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7 results on '"Ketty Lee"'

1. Sickle Cell Disease Newborn Screening—An Audit of a Twin Island State Pilot Program

Author

Shivon Belle Jarvis, Edda Hadeed, Ketty Lee, Marie-Dominique Hardy-Dessources, Jennifer M. Knight-Madden, and Claudine Richardson

Subjects
sickle cell disease, newborn screening, audit, Antigua and Barbuda, Pediatrics, RJ1-570
Abstract

The prevalence of Sickle Cell Disease (SCD) within the Caribbean region remains second only to that of West Africa. The Newborn Screening (NBS) Program in Antigua and Barbuda remains heavily dependent on grants, therefore ultimately facing sustainability challenges. Early intervention and implementation of preventative measures post-NBS result in significant improvements in morbidity, quality of life, and survival. This audit reviewed the pilot SCD NBS Program in Antigua and Barbuda from September 2020 to December 2021. A conclusive result was received by 99% of babies eligible for screening, 84.3% of which were HbFA, whilst 9.6% and 4.6% were HbFAS and HbFAC, respectively. This was comparable to other Caribbean countries. Sickle Cell Disease was noted in 0.5% of babies screened, which translates to 1 in 222 live births. Eighty-two percent of mothers were aware of their sickle cell status, compared to 3% of fathers. The importance of instituting a quality improvement team post the initiation of a screening program and the need for a robust public education program have been demonstrated by this audit.

Published
2023
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2. Newborn Screening for Sickle Cell Disease in the Caribbean: An Update of the Present Situation and of the Disease Prevalence

Author

Jennifer Knight-Madden, Ketty Lee, Gisèle Elana, Narcisse Elenga, Beatriz Marcheco-Teruel, Ngozi Keshi, Maryse Etienne-Julan, Lesley King, Monika Asnani, Marc Romana, and Marie-Dominique Hardy-Dessources

Subjects
sickle cell disease, newborn screening, Caribbean, Pediatrics, RJ1-570
Abstract

The region surrounding the Caribbean Sea is predominantly composed of island nations for its Eastern part and the American continental coast on its Western part. A large proportion of the population, particularly in the Caribbean islands, traces its ancestry to Africa as a consequence of the Atlantic slave trade during the XVI–XVIII centuries. As a result, sickle cell disease has been largely introduced in the region. Some Caribbean countries and/or territories, such as Jamaica and the French territories, initiated newborn screening (NBS) programs for sickle cell disease more than 20 years ago. They have demonstrated the major beneficial impact on mortality and morbidity resulting from early childhood care. However, similar programs have not been implemented in much of the region. This paper presents an update of the existing NBS programs and the prevalence of sickle cell disease in the Caribbean. It demonstrates the impact of the Caribbean Network of Researchers on Sickle Cell Disease and Thalassemia (CAREST) on the extension of these programs. The presented data illustrate the importance of advocacy in convincing policy makers of the feasibility and benefit of NBS for sickle cell disease when coupled to early care.

Published
2019
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4. Newborn Screening for Sickle Cell Disease in the Caribbean: An Update of the Present Situation and of the Disease Prevalence

Author

Maryse Etienne-Julan, Lesley King, Ketty Lee, Gisèle Elana, Ngozi Keshi, Jennifer Knight-Madden, Beatriz Marcheco-Teruel, Narcisse Elenga, Monika Asnani, Marc Romana, Marie-Dominique Hardy-Dessources, Sickle Cell Unit, Tropical Medicine Research Institute, CHU Fort de France, EA 3593 Université des Antilles et de la Guyane, Service de Pédiatrie, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Service de Neurologie [CHU Pointe à Pitre], CHU Pointe-à-Pitre/Abymes [Guadeloupe], Pharmacogénétique et abords thérapeutiques des maladies héréditaires, Université des Antilles et de la Guyane (UAG)-Université Paris Diderot - Paris 7 (UPD7)-IFR2-Institut National de la Santé et de la Recherche Médicale (INSERM), Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)), and Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)

Subjects
Thalassemia, Population, Prevalence, Disease, Article, 03 medical and health sciences, 0302 clinical medicine, Immunology and Microbiology (miscellaneous), parasitic diseases, medicine, Early childhood, education, Caribbean, Caribbean island, Newborn screening, education.field_of_study, newborn screening, lcsh:RJ1-570, Obstetrics and Gynecology, lcsh:Pediatrics, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, medicine.disease, 3. Good health, Geography, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, sickle cell disease, Atlantic slave trade, geographic locations, 030215 immunology, Demography
Abstract

The region surrounding the Caribbean Sea is predominantly composed of island nations for its Eastern part and the American continental coast on its Western part. A large proportion of the population, particularly in the Caribbean islands, traces its ancestry to Africa as a consequence of the Atlantic slave trade during the XVI&ndash, XVIII centuries. As a result, sickle cell disease has been largely introduced in the region. Some Caribbean countries and/or territories, such as Jamaica and the French territories, initiated newborn screening (NBS) programs for sickle cell disease more than 20 years ago. They have demonstrated the major beneficial impact on mortality and morbidity resulting from early childhood care. However, similar programs have not been implemented in much of the region. This paper presents an update of the existing NBS programs and the prevalence of sickle cell disease in the Caribbean. It demonstrates the impact of the Caribbean Network of Researchers on Sickle Cell Disease and Thalassemia (CAREST) on the extension of these programs. The presented data illustrate the importance of advocacy in convincing policy makers of the feasibility and benefit of NBS for sickle cell disease when coupled to early care.

Published
2019

5. Prevalence of sickle cell disease among Grenadian newborns

Author

Maryse Etienne-Julan, Ketty Lee, Magdalene Antoine, Marie-Dominique Hardy-Dessources, George Mitchell, Yonni Belfon, Tyhiesia Donald, Sharon Polson, Francis Martin, and Ali Drigo

Subjects
Male, Pediatrics, medicine.medical_specialty, Thalassemia, Population, Pilot Projects, Disease, Anemia, Sickle Cell, Screening programme, 03 medical and health sciences, 0302 clinical medicine, Neonatal Screening, Gene Frequency, medicine, Prevalence, Humans, Diagnostic laboratory, education, Allele frequency, education.field_of_study, Newborn screening, 030505 public health, business.industry, Health Policy, Public Health, Environmental and Occupational Health, Infant, Newborn, medicine.disease, University hospital, Phenotype, 030220 oncology & carcinogenesis, Grenada, Female, 0305 other medical science, business
Abstract

Objective To establish the birth prevalence of sickle cell disease in Grenada, with a view to assess the requirement for a population-based neonatal screening programme. Methods A two-year pilot neonatal screening programme, involving the Ministry of Health of Grenada, the Sickle Cell Association of Grenada, and the diagnostic laboratory of hemoglobinopathies of the University Hospital of Guadeloupe, was implemented in 2014–2015 under the auspices of the Caribbean Network of Researchers on Sickle Cell Disease and Thalassemia. Results Analysis of 1914 samples processed identified the following abnormal phenotypes: 10 FS, 2 FSC, 183 FAS, 63 FAC. These data indicate βs and βc allele frequencies of 0.054 and 0.018, respectively. Conclusion Neonatal screening conducted in the framework of this Caribbean cooperation can allow rapid detection and earlier management of affected children.

Published
2017

6. Hydroxyurea treatment does not increase blood viscosity and improves red blood cell rheology in sickle cell anemia

Author

Keyne Charlot, Philippe Connes, Nathalie Lemonne, Ketty Lee, Maryse Etienne-Julan, Yann Lamarre, Régine Hierso, Xavier Waltz, Marc Romana, Catherine Connes, Samir K. Ballas, Laboratoire Interuniversitaire de Biologie de la Motricité (LIBM ), Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])

Subjects
Adult, Male, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Blood viscosity, Anemia, Sickle Cell, macromolecular substances, Hematocrit, Rheology, Antisickling Agents, Erythrocyte Deformability, Internal medicine, medicine, Humans, Hydroxyurea, Erythrocyte deformability, Clinical severity, Online Only Articles, ComputingMilieux_MISCELLANEOUS, Sickle Hemoglobin, medicine.diagnostic_test, business.industry, hemic and immune systems, Hematology, Middle Aged, Blood Viscosity, medicine.disease, Sickle cell anemia, 3. Good health, Red blood cell, medicine.anatomical_structure, Endocrinology, Female, business
Abstract

The presence of sickle hemoglobin (HbS) in red blood cells (RBC) of patients with sickle cell anemia (SCA) is at the origin of their rheological abnormalities. Abnormal blood rheology has been shown to modulate the clinical severity and to also be involved in several complications of SCA.[1][1]–[3

Published
2015

7. CAREST--Multilingual Regional Integration for Health Promotion and Research on Sickle Cell Disease and Thalassemia

Author

Narcisse Elenga, Maryse Etienne-Julan, Gisèle Elana, Gillian Wheeler, Rosa M. Nieves, Jennifer Knight-Madden, Marie-Dominique Hardy-Dessources, Rinaldo Villaescusa, Marc Romana, Ketty Lee, Laurence Boutin, Lisiane Keclard-Christophe, Gylna Loko, Marvin Reid, Althea Jones Lecointe, Marie Laure Lalanne-Mistrih, Sickle Cell Unit, Tropical Medicine Research Institute, Protéines de la membrane érythrocytaire et homologues non-érythroides, Université des Antilles et de la Guyane (UAG)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut d'hématologie et d'immunologie, La Havane, Unité Transversale de la Drépanocytose, CHU Pointe-à-Pitre/Abymes [Guadeloupe], EA 3593 Université des Antilles et de la Guyane, Service de Pédiatrie, Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Centre d'investigation clinique Antilles-Guyane (CIC - Antilles Guyane), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de la Martinique [Fort de France]-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Epidémiologie Clinique et Médecine EA 4097 (ECM), UFR des sciences médicales de l'UAG, Dynamique des Structures et Interactions des Macromolécules Biologiques - Pôle de La Réunion (DSIMB Réunion), Biologie Intégrée du Globule Rouge (BIGR (UMR_S_1134 / U1134)), Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Université Paris Diderot - Paris 7 (UPD7)-Université de La Réunion (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU de la Martinique [Fort de France]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Transfusion Sanguine [Paris] (INTS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles (UA)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Université de La Réunion (UR)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Transfusion Sanguine [Paris] (INTS)

Subjects
medicine.medical_specialty, Pediatrics, congenital, hereditary, and neonatal diseases and abnormalities, Inservice Training, Thalassemia, Health Personnel, MEDLINE, Disease, Anemia, Sickle Cell, Health Promotion, AJPH Practice, 03 medical and health sciences, 0302 clinical medicine, Neonatal Screening, hemic and lymphatic diseases, Health care, medicine, Prevalence, Humans, Early childhood, Cooperative Behavior, Cultural Competency, Language, Newborn screening, business.industry, Research, Public Health, Environmental and Occupational Health, Infant, Newborn, [SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology, medicine.disease, 3. Good health, Health promotion, Caribbean Region, 030220 oncology & carcinogenesis, Family medicine, business, Cultural competence, 030215 immunology
Abstract

International audience; Sickle cell disease (SCD) is a significant problem in the Caribbean, where many individuals have African and Asian forebears. However, reliable prevalence data and specific health care programs for SCD are often missing in this region. Closer collaboration between Caribbean territories initiated in 2006 to set up strategies to promote better equity in the health care system for SCD patients led to the formation of CAREST: the Caribbean Network of Researchers on Sickle Cell Disease and Thalassemia. We present the effectiveness of collaborations established by CAREST to promote SCD newborn screening programs and early childhood care, to facilitate health worker training and approaches for prevention and treatment of SCD complications, and to carry out inter-Caribbean research studies.

Published
2016

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