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Your search keyword '"Kao, Mark"' showing total 10 results
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10 results on '"Kao, Mark"'

1. Intrathecal 2-hydroxypropyl-β-cyclodextrin decreases neurological disease progression in Niemann-Pick disease, type C1: a non-randomised, open-label, phase 1–2 trial

Author

Ory, Daniel S, Ottinger, Elizabeth A, Farhat, Nicole Yanjanin, King, Kelly A, Jiang, Xuntian, Weissfeld, Lisa, Berry-Kravis, Elizabeth, Davidson, Cristin D, Bianconi, Simona, Keener, Lee Ann, Rao, Ravichandran, Soldatos, Ariane, Sidhu, Rohini, Walters, Kimberly A, Xu, Xin, Thurm, Audrey, Solomon, Beth, Pavan, William J, Machielse, Bernardus N, Kao, Mark, Silber, Steven A, McKew, John C, Brewer, Carmen C, Vite, Charles H, Walkley, Steven U, Austin, Christopher P, and Porter, Forbes D

Published
2017
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4. ICMJE Disclosures

Author

Mora, Allan David, Kao, Mark, Alfred, Terrence, Shein, Gregory, Ling, Jeff, and Lunz, David

Subjects
FOS: Clinical medicine, education, 110323 Surgery, 110604 Sports Medicine, FOS: Health sciences, humanities, 110314 Orthopaedics
Abstract

Supplemental material, FAI765176_ICMJE for Return to Sports and Physical Activities After Open Reduction and Internal Fixation of Lisfranc Injuries in Recreational Athletes by Allan David Mora, Mark Kao, Terrence Alfred, Gregory Shein, Jeff Ling and David Lunz in Foot & Ankle International

Published
2018
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5. Pharmacokinetics and distribution of 2‐hydroxypropyl‐β‐cyclodextrin following a single intrathecal dose to cats.

Author

Kao, Mark L., Stellar, Susan, Solon, Eric, Lordi, Alfred, Kasica, Nicole, Swain, Gary, Bagel, Jessica H., Gurda, Brittney L., and Vite, Charles H.

Abstract

2‐Hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) is an experimental therapy for Niemann‐Pick disease type C (NPC) that reduced neuronal cholesterol and ganglioside storage, reduced Purkinje cell death, and increased lifespan in npc1−/− mice and NPC1 cats. In this study, tissue distribution was investigated in normal cats that received a single 120‐mg dose of [14C]‐HP‐β‐CD (approximately 200 μCi/cat) via the cerebellomedullary cistern (CBMC) and lumbar cistern. One cat was euthanized at each of various time points up to 24 hours postdose for subsequent processing and quantitative whole‐body autoradiographic analysis. HP‐β‐CD‐derived radioactivity absorbed from the CBMC was widely distributed to cat tissues; most tissues were observed to have reached their highest concentration at 1 hour postdose. HP‐β‐CD‐derived radioactivity penetrated into the deeper parts of the central nervous system with the highest concentration at 4 hours (403 μg Eq/g or 0.28 mM) and remained high (49.7 μg Eq/g or 0.03 mM) at 24 hours. The relatively long half‐life (11‐30 hours) in cerebral ventricles and the subarachnoid space surrounding the brain and spinal cord might contribute to the efficacy of HP‐β‐CD in NPC1 cats. Other tissues with high concentrations of radioactivity were nasal turbinates, pituitary gland, and urinary bladder, while relatively low concentrations were observed in blood and bile. [ABSTRACT FROM AUTHOR]

Published
2020
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9. Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann-Pick type C1 disease

Author

Vite, Charles H., primary, Bagel, Jessica H., additional, Swain, Gary P., additional, Prociuk, Maria, additional, Sikora, Tracey U., additional, Stein, Veronika M., additional, O’Donnell, Patricia, additional, Ruane, Therese, additional, Ward, Sarah, additional, Crooks, Alexandra, additional, Li, Su, additional, Mauldin, Elizabeth, additional, Stellar, Susan, additional, De Meulder, Marc, additional, Kao, Mark L., additional, Ory, Daniel S., additional, Davidson, Cristin, additional, Vanier, Marie T., additional, and Walkley, Steven U., additional

Published
2015
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10. Intracisternal cyclodextrin ameliorates neurological dysfunction, increases survival time, and stops Purkinje cell death in feline Niemann–Pick type C1 disease

Author

Vite, Charles H., primary, Bagel, Jessica H., additional, Swain, Gary P., additional, Prociuk, Maria, additional, Sikora, Tracey U., additional, O'Donnell, Patricia, additional, Ruane, Therese, additional, Ward, Sarah, additional, Crooks, Alexandra, additional, Li, Su, additional, Mauldin, Elizabeth, additional, Stein, Veronika, additional, Ory, Daniel S., additional, Kao, Mark L., additional, Davidson, Cristin, additional, Vanier, Marie T., additional, and Walkely, Steven U., additional

Published
2015
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