1. Peroxiredoxin 6 is a natural radioprotector.
- Author
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Sharapov MG, Gudkov SV, Gordeeva AE, Karp OE, Ivanov VE, Shelkovskaya OV, Bruskov VI, Novoselov VI, and Fesenko EE
- Subjects
- Animals, Injections, Intravenous, Intestine, Small drug effects, Intestine, Small pathology, Intestine, Small radiation effects, Male, Mice, Radiation Injuries, Experimental pathology, Severity of Illness Index, Survival Analysis, X-Rays, Peroxiredoxin VI pharmacology, Radiation Injuries, Experimental drug therapy, Radiation-Protective Agents pharmacology
- Abstract
After injection of 20 mg/kg peroxiredoxin 6 to male Kv:SHK mice 15 min before X-ray irradiation in the range of lethal doses (7-10 Gy), the mice remained alive for 30 days, whereas the mortality of the control animals was 100%. In the irradiated animals, peroxiredoxin 6 decreased the severity of radiation-induced leucopenia, granulocytopenia, and thrombocytopenia, increased the number of blood corpuscles, and prevented the mass death of epithelial cells and the destruction of the small intestine. Thus, peroxiredoxin 6 can be regarded as a prophylactic radioprotective agent.
- Published
- 2016
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