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Your search keyword '"Kao, Chai-Lin"' showing total 119 results
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119 results on '"Kao, Chai-Lin"'

6. A half sandwich Ru(II)-p-cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells.

Author

Sun, Yin-Hsuan, You, Huey-Ling, Narwane, Manmath, Koi, Ru Xin, Kao, Chai-Lin, Yuan, Shyng-Shiou F., Liao, Wei-Ting, Lu, Tsai-Te, and Hsu, Sodio C. N.

Subjects
CANCER cells, MELANOMA, CISPLATIN, DRUG efficacy, NITRIC oxide
Abstract

The Ru(II)-nitrite complex, Ru4, is explored to release nitric oxide (NO) under acidic conditions and selectively induce a cytotoxic effect towards SK-MEL-28 cisplatin-resistant malignant melanoma cells. These findings suggest that targeting the tumor-associated pHe level could be an effective strategy for the drug function of Ru(II)-nitrite compounds. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Glabraquinone A and B, new bisanthraquinones from Prismatomeris glabra (Korth.) Valeton.

Author

Primus, Phoebe Sussana, Wu, Carol Hsin-Yi, Kao, Chai-Lin, and Choo, Yeun-Mun

Subjects
AROMATIC compounds, ETHER (Anesthetic), ANTHRAQUINONES, CELL survival, CATECHOL
Abstract

Two new bisanthraquinones, glabraquinone A and B (1–2) were isolated from the root of Prismatomeris glabra (Korth.) Valeton. In addition to the new glabraquinones, six known anthraquinones, that is, 1-hydroxy-2-methoxy-6-methylanthraquinone (3), 1,2-dimethoxy-7-methylanthraquinone (4), lucidin (5), nordamnacanthal (6), damnacanthal (7) and 2-carboxaldehyde-3-hydroxyanthraquinone (8)) and an aromatic compound, that is, catechol diethyl ether (9) were isolated and characterized in this study. Compounds 1, 4 and 9 showed mild activity, reducing N2A cell viability to 77%, 82% and 77%, respectively, in anti-neuroblastoma assay. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Modular Self‐Assembling Dendrimer Nanosystems for Magnetic Resonance And Multimodality Imaging of Tumors

Author

DING, Ling, primary, LYU, Zhenbin, additional, PERLES‐BARBACARU, Teodora‐Adriana, additional, HUANG, Adela Ya‐Ting, additional, LIAN, Baoping, additional, JIANG, Yifan, additional, ROUSSEL, Tom, additional, GALANAKOU, Christina, additional, GIORGIO, Suzanne, additional, KAO, Chai‐Lin, additional, LIU, Xiaoxuan, additional, IOVANNA, Juan, additional, BERNARD, Monique, additional, VIOLA, Angèle, additional, and PENG, Ling, additional

Published
2023
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10. One-Step Synthesis of 3-(Fmoc-amino acid)-3,4-diaminobenzoic Acids

Author

Chien, Min-Cheng, primary, Lin, Yi Kai, additional, Liao, Yong, additional, Chen, Szu-Hsuan, additional, Chen, Yen-Wei, additional, Liang, Chien-Yu, additional, Molakaseema, Vijayasimha, additional, Hsu, Sodio C. N., additional, Lin, Chun-Cheng, additional, Chen, Hui-Ting, additional, and Kao, Chai-Lin, additional

Published
2023
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20. Effect of pHon the optimization of cysteine‐functionalized gold core‐silver shell nanoparticles for surface‐enhanced Ramanscattering‐based pesticide detection on apple peels

Author

Dayalan, Sandhiya, Sudewi, Sri, Zulfajri, Muhammad, Kao, Chai‐Lin, and Huang, Genin Gary

Abstract

The rapid detection and efficient properties of surface‐enhanced Raman scattering (SERS) have been widely exploited in food safety. In this study, the SERS impact of cysteine‐functionalized gold core‐silver shell bimetallic nanoparticle (Au@Ag@CysNPs) substrates with different pH treatments on pesticide compounds was examined. The pH‐dependent SERS impact of Au@Ag@CysNPs on detecting pesticide compounds exhibited different enhancements over the pH range of 2–11 and exited the highest enhancement at a pH of 5 for thiabendazole and thiram pesticides. The prepared Au@Ag@CysNPs were further utilized in SERS‐based rapid detection of pesticides on apple peels by directly dropping Au@Ag@CysNPs on the surface of the samples, where the target molecules could be identified without elution or extraction. These findings revealed that this Au@Ag@CysNPs substrate exhibited excellent SERS performances for pesticide compounds and good stability. With additional optimization, detection limits of 0.1 ng/cm2for thiabendazole and thiram on apple peels were obtained. This study investigates the SERS impact of Au@Ag@CysNPs on pesticide detection on fruit peels. The study found enhanced pH‐dependent performance for thiabendazole and thiram pesticides, with the highest enhancement at 5 pH. Au@Ag@CysNPs demonstrated excellent SERS performance and stability, with detection limits of 0.1 ng/cm2for thiabendazole and thiram. This process could be performed within 8 min.

Published
2023
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22. Bola‐Amphiphilic Glycodendrimers: New Carbohydrate‐Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

Author

Zhang, Wenzheng, primary, Dhumal, Dinesh, additional, Zhu, Xiaolei, additional, Ralahy, Brigino, additional, Ellert‐Miklaszewska, Aleksandra, additional, Wu, Jing, additional, Laurini, Erik, additional, Yao, Yi‐Wen, additional, Kao, Chai‐Lin, additional, Iovanna, Juan L., additional, Pricl, Sabrina, additional, Kaminska, Bozena, additional, Xia, Yi, additional, and Peng, Ling, additional

Published
2022
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27. An investigation on catalytic nitrite reduction reaction by bioinspired CuII complexes.

Author

Chang, Yu-Lun, Chen, Hsing-Yin, Chen, Si-Hong, Kao, Chai-Lin, Chiang, Michael Y., and Hsu, Sodio C. N.

Subjects
CATALYTIC reduction, NITROUS acid, ELECTRON donors, POLAR effects (Chemistry), PROTON transfer reactions, LIGANDS (Chemistry)
Abstract

Catalytic nitrite reductions by CuII complexes containing anionic Me2Tp, neutral Me2Tpm, or neutral iPrTIC ligands in the presence of L -ascorbic acid, which served as an electron donor and proton source, were investigated. The results showed that auxiliary ligands are important for copper-mediated catalytic nitrite reduction. Furthermore, the electronic effects of the ligand govern the nitrite reduction efficiency, which should be considered at two control points: one is the susceptibility of the LCuI-nitrite species to protonation and the other is the susceptibility of LCuII to reduction giving LCuI. In addition, an external strong acid leads to the production of nitrous acid, which may suggest that the reactivity of nitrous acid toward the LCuI species is a third control point. [ABSTRACT FROM AUTHOR]

Published
2022
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28. Expedient on-resin modification of a peptide C-terminus through a benzotriazole linker† †Electronic supplementary information (ESI) available: Experimental procedure and NMR spectra of synthetic peptides and relative derivatives. See DOI: 10.1039/c7sc03229c

Author

Selvaraj, Anand, Chen, Hui-Ting, Ya-Ting Huang, Adela, and Kao, Chai-Lin

Subjects
Chemistry
Abstract

Peptides with various C-terminal functionalization, including peptides and dendrimers, were prepared via SPPS and an efficient on-resin modification., A convenient and efficient chemical toolbox was developed for the on-resin C-terminal functionalization of various peptides. By transforming resin-bound 3,4-diaminobenzoic acid species with isoamyl nitrite, the resulting resin-bound benzotriazole entity can be efficiently displaced by nucleophiles during cleavage of the peptide–resin connection in a short reaction time. The resin cleavage step allowed for the use of various nucleophiles including water, EtOH, amines, thiol, and G5 poly(amidoamino) dendrimers with yields ranging from 66% to 82% within 5 h. This method was successfully applied to prepare the elastin sequence (VPGVG)4 through on-resin ligation in 77% yield in one day and a head-to-tail cyclic peptide, sunflower trypsin inhibitor-1, in 42% yield.

Published
2017

29. Simple and Rapid Synthesis of Branched Peptides through Microwave-Assisted On-Bead Ligation

Author

Molakaseema, Vijayasimha, Selvaraj, Anand, Chen, Hui-Ting, Chen, Yen-Wei, Liu, Yi-Chang, and Kao, Chai-Lin

Abstract

A rapid on-bead convergent method for preparing branched peptides was reported. Linear peptides were prepared on Dbz resin and ligated various branched cores, including lysine dendrons and other dendritic compounds. Alongside microwave irradiation, <1.5 equiv of peptides is sufficient to afford 50–65% yields of pure branched peptides without chromatographic purification. Remarkably, the desired compounds were prepared within hours.

Published
2022
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44. Structure and nitrite reduction reactivity study of bio-inspired copper(i)–nitro complexes in steric and electronic considerations of tridentate nitrogen ligands.

Author

Chuang, Wan-Jung, Narwane, Manmath, Chen, Hsing-Yin, Chang, Yu-Lun, Kao, Chai-Lin, Chiang, Michael Y., Lin, Ya-Fan, and Hsu, Sodio C. N.

Subjects
COPPER compounds synthesis, NITRITES, LIGANDS (Chemistry)
Abstract

Two copper(i)–nitro complexes [Tpm3-tBuCu(NO2)] (1) and [(Ph3P)2N][Tp3-tBuCu(NO2)] (2), containing steric bulky neutral tris(3-tert-butylpyrazolyl)methane and anionic hydrotris(3-tert-butylpyrazolyl)borate ligands, have been synthesized and characterized. Complex 2 adopts a unique κ2-binding mode of Tp3-tBu around the copper(i)–nitro environment in the solid state and shows a four-coordinated tetrahedral geometry surrounded by a nitro and three pz3-tBu groups in solution. Both complexes 1 and 2 allow for the stoichiometric reduction of NO2− to NO with H+ addition. The results of this effort show that increasing steric bulk and electron donation properties on the nitrogen ancillary ligand will improve the nitrite reduction ability of the copper(i)–nitro model complexes. [ABSTRACT FROM AUTHOR]

Published
2018
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46. Voltammetric Study and Electrodeposition of Zinc in Hydrophobic Room-Temperature Ionic Liquid 1-Butyl-1-methylpyrrolidinium Bis((trifluoromethyl)sulfonyl)imide ([BMP][TFSI]): A Comparison between Chloride and TFSI Salts of Zinc

Author

Wang, Yu-Sheng, Yeh, Hsin-Wen, Tang, Yi-Hsuan, Kao, Chai-Lin, and Chen, Po-Yu

Abstract

The voltammetric behavior, nucleation mechanism, and electrodeposition of zinc were carefully studied in hydrophobic room-temperature ionic liquid 1-butyl-1-methylpyrrolidinium bis((trifluoromethyl)sulfonyl)imide (RTIL [BMP][TFSI]). The Zn(II) species were introduced via the anodic dissolution of Zn, or the addition of Zn(TFSI)2and ZnCl2, respectively. Unexpectedly, ZnCl2shows a high solubility in [BMP][TFSI] where most metal chlorides are almost insoluble. For electrodeposition, ZnCl2hence can be used as a cheaper and time-saving alternative of the Zn(II) source. Two Zn salts show obviously different voltammetric behavior, which may result from the different Zn(II) species formed. Two redox couples of Zn(II) are observed in ZnCl2solutions but there is only one redox couple in Zn(TFSI)2solutions. Many phenomena imply that two Zn(II) species, one is partially Cl-coordinated and the other one is TFSI-coordinated, are produced from ZnCl2. The surface morphology of Zn deposits prepared from the two Zn salts at 80°C is not distinguishable but apparently changed with the electrodepositing potential. Similarly, the nucleation mechanism is independent of the Zn salts, and a 3-dimensional (3D) progressive nucleation with diffusion controlled growth is observed. Oppositely, the deposition/stripping efficiency of Zn is significantly influenced by the source of Zn(II); a much higher efficiency is observed in the Zn(TFSI)2solutions.

Published
2017
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47. Bola‐Amphiphilic Glycodendrimers: New Carbohydrate Mimicking Scaffolds to Target Carbohydrate‐Binding Proteins

Author

Wenzheng Zhang, Dinesh Dhumal, Xiaolei Zhu, Brigino Ralahy, Aleksandra Ellert‐Miklaszewska, Jing Wu, Erik Laurini, Yi‐Wen Yao, Chai‐Lin Kao, Juan L. Iovanna, Sabrina Pricl, Bozena Kaminska, Yi Xia, Ling Peng, Chongqing University [Chongqing], Centre Interdisciplinaire de Nanoscience de Marseille (CINaM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Nencki Institute of Experimental Biology, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Università degli studi di Trieste = University of Trieste, Kaohsiung Medical University [Kaohsiung, Taïwan] (KMU), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), University of Lódź, PENG, Ling, Zhang, Wenzheng, Dhumal, Dinesh, Zhu, Xiaolei, Ralahy, Brigino, Ellert-Miklaszewska, Aleksandra, Wu, Jing, Laurini, Erik, Yao, Yi-Wen, Kao, Chai-Lin, Iovanna, Juan L, Pricl, Sabrina, Kaminska, Bozena, Xia, Yi, and Peng, Ling

Subjects
Dendrimers, Bola-amphiphiles, glucose-dendrimer, glycodendrimers, mannose-dendrimer, targeted delivery, glycodendrimer, [CHIM.ORGA]Chemical Sciences/Organic chemistry, [CHIM.THER] Chemical Sciences/Medicinal Chemistry, Organic Chemistry, Bola-amphiphile, Carbohydrates, General Chemistry, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, [CHIM.ORGA] Chemical Sciences/Organic chemistry, Catalysis, Glucose, Lectins, Reactive Oxygen Species, Mannose
Abstract

International audience; Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola-amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola- amphiphilic feature enabled stronger binding to lectin compared to the conventional amphiphile. In addition, these dendrimers are able to target mannose receptors and glucose transporters expressed at the surface of cells, allowing effective and specific cellular uptake. This highlights their great promise for targeted delivery.

Published
2022

48. A half sandwich Ru(II)- p -cymene nitrite complex selectively induces cell death in cisplatin-resistant malignant melanoma cells.

Author

Sun YH, You HL, Narwane M, Koi RX, Kao CL, Yuan SF, Liao WT, Lu TT, and Hsu SCN

Subjects
Humans, Cell Line, Tumor, Monoterpenes pharmacology, Monoterpenes chemistry, Cell Death drug effects, Cisplatin pharmacology, Cisplatin chemistry, Ruthenium chemistry, Ruthenium pharmacology, Melanoma drug therapy, Melanoma pathology, Melanoma metabolism, Drug Resistance, Neoplasm drug effects, Antineoplastic Agents pharmacology, Antineoplastic Agents chemistry, Antineoplastic Agents chemical synthesis, Cymenes pharmacology, Cymenes chemistry, Nitrites chemistry, Nitrites pharmacology, Coordination Complexes chemistry, Coordination Complexes pharmacology, Coordination Complexes chemical synthesis, Nitric Oxide metabolism
Abstract

The Ru(II)-nitrite complex, Ru4, is explored to release nitric oxide (NO) under acidic conditions and selectively induce a cytotoxic effect towards SK-MEL-28 cisplatin-resistant malignant melanoma cells. These findings suggest that targeting the tumor-associated pHe level could be an effective strategy for the drug function of Ru(II)-nitrite compounds.

Published
2024
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49. Glabraquinone A and B, new bis anthraquinones from Prismatomeris glabra (Korth.) Valeton.

Author

Primus PS, Wu CH, Kao CL, and Choo YM

Subjects
Anthraquinones pharmacology, Plant Roots, Rubiaceae
Abstract

Two new bis anthraquinones, glabraquinone A and B ( 1 - 2 ) were isolated from the root of Prismatomeris glabra (Korth.) Valeton. In addition to the new glabraquinones, six known anthraquinones, that is, 1-hydroxy-2-methoxy-6-methylanthraquinone ( 3 ), 1,2-dimethoxy-7-methylanthraquinone ( 4 ), lucidin ( 5 ), nordamnacanthal ( 6 ), damnacanthal ( 7 ) and 2-carboxaldehyde-3-hydroxyanthraquinone ( 8 )) and an aromatic compound, that is, catechol diethyl ether ( 9 ) were isolated and characterized in this study. Compounds 1 , 4 and 9 showed mild activity, reducing N2A cell viability to 77%, 82% and 77%, respectively, in anti-neuroblastoma assay.

Published
2024
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50. Bola-Amphiphilic Glycodendrimers: New Carbohydrate-Mimicking Scaffolds to Target Carbohydrate-Binding Proteins.

Author

Zhang W, Dhumal D, Zhu X, Ralahy B, Ellert-Miklaszewska A, Wu J, Laurini E, Yao YW, Kao CL, Iovanna JL, Pricl S, Kaminska B, Xia Y, and Peng L

Subjects
Reactive Oxygen Species, Carbohydrates chemistry, Lectins chemistry, Glucose, Mannose chemistry, Dendrimers chemistry
Abstract

Dendrimers are appealing scaffolds for creating carbohydrate mimics with unique multivalent cooperativity. We report here novel bola-amphiphilic glycodendrimers bearing mannose and glucose terminals, and a hydrophobic thioacetal core responsive to reactive oxygen species. The peculiar bola-amphiphilic feature enabled stronger binding to lectin compared to conventional amphiphiles. In addition, these dendrimers are able to target mannose receptors and glucose transporters expressed at the surface of cells, thus allowing effective and specific cellular uptake. This highlights their great promise for targeted delivery., (© 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)

Published
2022
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