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Your search keyword '"Kauczor, H.-U."' showing total 255 results
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255 results on '"Kauczor, H.-U."'

1. An open-source tool for automated planning of overlapping ablation zones for percutaneous renal tumor treatment

Author

Franz, A. M., Mittmann, B. J., Roeser, J., Schmidberger, B., Meinke, M., Pereira, P. L., Kauczor, H. U., Richter, G. M., and Sommer, C. M.

Subjects
Physics - Medical Physics, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

Percutaneous thermal ablation is a minimally-invasive treatment option for renal cancer. To treat larger tumours, multiple overlapping ablations zones are required. Arrangements with a low number of ablation zones but coverage of the whole tumour volume are challenging to find for physicians. In this work, an open-source software tool with a new planning approach based on the automatic selection from a large number of randomized geometrical arrangements is presented. Two uncertainty parameters are introduced to account for tissue shrinking and tolerance of non-ablated tumour volume. For seven clinical renal T1a, T1b and T2a tumours, ablation plans were proposed by the software. All proposals are comparable to manual plans of an experienced physician with regard to the number of required ablation zones., Comment: Preprint version, accepted for publication in Bildverarbeitung f\"ur die Medizin (BVM) Proceedings 2020

Published
2019

6. The influence of contrast media on calcium-based imaging of the spine in dual-layer CT.

Author

Rahn, S., Skornitzke, S., Melzig, C., Reiner, T., Stiller, W., Heussel, C. P., Kauczor, H. U., Weber, T. F., and Do, T. D.

Subjects
CONTRAST media, BONE densitometry, MASS media influence, LUMBAR vertebrae, SPINE, BONE density
Abstract

This study aimed to evaluate the impact of contrast media application on CT attenuation of the bone using a novel calcium-only imaging technique (VCa) from dual-layer spectral detector CT (DLCT), which enables CT-based bone mineral density measurement unimpeded by soft tissue components. For this, true non-contrast (TNC) and venous phase images (VP) of n = 97 patients were acquired. CT attenuation of the first lumbar vertebra (L1) was measured in TNC-VCa, VP-VCa, and in virtual non-contrast images (VNC). CT attenuation was significantly higher in VP-VCa than in TNC-VCa (p < 0.001), although regression analyses revealed a strong linear association between these measures (R2 = 0.84). A statistical model for the prediction of TNC-VCa CT attenuation was established (TNC-VCa[HU] = − 6.81 + 0.87 × VP-VCa[HU]-0.55 × body weight[kg]) and yielded good agreement between observed and predicted values. Furthermore, a L1 CT attenuation threshold of 293 HU in VP-VCa showed a sensitivity of 90% and a specificity of 96% for detecting osteoporosis. The application of contrast media leads to an overestimation of L1 CT attenuation in VCa. However, CT attenuation values from VP-VCa can be used within CT-based opportunistic osteoporosis screening eighter by applying a separate threshold of 293 HU or by converting measured data to TNC-VCa CT attenuation with the given regression equation. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Mikrovaskuläre Veränderungen bei COVID-19

Author

Wagner, W. L., Hellbach, K., Fiedler, M. O., Salg, G. A., Wehrse, E., Ziener, C. H., Merle, U., Eckert, C., Weber, T. F., Stiller, W., Wielpütz, M. O., Dullin, C., Kenngott, H. G., Schlemmer, H.-P., Weigand, M. A., Schirmacher, P., Longerich, T., Kauczor, H.-U., Kommoss, F. K.-F., and Schwab, C.

Published
2020
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11. Combined effects of lung function, blood gases and kidney function on the exacerbation risk in stable COPD: Results from the COSYCONET cohort

Author

Stefan, Andreas, Robert, Bals, Jürgen, Behr, Kathrin, Kahnert, Burkhard, Bewig, Roland, Buhl, Ralf, Ewert, Beate, Stubbe, Joachim H, Ficker, Manfred, Gogol, Christian, Grohé, Rainer, Hauck, Matthias, Held, Berthold, Jany, Markus, Henke, Felix, Herth, Gerd, Höffken, Hugo A, Katus, Anne-Marie, Kirsten, Henrik, Watz, Rembert, Koczulla, Klaus, Kenn, Juliane, Kronsbein, Cornelia, Kropf-Sanchen, Christoph, Lange, Peter, Zabel, Michael, Pfeifer, Winfried J, Randerath, eeger Werner, Michael, Studnicka, Christian, Taube, Helmut, Teschler, Hartmut, Timmermann, Christian, Virchow J., Claus, Vogelmeier, Ulrich, Wagner, Tobias, Welte, Hubert, Wirtz, Trudzinski, F.C., Kahnert, K., Vogelmeier, C.F., Alter, P., Seiler, F., Fähndrich, S., Watz, H., Welte, T., Speer, T., Zewinger, S., Biertz, F., Kauczor, H.-U., Jörres, R.A., and Bals, R.

Published
2019
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12. Statins did not reduce the frequency of exacerbations in individuals with COPD and cardiovascular comorbidities in the COSYCONET cohort.

Author

Frantzi, N., Nguyen, X. P., Herr, C., Alter, P., Söhler, S., Soriano, D., Watz, H., Waschki, B., Trinkmann, F., Eichenlaub, M., Trudzinski, F. C., Michels-Zetsche, J. D., Omlor, A., Seiler, F., Moneke, I., Biertz, F., Rohde, G., Stolz, D., Welte, T., and Kauczor, H. U.

Subjects
CHRONIC obstructive pulmonary disease, DISEASE exacerbation, COMORBIDITY, STATINS (Cardiovascular agents), CARDIOVASCULAR diseases
Abstract

Background: The evidence regarding effects of statins on exacerbation risk in COPD remains controversial. Previous studies often excluded patients with cardiovascular comorbidities despite their high prevalence in COPD and role for exacerbations. Based on the cardioprotective properties of statins, we hypothesised that statins may reduce the risk of exacerbations especially in patients with cardiovascular comorbidities. Methods: One thousand eight hundred eighty seven patients of the German COPD cohort COSYCONET (COPD and Systemic Consequences Comorbidities Network) of GOLD grades 1–4 (37.8% female, mean age 64.78 ± 8.3) were examined at baseline and over a period of 4.5 years for the occurrence of at least one exacerbation or severe exacerbation per year in cross-sectional and longitudinal analyses adjusted for age, gender, BMI, GOLD grade and pack-years. Due to their collinearity, various cardiovascular diseases were tested in separate analyses, whereby the potential effect of statins in the presence of a specific comorbidity was tested as interaction between statins and comorbidity. We also identified patients who never took statins, always took statins, or initiated statin intake during the follow-up. Results: One thousand three hundred six patients never took statins, 31.6% were statin user, and 12.9% initiated statins during the follow-up. Most cardiovascular diseases were significantly (p < 0.05)may associated with an increased risk of COPD exacerbations, but in none of them the intake of statins was a significant attenuating factor, neither overall nor in modulating the increased risk linked to the specific comorbidities. The results of the cross-sectional and longitudinal analyses were consistent with each other, also those regarding at least 1 exacerbation or at least 1 severe exacerbation per year. Conclusion: These findings complement the existing literature and may suggest that even in patients with COPD, cardiovascular comorbidities and a statin therapy that targets these comorbidities, the effects of statins on exacerbation risk are either negligible or more subtle than a reduction in exacerbation frequency. Trial registration: Trial registration ClinicalTrials.gov, Identifier: NCT01245933. Other Study ID (BMBF grant): 01GI0881, registered 18 November 2010, study start 2010–11, primary completion 2013–12, study completion 2023–09. https://clinicaltrials.gov/study/NCT01245933?cond=COPD&term=COSYCONET&rank=3 [ABSTRACT FROM AUTHOR]

Published
2024
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39. Pulmonary and systemic pathology in COVID-19—holistic pathological analyses

Author

Jonigk, D, Werlein, C, Lee, PD, Kauczor, H-U, Länger, F, and Ackermann, M

Subjects
Post-Acute COVID-19 Syndrome, SARS-CoV-2, COVID-19, Humans, 1103 Clinical Sciences, Thrombosis, Review Article, General Medicine, Lung, Pandemics, 1117 Public Health and Health Services
Abstract

Hintergrund: Die COVID-19-Pandemie stellt den dritten weltweiten Coronavirus-assoziierten Erkrankungsausbruch der letzten 20 Jahre dar. Klinisch dominiert die pulmonale Beteiligung mit einem akuten Lungenversagen (ARDS) bei schweren Verläufen, jedoch können auch andere Organsysteme wie das Herz-Kreislauf-System, Zentralnervensystem und der Gastrointestinaltrakt betroffen sein. Der Pathomechanismus der Organschädigung sowohl für die Lunge wie auch für die nichtpulmonalen Organsysteme war zu Beginn der Pandemie weitestgehend unklar. Methode: Selektive Literaturübersicht bezüglich der morphologischen Veränderungen und zugrunde liegenden Pathomechanismen bei COVID-19 mit Fokussierung auf bildgebende Verfahren. Ergebnisse: Immunhistochemische, elektronenmikroskopische und molekularpathologische Analysen an Autopsiegewebe führten zu einem besseren Verständnis der Pathophysiologie von COVID-19 einschließlich der molekularen Regulationsmechanismen. Hierbei konnte gezeigt werden, dass die sogenannte intussuszeptive Angiogenese (IA) in den betroffenen Organen von COVID-19-Patienten ein zentrales Schadensmuster darstellt. Bei der IA verändert sich ein bestehendes Gefäß durch Einstülpung des Endothels und Ausbildung eines intraluminalen Septums, wodurch schließlich zwei neue Lumina entstehen. Hierdurch verändert sich die Hämodynamik, unter anderem durch Verlust der laminaren Strömung mit Ausbildung turbulenter inhomogener Flussgeschwindigkeiten. Die Induktion der IA ist einerseits auf eine thrombotisch bedingte Ischämie zurückzuführen, doch geht sie andererseits selbst mit einem erhöhten Risiko für weitere Mikrothromben einher, die bei COVID-19-Patientinnen und Patienten in Lunge, Herz, Leber, Nieren, Gehirn und Plazenta nachgewiesen wurden. Schlussfolgerung: In Autopsiematerial von Patientinnen und Patienten mit COVID-19 konnten ultrastrukturell in verschiedenen Geweben eine veränderte Mikrovaskularität, eine IA sowie multifokale Thromben nachgewiesen werden. Diese Veränderungen sind als mögliche Faktoren für postakute interstitiell-fibrotische Organveränderungen wie auch das klinische Bild des Long COVID zu betrachten.

Published
2022

48. CT-guided Irreversible Electroporation in an Acute Porcine Liver Model: Effect of Previous Transarterial Iodized Oil Tissue Marking on Technical Parameters, 3D Computed Tomographic Rendering of the Electroporation Zone, and Histopathology

Author

Sommer, C. M., Fritz, S., Vollherbst, D., Zelzer, S., Wachter, M. F., Bellemann, N., Gockner, T., Mokry, T., Schmitz, A., Aulmann, S., Stampfl, U., Pereira, P., Kauczor, H. U., Werner, J., and Radeleff, B. A.

Published
2015
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49. Sex-Specific Associations of Comorbidome and Pulmorbidome with Mortality in Chronic Obstructive Pulmonary Disease: Results from COSYCONET

Author

Trudzinski, F.C., primary, Jörres, R., additional, Alter, P., additional, Walter, J., additional, Watz, H., additional, Koch, A., additional, John, M., additional, Lommatzsch, M., additional, Vogelmeier, C., additional, Kauczor, H.-U., additional, Welte, T., additional, Behr, J., additional, Tufman, A.L.H., additional, Bals, R., additional, Herth, F.J., additional, and Kahnert, K., additional

Published
2022
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50. Geschlechtsspezifische Unterschiede des Komorbidoms und des Pulmorbidoms im Hinnblick auf die Prognose der COPD: Ergebnisse von COSYCONET

Author

Trudzinski, F C, additional, Jörres, R A, additional, Alter, P, additional, Walter, J, additional, Watz, H, additional, Koch, A, additional, John, M, additional, Lommatzsch, M, additional, Vogelmeier, C F, additional, Kauczor, H U, additional, Welte, T, additional, Behr, J, additional, Tufman, A, additional, Bals, R, additional, Herth, FJ F, additional, and Kahnert, K, additional

Published
2022
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