Search

Archaeologists have traditionally framed the impacts of natural disasters in terms of societal collapse versus cultural resilience. The 7.3ka cal BP Kikai-Akahoya (K-Ah) ‘super-eruption’ in south-western Japan was among the largest volcanic events of the Holocene. Here, the authors deploy a multi-proxy approach to examine how K-Ah devastated Tanegashima Island. While local Jōmon populations were annihilated, surrounding communities survived and eventually returned, adjusting their subsistence base to survive in the damaged environment. The article concludes that neither ‘collapse’ nor ‘resilience’ fully capture the complex dynamics of this process and that more research is needed to understand how disasters shape cultural trajectories.

Background Coronavirus disease 2019 (COVID-19) messenger RNA (mRNA) vaccines were authorized in the United States in December 2020. Although vaccine effectiveness (VE) against mild infection declines markedly after several months, limited understanding exists on the long-term durability of protection against COVID-19–associated hospitalization. Methods Case-control analysis of adults (≥18 years) hospitalized at 21 hospitals in 18 states 11 March–15 December 2021, including COVID-19 case patients and reverse transcriptase-polymerase chain reaction–negative controls. We included adults who were unvaccinated or vaccinated with 2 doses of a mRNA vaccine before the date of illness onset. VE over time was assessed using logistic regression comparing odds of vaccination in cases versus controls, adjusting for confounders. Models included dichotomous time ( Results A total of 10 078 patients were included, 4906 cases (23% vaccinated) and 5172 controls (62% vaccinated). Median age was 60 years (interquartile range, 46–70), 56% were non-Hispanic White, and 81% had ≥1 medical condition. Among immunocompetent adults, VE Conclusions In a period largely predating Omicron variant circulation, effectiveness of 2 mRNA doses against COVID-19–associated hospitalization was largely sustained through 9 months.

In Southwest Asia, early ceramics are generally associated with sedentary farming communities. This is unlike many other parts of Asia, where ceramics were first manufactured by hunter-gatherers. Radiocarbon evidence indicates that sustained production of ceramic containers (pottery) began at several sites in Anatolia, Upper Mesopotamia and the northern Levant around 7000 BC or slightly later, although there are indications that very small-scale production of pottery sometimes occurred at even earlier dates. In other regions (e.g. the southern Levant, Cyprus) pottery does not become common until centuries later. This paper examines Southwest Asian ceramic production in terms of its timing, technology and use, as well as its social and economic contexts. It also considers the legacy of early archaeological studies of Southwest Asian pottery for our general understanding of the emergence of ceramics. For example, Gordon Childe's concept of a ‘Neolithic package’ promoted a close association between the emergence of farming and pottery, which cannot be supported for many parts of Asia.

Background The benefits of early continuous neuromuscular blockade in patients with acute respiratory distress syndrome (ARDS) who are receiving mechanical ventilation remain unclear. Meth...

Importance Data on the efficacy of hydroxychloroquine for the treatment of coronavirus disease 2019 (COVID-19) are needed. Objective To determine whether hydroxychloroquine is an efficacious treatment for adults hospitalized with COVID-19. Design, Setting, and Participants This was a multicenter, blinded, placebo-controlled randomized trial conducted at 34 hospitals in the US. Adults hospitalized with respiratory symptoms from severe acute respiratory syndrome coronavirus 2 infection were enrolled between April 2 and June 19, 2020, with the last outcome assessment on July 17, 2020. The planned sample size was 510 patients, with interim analyses planned after every 102 patients were enrolled. The trial was stopped at the fourth interim analysis for futility with a sample size of 479 patients. Interventions Patients were randomly assigned to hydroxychloroquine (400 mg twice daily for 2 doses, then 200 mg twice daily for 8 doses) (n = 242) or placebo (n = 237). Main Outcomes and Measures The primary outcome was clinical status 14 days after randomization as assessed with a 7-category ordinal scale ranging from 1 (death) to 7 (discharged from the hospital and able to perform normal activities). The primary outcome was analyzed with a multivariable proportional odds model, with an adjusted odds ratio (aOR) greater than 1.0 indicating more favorable outcomes with hydroxychloroquine than placebo. The trial included 12 secondary outcomes, including 28-day mortality. Results Among 479 patients who were randomized (median age, 57 years; 44.3% female; 37.2% Hispanic/Latinx; 23.4% Black; 20.1% in the intensive care unit; 46.8% receiving supplemental oxygen without positive pressure; 11.5% receiving noninvasive ventilation or nasal high-flow oxygen; and 6.7% receiving invasive mechanical ventilation or extracorporeal membrane oxygenation), 433 (90.4%) completed the primary outcome assessment at 14 days and the remainder had clinical status imputed. The median duration of symptoms prior to randomization was 5 days (interquartile range [IQR], 3 to 7 days). Clinical status on the ordinal outcome scale at 14 days did not significantly differ between the hydroxychloroquine and placebo groups (median [IQR] score, 6 [4-7] vs 6 [4-7]; aOR, 1.02 [95% CI, 0.73 to 1.42]). None of the 12 secondary outcomes were significantly different between groups. At 28 days after randomization, 25 of 241 patients (10.4%) in the hydroxychloroquine group and 25 of 236 (10.6%) in the placebo group had died (absolute difference, −0.2% [95% CI, −5.7% to 5.3%]; aOR, 1.07 [95% CI, 0.54 to 2.09]). Conclusions and Relevance Among adults hospitalized with respiratory illness from COVID-19, treatment with hydroxychloroquine, compared with placebo, did not significantly improve clinical status at day 14. These findings do not support the use of hydroxychloroquine for treatment of COVID-19 among hospitalized adults. Trial Registration ClinicalTrials.gov:NCT04332991

The invention of pottery was a fundamental technological advancement with far-reaching economic and cultural consequences. Pottery containers first emerged in East Asia during the Late Pleistocene in a wide range of environmental settings, but became particularly prominent and much more widely dispersed after climatic warming at the start of the Holocene. Some archaeologists argue that this increasing usage was driven by environmental factors, as warmer climates would have generated a wider range of terrestrial plant and animal resources that required processing in pottery. However, this hypothesis has never been directly tested. Here, in one of the largest studies of its kind, we conducted organic residue analysis of >800 pottery vessels selected from 46 Late Pleistocene and Early Holocene sites located across the Japanese archipelago to identify their contents. Our results demonstrate that pottery had a strong association with the processing of aquatic resources, irrespective of the ecological setting. Contrary to expectations, this association remained stable even after the onset of Holocene warming, including in more southerly areas, where expanding forests provided new opportunities for hunting and gathering. Nevertheless, the results indicate that a broader array of aquatic resources was processed in pottery after the start of the Holocene. We suggest this marks a significant change in the role of pottery of hunter-gatherers, corresponding to an increased volume of production, greater variation in forms and sizes, the rise of intensified fishing, the onset of shellfish exploitation, and reduced residential mobility.

The goal of this contribution is to stimulate a wider reflection on the role of food consumption practices throughout prehistory. We focussed on the Jōmon communities of Hokkaidō Island in Northern Japan since these mobile foragers underwent a process of economic diversification and intensification, eventually leading to higher levels of sedentism across the Pleistocene-Holocene transition. Moreover, dynamic social settings and expansion of the subsistence base at the start of the Holocene would have provided rich opportunities for novelfood combinations, and potentially, the rise of diverse regional cuisines. We investigated tool kits and resource landscapes, and sampled pottery from a range of sites, phases and regions. We then applied organic residueanalysis to confirm the actual spatiotemporal patterning in cuisine. Although we predicted that ruminants and nuts would have played a major role in local cuisine, especially in inland areas, our results indicate that aquaticresources were central to pottery-based cuisines across the island, and that other food groups had probably been processed in other ways. While organic residue analysis enabled us to reconstruct some major patterns in Jōmoncuisine, we conclude that archaeologists will need to look “beyond the cooking pot” to fully appreciate the full diversity of local foodways.

The Neolithic is a key topic in the study of Old World prehistory but how the Neolithic is defined varies between regions. In East Asia the invention of pottery is often seen as marking the start of the Neolithic. In contrast to this ‘eastern’ perspective, in western parts of Eurasia it is the presence of agriculture that usually defines the onset of a Neolithic way of life. This paper adopts a comparative perspective, examining the origins and development of pottery, agriculture and sedentary life in East Asia and Southwest Asia. We suggest that a comparative perspective indicates that some of the most enduring themes of Neolithic studies need to be reconsidered, namely: (1) the idea of a Neolithic package consisting of a number of associated traits (including, among other things, agriculture, sedentary sites, and pottery) that developed and spread together, (2) the notion of the Neolithic as a revolutionary event marking a sharp break from the preceding Palaeolithic period, and (3) the enduring impact of the Neolithic on later periods.

Copyright © 2016 Antiquity Publications Ltd. Where did pottery first appear in the Old World? Statistical modelling of radiocarbon dates suggests that ceramic vessel technology had independent origins in two different hunter-gatherer societies. Regression models were used to estimate average rates of spread and geographic dispersal of the new technology. The models confirm independent origins in East Asia (c. 16000 cal BP) and North Africa (c. 12000 cal BP). The North African tradition may have later influenced the emergence of Near Eastern pottery, which then flowed west into Mediterranean Europe as part of a Western Neolithic, closely associated with the uptake of farming.

Background The purpose of this study was to see if 3-dimensional (3D) magnetic resonance imaging (MRI) could improve our understanding of rotator cuff tendon tear shapes. We believed that 3D MRI would be more accurate than two-dimensional (2D) MRI for classifying tear shapes. Methods We performed a retrospective review of MRI studies of patients with arthroscopically proven full-thickness rotator cuff tears. Two orthopedic surgeons reviewed the information for each case, including scope images, and characterized the shape of the cuff tear into crescent, longitudinal, U- or L-shaped longitudinal, and massive type. Two musculoskeletal radiologists reviewed the corresponding MRI studies independently and blind to the arthroscopic findings and characterized the shape on the basis of the tear's retraction and size using 2D MRI. The 3D reconstructions of each cuff tear were reviewed by each radiologist to characterize the shape. Statistical analysis included 95% confidence intervals and intraclass correlation coefficients. Results The study reviewed 34 patients. The accuracy for differentiating between crescent-shaped, longitudinal, and massive tears using measurements on 2D MRI was 70.6% for reader 1 and 67.6% for reader 2. The accuracy for tear shape characterization into crescent and longitudinal U- or L-shaped using 3D MRI was 97.1% for reader 1 and 82.4% for reader 2. When further characterizing the longitudinal tears as massive or not using 3D MRI, both readers had an accuracy of 76.9% (10 of 13). The overall accuracy of 3D MRI was 82.4% (56 of 68), significantly different (P = .021) from 2D MRI accuracy (64.7%). Conclusion Our study has demonstrated that 3D MR reconstructions of the rotator cuff improve the accuracy of characterizing rotator cuff tear shapes compared with current 2D MRI–based techniques.

The Neolithic in north-east Asia is defined by the presence of ceramic containers, rather than agriculture, among hunter-gatherer communities. The role of pottery in such groups has, however, hitherto been unclear. This article presents the results of organic residue analysis of Neolithic pottery from Sakhalin Island in the Russian Far East. Results indicate that early pottery on Sakhalin was used for the processing of aquatic species, and that its adoption formed part of a wider Neolithic transition involving the reorientation of local lifeways towards the exploitation of marine resources.

Lipid residue analysis has become a common technique for the identification of the organic residues remaining from resources processed in archaeological ceramic vessels. However, recovery of lipids from the vessels can be problematic in cases of high age and/or very small sample amounts. Here we show that acid-catalyzed direct extraction and methylation offers an efficient way to obtain enough fatty acids for quantification and stable carbon isotope analysis. We compared this technique with the more conventional technique of ultrasonically aided solvent extraction followed by silylation, which gave no measurable yields. Both techniques were applied on the absorbed residues of six extremely small sample amounts of less than 0.1 g of ceramic powder each from the Sankakuyama I site, Kyushu, South Japan (~ 13,900–13,300 cal BP). They belong to one of the oldest so far reported pottery traditions in the world, the Japanese Incipient Jōmon. δ 13 C analysis of the identified target C 16:0 and C 18:0 fatty acids indicated that the examined vessels were used for food-processing purposes, pointing to a significant contribution of terrestrial animal sources in the residues.

The invention of ceramic objects made from fire-hardened clay represents an important and early step in the development of pyrotechnology. This paper examines pottery invention and innovation by hunter-gatherers in East Asia and by farmers in the Near East to examine how prehistoric communities in different socio-economic systems came to rely heavily on fired-clay containers. Drawing on advances in archaeological science, it examines from a comparative perspective early pottery's broader entanglements related to technology and use and argues that early pottery production by farmers in the Near East can be viewed as a process of innovation in a longer tradition of container technology, while the first hunter-gatherer pottery production in East Asia provides a better case for independent invention.

Lung abscesses are intraparenchymal collections of purulent and necrotic tissue caused by infectious organisms that present with subacute pulmonary symptoms. Primary lung abscess is classically a disease of middle-aged men. Infection and subsequent abscess formation result from large-volume aspiration of oral secretions. Therefore, conditions that predispose to aspiration also predispose to lung abscess. Such conditions include all causes of depressed sensorium as well as both mechanical and neurologic causes of dysphagia. The burden of oral anaerobes also plays an important role in disease pathogenesis. It can be difficult to differentiate a lung abscess from pneumonia. Patients with lung abscess generally appear less acutely ill, and have fewer rigors or shaking chills. These infections are typically polymicrobial and difficult to accurately culture, requiring empiric therapy with antibiotics with broad anaerobic coverage. Most patients respond well to antimicrobials, but mortality remains high in the subset who fails medical therapy.

The earliest pots in the world are from East Asia and date to the Late Pleistocene. However, ceramic vessels were only produced in large numbers during the warmer and more stable climatic conditions of the Holocene. It has long been assumed that the expansion of pottery was linked with increased sedentism and exploitation of new resources that became available with the ameliorated climate, but this hypothesis has never been tested. Through chemical analysis of their contents, we herein investigate the use of pottery across an exceptionally long 9,000-y sequence from the Jomon site of Torihama in western Japan, intermittently occupied from the Late Pleistocene to the mid-Holocene. Molecular and isotopic analyses of lipids from 143 vessels provides clear evidence that pottery across this sequence was predominantly used for cooking marine and freshwater resources, with evidence for diversification in the range of aquatic products processed during the Holocene. Conversely, there is little indication that ruminant animals or plants were processed in pottery, although it is evident from the faunal and macrobotanical remains that these foods were heavily exploited. Supported by other residue analysis data from Japan, our results show that the link between pottery and fishing was established in the Late Paleolithic and lasted well into the Holocene, despite environmental and socio-economic change. Cooking aquatic products in pottery represents an enduring social aspect of East Asian hunter-gatherers, a tradition based on a dependable technology for exploiting a sustainable resource in an uncertain and changing world.