ADA ratio is significantly lower in TB than in non-TB pleural effusions and that the LDH/ADA ratio may be useful in differentiating pleural TB from other pleural exudates. We compared the pleural LDH/ADA ratios, ADA levels, and lymphocyte predominance of a prospectively collected cohort of patients with proven pleural TB (n = 160) to those with a definitive alternative diagnosis (n = 68). The mean pleural fluid LDH/ADA ratio was lower in patients with pleural TB than alternative diagnoses (6.2 vs. 34.3, p < 0.001). The area under the receiver operating characteristic curve was 0.92 (p < 0.001) for LDH/ADA ratio and 0.88 (p < 0.001) for an ADA ≥40 U/L alone. A ratio of ≤12.5 had the best overall diagnostic efficiency, while a ratio of ≤10 had a specificity of 90% and a positive predictive value of 95%, with a sensitivity of 78%, making it a clinically useful "rule in" value for pleural TB in high incidence settings. When comparing the LDH/ADA ratio to an ADA level ≥40 U/L in the presence of a lymphocyte predominant effusion, the latter performed better. When lymphocyte values are unavailable, our data suggest that the LDH/ADA ratio is valuable in distinguishing TB effusions from other pleural exudates. [ABSTRACT FROM AUTHOR]

Published
2021
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39. Recurrent Pulmonary Aneurysms

Author

Bennji, Sami M., primary, du Preez, Leonard, additional, Griffith-Richards, Stephanie, additional, Smit, Derrick P., additional, Rigby, Jonathan, additional, Koegelenberg, Coenraad F.N., additional, Irusen, Elvis M., additional, and Allwood, Brian W., additional

Published
2017
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48. Malignant Pleural Effusions: Mistletoe Spray Instead of Talc Poudrage?

Author

Shaw, Jane A. and Koegelenberg, Coenraad F.N.

Subjects
*PLEURAL effusions, *PLEURA cancer, *CATHETERIZATION, *FEVER, *EVALUATION of medical care, *MEDICAL care costs, *QUALITY of life, *SERIAL publications, *TALC, *THORACOSCOPY, *VISCUM, *DISEASE management, *DISEASE relapse, *PLANT extracts, *TREATMENT effectiveness, *CHEST tubes, *PLEURODESIS, *CANCER treatment, *THERAPEUTICS
Abstract

The article discusses research being done on the management of malignant pleural effusion (MPE). It references the study "Pleurodesis Using Mistletoe Extracts Delivered via a Spray Catheter During Semi-Rigid Pleuroscopy for Managing Symptomatic Malignant Pleural Effusion," by J. S. Eom in this issue. Topics covered include the shortage of high-quality evidence on the therapeutic approach to MPE, the use of talc as chemical pleurodesis, and the anticancer effects of mistletoe extract.

Published
2018
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