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IRIS (Infrared Imaging Spectrograph) is the near-infrared (0.84 to 2.4 micron) diffraction-limited imager and Integral Field Spectrograph (IFS) designed for the Thirty Meter Telescope (TMT) and the Narrow-Field Infrared Adaptive Optics System ( NFIRAOS ). The imager will have a 34 arcsec x 34 arcsec field of view with 4 milliarcseconds (mas) pixels. The IFS consists of a lenslet array and slicer, enabling four plate scales from 4 mas to 50 mas, with multiple gratings and filters. We will report the progress on the development of the IRIS Data Reduction System ( DRS ) in the final design phase. The IRIS DRS is being developed in Python with the software architecture based on the James Webb Space Telescope science calibration pipeline. We are developing a library of algorithms as individual Python classes that can be configured independently and bundled into pipelines. We will interface this with the observatory software to run online during observations and we will release the package publicly for scientists to develop custom analyses. It also includes a C library for readout processing to be used for both in real-time processing (e.g., up-the-ramp, MCDS) as well the ability for astronomers to use for offline reduction. Lastly, we will also discuss the development of the IRIS simulation packages that simulate raw spectra and image readout-data from the Hawaii-4RG detectors, which helps in developing reduction algorithms during this design phase., Software and Cyberinfrastructure for Astronomy VI, December 14-18, 2020, Online Only, United States, Series: Proceedings of SPIE

The Thirty Meter Telescope (TMT) is a massive international undertaking with a myriad of software packages delivered by partners around the world. A comprehensive software development process with a focus on quality assurance has been established and agreed to by the partners to ensure a consistent and well-integrated system. Additionally, thorough requirements verification is necessary to ensure the deliverables meet the needs and requirements of the observatory. As software engineering continues to progress, technologies such as cloud-based collaboration tools and automated testing through continuous integration systems have become common place and facilitate the development and verification processes. We describe how TMT leverages the use of modern software development tools and methodologies to promote a cohesive and complete software system, using the recent construction and delivery of TMT Common Software as an example.

The transition from construction to operations of the Thirty-Meter-Telescope (TMT) will happen over a phase of "early-operations” that will last several years to encompass the technical and science commissioning of its main systems, and will conclude when the facility enters "steady-state operations” (early 2030s according to the current schedule). In this talk, we will present the current plan for technical and scientific operations of the Thirty-Meter-Telescope, including a description of its organizational structure, staffing and day-to-day activities. TMT's science operations model will be aimed at optimizing the science impact of the TMT and its operations efficiency, while providing a high-level of support to TMT users over all phases (submission, implementation and (post-)execution) of their science programs.

The TMT Software System consists of software components that interact with one another through a software infrastructure called TMT Common Software (CSW). CSW defines the types of components in the software system and their functional roles, software services for integrating components, and library code that is used by developers to create the components and subsystems that make up the TMT Software System. The unique features of CSW include the use of multiple, open-source products as the basis of the services, and an approach that works to reduce the amount of CSW-produced infrastructure code. The core of CSW is implemented on the JVM in the Scala programming language with both Java and Scala programming interfaces as well as limited access from C/C++ and Python. The source code for CSW is open source and available on GitHub. TMT CSW has recently completed its construction phase and has been delivered to the project by our India partners. This paper summarizes the technical design, construction process, construction deliverables, changes in the design during implementation, and lessons learned.

The Thirty Meter Telescope (TMT) is a massive international undertaking with a myriad of software packages delivered by partners around the world. The Executive Software (ESW) package is the part of the TMT software system that is responsible for providing unified high-level control of observatory operations. It consists of five parts: a) a Sequencer Component that can be tailored to various sequencing needs by the loading of custom “scripts”, written in a TMT sequencing Domain Specific Language (DSL); b) a collection of these sequencing scripts used for critical observing tasks such as acquisition; c) user interface (UI) infrastructure that provides browser-based UI standards and access to TMT components and services; d) the set of UIs that observatory staff will use during operations to conduct TMT activities such as observing; and e) tools that assist in the visualization of observation data for quality assurance. In this paper, we describe the design of ESW, and give an update on the current status of the package, which is currently under construction.

The InfraRed Imaging Spectrograph (IRIS) is the first-light client instrument for the Narrow Field Infrared Adaptive Optics System (NFIRAOS) on the Thirty Meter Telescope (TMT). Now approaching the end of its final design phase, we provide an overview of the instrument control software. The design is challenging since IRIS has interfaces with many systems at different stages of development (e.g., NFIRAOS, telescope control system, observatory sequencers), and will be built using the newly-developed TMT Common Software (CSW), which provides framework code (Java/Scala), and services (e.g., commands, telemetry). Lower-level software will be written in a combination of Java and C/C++ to communicate with hardware, such as motion controllers and infrared detectors. The overall architecture and philosophy of the IRIS software is presented, as well as a summary of the individual software components and their interactions with other systems., Comment: 20 pages, 9 figures, SPIE (2020) 11452-28

Infrared Imaging Spectrograph (IRIS) is the first light instrument for the Thirty Meter Telescope (TMT) that consists of a near-infrared (0.84 to 2.4 micron) imager and integral field spectrograph (IFS) which operates at the diffraction-limit utilizing the Narrow-Field Infrared Adaptive Optics System (NFIRAOS). The imager will have a 34 arcsec x 34 arcsec field of view with 4 milliarcsecond (mas) pixels. The IFS consists of a lenslet array and slicer, enabling four plate scales from 4 mas to 50 mas, multiple gratings and filters, which in turn will operate hundreds of individual modes. IRIS, operating in concert with NFIRAOS will pose many challenges for the data reduction system (DRS). Here we present the updated design of the real-time and post-processing DRS. The DRS will support two modes of operation of IRIS: (1) writing the raw readouts sent from the detectors and performing the sampling on all of the readouts for a given exposure to create a raw science frame; and (2) reduction of data from the imager, lenslet array and slicer IFS. IRIS is planning to save the raw readouts for a given exposure to enable sophisticated processing capabilities to the end users, such as the ability to remove individual poor seeing readouts to improve signal-to-noise, or from advanced knowledge of the point spread function (PSF). The readout processor (ROP) is a key part of the IRIS DRS design for writing and sampling of the raw readouts into a raw science frame, which will be passed to the TMT data archive. We discuss the use of sub-arrays on the imager detectors for saturation/persistence mitigation, on-detector guide windows, and fast readout science cases (< 1 second)., 14 pages, 5 figures, 6 tables, Proceeding 10707-112 of the SPIE Astronomical Telescopes + Instrumentation 2018

The InfraRed Imaging Spectrograph (IRIS) is the first-light client instrument for the Narrow Field Infrared Adaptive Optics System (NFIRAOS) on the Thirty Meter Telescope (TMT). IRIS includes three natural guide star (NGS) On-Instrument Wavefront Sensors (OIWFS) to measure tip/tilt and focus errors in the instrument focal plane. NFIRAOS also has an internal natural guide star wavefront sensor, and IRIS and NFIRAOS must precisely coordinate the motions of their wavefront sensor positioners to track the locations of NGSs while the telescope is dithering (offsetting the telescope to cover more area), to avoid a costly re-acquisition time penalty. First, we present an overview of the sequencing strategy for all of the involved subsystems. We then predict the motion of the telescope during dithers based on finite-element models provided by TMT, and finally analyze latency and jitter issues affecting the propagation of position demands from the telescope control system to individual motor controllers., 21 pages, 19 figures, SPIE (2018) 10707-49

The near-infrared instruments in the upcoming Thirty Meter Telescope (TMT) will be assisted by a multi conjugate Adaptive Optics (AO) system. For the efficient operation of the AO system, during observations, a near-infrared guide star catalog which goes as faint as 22 mag in JVega band is essential and such a catalog does not exist. A methodology, based on stellar atmospheric models, to compute the expected near-infrared magnitudes of stellar sources from their optical magnitudes is developed. The method is applied and validated in JHKs bands for a magnitude range of JVega 16–22 mag. The methodology is also applied and validated using the reference catalog of PAN STARRS. We verified that the properties of the final PAN STARRS optical catalog will satisfy the requirements of TMT IRGSC and will be one of the potential sources for the generation of the final catalog. In a broader context, this methodology is applicable for the generation of a guide star catalog for any existing/upcoming near-infrared telescopes.

The TMT Software System consists of software components that interact with one another through a software infrastructure called TMT Common Software (CSW). CSW consists of software services and library code that is used by developers to create the subsystems and components that participate in the software system. CSW also defines the types of components that can be constructed and their roles. The use of common component types and shared middleware services allows standardized software interfaces for the components. A software system called the TMT Interface Database System was constructed to support the documentation of the interfaces for components based on CSW. The programmer describes a subsystem and each of its components using JSON-style text files. A command interface file describes each command a component can receive and any commands a component sends. The event interface files describe status, alarms, and events a component publishes and status and events subscribed to by a component. A web application was created to provide a user interface for the required features. Files are ingested into the software system’s database. The user interface allows browsing subsystem interfaces, publishing versions of subsystem interfaces, and constructing and publishing interface control documents that consist of the intersection of two subsystem interfaces. All published subsystem interfaces and interface control documents are versioned for configuration control and follow the standard TMT change control processes. Subsystem interfaces and interface control documents can be visualized in the browser or exported as PDF files.

TMT Common Software (CSW). CSW consists of software services and library code that is used by developers to create the subsystems and components that participate in the software system. CSW also defines the types of components that can be constructed and their functional roles in the software system. TMT CSW has recently passed its preliminary design review. The unique features of CSW include its use of multiple, open-source products as the basis for services, and an approach that works to reduce the amount of CSW-provided infrastructure code. Considerable prototyping was completed during this phase to mitigate risk with results that demonstrate the validity of this design approach and the selected service implementation products. This paper describes the latest design of TMT CSW, key features, and results from the prototyping effort.

The purpose of the Observatory Software System (OSW) is to integrate all software and hardware components of the Thirty Meter Telescope (TMT) to enable observations and data capture; thus it is a complex software system that is defined by four principal software subsystems: Common Software (CSW), Executive Software (ESW), Data Management System (DMS) and Science Operations Support System (SOSS), all of which have interdependencies with the observatory control systems and data acquisition systems. Therefore, the software development process and plan must consider dependencies to other subsystems, manage architecture, interfaces and design, manage software scope and complexity, and standardize and optimize use of resources and tools. Additionally, the TMT Observatory Software will largely be developed in India through TMT’s workshare relationship with the India TMT Coordination Centre (ITCC) and use of Indian software industry vendors, which adds complexity and challenges to the software development process, communication and coordination of activities and priorities as well as measuring performance and managing quality and risk. The software project management challenge for the TMT OSW is thus a multi-faceted technical, managerial, communications and interpersonal relations challenge. The approach TMT is using to manage this multifaceted challenge is a combination of establishing an effective geographically distributed software team (Integrated Product Team) with strong project management and technical leadership provided by the TMT Project Office (PO) and the ITCC partner to manage plans, process, performance, risk and quality, and to facilitate effective communications; establishing an effective cross-functional software management team composed of stakeholders, OSW leadership and ITCC leadership to manage dependencies and software release plans, technical complexities and change to approved interfaces, architecture, design and tool set, and to facilitate effective communications; adopting an agile-based software development process across the observatory to enable frequent software releases to help mitigate subsystem interdependencies; defining concise scope and work packages for each of the OSW subsystems to facilitate effective outsourcing of software deliverables to the ITCC partner, and to enable performance monitoring and risk management. At this stage, the architecture and high-level design of the software system has been established and reviewed. During construction each subsystem will have a final design phase with reviews, followed by implementation and testing. The results of the TMT approach to the Observatory Software development process will only be preliminary at the time of the submittal of this paper, but it is anticipated that the early results will be a favorable indication of progress.

The InfraRed Imaging Spectrograph (IRIS) will be a first-light client instrument for the Narrow Field Infrared Adaptive Optics System (NFIRAOS) on the Thirty Meter Telescope. IRIS includes three configurable tip/tilt (TT) or tip/tilt/focus (TTF) On-Instrument Wavefront Sensors (OIWFS). These sensors are positioned over natural guide star (NGS) asterisms using movable polar-coordinate pick-off arms (POA) that patrol an approximately 2-arcminute circular field-of-view (FOV). The POAs are capable of colliding with one another, so an algorithm for coordinated motion that avoids contact is required. We have adopted an approach in which arm motion is evaluated using the gradient descent of a scalar potential field that includes an attractive component towards the goal configuration (locations of target stars), and repulsive components to avoid obstacles (proximity to adjacent arms). The resulting vector field is further modified by adding a component transverse to the repulsive gradient to avoid problematic local minima in the potential. We present path planning simulations using this computationally inexpensive technique, which exhibit smooth and efficient trajectories., Comment: 10 pages, 5 figures, SPIE (2016) 9913-29

TPS5614 Background: Advanced endometrial cancer (EC) progressing after 1 or more lines of chemotherapy is an area of unmet need with objective tumour response rates to subsequent lines of chemotherapy of ≤20%. DNA mismatch repair (MMR) deficiency, seen in approximately 15% of EC, is associated with a high mutational load and in addition, up to 90% of ECs are reported to have PDL1/ PD1 expressions. These factors make immune check point inhibition an ideal target for treatment. Methods: DESIGN: Multicentre phase 2 trial in two cohorts. ELIGIBILITY: Advanced, unresectable endometrial cancer that is either MMR-proficient and progressing after 1-3 lines of chemotherapy, or MMR-deficient and progressing after 0-3 lines of chemotherapy. ENDPOINTS: Objective tumour response rate (OTRR) according to iRECIST (primary) and RECIST 1.1, disease control rates at 16 and 24 weeks, progression free survival, overall survival, duration of OTR and DC, adverse events, health related quality of life. Tertiary correlative objectives: Associations between immunologic (including PD-L1), DNA mismatch repair (MMR) and other genetic characteristics with clinical outcomes; and family history of cancer and referral to familial cancer services. INTERVENTION: Durvalumab 1500 mg intravenously every 28 days until disease progression or prohibitive toxicity. STATISTICS: Total of 70 participants in two cohorts (35 each) will have 90% power to distinguish a difference in observed OTRR of ≥20% versus ≤5% (uninteresting rate) using Simon’s 2-stage minimax design with 10% type 1 error rate and allowing 10% ineligibility and missing data. Durvalumab will be considered worthy of pursuit if 4 or more OTR are observed in the first 32 participants in each cohort (OTRR ≥12.5%). BIOSPECIMENS: Tumour tissue and serial bloods (5 time points) will be collected for translational research. PHAEDRA is an investigator-initiated, cooperative-group trial led by ANZGOG, in collaboration with NHMRC Clinical Trials Centre, University of Sydney. Australian New Zealand Clinical Trials Registry: Clinical trial information: ACTRN12617000106336.

5508Background: 110 (19%) of the 570 women with PRROC enrolled in SBS stopped chemotherapy within 8 weeks. We sought to identify baseline characteristics, including QOL and clinical factors, that w...

5536 Background: The primary endpoint for clinical trials in PRR/PPS ≥ 3 ROC is progression free survival (PFS) and symptom benefit is not typically measured or reported. The primary aim of GCIG SB...

5564 Background: Women with PRR/PPS ≥ 3 ROC are a heterogeneous group with unpredictable response to palliative chemotherapy (PC). GCIG SBS recently completed recruitment of 949 patients treated wi...