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1. Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, Capper, David, Andreiuolo, Felipe, Gessi, Marco, Kölsche, Christian, Reinhardt, Annekathrin, Sievers, Philipp, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail K., Gielen, Gerrit H., Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Hovestadt, Volker, Daenekas, Bjarne, Rode, Agata, Hamelmann, Stefan, Previti, Christopher, Jäger, Natalie, Buchhalter, Ivo, Blattner-Johnson, Mirjam, Jones, Barbara C., Warmuth-Metz, Monika, Bison, Brigitte, Grund, Kerstin, Sutter, Christian, Hirsch, Steffen, Dikow, Nicola, Hasselblatt, Martin, Schüller, Ulrich, Koch, Arend, Gerber, Nicolas U., White, Christine L., Buntine, Molly K., Kinross, Kathryn, Algar, Elizabeth M., Hansford, Jordan R., Gottardo, Nicholas G., Schuhmann, Martin U., Thomale, Ulrich W., Hernáiz Driever, Pablo, Gnekow, Astrid, Witt, Olaf, Müller, Hermann L., Calaminus, Gabriele, Fleischhack, Gudrun, Kordes, Uwe, Mynarek, Martin, Rutkowski, Stefan, Frühwald, Michael C., Kramm, Christof M., von Deimling, Andreas, Pietsch, Torsten, Sahm, Felix, Pfister, Stefan M., and Jones, David. T. W.

Published
2023
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2. Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, Capper, David, Andreiuolo, Felipe, Gessi, Marco, Kölsche, Christian, Reinhardt, Annekathrin, Sievers, Philipp, Wefers, Annika K., Ebrahimi, Azadeh, Suwala, Abigail K., Gielen, Gerrit H., Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Hovestadt, Volker, Daenekas, Bjarne, Rode, Agata, Hamelmann, Stefan, Previti, Christopher, Jäger, Natalie, Buchhalter, Ivo, Blattner-Johnson, Mirjam, Jones, Barbara C., Warmuth-Metz, Monika, Bison, Brigitte, Grund, Kerstin, Sutter, Christian, Hirsch, Steffen, Dikow, Nicola, Hasselblatt, Martin, Schüller, Ulrich, Koch, Arend, Gerber, Nicolas U., White, Christine L., Buntine, Molly K., Kinross, Kathryn, Algar, Elizabeth M., Hansford, Jordan R., Gottardo, Nicholas G., Schuhmann, Martin U., Thomale, Ulrich W., Hernáiz Driever, Pablo, Gnekow, Astrid, Witt, Olaf, Müller, Hermann L., Calaminus, Gabriele, Fleischhack, Gudrun, Kordes, Uwe, Mynarek, Martin, Rutkowski, Stefan, Frühwald, Michael C., Kramm, Christof M., von Deimling, Andreas, Pietsch, Torsten, Sahm, Felix, Pfister, Stefan M., and Jones, David. T. W.

Published
2024
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3. Implementation of DNA Methylation Array Profiling in Pediatric Central Nervous System Tumors: The AIM BRAIN Project: An Australian and New Zealand Children's Hematology and Oncology Group Study

Author

White, Christine L., Kinross, Kathryn M., Buntine, Molly K., Rasouli, Elnaz, Strong, Robyn, Jones, Janelle M., Cain, Jason E., Sturm, Dominik, Sahm, Felix, Jones, David T.W., Pfister, Stefan M., Robertson, Thomas, D'Arcy, Colleen, Rodriguez, Michael L., Dyke, Jason M., Junckerstorff, Reimar, Bhuva, Dharmesh D., Davis, Melissa J., Wood, Paul, Hassall, Tim, Ziegler, David S., Kellie, Stewart, McCowage, Geoffrey, Alvaro, Frank, Kirby, Maria, Heath, John A., Tsui, Karen, Dodgshun, Andrew, Eisenstat, David D., Khuong-Quang, Dong-Anh, Wall, Meaghan, Algar, Elizabeth M., Gottardo, Nicholas G., and Hansford, Jordan R.

Published
2023
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4. Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology

Author

Sturm, Dominik, primary, Capper, David, additional, Andreiuolo, Felipe, additional, Gessi, Marco, additional, Kölsche, Christian, additional, Reinhardt, Annekathrin, additional, Sievers, Philipp, additional, Wefers, Annika K., additional, Ebrahimi, Azadeh, additional, Suwala, Abigail K., additional, Gielen, Gerrit H., additional, Sill, Martin, additional, Schrimpf, Daniel, additional, Stichel, Damian, additional, Hovestadt, Volker, additional, Daenekas, Bjarne, additional, Rode, Agata, additional, Hamelmann, Stefan, additional, Previti, Christopher, additional, Jäger, Natalie, additional, Buchhalter, Ivo, additional, Blattner-Johnson, Mirjam, additional, Jones, Barbara C., additional, Warmuth-Metz, Monika, additional, Bison, Brigitte, additional, Grund, Kerstin, additional, Sutter, Christian, additional, Hirsch, Steffen, additional, Dikow, Nicola, additional, Hasselblatt, Martin, additional, Schüller, Ulrich, additional, Koch, Arend, additional, Gerber, Nicolas U., additional, White, Christine L., additional, Buntine, Molly K., additional, Kinross, Kathryn, additional, Algar, Elizabeth M., additional, Hansford, Jordan R., additional, Gottardo, Nicholas G., additional, Schuhmann, Martin U., additional, Thomale, Ulrich W., additional, Hernáiz Driever, Pablo, additional, Gnekow, Astrid, additional, Witt, Olaf, additional, Müller, Hermann L., additional, Calaminus, Gabriele, additional, Fleischhack, Gudrun, additional, Kordes, Uwe, additional, Mynarek, Martin, additional, Rutkowski, Stefan, additional, Frühwald, Michael C., additional, Kramm, Christof M., additional, von Deimling, Andreas, additional, Pietsch, Torsten, additional, Sahm, Felix, additional, Pfister, Stefan M., additional, and Jones, David. T. W., additional

Published
2023
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5. A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma

Author

Ng, Chia Huan, primary, Obrecht, Denise, additional, Wells, Olivia, additional, Zapotocky, Michal, additional, Sumerauer, David, additional, Coltin, Hallie, additional, Khuong-Quang, Dong-Anh, additional, Eisenstat, David D, additional, Kinross, Kathryn M, additional, White, Christine L, additional, Algar, Elizabeth M, additional, Luck, Amanda, additional, Witt, Hendrik, additional, Schüller, Ulrich, additional, Mynarek, Martin, additional, Pietsch, Torsten, additional, Gerber, Nicolas U, additional, Benesch, Martin, additional, Warmuth-Metz, Monika, additional, Kortmann, Rolf, additional, Bison, Brigitte, additional, Taylor, Michael D, additional, Rutkowski, Stefan, additional, Pfister, Stefan M, additional, Jones, David T W, additional, Gottardo, Nicholas G, additional, von Hoff, Katja, additional, Pajtler, Kristian W, additional, Ramaswamy, Vijay, additional, and Hansford, Jordan R, additional

Published
2023
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6. Supplementary Figures 4-6 from The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Author

Wall, Meaghan, primary, Poortinga, Gretchen, primary, Stanley, Kym L., primary, Lindemann, Ralph K., primary, Bots, Michael, primary, Chan, Christopher J., primary, Bywater, Megan J., primary, Kinross, Kathryn M., primary, Astle, Megan V., primary, Waldeck, Kelly, primary, Hannan, Katherine M., primary, Shortt, Jake, primary, Smyth, Mark J., primary, Lowe, Scott W., primary, Hannan, Ross D., primary, Pearson, Richard B., primary, Johnstone, Ricky W., primary, and McArthur, Grant A., primary

Published
2023
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7. Supplementary Data 2 from Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Author

Parmenter, Tiffany J., primary, Kleinschmidt, Margarete, primary, Kinross, Kathryn M., primary, Bond, Simon T., primary, Li, Jason, primary, Kaadige, Mohan R., primary, Rao, Aparna, primary, Sheppard, Karen E., primary, Hugo, Willy, primary, Pupo, Gulietta M., primary, Pearson, Richard B., primary, McGee, Sean L., primary, Long, Georgina V., primary, Scolyer, Richard A., primary, Rizos, Helen, primary, Lo, Roger S., primary, Cullinane, Carleen, primary, Ayer, Donald E., primary, Ribas, Antoni, primary, Johnstone, Ricky W., primary, Hicks, Rodney J., primary, and McArthur, Grant A., primary

Published
2023
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8. Data from Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Author

Parmenter, Tiffany J., primary, Kleinschmidt, Margarete, primary, Kinross, Kathryn M., primary, Bond, Simon T., primary, Li, Jason, primary, Kaadige, Mohan R., primary, Rao, Aparna, primary, Sheppard, Karen E., primary, Hugo, Willy, primary, Pupo, Gulietta M., primary, Pearson, Richard B., primary, McGee, Sean L., primary, Long, Georgina V., primary, Scolyer, Richard A., primary, Rizos, Helen, primary, Lo, Roger S., primary, Cullinane, Carleen, primary, Ayer, Donald E., primary, Ribas, Antoni, primary, Johnstone, Ricky W., primary, Hicks, Rodney J., primary, and McArthur, Grant A., primary

Published
2023
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9. Supplementary Figures 9-11 from The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Author

Wall, Meaghan, primary, Poortinga, Gretchen, primary, Stanley, Kym L., primary, Lindemann, Ralph K., primary, Bots, Michael, primary, Chan, Christopher J., primary, Bywater, Megan J., primary, Kinross, Kathryn M., primary, Astle, Megan V., primary, Waldeck, Kelly, primary, Hannan, Katherine M., primary, Shortt, Jake, primary, Smyth, Mark J., primary, Lowe, Scott W., primary, Hannan, Ross D., primary, Pearson, Richard B., primary, Johnstone, Ricky W., primary, and McArthur, Grant A., primary

Published
2023
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10. Supplementary Data 1 from Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Author

Parmenter, Tiffany J., primary, Kleinschmidt, Margarete, primary, Kinross, Kathryn M., primary, Bond, Simon T., primary, Li, Jason, primary, Kaadige, Mohan R., primary, Rao, Aparna, primary, Sheppard, Karen E., primary, Hugo, Willy, primary, Pupo, Gulietta M., primary, Pearson, Richard B., primary, McGee, Sean L., primary, Long, Georgina V., primary, Scolyer, Richard A., primary, Rizos, Helen, primary, Lo, Roger S., primary, Cullinane, Carleen, primary, Ayer, Donald E., primary, Ribas, Antoni, primary, Johnstone, Ricky W., primary, Hicks, Rodney J., primary, and McArthur, Grant A., primary

Published
2023
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11. Supplementary Figures 7-8 from The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Author

Wall, Meaghan, primary, Poortinga, Gretchen, primary, Stanley, Kym L., primary, Lindemann, Ralph K., primary, Bots, Michael, primary, Chan, Christopher J., primary, Bywater, Megan J., primary, Kinross, Kathryn M., primary, Astle, Megan V., primary, Waldeck, Kelly, primary, Hannan, Katherine M., primary, Shortt, Jake, primary, Smyth, Mark J., primary, Lowe, Scott W., primary, Hannan, Ross D., primary, Pearson, Richard B., primary, Johnstone, Ricky W., primary, and McArthur, Grant A., primary

Published
2023
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12. Supplementary Tables 1-2 from The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Author

Wall, Meaghan, primary, Poortinga, Gretchen, primary, Stanley, Kym L., primary, Lindemann, Ralph K., primary, Bots, Michael, primary, Chan, Christopher J., primary, Bywater, Megan J., primary, Kinross, Kathryn M., primary, Astle, Megan V., primary, Waldeck, Kelly, primary, Hannan, Katherine M., primary, Shortt, Jake, primary, Smyth, Mark J., primary, Lowe, Scott W., primary, Hannan, Ross D., primary, Pearson, Richard B., primary, Johnstone, Ricky W., primary, and McArthur, Grant A., primary

Published
2023
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13. Supplementary Methods from Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Author

Parmenter, Tiffany J., primary, Kleinschmidt, Margarete, primary, Kinross, Kathryn M., primary, Bond, Simon T., primary, Li, Jason, primary, Kaadige, Mohan R., primary, Rao, Aparna, primary, Sheppard, Karen E., primary, Hugo, Willy, primary, Pupo, Gulietta M., primary, Pearson, Richard B., primary, McGee, Sean L., primary, Long, Georgina V., primary, Scolyer, Richard A., primary, Rizos, Helen, primary, Lo, Roger S., primary, Cullinane, Carleen, primary, Ayer, Donald E., primary, Ribas, Antoni, primary, Johnstone, Ricky W., primary, Hicks, Rodney J., primary, and McArthur, Grant A., primary

Published
2023
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14. Data from The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Author

Wall, Meaghan, primary, Poortinga, Gretchen, primary, Stanley, Kym L., primary, Lindemann, Ralph K., primary, Bots, Michael, primary, Chan, Christopher J., primary, Bywater, Megan J., primary, Kinross, Kathryn M., primary, Astle, Megan V., primary, Waldeck, Kelly, primary, Hannan, Katherine M., primary, Shortt, Jake, primary, Smyth, Mark J., primary, Lowe, Scott W., primary, Hannan, Ross D., primary, Pearson, Richard B., primary, Johnstone, Ricky W., primary, and McArthur, Grant A., primary

Published
2023
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16. Supplementary Figure 12 from The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Author

Wall, Meaghan, primary, Poortinga, Gretchen, primary, Stanley, Kym L., primary, Lindemann, Ralph K., primary, Bots, Michael, primary, Chan, Christopher J., primary, Bywater, Megan J., primary, Kinross, Kathryn M., primary, Astle, Megan V., primary, Waldeck, Kelly, primary, Hannan, Katherine M., primary, Shortt, Jake, primary, Smyth, Mark J., primary, Lowe, Scott W., primary, Hannan, Ross D., primary, Pearson, Richard B., primary, Johnstone, Ricky W., primary, and McArthur, Grant A., primary

Published
2023
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17. Supplementary Figures and Tables from Response of BRAF-Mutant Melanoma to BRAF Inhibition Is Mediated by a Network of Transcriptional Regulators of Glycolysis

Author

Parmenter, Tiffany J., primary, Kleinschmidt, Margarete, primary, Kinross, Kathryn M., primary, Bond, Simon T., primary, Li, Jason, primary, Kaadige, Mohan R., primary, Rao, Aparna, primary, Sheppard, Karen E., primary, Hugo, Willy, primary, Pupo, Gulietta M., primary, Pearson, Richard B., primary, McGee, Sean L., primary, Long, Georgina V., primary, Scolyer, Richard A., primary, Rizos, Helen, primary, Lo, Roger S., primary, Cullinane, Carleen, primary, Ayer, Donald E., primary, Ribas, Antoni, primary, Johnstone, Ricky W., primary, Hicks, Rodney J., primary, and McArthur, Grant A., primary

Published
2023
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18. Supplementary Figures 1-3 from The mTORC1 Inhibitor Everolimus Prevents and Treats Eμ-Myc Lymphoma by Restoring Oncogene-Induced Senescence

Author

Wall, Meaghan, primary, Poortinga, Gretchen, primary, Stanley, Kym L., primary, Lindemann, Ralph K., primary, Bots, Michael, primary, Chan, Christopher J., primary, Bywater, Megan J., primary, Kinross, Kathryn M., primary, Astle, Megan V., primary, Waldeck, Kelly, primary, Hannan, Katherine M., primary, Shortt, Jake, primary, Smyth, Mark J., primary, Lowe, Scott W., primary, Hannan, Ross D., primary, Pearson, Richard B., primary, Johnstone, Ricky W., primary, and McArthur, Grant A., primary

Published
2023
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19. A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma

Author

Ng, Chia Huan, Obrecht, Denise, Wells, Olivia, Zapotocky, Michal, Sumerauer, David, Coltin, Hallie, Khuong-Quang, Dong-Anh, Eisenstat, David D; https://orcid.org/0000-0002-5976-0798, Kinross, Kathryn M, White, Christine L, Algar, Elizabeth M, Luck, Amanda, Witt, Hendrik, Schüller, Ulrich; https://orcid.org/0000-0002-8731-1121, Mynarek, Martin; https://orcid.org/0000-0003-3302-2719, Pietsch, Torsten, Gerber, Nicolas U, Benesch, Martin, Warmuth-Metz, Monika; https://orcid.org/0000-0002-3544-319X, Kortmann, Rolf, Bison, Brigitte, Taylor, Michael D, Rutkowski, Stefan, Pfister, Stefan M, Jones, David T W; https://orcid.org/0000-0002-2036-5141, Gottardo, Nicholas G; https://orcid.org/0000-0002-1082-6776, von Hoff, Katja; https://orcid.org/0000-0002-5669-8546, Pajtler, Kristian W; https://orcid.org/0000-0002-3562-6121, Ramaswamy, Vijay; https://orcid.org/0000-0002-6557-895X, Hansford, Jordan R; https://orcid.org/0000-0001-7733-383X, Ng, Chia Huan, Obrecht, Denise, Wells, Olivia, Zapotocky, Michal, Sumerauer, David, Coltin, Hallie, Khuong-Quang, Dong-Anh, Eisenstat, David D; https://orcid.org/0000-0002-5976-0798, Kinross, Kathryn M, White, Christine L, Algar, Elizabeth M, Luck, Amanda, Witt, Hendrik, Schüller, Ulrich; https://orcid.org/0000-0002-8731-1121, Mynarek, Martin; https://orcid.org/0000-0003-3302-2719, Pietsch, Torsten, Gerber, Nicolas U, Benesch, Martin, Warmuth-Metz, Monika; https://orcid.org/0000-0002-3544-319X, Kortmann, Rolf, Bison, Brigitte, Taylor, Michael D, Rutkowski, Stefan, Pfister, Stefan M, Jones, David T W; https://orcid.org/0000-0002-2036-5141, Gottardo, Nicholas G; https://orcid.org/0000-0002-1082-6776, von Hoff, Katja; https://orcid.org/0000-0002-5669-8546, Pajtler, Kristian W; https://orcid.org/0000-0002-3562-6121, Ramaswamy, Vijay; https://orcid.org/0000-0002-6557-895X, and Hansford, Jordan R; https://orcid.org/0000-0001-7733-383X

Abstract

BACKGROUND ZFTA-RELA (formerly known as c11orf-RELA) fused supratentorial ependymoma (ZFTAfus ST-EPN) has been recognized as a novel entity in the 2016 WHO classification of CNS tumors and further defined in the recent 2021 edition. ZFTAfus ST-EPN was reported to portend poorer prognosis when compared to its counterpart, YAP1 ST-EPN in some previously published series. The aim of this study was to determine the treatment outcome of molecularly confirmed and conventionally treated ZFTAfus ST-EPN patients treated in multiple institutions. METHODS We conducted a retrospective analysis of all pediatric patients with molecularly confirmed ZFTAfus ST-EPN patients treated in multiple institutions in 5 different countries (Australia, Canada, Germany, Switzerland, and Czechia). Survival outcomes were analyzed and correlated with clinical characteristics and treatment approaches. RESULTS A total of 108 patients were collated from multiple institutions in 5 different countries across three continents. We found across the entire cohort that the 5- and 10-year PFS were 65% and 63%, respectively. The 5- and 10-year OS of this cohort of patients were 87% and 73%. The rates of gross total resection (GTR) were high with 84 out of 108 (77.8%) patients achieving GTR. The vast majority of patients also received post-operative radiotherapy, 98 out of 108 (90.7%). Chemotherapy did not appear to provide any survival benefit in our patient cohort. CONCLUSION This is the largest study to date of contemporaneously treated molecularly confirmed ZFTAfus ST-EPN patients which identified markedly improved survival outcomes compared to previously published series. This study also re-emphasizes the importance of maximal surgical resection in achieving optimal outcomes in pediatric patients with supratentorial ependymoma.

Published
2023

20. ATRT-17. A phase II study of continuous low dose panobinostat in paediatric patients with malignant rhabdoid tumours and atypical teratoid rhabdoid tumours.

Author

Wood, Paul, primary, Desai, Jayesh, additional, Waldeck, Kelly, additional, Cain, Jason, additional, Gottardo, Nicholas, additional, Strong, Robyn, additional, Kinross, Kathryn, additional, Carr, Michelle, additional, Jones, Janelle, additional, Wong, Lily, additional, Ziegler, David, additional, Hansford, Jordan, additional, Michael, Michael, additional, and Ashley, David, additional

Published
2022
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21. EPEN-36. THE TREATMENT OUTCOME OF PAEDIATRIC SUPRATENTORIAL C11ORF95-RELA FUSED EPENDYMOMA: A COMBINED REPORT FROM E-HIT SERIES AND AUSTRALIAN NEW ZEALAND CHILDREN’S HAEMATOLOGY/ONCOLOGY GROUP

Author

Ng, Chia Huan, primary, Obrecht, Denise, additional, Buntine, Molly, additional, Wells, Olivia, additional, Campbell, Martin A, additional, Bhatia, Kanika, additional, Sullivan, Michael, additional, Williams, Molly, additional, Quang, Dong Anh Khuong, additional, Kinross, Kathryn, additional, White, Christine, additional, Algar, Elizabeth, additional, Witt, Hendrik, additional, Schuller, Ulrich, additional, Mynarek, Martin, additional, Pietsch, Torsten, additional, Gerber, Nicolas U, additional, Benesch, Martin, additional, Warmuth-Metz, Monika, additional, Kortmann, Rolf, additional, Bison, Brigitte, additional, Taylor, Michael D, additional, Ramaswamy, Vijay, additional, Rutkowski, Stefan, additional, Pfister, Stefan M, additional, Jones, David T W, additional, Gottardo, Nicholas G, additional, Von Hoff, Katja, additional, Pajtler, Kristian W, additional, and Hansford, Jordan R, additional

Published
2020
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22. ATRT-08. A PHASE II STUDY OF CONTINUOUS LOW DOSE PANOBINOSTAT IN PAEDIATRIC PATIENTS WITH MALIGNANT RHABDOID TUMORS/ATYPICAL TERATOID RHABDOID TUMORS

Author

Wood, Paul, primary, Desai, Jayesh, additional, Waldeck, Kelly, additional, Cain, Jason, additional, Gottardo, Nick, additional, Strong, Robyn, additional, Kinross, Kathryn, additional, Carr, Michelle, additional, Jones, Janelle, additional, Wong, Lily, additional, Ziegler, David, additional, Hansford, Jordan, additional, Michael, Michael, additional, and Ashley, David, additional

Published
2020
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24. GENE-04. ESTABLISHING A MOLECULAR PROFILING SERVICE FOR CHILDREN’S CENTRAL NERVOUS SYSTEM TUMORS IN AUSTRALASIA – THE AUSTRALIAN AND NEW ZEALAND CHILDREN’S HAEMATOLOGY AND ONCOLOGY GROUP (ANZCHOG) AIM BRAIN PROJECT

Author

White, Christine, primary, Kinross, Kathryn, additional, Strong, Robyn, additional, Jones, David, additional, Pfister, Stefan, additional, Hansford, Jordan, additional, Gottardo, Nicholas, additional, and Algar, Elizabeth, additional

Published
2019
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25. Host immunity contributes to the anti-melanoma activity of BRAF inhibitors

Author

Knight, Deborah A., primary, Ngiow, Shin Foong, additional, Li, Ming, additional, Parmenter, Tiffany, additional, Mok, Stephen, additional, Cass, Ashley, additional, Haynes, Nicole M., additional, Kinross, Kathryn, additional, Yagita, Hideo, additional, Koya, Richard C., additional, Graeber, Thomas G., additional, Ribas, Antoni, additional, McArthur, Grant A., additional, and Smyth, Mark J., additional

Published
2015
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26. Ubiquitous expression of thePik3ca H1047Rmutation promotes hypoglycemia, hypoinsulinemia, and organomegaly

Author

Kinross, Kathryn M., primary, Montgomery, Karen G., additional, Mangiafico, Salvatore P., additional, Hare, Lauren M., additional, Kleinschmidt, Margarete, additional, Bywater, Megan J., additional, Poulton, Ingrid J., additional, Vrahnas, Christina, additional, Henneicke, Holger, additional, Malaterre, Jordane, additional, Waring, Paul M., additional, Cullinane, Carleen, additional, Sims, Natalie A., additional, McArthur, Grant A., additional, Andrikopoulos, Sofianos, additional, and Phillips, Wayne A., additional

Published
2014
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27. Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.

Author

Kinross, Kathryn M., Montgomery, Karen G., Mangiafico, Salvatore P., Hare, Lauren M., Kleinschmidt, Margarete, Bywater, Megan J., Poulton, Ingrid J., Vrahnas, Christina, Henneicke, Holger, Malaterre, Jordane, Waring, Paul M., Cullinane, Carleen, Sims, Natalie A., McArthur, Grant A., Andrikopoulos, Sofianos, and Phillips, Wayne A.

Subjects
*MOLECULAR genetics, *GENE expression, *HYPOGLYCEMIA, *GLUCOSE metabolism, *CARBOHYDRATE metabolism
Abstract

Mutations in PIK3CA, the gene encoding the p1 10a catalytic subunit of PI3K, are among the most common mutations found in human cancer and have also recently been implicated in a range of overgrowth syndromes in humans. We have used a novel inducible "exon-switch" approach to knock in the constitutively active Pik3caH1047R mutation into the endogenous Pik3ca gene of the mouse. Ubiquitous expression of the Pik3caH1047R mutation throughout the body resulted in a dramatic increase in body weight within 3 weeks of induction (mutant 150 ± 5%; wild-type 117 ± 3%, mean ± SEM), which was associated with increased organ size rather than adiposity. Severe metabolic effects, including a reduction in blood glucose levels to 59 ± 4% of baseline (11 days postinduction) and undetectable insulin levels, were also observed. Pik3caH1047R mutant mice died earlier (median survival 46.5 d post-mutation induction) than wild-type control mice (100% survival > 250 days). Although deletion of Akt2 increased median survival by 44%, neither organ overgrowth, nor hypoglycemia were rescued, indicating that both the growth and metabolic functions of constitutive PI3K activity can be Akt2 independent This mouse model demonstrates the critical role of PI3K in the regulation of both organ size and glucose metabolism at the whole animal level. [ABSTRACT FROM AUTHOR]

Published
2015
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29. Host immunity contributes to the anti-melanoma activity of BRAF inhibitors.

Author

Knight, Deborah A, Ngiow, Shin Foong, Li, Ming, Parmenter, Tiffany, Mok, Stephen, Cass, Ashley, Haynes, Nicole M, Kinross, Kathryn, Yagita, Hideo, Koya, Richard C, Graeber, Thomas G, Ribas, Antoni, McArthur, Grant A, and Smyth, Mark J

Subjects
*MELANOMA, *BRAF genes, *KINASE inhibitors, *IMMUNOLOGY
Abstract

A correction to the article "Host Immunity Contributes to the Anti-Melanoma Activity of BRAF Inhibitors" that was published in a 2013 issue is presented.

Published
2016
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31. Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.

Author

Kinross KM, Montgomery KG, Mangiafico SP, Hare LM, Kleinschmidt M, Bywater MJ, Poulton IJ, Vrahnas C, Henneicke H, Malaterre J, Waring PM, Cullinane C, Sims NA, McArthur GA, Andrikopoulos S, and Phillips WA

Subjects
Amino Acid Substitution, Animals, Class I Phosphatidylinositol 3-Kinases, Female, Gene Expression, Gene Knock-In Techniques, Glucose metabolism, Humans, Hypoglycemia metabolism, Mice, Mice, Knockout, Mice, Mutant Strains, Mice, Transgenic, Mutant Proteins genetics, Mutant Proteins metabolism, Organ Size genetics, Organ Size physiology, Proto-Oncogene Proteins c-akt deficiency, Proto-Oncogene Proteins c-akt genetics, Proto-Oncogene Proteins c-akt metabolism, Weight Gain, Hypoglycemia enzymology, Hypoglycemia genetics, Insulin blood, Mutation, Phosphatidylinositol 3-Kinases genetics, Phosphatidylinositol 3-Kinases metabolism
Abstract

Mutations in PIK3CA, the gene encoding the p110α catalytic subunit of PI3K, are among the most common mutations found in human cancer and have also recently been implicated in a range of overgrowth syndromes in humans. We have used a novel inducible "exon-switch" approach to knock in the constitutively active Pik3ca(H1047R) mutation into the endogenous Pik3ca gene of the mouse. Ubiquitous expression of the Pik3ca(H1047R) mutation throughout the body resulted in a dramatic increase in body weight within 3 weeks of induction (mutant 150 ± 5%; wild-type 117 ± 3%, mean ± sem), which was associated with increased organ size rather than adiposity. Severe metabolic effects, including a reduction in blood glucose levels to 59 ± 4% of baseline (11 days postinduction) and undetectable insulin levels, were also observed. Pik3ca(H1047R) mutant mice died earlier (median survival 46.5 d post-mutation induction) than wild-type control mice (100% survival > 250 days). Although deletion of Akt2 increased median survival by 44%, neither organ overgrowth, nor hypoglycemia were rescued, indicating that both the growth and metabolic functions of constitutive PI3K activity can be Akt2 independent. This mouse model demonstrates the critical role of PI3K in the regulation of both organ size and glucose metabolism at the whole animal level., (© FASEB.)

Published
2015
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