20 results on '"Kapralov M"'
Search Results
2. Diatoms in the Orgueil Meteorite
- Author
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Hoover, R. B., Rozanov, A. Yu., Krasavin, E. A., Ryumin, A. K., and Kapralov, M. I.
- Published
- 2018
- Full Text
- View/download PDF
3. Temperature responses of the Rubisco maximum carboxylase activity across domains of life: phylogenetic signals, trade-offs, and importance for carbon gain
- Author
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Galmés, J., Kapralov, M. V., Copolovici, L. O., Hermida-Carrera, C., and Niinemets, Ü.
- Published
- 2015
- Full Text
- View/download PDF
4. Sparse {Fourier Transform} by Traversing {Cooley-Tukey FFT} Computation Graphs
- Author
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Bringmann, K., Kapralov, M., Makarov, M., Nakos, V., Yagudin, A., and Zandieh, A.
- Abstract
Computing the dominant Fourier coefficients of a vector is a common task in many fields, such as signal processing, learning theory, and computational complexity. In the Sparse Fast Fourier Transform (Sparse FFT) problem, one is given oracle access to a $d$-dimensional vector $x$ of size $N$, and is asked to compute the best $k$-term approximation of its Discrete Fourier Transform, quickly and using few samples of the input vector $x$. While the sample complexity of this problem is quite well understood, all previous approaches either suffer from an exponential dependence of runtime on the dimension $d$ or can only tolerate a trivial amount of noise. This is in sharp contrast with the classical FFT algorithm of Cooley and Tukey, which is stable and completely insensitive to the dimension of the input vector: its runtime is $O(N\log N)$ in any dimension $d$. In this work, we introduce a new high-dimensional Sparse FFT toolkit and use it to obtain new algorithms, both on the exact, as well as in the case of bounded $\ell_2$ noise. This toolkit includes i) a new strategy for exploring a pruned FFT computation tree that reduces the cost of filtering, ii) new structural properties of adaptive aliasing filters recently introduced by Kapralov, Velingker and Zandieh'SODA'19, and iii) a novel lazy estimation argument, suited to reducing the cost of estimation in FFT tree-traversal approaches. Our robust algorithm can be viewed as a highly optimized sparse, stable extension of the Cooley-Tukey FFT algorithm. Finally, we explain the barriers we have faced by proving a conditional quadratic lower bound on the running time of the well-studied non-equispaced Fourier transform problem. This resolves a natural and frequently asked question in computational Fourier transforms. Lastly, we provide a preliminary experimental evaluation comparing the runtime of our algorithm to FFTW and SFFT 2.0.
- Published
- 2021
5. ENZYMATIC CHARACTERIZATION AND DISTRIBUTION OF delta-CA: A POTENTIAL INDICATOR OF PAST pCO(2)
- Author
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Lee, R, Young, J, Kapralov, M, Filatov, D, Smith, A, and Rickaby, R
- Published
- 2016
6. Leaf epidermal structure in the dwarf succulent genusConophytumN.E. Br. (Aizoaceae)
- Author
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Young, A.J., primary, Suarez, L. Pulido, additional, Kapralov, M., additional, and Opel, M.R., additional
- Published
- 2017
- Full Text
- View/download PDF
7. Single Pass Spectral Sparsification in Dynamic Streams
- Author
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Kapralov, M., primary, Lee, Y. T., additional, Musco, C. N., additional, Musco, C. P., additional, and Sidford, A., additional
- Published
- 2017
- Full Text
- View/download PDF
8. Temperature responses of the Rubisco maximum carboxylase activity across domains of life: phylogenetic signals, trade-offs, and importance for carbon gain
- Author
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Galmés, J., primary, Kapralov, M. V., additional, Copolovici, L. O., additional, Hermida-Carrera, C., additional, and Niinemets, Ü., additional
- Published
- 2014
- Full Text
- View/download PDF
9. Leaf epidermal structure in the dwarf succulent genus Conophytum N.E. Br. (Aizoaceae)
- Author
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Young, A.J., Suarez, L. Pulido, Kapralov, M., and Opel, M.R.
- Published
- 2017
- Full Text
- View/download PDF
10. The evolution, ecology and conservation of Conophytum N.E.Br. (Aizoaceae) ��� a diverse genus of dwarf succulent plants in an arid biodiversity hotspot in southern Africa
- Author
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Bentley, L, Bourke, D, Young, A, and Kapralov, M
- Subjects
QK - Abstract
Conophytum N.E.Br. (Aizoaceae) is a genus of dwarf succulent plants endemic to western South Africa and southern Namibia. It is highly diverse, with 106 constituent species and is considered a model genus for the Succulent Karoo Biome, an arid region with uniquely high desiccation-tolerant (succulent) plant diversity, based on its variety of distribution types and growth forms. The aim of this project was twofold: to provide a clearer understanding of the patterns and drivers of speciation in the genus, and to identify conservation strategies that maximise the likely survival of these species, based on spatial ecological analyses of their current distributions. The biodiversity of the Succulent Karoo biome is increasingly vulnerable to a multitude of threats, mostly as a consequence of growing levels of human activity. The current and future conservation of Conophytum is dependent on evidence-based interventions that, in particular, help mitigate the effects of a changing climate and illegal collecting. First, an updated phylogeny was produced providing the foundation to many of the analyses undertaken in this thesis, beginning with an assessment of the drivers of diversification. For the first time, nuclear gene regions and sequences from almost all species in the genus (102 of 106) were included in the development of phylogenetic hypotheses. From there, a selection of 12 pertinent characters was mapped over the phylogeny and phylogenetic signal was calculated in a univariate and multivariate manner. This, along with correlations in character evolution, was used to infer potential drivers of diversification. Nocturnal flowering was found to characterise certain clades and was correlated with pollen type D and flower structure A2, suggesting an influence of pollinator specialisation on evolution, while windowed leaves characterised one particularly large, strongly supported clade in the phylogeny, and, through correlated evolution with other traits such as the presence of bladder cells, suggested a key influence of the abiotic environment in this clade���s formation. This abiotic influence on speciation was further investigated using spatial environmental data to determine differences in the abiotic preferences of individual Conophytum species and five large, strongly supported clades in the phylogeny. Geological, topographical and climatic variables were mapped onto the phylogeny, while differences in clade and species��� environmental preferences were assessed. Associations between environmental variables and the evolution of certain traits were also analysed. Variation in precipitation/moisture, elevation and slope were identified as key drivers of diversification in the genus, with niche divergence prevalent in driving speciation. Additionally, some clades were characterised by both nocturnal flowering and certain leaf traits (e.g. very long trichomes, sunken stomata), suggesting a possible interaction between biotic and abiotic diversification drivers. These interactions were analysed mainly by calculating correlations between nocturnal flowering and abiotic variables. Nocturnal flowering was strongly correlated with a lower mean annual temperature, suggesting a possible climatic influence on pollinator assemblages potentially driving a greater likelihood of species in cooler locations to be nocturnally moth pollinated. After gaining a greater understanding of what drove diversity in Conophytum, attention switched to the vulnerability of this diversity to future changes in climate by projecting range change responses using species distribution models (SDMs). These analyses focused on the more broadly distributed species (a minimum of 20 occurrence points) to facilitate the building of statistically robust models, comparing climate change vulnerability at both the species- and clade-levels. For four of the five clades, and for the genus as a whole, range size reduction was prevalent, with a range contraction from the north occurring as conditions in the north of the genus��� range become unsuitable through lower winter rainfall and increased temperatures, while the more mesic southern reaches of South Africa remain unsuitable for Conophytum inhabitation. One clade, however, characterised by bladder cells and windowed leaves which give constituent species better adaptation to hotter conditions, may include some species that benefit from predicted future climate conditions. Two new regions were prioritised based on these projections for future protection, as these successfully cover the areas of high current and future diversity in the genus, along with protecting separate clades and thereby maintaining phylogenetic diversity. As SDMs excluded narrow endemics in the genus because of the low numbers of occurrence points available, a final assessment on the abiotic environmental preferences and trait associations of narrow endemic Conophytum species was performed to better understand their ecology and to aid their conservation. These taxa make up a sizable proportion of species in the genus (~33%) and are some of the most vulnerable Conophytum species through their small range and population sizes. This assessment demonstrated a preference of these species for more high-stress environments (steeper slopes, higher elevation and low moisture) compared to broadly distributed species, and identified that these taxa are predominantly diurnal flowering, although this was likely to be because narrow endemic distribution overlaps strongly with diurnal wasp pollinators. This study also identified an important region for the conservation of narrow endemics and these ecological findings will assist prioritising regions for protection or translocation. The findings of this project shed light on the evolution of Conophytum and its vulnerability to anthropogenic impacts and provide an improved basis for understanding of the genus��� ecology and biogeography. Based on these findings, Conophytum can now act as an ideal model genus for the Succulent Karoo, a uniquely biodiverse arid hotspot. An improved understanding of the evolution and vulnerability of Conophytum provides important evidence for drivers of rapid speciation in a region known for its diversifications and, perhaps even more importantly, highlights threats and important conservation strategies for the Succulent Karoo in an uncertain future.
- Published
- 2022
- Full Text
- View/download PDF
11. High-Energy Proton-Beam-Induced Polymerization/Oxygenation of Hydroxynaphthalenes on Meteorites and Nitrogen Transfer from Urea: Modeling Insoluble Organic Matter?
- Author
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Raffaele Saladino, Michail Kapralov, Ernesto Di Mauro, Jiří Šponer, Bruno Mattia Bizzarri, Judit E. Šponer, Marco d'Ischia, Eugene Krasavin, Paola Manini, Klaudia Mrazikova, Valeria Lino, Bizzarri, B. M., Manini, P., Lino, V., D'Ischia, M., Kapralov, M., Krasavin, E., Mráziková, K., Šponer, J., Šponer, J. E., Di, Mauro, and E., Saladino
- Subjects
chemistry.chemical_classification ,insoluble organic matters, meteorites, polycycles, prebiotic chemistry, proton beams ,010405 organic chemistry ,Organic Chemistry ,General Chemistry ,010402 general chemistry ,01 natural sciences ,Catalysis ,0104 chemical sciences ,Quinone ,Benzopyran ,chemistry.chemical_compound ,chemistry ,Polymerization ,Chondrite ,Urea ,Organic chemistry ,Organic matter ,Benzofuran ,Achondrite - Abstract
Formation and structural modification of oxygenated polycyclic aromatic hydrocarbons (oxyPAHs) by UV irradiation on minerals have recently been proposed as a possible channel of PAH transformation in astrochemical and prebiotic scenarios of possible relevance for the origin of life. Herein, it is demonstrated that high-energy proton-beam irradiation in the presence of various meteorites, including stony iron, achondrite, and chondrite types, promotes the conversion of two representative oxyPAH compounds, 1-naphthol and 1,8-dihydroxynaphthalene, to complex mixtures of oxygenated and oligomeric derivatives. The main identified products include polyhydroxy derivatives, isomeric dimers encompassing benzofuran and benzopyran scaffolds, and, notably, a range of quinones and perylene derivatives. Addition of urea, a prebiotically relevant chemical precursor, expanded the range of identified species to include, among others, quinone diimines. Proton-beam irradiation of oxyPAH modulated by nitrogen-containing compounds such as urea is proposed as a possible contributory mechanism for the formation and processing of insoluble organic matter in meteorites and in prebiotic processes.
- Published
- 2020
12. Can metals and radionuclides in Shiveluch (Kamchatka) volcanic ash affect human health?
- Author
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Zinicovscaia I, Chernyagina O, Chaligava O, Grozdov D, Fedorenko M, and Kapralov M
- Subjects
- Humans, Radium analysis, Risk Assessment, Thorium analysis, Volcanic Eruptions, Metals analysis, Radioisotopes analysis
- Abstract
Volcanic eruption is associated with the release of large volumes of pollutants in the environment, which can pose a risk to humans and other living organisms. The elemental and radioisotope composition of ash released during the Shiveluch Volcano eruption in 2023 was analyzed using ICP-MS and low-background gamma spectrometry. The ash consisted of 59% SiO
2 , 16.7% Al2 O3 , 5.3% CaO, 4.6 % Na2 O, 4.5% Fe2 O3 , 1.4% K2 O, 0.48% TiO2 , 0.17% P2 O5 , 0.15% S, 0.078% MnO and 44 trace elements. Hazard Quotient and Hazard Index were calculated in order to evaluate the potential health risks to children and adults due to exposure to contaminants via inhalation, ingestion, and dermal contact. All values were below the unit, indicating a low probability of non-carcinogenic and cancerogenic risk occurrence in target groups. The average activity concentrations of the natural radionuclides were 350, 12.4 and 4.84 Bq/kg for40 K,226 Ra and232 Th. Radiological indices, including external and internal risk assessment, radium equivalent activity, annual effective dose, gamma index, and excess lifetime cancer risk were calculated to estimate the radiological hazard for the population. The values of all indices were below the recommended safety limits, indicating a low level of hazard for the exposed population., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier Ltd. All rights reserved.)- Published
- 2024
- Full Text
- View/download PDF
13. Plant-derived compounds as potential leads for new drug development targeting COVID-19.
- Author
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Liu L, Kapralov M, and Ashton M
- Subjects
- Animals, Humans, Aged, SARS-CoV-2, Inflammation, Phytochemicals, COVID-19, Plants, Medicinal
- Abstract
COVID-19, which was first identified in 2019 in Wuhan, China, is a respiratory illness caused by a virus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although some patients infected with COVID-19 can remain asymptomatic, most experience a range of symptoms that can be mild to severe. Common symptoms include fever, cough, shortness of breath, fatigue, loss of taste or smell and muscle aches. In severe cases, complications can arise including pneumonia, acute respiratory distress syndrome, organ failure and even death, particularly in older adults or individuals with underlying health conditions. Treatments for COVID-19 include remdesivir, which has been authorised for emergency use in some countries, and dexamethasone, a corticosteroid used to reduce inflammation in severe cases. Biological drugs including monoclonal antibodies, such as casirivimab and imdevimab, have also been authorised for emergency use in certain situations. While these treatments have improved the outcome for many patients, there is still an urgent need for new treatments. Medicinal plants have long served as a valuable source of new drug leads and may serve as a valuable resource in the development of COVID-19 treatments due to their broad-spectrum antiviral activity. To date, various medicinal plant extracts have been studied for their cellular and molecular interactions, with some demonstrating anti-SARS-CoV-2 activity in vitro. This review explores the evaluation and potential therapeutic applications of these plants against SARS-CoV-2. This review summarises the latest evidence on the activity of different plant extracts and their isolated bioactive compounds against SARS-CoV-2, with a focus on the application of plant-derived compounds in animal models and in human studies., (© 2024 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.)
- Published
- 2024
- Full Text
- View/download PDF
14. Meteorite-catalyzed intermolecular trans -glycosylation produces nucleosides under proton beam irradiation.
- Author
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Bizzarri BM, Fanelli A, Kapralov M, Krasavin E, and Saladino R
- Abstract
Di-glycosylated adenines act as glycosyl donors in the intermolecular trans -glycosylation of pyrimidine nucleobases under proton beam irradiation conditions. Formamide and chondrite meteorite NWA 1465 increased the yield and the selectivity of the reaction. The glycosyl transfer process was highly regioselective in yielding canonical N
1 -pyrimidine nucleosides, the natural β-anomers prevailing in the presence of formamide and NWA 1465. These data highlight the possible role of intermolecular trans -glycosylation in the prebiotic formation of purine and pyrimidine nucleosides, avoiding the occurrence of independent synthetic pathways., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)- Published
- 2021
- Full Text
- View/download PDF
15. High-Energy Proton-Beam-Induced Polymerization/Oxygenation of Hydroxynaphthalenes on Meteorites and Nitrogen Transfer from Urea: Modeling Insoluble Organic Matter?
- Author
-
Bizzarri BM, Manini P, Lino V, d'Ischia M, Kapralov M, Krasavin E, Mráziková K, Šponer J, Šponer JE, Di Mauro E, and Saladino R
- Abstract
Formation and structural modification of oxygenated polycyclic aromatic hydrocarbons (oxyPAHs) by UV irradiation on minerals have recently been proposed as a possible channel of PAH transformation in astrochemical and prebiotic scenarios of possible relevance for the origin of life. Herein, it is demonstrated that high-energy proton-beam irradiation in the presence of various meteorites, including stony iron, achondrite, and chondrite types, promotes the conversion of two representative oxyPAH compounds, 1-naphthol and 1,8-dihydroxynaphthalene, to complex mixtures of oxygenated and oligomeric derivatives. The main identified products include polyhydroxy derivatives, isomeric dimers encompassing benzofuran and benzopyran scaffolds, and, notably, a range of quinones and perylene derivatives. Addition of urea, a prebiotically relevant chemical precursor, expanded the range of identified species to include, among others, quinone diimines. Proton-beam irradiation of oxyPAH modulated by nitrogen-containing compounds such as urea is proposed as a possible contributory mechanism for the formation and processing of insoluble organic matter in meteorites and in prebiotic processes., (© 2020 Wiley-VCH GmbH.)
- Published
- 2020
- Full Text
- View/download PDF
16. Author Correction: Proton irradiation: a key to the challenge of N-glycosidic bond formation in a prebiotic context.
- Author
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Saladino R, Bizzarri BM, Botta L, Šponer J, Šponer JE, Georgelin T, Jaber M, Rigaud B, Kapralov M, Timoshenko GN, Rozanov A, Krasavin E, Timperio AM, and Di Mauro E
- Abstract
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
- Published
- 2019
- Full Text
- View/download PDF
17. Proton irradiation: a key to the challenge of N-glycosidic bond formation in a prebiotic context.
- Author
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Saladino R, Bizzarri BM, Botta L, Šponer J, Šponer JE, Georgelin T, Jaber M, Rigaud B, Kapralov M, Timoshenko GN, Rozanov A, Krasavin E, Timperio AM, and Mauro ED
- Abstract
The formation of nucleosides in abiotic conditions is a major hurdle in origin-of-life studies. We have determined the pathway of a general reaction leading to the one-pot synthesis of ribo- and 2'-deoxy-ribonucleosides from sugars and purine nucleobases under proton irradiation in the presence of a chondrite meteorite. These conditions simulate the presumptive conditions in space or on an early Earth fluxed by slow protons from the solar wind, potentially mimicking a plausible prebiotic scenario. The reaction (i) requires neither pre-activated precursors nor intermediate purification/concentration steps, (ii) is based on a defined radical mechanism, and (iii) is characterized by stereoselectivity, regioselectivity and (poly)glycosylation. The yield is enhanced by formamide and meteorite relative to the control reaction.
- Published
- 2017
- Full Text
- View/download PDF
18. Nonenzymatic Oligomerization of 3',5'-Cyclic CMP Induced by Proton and UV Irradiation Hints at a Nonfastidious Origin of RNA.
- Author
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Costanzo G, Giorgi A, Scipioni A, Timperio AM, Mancone C, Tripodi M, Kapralov M, Krasavin E, Kruse H, Šponer J, Šponer JE, Ranc V, Otyepka M, Pino S, and Di Mauro E
- Subjects
- Circular Dichroism, Evolution, Chemical, Models, Chemical, Polymerization, Protons, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Ultraviolet Rays, Cyclic CMP chemistry, Cyclic CMP radiation effects, Oligoribonucleotides chemical synthesis, RNA chemical synthesis
- Abstract
We report that 3',5'-cyclic CMP undergoes nonenzymatic di- and trimerization at 20 °C under dry conditions upon proton or UV irradiation. The reaction involves stacking of the cyclic monomers and subsequent polymerization through serial transphosphorylations between the stacked monomers. Proton- and UV-induced oligomerization of 3',5'-cyclic CMP demonstrates that pyrimidines-similar to purines-might also have taken part in the spontaneous generation of RNA under plausible prebiotic conditions as well as in an extraterrestrial context. The observed polymerization of naturally occurring 3',5'-cyclic nucleotides supports the possibility that the extant genetic nucleic acids might have originated by way of a straight Occamian path, starting from simple reactions between plausibly preactivated monomers., (© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)
- Published
- 2017
- Full Text
- View/download PDF
19. First Evidence on the Role of Heavy Ion Irradiation of Meteorites and Formamide in the Origin of Biomolecules.
- Author
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Saladino R, Carota E, Botta G, Kapralov M, Timoshenko GN, Rozanov A, Krasavin E, and Di Mauro E
- Subjects
- Catalysis, Evolution, Chemical, Boron, Formamides radiation effects, Heavy Ions, Meteoroids, Origin of Life
- Abstract
Formamide (NH
2 CHO) has been irradiated in condensed phase at 273 K by11 B-boron beams in the presence of powdered meteorites of the chondrite and stony-iron types. Relative to the controls (no radiation or no catalysis), a variegate panel of compounds was observed, including purine and pyrimidine nucleobases (uracil, cytosine, adenine, and guanine), nucleobase analogues, heterocycles, and carboxylic acids involved in metabolic pathways. The presence of amino imidazole carbonitrile (AICN), 4,6-diamino purine (4,6-DAP) and 2,4-diamino pyrimidine (2,4-DAPy) among the observed products suggests the occurrence of an unified mechanism based on the generation of radical cyanide species (•CN). These observations contribute to outline plausible prebiotic scenarios involving11 B-boron as energy source.- Published
- 2016
- Full Text
- View/download PDF
20. Meteorite-catalyzed syntheses of nucleosides and of other prebiotic compounds from formamide under proton irradiation.
- Author
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Saladino R, Carota E, Botta G, Kapralov M, Timoshenko GN, Rozanov AY, Krasavin E, and Di Mauro E
- Subjects
- Amino Acids chemical synthesis, Amino Acids radiation effects, Carboxylic Acids chemical synthesis, Carboxylic Acids radiation effects, Catalysis, Models, Chemical, Molecular Structure, Origin of Life, Protons, Evolution, Chemical, Formamides chemistry, Formamides radiation effects, Meteoroids, Nucleosides chemical synthesis, Nucleosides radiation effects
- Abstract
Liquid formamide has been irradiated by high-energy proton beams in the presence of powdered meteorites, and the products of the catalyzed resulting syntheses were analyzed by mass spectrometry. Relative to the controls (no radiation, or no formamide, or no catalyst), an extremely rich, variegate, and prebiotically relevant panel of compounds was observed. The meteorites tested were representative of the four major classes: iron, stony iron, chondrites, and achondrites. The products obtained were amino acids, carboxylic acids, nucleobases, sugars, and, most notably, four nucleosides: cytidine, uridine, adenosine, and thymidine. In accordance with theoretical studies, the detection of HCN oligomers suggests the occurrence of mechanisms based on the generation of radical cyanide species (CN·) for the synthesis of nucleobases. Given that many of the compounds obtained are key components of extant organisms, these observations contribute to outline plausible exogenous high-energy-based prebiotic scenarios and their possible boundary conditions, as discussed.
- Published
- 2015
- Full Text
- View/download PDF
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