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209 results on '"Khokha, Rama"'

2. Systemic inflammatory prognostic scores in advanced pancreatic adenocarcinoma

Author

Ma, Lucy X., Wang, Yifan, Espin-Garcia, Osvaldo, Allen, Michael J., Jang, Gun Ho, Zhang, Amy, Dodd, Anna, Ramotar, Stephanie, Hutchinson, Shawn, Tehfe, Mustapha, Ramjeesingh, Ravi, Biagi, James, Wilson, Julie M., Notta, Faiyaz, Fischer, Sandra E., Zogopoulos, George, Gallinger, Steven, Grant, Robert C., Khokha, Rama, Chan, Nathan, Grünwald, Barbara T., Knox, Jennifer J., and O’Kane, Grainne M.

Published
2023
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3. Differential DNA damage repair and PARP inhibitor vulnerability of the mammary epithelial lineages

Author

Kim, Hyeyeon, Aliar, Kazeera, Tharmapalan, Pirashaanthy, McCloskey, Curtis W., Kuttanamkuzhi, Abhijith, Grünwald, Barbara T., Palomero, Luis, Mahendralingam, Mathepan J., Waas, Matthew, Mer, Arvind S., Elliott, Mitchell J., Zhang, Bowen, Al-Zahrani, Khalid N., Langille, Ellen R., Parsons, Michael, Narala, Swami, Hofer, Stefan, Waterhouse, Paul D., Hakem, Razqallah, Haibe-Kains, Benjamin, Kislinger, Thomas, Schramek, Daniel, Cescon, David W., Pujana, Miquel A., Berman, Hal K., and Khokha, Rama

Published
2023
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5. PDGFRα+ stromal adipocyte progenitors transition into epithelial cells during lobulo-alveologenesis in the murine mammary gland.

Author

Joshi, Purna A, Waterhouse, Paul D, Kasaian, Katayoon, Fang, Hui, Gulyaeva, Olga, Sul, Hei Sook, Boutros, Paul C, and Khokha, Rama

Subjects
Mammary Glands, Animal, Adipocytes, Stromal Cells, Epithelial Cells, Animals, Humans, Mice, Receptor, Platelet-Derived Growth Factor alpha, Cell Differentiation, Cell Lineage, Mammary Glands, Animal, Receptor, Platelet-Derived Growth Factor alpha, Breast Cancer, Stem Cell Research, Stem Cell Research - Nonembryonic - Non-Human, Cancer, Regenerative Medicine, 1.1 Normal biological development and functioning, 2.1 Biological and endogenous factors
Abstract

The mammary gland experiences substantial remodeling and regeneration during development and reproductive life, facilitated by stem cells and progenitors that act in concert with physiological stimuli. While studies have focused on deciphering regenerative cells within the parenchymal epithelium, cell lineages in the stroma that may directly contribute to epithelial biology is unknown. Here we identify, in mouse, the transition of a PDGFRα+ mesenchymal cell population into mammary epithelial progenitors. In addition to being adipocyte progenitors, PDGFRα+ cells make a de novo contribution to luminal and basal epithelia during mammary morphogenesis. In the adult, this mesenchymal lineage primarily generates luminal progenitors within lobuloalveoli during sex hormone exposure or pregnancy. We identify cell migration as a key molecular event that is activated in mesenchymal progenitors in response to epithelium-derived chemoattractant. These findings demonstrate a stromal reservoir of epithelial progenitors and provide insight into cell origins and plasticity during mammary tissue growth.

Published
2019

6. Modification of BRCA1-associated breast cancer risk by HMMR overexpression

Author

Mateo, Francesca, He, Zhengcheng, Mei, Lin, de Garibay, Gorka Ruiz, Herranz, Carmen, García, Nadia, Lorentzian, Amanda, Baiges, Alexandra, Blommaert, Eline, Gómez, Antonio, Mirallas, Oriol, Garrido-Utrilla, Anna, Palomero, Luis, Espín, Roderic, Extremera, Ana I., Soler-Monsó, M. Teresa, Petit, Anna, Li, Rong, Brunet, Joan, Chen, Ke, Tan, Susanna, Eaves, Connie J., McCloskey, Curtis, Hakem, Razq, Khokha, Rama, Lange, Philipp F., Lázaro, Conxi, Maxwell, Christopher A., and Pujana, Miquel Angel

Published
2022
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7. Mammary molecular portraits reveal lineage-specific features and progenitor cell vulnerabilities

Author

Casey, Alison E, Sinha, Ankit, Singhania, Rajat, Livingstone, Julie, Waterhouse, Paul, Tharmapalan, Pirashaanthy, Cruickshank, Jennifer, Shehata, Mona, Drysdale, Erik, Fang, Hui, Kim, Hyeyeon, Isserlin, Ruth, Bailey, Swneke, Medina, Tiago, Deblois, Genevieve, Shiah, Yu-Jia, Barsyte-Lovejoy, Dalia, Hofer, Stefan, Bader, Gary, Lupien, Mathieu, Arrowsmith, Cheryl, Knapp, Stefan, De Carvalho, Daniel, Berman, Hal, Boutros, Paul C, Kislinger, Thomas, and Khokha, Rama

Subjects
Prevention, Stem Cell Research - Nonembryonic - Non-Human, Cancer, Biotechnology, Human Genome, Stem Cell Research - Nonembryonic - Human, Breast Cancer, Stem Cell Research, Regenerative Medicine, Genetics, 1.1 Normal biological development and functioning, Underpinning research, Generic health relevance, Animals, Breast Neoplasms, Cell Line, Tumor, Cell Lineage, DNA Methylation, DNA, Neoplasm, Epigenesis, Genetic, Epigenomics, Humans, Mice, Mice, Transgenic, Neoplastic Stem Cells, Progesterone, Proteome, RNA, Neoplasm, Risk Factors, Transcriptome, Tumor Suppressor Protein p53, Up-Regulation, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female. Perturbations of these lineages underpin breast cancer risk, yet our understanding of normal mammary cell composition is incomplete. Here, we build a multimodal resource for the adult gland through comprehensive profiling of primary cell epigenomes, transcriptomes, and proteomes. We define systems-level relationships between chromatin-DNA-RNA-protein states, identify lineage-specific DNA methylation of transcription factor binding sites, and pinpoint proteins underlying progesterone responsiveness. Comparative proteomics of estrogen and progesterone receptor-positive and -negative cell populations, extensive target validation, and drug testing lead to discovery of stem and progenitor cell vulnerabilities. Top epigenetic drugs exert cytostatic effects; prevent adult mammary cell expansion, clonogenicity, and mammopoiesis; and deplete stem cell frequency. Select drugs also abrogate human breast progenitor cell activity in normal and high-risk patient samples. This integrative computational and functional study provides fundamental insight into mammary lineage and stem cell biology.

Published
2018

9. Metabolicshift to serine pathway induced by lipids confers oncogenic properties in non-transformed breast cells

Author

Eduardo, Mariana Bustamante, primary, Cottone, Gannon, additional, McCloskey, Curtis W., additional, Liu, Shiyu, additional, Zappia, Maria Paula, additional, Benevolenskaya, Elizaveta V., additional, Islam, A.B.M.M.K., additional, Frolov, Maxim V., additional, Palma, Flavio R., additional, Gao, Peng, additional, Setya, Joel, additional, Gao, Hongyu, additional, Xuei, Xiaoling, additional, Khokha, Rama, additional, Locasale, Jason, additional, Bonini, Marcelo G., additional, Chandel, Navdeep S., additional, Khan, Seema A., additional, and Clare, Susan E., additional

Published
2024
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11. Mammary epithelial cells have lineage-rooted metabolic identities

Author

Mahendralingam, Mathepan Jeya, Kim, Hyeyeon, McCloskey, Curtis William, Aliar, Kazeera, Casey, Alison Elisabeth, Tharmapalan, Pirashaanthy, Pellacani, Davide, Ignatchenko, Vladimir, Garcia-Valero, Mar, Palomero, Luis, Sinha, Ankit, Cruickshank, Jennifer, Shetty, Ronak, Vellanki, Ravi N., Koritzinsky, Marianne, Stambolic, Vid, Alam, Mina, Schimmer, Aaron David, Berman, Hal Kenneth, Eaves, Connie J., Pujana, Miquel Angel, Kislinger, Thomas, and Khokha, Rama

Published
2021
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13. RANKL/RANK control Brca1 mutation-driven mammary tumors

Author

Sigl, Verena, Owusu-Boaitey, Kwadwo, Joshi, Purna A, Kavirayani, Anoop, Wirnsberger, Gerald, Novatchkova, Maria, Kozieradzki, Ivona, Schramek, Daniel, Edokobi, Nnamdi, Hersl, Jerome, Sampson, Aishia, Odai-Afotey, Ashley, Lazaro, Conxi, Gonzalez-Suarez, Eva, Pujana, Miguel A, CIMBA, for, Heyn, Holger, Vidal, Enrique, Cruickshank, Jennifer, Berman, Hal, Sarao, Renu, Ticevic, Melita, Uribesalgo, Iris, Tortola, Luigi, Rao, Shuan, Tan, Yen, Pfeiler, Georg, Lee, Eva YHP, Bago-Horvath, Zsuzsanna, Kenner, Lukas, Popper, Helmuth, Singer, Christian, Khokha, Rama, Jones, Laundette P, and Penninger, Josef M

Subjects
Biochemistry and Cell Biology, Biological Sciences, Stem Cell Research, Cancer, Aging, Genetic Testing, Genetics, Prevention, Breast Cancer, Aetiology, 2.1 Biological and endogenous factors, Animals, BRCA1 Protein, BRCA2 Protein, Breast Neoplasms, Cell Proliferation, Cells, Cultured, DNA Damage, Epithelial Cells, Estrogen Receptor alpha, Female, Genotype, Humans, Mice, Mice, Inbred C57BL, Mice, Transgenic, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B, Receptors, Progesterone, Recombinant Fusion Proteins, Stem Cells, Tumor Suppressor Protein p53, BRCA1, RANK, RANKL, inherited breast cancer, mammary progenitor cells, Clinical Sciences, Developmental Biology, Biochemistry and cell biology
Abstract

Breast cancer is the most common female cancer, affecting approximately one in eight women during their life-time. Besides environmental triggers and hormones, inherited mutations in the breast cancer 1 (BRCA1) or BRCA2 genes markedly increase the risk for the development of breast cancer. Here, using two different mouse models, we show that genetic inactivation of the key osteoclast differentiation factor RANK in the mammary epithelium markedly delayed onset, reduced incidence, and attenuated progression of Brca1;p53 mutation-driven mammary cancer. Long-term pharmacological inhibition of the RANK ligand RANKL in mice abolished the occurrence of Brca1 mutation-driven pre-neoplastic lesions. Mechanistically, genetic inactivation of Rank or RANKL/RANK blockade impaired proliferation and expansion of both murine Brca1;p53 mutant mammary stem cells and mammary progenitors from human BRCA1 mutation carriers. In addition, genome variations within the RANK locus were significantly associated with risk of developing breast cancer in women with BRCA1 mutations. Thus, RANKL/RANK control progenitor cell expansion and tumorigenesis in inherited breast cancer. These results present a viable strategy for the possible prevention of breast cancer in BRCA1 mutant patients.

Published
2016

14. FABP7 Progenitors are a Targetable Metabolic Root in theBRCA1Breast

Author

McCloskey, Curtis W., primary, Zhang, Bowen, additional, Waas, Matthew, additional, Abazari, Golnaz, additional, Vyas, Foram, additional, Aliar, Kazeera, additional, Tharmapalan, Pirashaanthy, additional, Kuttanamkuzhi, Abhijith, additional, Narala, Swami, additional, Cruikshank, Jennifer, additional, Hofer, Stefan O.P., additional, Jackson, Hartland W., additional, Kislinger, Thomas, additional, Berman, Hal K., additional, and Khokha, Rama, additional

Published
2023
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16. A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland

Author

Shiah, Yu-Jia, Tharmapalan, Pirashaanthy, Casey, Alison E, Joshi, Purna A, McKee, Trevor D, Jackson, Hartland W, Beristain, Alexander G, Chan-Seng-Yue, Michelle A, Bader, Gary D, Lydon, John P, Waterhouse, Paul D, Boutros, Paul C, and Khokha, Rama

Subjects
Biochemistry and Cell Biology, Biological Sciences, Breast Cancer, Stem Cell Research - Nonembryonic - Non-Human, Cancer, Stem Cell Research, Regenerative Medicine, Stem Cell Research - Nonembryonic - Human, 1.1 Normal biological development and functioning, Underpinning research, Clinical Sciences, Biochemistry and cell biology
Abstract

Progesterone drives mammary stem and progenitor cell dynamics through paracrine mechanisms that are currently not well understood. Here, we demonstrate that CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), is a crucial instructor of hormone-induced mammary stem and progenitor cell function. Progesterone elicits specific changes in the transcriptome of basal and luminal mammary epithelial populations, where CXCL12 and CXCR4 represent a putative ligand-receptor pair. In situ, CXCL12 localizes to progesterone-receptor-positive luminal cells, whereas CXCR4 is induced in both basal and luminal compartments in a progesterone-dependent manner. Pharmacological inhibition of CXCR4 signaling abrogates progesterone-directed expansion of basal (CD24+CD49fhi) and luminal (CD24+CD49flo) subsets. This is accompanied by a marked reduction in CD49b+SCA-1- luminal progenitors, their functional capacity, and lobuloalveologenesis. These findings uncover CXCL12 and CXCR4 as novel paracrine effectors of hormone signaling in the adult mammary gland, and present a new avenue for potentially targeting progenitor cell growth and malignant transformation in breast cancer.

Published
2015

18. Hourglass, a rapid analysis framework for heterogeneous bioimaging data, identifies sex disparity in IL‐6/STAT3‐associated immune phenotypes in pancreatic cancer

Author

Aliar, Kazeera, primary, Waterhouse, Henry R, additional, Vyas, Foram, additional, Krebs, Niklas, additional, Zhang, Bowen, additional, Poulton, Emily, additional, Chan, Nathan, additional, Gonzalez, Ricardo, additional, Jang, Gun Ho, additional, Bronsert, Peter, additional, Fischer, Sandra E, additional, Gallinger, Steven, additional, Grünwald, Barbara T, additional, and Khokha, Rama, additional

Published
2023
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19. Droplet based low input proteomic platform for rare cell populations

Author

Waas, Matthew, primary, Khoo, Amanda, additional, Tharmapalan, Pirashaanthy, additional, McCloskey, Curtis W, additional, Govindarajan, Meinusha, additional, Zhang, Bowen, additional, Khan, Shahbaz, additional, Waterhouse, Paul, additional, Khokha, Rama, additional, and Kislinger, Thomas, additional

Published
2023
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21. Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

Author

Li, Li, Guturi, Kiran Kumar Naidu, Gautreau, Brandon, Patel, Parasvi S., Saad, Amine, Morii, Mayako, Mateo, Francesca, Palomero, Luis, Barbour, Haithem, Gomez, Antonio, Ng, Deborah, Kotlyar, Max, Pastrello, Chiara, Jackson, Hartland W., Khokha, Rama, Jurisica, Igor, Affar, El Bachir, Raught, Brian, Sanchez, Otto, Alaoui-Jamali, Moulay, Pujana, Miguel A., Hakem, Anne, and Hakem, Razq

Subjects
Ligases -- Health aspects, Cellular signal transduction -- Genetic aspects -- Health aspects, Breast cancer -- Genetic aspects -- Development and progression -- Care and treatment, Health care industry
Abstract

The E3 ubiquitin ligase RNF8 plays critical roles in maintaining genomic stability by promoting the repair of DNA double-strand breaks (DSBs) through ubiquitin signaling. Abnormal activation of Notch signaling and defective repair of DSBs promote breast cancer risk. Here, we found that low expression of the full- length RNF8 correlated with poor prognosis for breast cancer patients. Our data revealed that in addition to its role in the repair of DSBs, RNF8 regulated Notch1 signaling and cell-fate determination of mammary luminal progenitors. Mechanistically, RNF8 acted as a negative regulator of Notch signaling by ubiquitylating the active NOTCH1 protein (N1ICD), leading to its degradation. Consistent with abnormal activation of Notch signaling and impaired repair of DSBs in Rn/8-mutant mammary epithelial cells, we observed increased risk of mammary tumorigenesis in mouse models for RNF8 deficiency. Notably, deficiency of RNF8 sensitized breast cancer cells to combination of pharmacological inhibitors of Notch signaling and poly(ADP-ribose) polymerase (PARP), suggesting implications for treatment of breast cancer associated with impaired RNF8 expression or function., Introduction Regulation of Notch signaling and repair of double-strand breaks (DSBs) is critical for maintaining tissue homeostasis and suppression of cancer. Notch signaling is important for the control of cell-fate [...]

Published
2018
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23. Supplementary Data from GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

Author

O’Kane, Grainne M., primary, Grünwald, Barbara T., primary, Jang, Gun-Ho, primary, Masoomian, Mehdi, primary, Picardo, Sarah, primary, Grant, Robert C., primary, Denroche, Robert E., primary, Zhang, Amy, primary, Wang, Yifan, primary, Miller, Jessica K., primary, Lam, Bernard, primary, Krzyzanowski, Paul M., primary, Lungu, Ilinca M., primary, Bartlett, John M.S., primary, Peralta, Melanie, primary, Vyas, Foram, primary, Khokha, Rama, primary, Biagi, James, primary, Chadwick, Dianne, primary, Ramotar, Stephanie, primary, Hutchinson, Shawn, primary, Dodd, Anna, primary, Wilson, Julie M., primary, Notta, Faiyaz, primary, Zogopoulos, George, primary, Gallinger, Steven, primary, Knox, Jennifer J., primary, and Fischer, Sandra E., primary

Published
2023
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24. Figure S6 from A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

Author

Romero, Joan M., primary, Grünwald, Barbara, primary, Jang, Gun-Ho, primary, Bavi, Prashant P., primary, Jhaveri, Aaditeya, primary, Masoomian, Mehdi, primary, Fischer, Sandra E., primary, Zhang, Amy, primary, Denroche, Robert E., primary, Lungu, Ilinca M., primary, De Luca, Angela, primary, Bartlett, John M.S., primary, Xu, Jing, primary, Li, Niandong, primary, Dhaliwal, Sharon, primary, Liang, Sheng-Ben, primary, Chadwick, Dianne, primary, Vyas, Foram, primary, Bronsert, Peter, primary, Khokha, Rama, primary, McGaha, Tracy L., primary, Notta, Faiyaz, primary, Ohashi, Pamela S., primary, Done, Susan J., primary, O'Kane, Grainne M., primary, Wilson, Julie M., primary, Knox, Jennifer J., primary, Connor, Ashton, primary, Wang, Yifan, primary, Zogopoulos, George, primary, and Gallinger, Steven, primary

Published
2023
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25. Table S3 from A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

Author

Romero, Joan M., primary, Grünwald, Barbara, primary, Jang, Gun-Ho, primary, Bavi, Prashant P., primary, Jhaveri, Aaditeya, primary, Masoomian, Mehdi, primary, Fischer, Sandra E., primary, Zhang, Amy, primary, Denroche, Robert E., primary, Lungu, Ilinca M., primary, De Luca, Angela, primary, Bartlett, John M.S., primary, Xu, Jing, primary, Li, Niandong, primary, Dhaliwal, Sharon, primary, Liang, Sheng-Ben, primary, Chadwick, Dianne, primary, Vyas, Foram, primary, Bronsert, Peter, primary, Khokha, Rama, primary, McGaha, Tracy L., primary, Notta, Faiyaz, primary, Ohashi, Pamela S., primary, Done, Susan J., primary, O'Kane, Grainne M., primary, Wilson, Julie M., primary, Knox, Jennifer J., primary, Connor, Ashton, primary, Wang, Yifan, primary, Zogopoulos, George, primary, and Gallinger, Steven, primary

Published
2023
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27. Abstract A031: Proteogenomic analysis of the PDAC epithelium reveals tissue markers of subtype identity and biology

Author

Grünwald, Barbara T., primary, Vyas, Foram, additional, Geuenich, Michael, additional, Chan, Nathan, additional, Gonzalez, Ricardo, additional, Aliar, Kazeera, additional, Krebs, Niklas, additional, Devisme, Antoine, additional, Andrieux, Geoffroy, additional, Jang, Gun Ho, additional, O'Kane, Grainne, additional, Wilson, Julie, additional, Knox, Jennifer, additional, Notta, Faiyaz, additional, Campbell, Kieran, additional, Gallinger, Steven, additional, Boerries, Melanie, additional, Fischer, Sandra, additional, Kislinger, Thomas, additional, and Khokha, Rama, additional

Published
2022
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30. Hourglass, a tool to mine bioimaging data, uncovers sex-disparities in the IL-6-associated T cell response in pancreatic tumors

Author

Aliar, Kazeera, primary, Waterhouse, Henry R., additional, Vyas, Foram, additional, Krebs, Niklas, additional, Poulton, Emily, additional, Zhang, Bowen, additional, Chan, Nathan, additional, Bronsert, Peter, additional, Fischer, Sandra E., additional, Gallinger, Steven, additional, Grünwald, Barbara T., additional, and Khokha, Rama, additional

Published
2022
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31. Glycoproteomics Identifies Plexin-B3 as a Targetable Cell Surface Protein Required for the Growth and Invasion of Triple-Negative Breast Cancer Cells

Author

Kuhlmann, Laura, primary, Govindarajan, Meinusha, additional, Mejia-Guerrero, Salvador, additional, Ignatchenko, Vladimir, additional, Liu, Lydia Y., additional, Grünwald, Barbara T., additional, Cruickshank, Jennifer, additional, Berman, Hal, additional, Khokha, Rama, additional, and Kislinger, Thomas, additional

Published
2022
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33. Correction: GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

Author

O'Kane, Grainne M., primary, Grünwald, Barbara T., additional, Jang, Gun-Ho, additional, Masoomian, Mehdi, additional, Picardo, Sarah, additional, Grant, Robert C., additional, Denroche, Robert E., additional, Zhang, Amy, additional, Wang, Yifan, additional, Miller, Jessica K., additional, Lam, Bernard, additional, Krzyzanowski, Paul M., additional, Lungu, Ilinca M., additional, Bartlett, John M.S., additional, Peralta, Melanie, additional, Vyas, Foram, additional, Khokha, Rama, additional, Biagi, James, additional, Chadwick, Dianne, additional, Ramotar, Stephanie, additional, Hutchinson, Shawn, additional, Dodd, Anna, additional, Wilson, Julie M., additional, Notta, Faiyaz, additional, Zogopoulos, George, additional, Gallinger, Steven, additional, Knox, Jennifer J., additional, and Fischer, Sandra E., additional

Published
2022
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34. Glycoproteomics Identifies Plexin-B3 as Targetable Cell Surface Protein Required for Growth and Invasion of Triple Negative Breast Cancer Cells

Author

Kuhlmann, Laura, primary, Govindarajan, Meinusha, additional, Mejia-Guerrero, Salvador, additional, Ignatchenko, Vladimir, additional, Liu, Lydia Y., additional, Grünwald, Barbara T., additional, Cruickshank, Jennifer, additional, Berman, Hal, additional, Khokha, Rama, additional, and Kislinger, Thomas, additional

Published
2022
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35. Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

Author

Hezaveh, Kebria, primary, Shinde, Rahul S., additional, Klötgen, Andreas, additional, Halaby, Marie Jo, additional, Lamorte, Sara, additional, Ciudad, M. Teresa, additional, Quevedo, Rene, additional, Neufeld, Luke, additional, Liu, Zhe Qi, additional, Jin, Robbie, additional, Grünwald, Barbara T., additional, Foerster, Elisabeth G., additional, Chaharlangi, Danica, additional, Guo, Mengdi, additional, Makhijani, Priya, additional, Zhang, Xin, additional, Pugh, Trevor J., additional, Pinto, Devanand M., additional, Co, Ileana L., additional, McGuigan, Alison P., additional, Jang, Gun Ho, additional, Khokha, Rama, additional, Ohashi, Pamela S., additional, O’Kane, Grainne M., additional, Gallinger, Steven, additional, Navarre, William W., additional, Maughan, Heather, additional, Philpott, Dana J., additional, Brooks, David G., additional, and McGaha, Tracy L., additional

Published
2022
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36. Abstract PO-107: Fibroblast differentiation trajectories elicit regional tissue states in pancreatic cancer

Author

Grünwald, Barbara T., primary, McCloskey, Curtis, additional, Devisme, Antoine, additional, Vyas, Foram, additional, Andrieux, Geoffroy, additional, Aliar, Kazeera, additional, Notta, Faiyaz, additional, O’Kane, Grainne, additional, Wilson, Julie, additional, Knox, Jennifer, additional, Fischer, Sandra, additional, Kislinger, Thomas, additional, Boerries, Melanie, additional, Gallinger, Steven, additional, and Khokha, Rama, additional

Published
2021
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38. Spatially confined sub-tumor microenvironments in pancreatic cancer

Author

Grünwald, Barbara T., primary, Devisme, Antoine, additional, Andrieux, Geoffroy, additional, Vyas, Foram, additional, Aliar, Kazeera, additional, McCloskey, Curtis W., additional, Macklin, Andrew, additional, Jang, Gun Ho, additional, Denroche, Robert, additional, Romero, Joan Miguel, additional, Bavi, Prashant, additional, Bronsert, Peter, additional, Notta, Faiyaz, additional, O’Kane, Grainne, additional, Wilson, Julie, additional, Knox, Jennifer, additional, Tamblyn, Laura, additional, Udaskin, Molly, additional, Radulovich, Nikolina, additional, Fischer, Sandra E., additional, Boerries, Melanie, additional, Gallinger, Steven, additional, Kislinger, Thomas, additional, and Khokha, Rama, additional

Published
2021
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39. TIMP1 expression underlies sex disparity in liver metastasis and survival in pancreatic cancer

Author

Hermann, Chris D., primary, Schoeps, Benjamin, additional, Eckfeld, Celina, additional, Munkhbaatar, Enkhtsetseg, additional, Kniep, Lukas, additional, Prokopchuk, Olga, additional, Wirges, Nils, additional, Steiger, Katja, additional, Häußler, Daniel, additional, Knolle, Percy, additional, Poulton, Emily, additional, Khokha, Rama, additional, Grünwald, Barbara T., additional, Demir, Ihsan Ekin, additional, and Krüger, Achim, additional

Published
2021
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42. Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis

Author

Li, Li, primary, Guturi, Kiran Kumar Naidu, additional, Gautreau, Brandon, additional, Patel, Parasvi S., additional, Saad, Amine, additional, Morii, Mayako, additional, Mateo, Francesca, additional, Palomero, Luis, additional, Barbour, Haithem, additional, Gomez, Antonio, additional, Ng, Deborah, additional, Kotlyar, Max, additional, Pastrello, Chiara, additional, Jackson, Hartland W., additional, Khokha, Rama, additional, Jurisica, Igor, additional, Affar, El Bachir, additional, Raught, Brian, additional, Sanchez, Otto, additional, Alaoui-Jamali, Moulay, additional, Pujana, Miguel A., additional, Hakem, Anne, additional, and Hakem, Razq, additional

Published
2021
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43. Mammary lineage dictates homologous recombination repair and PARP inhibitor vulnerability

Author

Kim, Hyeyeon, primary, Casey, Alison E., additional, Palomero, Luis, additional, Aliar, Kazeera, additional, Mahendralingam, Mathepan, additional, Parsons, Michael, additional, Narala, Swami, additional, Mateo, Francesca, additional, Hofer, Stefan, additional, Waterhouse, Paul D., additional, Kislinger, Thomas, additional, Pujana, Miquel A., additional, Berman, Hal K., additional, and Khokha, Rama, additional

Published
2021
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44. Spatially confined sub-tumor microenvironments orchestrate pancreatic cancer pathobiology

Author

Grünwald, Barbara T, primary, Devisme, Antoine, additional, Andrieux, Geoffroy, additional, Vyas, Foram, additional, Aliar, Kazeera, additional, McCloskey, Curtis W, additional, Macklin, Andrew, additional, Jang, Gun Ho, additional, Denroche, Robert, additional, Romero, Joan Miguel, additional, Bavi, Prashant, additional, Bronsert, Peter, additional, Notta, Faiyaz, additional, O’Kane, Grainne, additional, Wilson, Julie, additional, Knox, Jennifer, additional, Tamblyn, Laura, additional, Radulovich, Nikolina, additional, Fischer, Sandra E, additional, Boerries, Melanie, additional, Gallinger, Steven, additional, Kislinger, Thomas, additional, and Khokha, Rama, additional

Published
2021
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45. Abstract PR-002: Stromal phenotypic heterogeneity fosters pancreatic cancer progression

Author

Grünwald, Barbara T., primary, Devisme, Antoine, additional, Vyas, Foram, additional, Andrieux, Geoffroy, additional, Jang, Gun Ho, additional, Aliar, Kazeera, additional, McCloskey, Curtis, additional, Macklin, Andrew, additional, Romero, Joan Miguel, additional, Tamblyn, Laura, additional, Radulovich, Nikolina, additional, Bronsert, Peter, additional, O’Kane, Grainne, additional, Wilson, Julie, additional, Knox, Jennifer, additional, Fischer, Sandra, additional, Kislinger, Thomas, additional, Boerries, Melanie, additional, Gallinger, Steven, additional, and Khokha, Rama, additional

Published
2020
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47. A Four-Chemokine Signature Is Associated with a T-cell–Inflamed Phenotype in Primary and Metastatic Pancreatic Cancer

Author

Romero, Joan M., primary, Grünwald, Barbara, additional, Jang, Gun-Ho, additional, Bavi, Prashant P., additional, Jhaveri, Aaditeya, additional, Masoomian, Mehdi, additional, Fischer, Sandra E., additional, Zhang, Amy, additional, Denroche, Robert E., additional, Lungu, Ilinca M., additional, De Luca, Angela, additional, Bartlett, John M.S., additional, Xu, Jing, additional, Li, Niandong, additional, Dhaliwal, Sharon, additional, Liang, Sheng-Ben, additional, Chadwick, Dianne, additional, Vyas, Foram, additional, Bronsert, Peter, additional, Khokha, Rama, additional, McGaha, Tracy L., additional, Notta, Faiyaz, additional, Ohashi, Pamela S., additional, Done, Susan J., additional, O'Kane, Grainne M., additional, Wilson, Julie M., additional, Knox, Jennifer J., additional, Connor, Ashton, additional, Wang, Yifan, additional, Zogopoulos, George, additional, and Gallinger, Steven, additional

Published
2020
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48. GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

Author

O’Kane, Grainne M., primary, Grünwald, Barbara T., additional, Jang, Gun-Ho, additional, Masoomian, Mehdi, additional, Picardo, Sarah, additional, Grant, Robert C., additional, Denroche, Robert E., additional, Zhang, Amy, additional, Wang, Yifan, additional, Miller, Jessica K., additional, Lam, Bernard, additional, Krzyzanowski, Paul M., additional, Lungu, Ilinca M., additional, Bartlett, John M.S., additional, Peralta, Melanie, additional, Vyas, Foram, additional, Khokha, Rama, additional, Biagi, James, additional, Chadwick, Dianne, additional, Ramotar, Stephanie, additional, Hutchinson, Shawn, additional, Dodd, Anna, additional, Wilson, Julie M., additional, Notta, Faiyaz, additional, Zogopoulos, George, additional, Gallinger, Steven, additional, Knox, Jennifer J., additional, and Fischer, Sandra E., additional

Published
2020
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49. Mammary epithelial cells have lineage-restricted metabolic identities

Author

Mahendralingam, Mathepan, primary, Aliar, Kazeera, additional, Elisabeth Casey, Alison, additional, Pellacani, Davide, additional, Kim, Hyeyeon, additional, Ignatchenko, Vladimir, additional, Valero, Mar Garcia, additional, Palomero, Luis, additional, Sinha, Ankit, additional, Stambolic, Vid, additional, Alam, Mina, additional, Schimmer, Aaron, additional, Berman, Hal, additional, Angel Pujana, Miquel, additional, Eaves, Connie, additional, Kislinger, Thomas, additional, and Khokha, Rama, additional

Published
2019
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50. Metalloprotease inhibitor TIMP proteins control FGF-2 bioavailability and regulate skeletal growth

Author

Saw, Sanjay, primary, Aiken, Alison, additional, Fang, Hui, additional, McKee, Trevor D., additional, Bregant, Sarah, additional, Sanchez, Otto, additional, Chen, Yan, additional, Weiss, Ashley, additional, Dickson, Brendan C., additional, Czarny, Bertrand, additional, Sinha, Ankit, additional, Fosang, Amanda, additional, Dive, Vincent, additional, Waterhouse, Paul D., additional, Kislinger, Thomas, additional, and Khokha, Rama, additional

Published
2019
Full Text
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