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33 results on '"Kayano, Hidekazu"'

6. Clinical impact and characteristics of erythroid dysplasia in adult aplastic anaemia: Results from a multicentre registry.

Author

Maeda, Tomoya, Matsuda, Akira, Kanda, Junya, Kawabata, Hiroshi, Ishikawa, Takayuki, Tohyama, Kaoru, Kitanaka, Akira, Araseki, Kayano, Shimbo, Kei, Hata, Tomoko, Suzuki, Takahiro, Kayano, Hidekazu, Usuki, Kensuke, Shindo‐Ueda, Maki, Arima, Nobuyoshi, Nohgawa, Masaharu, Ohta, Akiko, Chiba, Shigeru, Miyazaki, Yasushi, and Nakao, Shinji

Subjects
APLASTIC anemia, DYSPLASIA, AGE differences, OVERALL survival, ADULTS, PAROXYSMAL hemoglobinuria
Abstract

Summary: Morphological dysplasia in haematopoietic cells, defined by a 10% threshold in each lineage, is one of the diagnostic criteria for myelodysplastic neoplasms. Dysplasia limited to the erythroid lineage has also been reported in some cases of aplastic anaemia (AA); however, its significance remains unclear. We herein examined the impact of erythroid dysplasia on immunosuppressive therapy responses and survival in AA patients. The present study included 100 eligible AA patients without ring sideroblasts. Among them, 32 had dysplasia in the erythroid lineage (AA with minimal dysplasia [mini‐D]). No significant sex or age differences were observed between AA groups with and without erythroid dysplasia. In severe/very severe AA and non‐severe AA patients, a response to anti‐thymocyte globulin + ciclosporin within 12 months was observed in 80.0% and 60.0% of AA with mini‐D and 42.9% and 90.0% of those without dysplasia, with no significant difference (p = 0.29 and p = 0.24 respectively). Overall survival and leukaemia‐free survival did not significantly differ between the groups. Collectively, the present results indicate that the presence of erythroid dysplasia did not significantly affect clinical characteristics or outcomes in AA patients, suggesting that its presence in AA is acceptable. Therefore, erythroid dysplasia should not exclude an AA diagnosis. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Interobserver concordance of assessments of dysplasia and blast counts for the diagnosis of patients with cytopenia: From the Japanese central review study

Author

Matsuda, Akira, Kawabata, Hiroshi, Tohyama, Kaoru, Maeda, Tomoya, Araseki, Kayano, Hata, Tomoko, Suzuki, Takahiro, Kayano, Hidekazu, Shimbo, Kei, Usuki, Kensuke, Chiba, Shigeru, Ishikawa, Takayuki, Arima, Nobuyoshi, Nohgawa, Masaharu, Ohta, Akiko, Miyazaki, Yasushi, Nakao, Sinnji, Ozawa, Keiya, Arai, Shunya, Kurokawa, Mineo, Mitani, Kinuko, and Takaori-Kondo, Akifumi

Published
2018
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9. Serum ferritin levels at diagnosis predict prognosis in patients with low blast count myelodysplastic syndromes

Author

Kawabata, Hiroshi, Usuki, Kensuke, Shindo-Ueda, Maki, Kanda, Junya, Tohyama, Kaoru, Matsuda, Akira, Araseki, Kayano, Hata, Tomoko, Suzuki, Takahiro, Kayano, Hidekazu, Shimbo, Kei, Chiba, Shigeru, Ishikawa, Takayuki, Arima, Nobuyoshi, Nohgawa, Masaharu, Miyazaki, Yasushi, Kurokawa, Mineo, Arai, Shunya, Mitani, Kinuko, and Takaori-Kondo, Akifumi

Published
2019
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12. Validation of the revised International Prognostic Scoring System in patients with myelodysplastic syndrome in Japan: results from a prospective multicenter registry

Author

Kawabata, Hiroshi, Tohyama, Kaoru, Matsuda, Akira, Araseki, Kayano, Hata, Tomoko, Suzuki, Takahiro, Kayano, Hidekazu, Shimbo, Kei, Zaike, Yuji, Usuki, Kensuke, Chiba, Shigeru, Ishikawa, Takayuki, Arima, Nobuyoshi, Nogawa, Masaharu, Ohta, Akiko, Miyazaki, Yasushi, Mitani, Kinuko, Ozawa, Keiya, Arai, Shunya, Kurokawa, Mineo, Takaori-Kondo, Akifumi, and The Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes

Published
2017
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15. Chronic Enteropathy Associated with SLCO2A1 with Pachydermoperiostosis

Author

Tsuzuki, Yoshikazu, Aoyagi, Ryutaro, Miyaguchi, Kazuya, Ashitani, Keigo, Ohgo, Hideki, Yamaoka, Minoru, Ishizawa, Keisuke, Kayano, Hidekazu, Hisamatsu, Tadakazu, Umeno, Junji, Hosoe, Naoki, Matsumoto, Takayuki, Nakamoto, Hidetomo, and Imaeda, Hiroyuki

Subjects
pachydermoperiostosis, Male, Osteoarthropathy, Primary Hypertrophic, hemic and lymphatic diseases, Mutation, SLCO2A1, Humans, Organic Anion Transporters, Case Report, Middle Aged, CEAS, Inflammatory Bowel Diseases, Ulcer
Abstract

A 49-year-old man complained of chronic palpitation and shortness of breath, which had recently become exacerbated. A blood examination indicated severe refractory anemia and hypoproteinemia. Physical examinations revealed anemia, a systolic murmur, and spoon nails. Multiple nonspecific ileal ulcers were observed. A pathological examination indicated a small granuloma with CD68-positive histiocytes. He had a deeply wrinkled forehead, chiseled face, and clubbed fingers. Radiography revealed periostosis of the fingers and long bones in the limb. He was diagnosed with pachydermoperiostosis. SLCO2A1 demonstrated a c.1807C>T homo-mutation. He was also diagnosed with SLCO2A1-associated chronic enteropathy and thus was treated with 5-aminosalicylic acid, which temporarily improved the ileal ulcers, anemia, and hypoalbuminemia.

Published
2020

16. Bendamustine-induced rash is associated with a favorable prognosis in patients with indolent B-cell lymphoma

Author

Takahashi, Naoki, primary, Tsukasaki, Kunihiro, additional, Tanae, Ken, additional, Kohri, Mika, additional, Asou, Chie, additional, Okamura, Daisuke, additional, Ishikawa, Maho, additional, Maeda, Tomoya, additional, Kawai, Nobutaka, additional, Matsuda, Akira, additional, Sato, Tsugumi, additional, Kayano, Hidekazu, additional, Arai, Eiichi, additional, and Asou, Norio, additional

Published
2022
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23. Epstein–Barr virus-associated hemophagocytic syndrome in a patient with ulcerative colitis during treatment with azathioprine: A case report and review of literature

Author

Miyaguchi, Kazuya, primary, Yamaoka, Minoru, additional, Tsuzuki, Yoshikazu, additional, Ashitani, Keigo, additional, Ohgo, Hideki, additional, Miyagawa, Yoshitaka, additional, Ishizawa, Keisuke, additional, Kayano, Hidekazu, additional, Nakamoto, Hidetomo, additional, and Imaeda, Hiroyuki, additional

Published
2018
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25. A Case of Abdominal Aortic Retroperitoneal and Mesenteric Amyloid Light Chain Amyloidoma

Author

Yokota, Kazuhiro, Kishida, Dai, Kayano, Hidekazu, Yazaki, Masahide, Shimada, Yuki, Akiyama, Yuji, and Mimura, Toshihide

Subjects
Article Subject
Abstract

We report the case of a Japanese woman with amyloid light chain (AL) amyloidoma in the abdominal aortic retroperitoneum and mesentery. Irregular soft tissue mass lesions with calcification in the abdominal aortic retroperitoneum and mesentery were initially detected by computed tomography at another hospital. The lesions gradually compressed the duodenum, causing symptoms of bowel obstruction. The patient was clinically diagnosed with retroperitoneal fibrosis, and prednisolone was administered at a dose of 40 mg/day. However, the lesions did not change in size and her symptoms continued. She was transferred to our hospital and underwent mesenteric biopsy for histopathology using abdominal laparotomy. The histopathological and immunohistological findings of the mesenteric specimen demonstrated lambda light chain deposition. Accordingly, the patient was finally diagnosed with AL amyloidoma with no evidence of systemic amyloidosis. After laparotomy, her general condition worsened because of complications of pneumonia and deep vein thrombosis. She died suddenly from acute myocardial infarction. We have concluded that abdominal aortic retroperitoneal and mesenteric AL amyloidoma may have very poor prognoses in accordance with previous reports. In addition, the size and location of AL amyloidoma directly influence the prognosis. We suggest that early histopathology is important for improving prognosis.

Published
2016
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27. Association of Increased Ring Ssideroblasts with Inferior Survival in Patients with Myelodysplastic Syndrome with Multi-Lineage Dysplasia

Author

Kawabata, Hiroshi, primary, Tohyama, Kaoru, additional, Matsuda, Akira, additional, Araseki, Kayano, additional, Hata, Tomoko, additional, Suzuki, Takahiro, additional, Kayano, Hidekazu, additional, Shinbo, Kei, additional, Usuki, Kensuke, additional, Hangaishi, Akira, additional, Chiba, Shigeru, additional, Masaharu, Nogawa, additional, Arima, Nobuyoshi, additional, Ishikawa, Takayuki, additional, Ozawa, Keiya, additional, Arai, Shunya, additional, Kurokawa, Mineo, additional, and Takaori-Kondo, Akifumi, additional

Published
2016
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28. Proposal of criteria for dyserythropoiesis in the diagnosis of myelodysplastic syndromes

Author

Kawai, Nobutaka, primary, Matsuda, Akira, additional, Jinnai, Itsuro, additional, Ichimura, Takaya, additional, Kayano, Hidekazu, additional, Okamura, Daisuke, additional, Ishikawa, Maho, additional, Maeda, Tomoya, additional, Hata, Tomoko, additional, Miyazaki, Yasushi, additional, Asou, Norio, additional, Bessho, Masami, additional, and Tomonaga, Masao, additional

Published
2015
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30. Tu1116 Eosinophilic Infiltration in the Upper Gastrointestinal Tract in Patients With Bronchial Asthma

Author

Imaeda, Hiroyuki, primary, Yamaoka, Minoru, additional, Yoneno, Kazuaki, additional, Ohgo, Hideki, additional, Kobayashi, Takehito, additional, Noguchi, Toru, additional, Uchida, Yoshitaka, additional, Soma, Tomoyuki, additional, Kayano, Hidekazu, additional, Kanazawa, Minoru, additional, Nakamoto, Hidetomo, additional, and Nagata, Makoto, additional

Published
2015
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31. A case of duodenal Brunner’s glands hyperplasia with mushroom-like form

Author

Shinomiya, Takashi, primary, Ohgo, Hideki, additional, Yamaoka, Minoru, additional, Kusano, Takeru, additional, Ashitani, Keigo, additional, Noguchi, Toru, additional, Kanno, Ryuu, additional, Kobayashi, Takehito, additional, Kinoshita, Shunsuke, additional, Inoue, Kiyoaki, additional, Kin, Rei, additional, Kayano, Hidekazu, additional, Yamamoto, Keiji, additional, Nakamoto, Hidetomo, additional, Hayakawa, Takehiko, additional, and Imaeda, Hiroyuki, additional

Published
2015
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32. [Thoracic SMARCA4-deficient undifferentiated tumor resembling malignant lymphoma].

Author

Asou C, Maeda T, Yamaguchi O, Okamura D, Ishikawa M, Kohri M, Tsukasaki K, Matsuda A, Asou N, Satoh T, Kayano H, and Takahashi N

Subjects
Humans, Male, Middle Aged, Biomarkers, Tumor, DNA Helicases, Fluorodeoxyglucose F18, Nuclear Proteins, Transcription Factors, Lymphoma diagnosis, Positron Emission Tomography Computed Tomography methods
Abstract

We present a case of thoracic SMARCA4-deficient undifferentiated tumor that needed to be differentiated from malignant lymphoma owing to multiple lymph node swelling and marrow involvement. A 52-year-old man developed multiple lymphadenopathies along with anorexia, general fatigue, fever, and sweating 2 months prior to admission. 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) scan revealed a mass lesion on the right upper lung, generalized lymph node swelling, and bone metastasis, indicating the presence of suspicious lung cancer; therefore, he was referred to our hospital. Malignant lymphoma was suspected at the time of admission because of elevated levels of lactate dehydrogenase (11,977 U/l) and soluble interleukin 2 receptor (2,152 U/ml) as well as marrow infiltration of large abnormal cells. On day 11, the patient died from rapid respiratory failure. Histological and immunohistochemical features of the pleural effusion cell block led to the diagnosis of thoracic SMARCA4-deficient undifferentiated tumor. Thoracic SMARCA4-deficient undifferentiated tumor was recently introduced in the 2021 World Health Organization classification of lung tumors, with most patients being young adults with a history of heavy smoking and poor prognosis. Because of the multiple lymph node swelling and marrow involvement, this undifferentiated tumor should be distinguished from malignant lymphoma.

Published
2023
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33. [Myelodysplastic/myeloproliferative neoplasm: a histopathological review].

Author

Kayano H

Subjects
Bone Marrow pathology, Erythropoiesis, Humans, Hematologic Neoplasms pathology, Myelodysplastic-Myeloproliferative Diseases pathology
Abstract

Myelodysplastic syndromes/myeloproliferative neoplasm (MDS/MPN) is a type of myeloid neoplasm where at least one hematopoietic lineage exhibiting cytopenia clinically coexists with other (s) exhibiting hypercytosis. There is ineffective erythropoiesis and bone marrow coexistence of at least one hematopoietic lineage morphologically characterized by dysplasia of blood cells and other (s) characterized by pronounced proliferation. At a molecular level, various abnormalities have been identified that overlap with related diseases, and a prerequisite for MDS/MPN diagnosis includes ruling out various hematopoietic tumors and reactive conditions. Therefore, a multilateral approach involving clinical findings, morphology, and molecular biology is needed. Herein, we introduce the pathological features of MDS/MPN and the relationship between molecular abnormalities and morphological characteristics.

Published
2018
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