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Under investigation is the (2+1)-dimensional version of fifth-order equation, which is an extension of the (1+1)-dimensional fifth-order equation. First, the [Formula: see text]-soliton solutions of this (2+1)-dimensional equation are constructed by using its Hirota bilinear form. Second, through using long-wave limit technique and selecting appropriate parameters for the [Formula: see text]-soliton solutions, diverse localized wave structures including kink soliton, breather, lump solution and their mixed interaction behaviors are obtained, and relevant dynamics features are discussed and analyzed graphically. Finally, some mathematical properties and special physical phenomena are summarized. The results obtained in this paper might be helpful to deepen the understanding of the interaction evolution of nonlinear localized waves.

This paper deals with localized waves in the (3+1)-dimensional Boiti–Leon–Manna–Pempinelli equation in the incompressible fluid. Based on Hirota’s bilinear method, N-soliton solutions related to Boiti–Leon–Manna–Pempinelli equation are constructed. Novel nonlinear wave phenomena are obtained by selecting appropriate parameters to N-soliton solutions, and time evolutions of different kinds of solitary waves are investigated in detail. Rich elastic interactions are illustrated analytically and graphically. More specifically, the inelastic interactions, i.e., fusion and fission of solitary waves, are constructed by choosing special parameters on kink solitons and breathers. The analysis of the influence of parameters on propagation is revealed in three tables. The results have potential applications in fluid mechanics.

Objective: This study aimed to explore the factors influencing dental caries among 3–5-year-old children in Guizhou Province and the interrelationship between these factors using structural equation modeling, while providing theoretical references to improve the prevention and control strategy.Materials and Methods: A total of 1,291 children aged 3–5 years in Guizhou Province were selected by a multistage stratified and whole group random sampling to examine the caries prevalence in whole-mouth deciduous teeth crowns, and parents were surveyed with questionnaires to analyze the caries-related factors. IBM SPSS Statistics v 23.0 software (IBM, Armonk, NY, USA) was used for statistical analysis.Results: The caries prevalence of children aged 3–5 years in Guizhou Province was 63.1%, the mean decayed-missing-filled teeth was 3.32, the caries filling rate was 0.5%, and there was no statistically significant difference between urban and rural areas and among genders in each age group; results of logistic regression analysis showed that the caries risk increased with the following factors: age, brushing frequency Conclusions: With an overall poor situation about oral hygiene habits, oral healthcare attitude of the parents, and behavior transformation, the prevalence of dental caries in the deciduous teeth of children aged 3–5 years in Guizhou Province is high, and their caries status was severe, with more than 99% of the caries cases that were untreated. Therefore, prevention and treatment measures of caries in preschool children need strengthening through the improvement of public awareness and the enhancement of the management of oral health habits of their children.

Copper nanoparticles encapsulated by carbon (Cu-NPs@C) were synthesized by a two-step method by mixing cupric chloride and glucose in a solution, followed by carbonization. The microstructures and antibacterial activities of the Cu-NPs@C samples were characterized by TEM, XRD, XPS, nitrogen adsorption and antibacterial activity tests. Results indicated that the as-synthesized Cu-NPs had a FCC crystal structure and a spherical morphology of diameter 4-46 nm and were well dispersed in the porous graphitic carbon layers. When the mass ratio of cupric chloride to glucose was less than 1:5, the Cu-NPs@C were of pure metallic copper without any oxides, and were stable against ambient air oxidation. The Cu-NPs@C synthesized with a mass ratio of cupric chloride to glucose of 1:5 had a specific surface area of 418 m2/g, which showed much higher antibacterial activities against three different common bacteria (Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa) than pure nano-copper powder. It was believed that the carbon layers are responsible for capturing the bacteria while the copper ions released from the copper nanoparticles kill them. The outer carbon layers effectively protected the metallic copper inside from oxidation. These findings indicate that Cu-NPs@C can be used as a stable antibacterial agent in biomedical applications.

In this study, the immobilization with sodium alginate (SA) for cultivating microalgae in entrapped matrix gel beads was conducted for separating it from water. Batch experiments with a period of 5 days were carried out for free and immobilized Scenedesmus obliquus simultaneously under two trophic modes, to compare the removal performances of different initial ammonium (NH4+-N) concentrations. In both free and immobilized form, the positive C-dependent effect in mixotrophy and the negative N-dependent effect in heterotrophy were observed. And the performances of immobilized form were all superior to that of free form, which showed greater tolerance to high concentration, maximally representing 96.6 ± 0.1% removal in 50 mg/L of NH4+-N in mixotrophy. Assimilation of NH4+-N was the main removal pathway resulting the protein synthesis with the dominant component including glutamic acid (Glu), cystine (Cys), arginine (Arg) and proline (Pro). The results demonstrated a systematic understanding for NH4+-N removal in microalgae-based system.

In this paper, the higher-order nonlinear self-dual network equation is investigated. Firstly, an integrable lattice hierarchy associated with this equation is constructed from a discrete matrix spectral problem without the denominator. Secondly, the condition of modulational instability for this equation is given. Thirdly, the infinitely many conservation laws are constructed on the basis of its new Lax representation. Finally, the discrete generalised $$(m, N-m)$$ -fold Darboux transformation (DT) with non-zero constant as seed solution is used to derive new rational soliton (RS) and mixed interaction solutions. As an application, RS solutions can be obtained by the discrete generalised $$(1, N-1)$$ -fold DT (i.e., generalised $$(m, N-m)$$ -fold DT with $$m=1$$ ), and mixed interaction solutions of the usual sech-type soliton (US) and RS can be derived by the discrete generalised $$(2, N-2)$$ -fold DT (i.e., generalised $$(m, N-m)$$ -fold DT with $$m=2$$ ). We also perform the numerical simulations for such soliton solutions to explore their dynamical behaviours. Results given in this paper may have some prospective applications for understanding the propagation of electrical signals.

This paper deals with localized waves in the (2+1)-dimensional Caudrey-Dodd-Gibbon-Kotera-Sawada (CDGKS) equation in the incompressible fluid. Based on Hirota’s bilinear method, N-soliton solutions related to CDGKS equation are constructed. For the case N = 5 and N = 6, the exact expression of multiple localized wave solutions comprising lump solitons are obtained by using the long wave limit method. A variety of interactions are illustrated analytically and graphically. The influence of parameters on propagation is analyzed and summarized. The results and phenomena obtained in this paper enrich the dynamic behavior of the evolution of nonlinear localized waves.

Application of microalgae in wastewater treatment is regarded as a potential green technology. However, its engineering application has been largely hindered because of the difficulty of biomass separation and harvesting. This study aimed to identify the key parameters influencing the process of microalgae immobilization. To do this, the study focused on immobilization technology and

Hou-Po-Da-Huang Tang (HPDHT) was used for the treatment of intestinal tract diseases in China. However, the underlying mechanisms via the intestinal bacteria remain largely unclear. Therefore, the aim of this study was to evaluate the metabolism of HPDHT by the human intestinal bacteria and its modulating effect on the intestinal bacteria. As a result, a total of 34 compounds were identified in HPDHT and transformed HPDHT (T-HPDHT). Among them, 12 metabolites were proved to be transformed by human intestinal bacteria. In vitro assays showed that T-HPDHT exhibited more significant elevation of free radical scavenging activity and suppression on the production of nitric oxide (NO) and TNF-α when comparing to HPDHT. Additionally, in vivo experiment confirmed that HPDHT significantly increased activity of superoxide dismutase (SOD), attenuated the malondialdehyde (MDA) and TNF-α levels in the conventional rats compared with that of pseudo germ-free (PGF) rats. In addition, HPDHT could significantly enhance the mean counts of Bifidobacterium and Lactobacillus and inhibit the growth of Clostridium, and Enterobacteriaceae, relative to controls. Due to the transformation of HPDHT being dependent on the bacterial strain, the effect of HPDHT on the selective growth of Bifidobacterium bifidum 29521 and Lactobacillus plantarum 8014 was evaluated. The kinetic parameters of microbial growth and prebiotic activity scores indicated that HPDHT could selectively stimulate the growth of the strains Bifidobacterium bifidum 29521 and Lactobacillus plantarum 8014. Taken together, metabolism of HPDHT by intestinal bacteria is a critical step towards the emergence of their anti-oxidation, anti-inflammation and prebiotic activities. This study provided valuable information for further pharmacological research on HPDHT.

Bone cancer pain is a challenge for its not completely clarified mechanism and broad clinical morbidity. Therefore, novel and more effective drugs are urgent needed for improvement of patients' quality of life. Glutamate receptors have been associated with the development of the central sensitization of chronic pain. Inhibition of N-methyl-d-aspartate (NMDA) and metabotropic glutamate (mGlu) receptors can effectively attenuate bone cancer pain, respectively. Herein, our results indicated that levo-Corydalmine (l-CDL), a compound from Corydalis yanhusuo W.T. Wang, which has been used in traditional Chinese medicine for pain relief could effectively attenuate bone cancer pain induced by tibia bone cavity tumor cell implantation (TCI) through simultaneously inhibiting the NMDA and mGlu1/5 receptors in rat spinal cord without notable side effects. Both intragastric and intrathecal administration of l-CDL significantly alleviated the mechanical hypersensitivity induced by TCI in rats, and the analgesic effect of l-CDL could be reversed by intrathecal administration of NMDA receptor agonist NMDA and mGlu1/5 receptor agonist DHPG but not AMPA receptor agonist AMPA. l-CDL could also selectively suppress NMDA and DHPG induced rapid rise in Ca2+ oscillations in primary cultures neurons of spinal cord in vitro. The antinociception of l-CDL were partially mediated by the reduced phosphorylation of PKC γ and ERK1/2 in spinal cord of TCI rats in a NMDA and mGlu1/5 dependent manner. In conclusion, these results suggested that l-CDL attenuates TCI induced bone cancer pain through simultaneously inhibiting the NMDA and mGlu1/5 receptors and the downstream PKC γ, ERK1/2 signaling pathways in the spinal cord.

Objective: The aim of this research was to develop a novel ALA fusion protein for target to the malignant cells surface with high uPAR expression and locally release of the scorpion toxin AGAP in an uPA-cleavable manner. It will provide an effective approach for controlled release of the peptide toxins to treat cancerous cells. Methods: The ALA fusion proteins were expressed in pichia pastoris, and the recombinant proteins were purified by Ni-NTA affinity chromatography. The proteins were added to human breast cancer cells (MDA-MB-231) and human embryonic kidney cells (HEK-293) in order to investigate the characteristic of selective targeting and releasing of scorpion toxin AGAP in cancer cells with high uPAR expression. The inhibitory effect of ALA on MDA-MB-231, MCF7, LO2 and HEK-293 was evaluated by MTT assay. Moreover, the antiproliferation mechanism of ALA was determined by flow cytometric and western blot analysis. Results: The results showed that ALA could target MDA-MB-231 cells and the scorpion toxin AGAP could be released with high efficiency and selectivity. ALA inhibited the growth and invasion of breast cancer cells MDA-MB231. Also, cell apoptosis pathway was found to be associated with the inhibition mechanism of ALA according to the data of flow cytometric and western blot analysis. Therefore, ALA could be a novel antitumor candidate for targeting treatment of malignant cell. Conclusions: This study successfully demonstrated that fusion of biotoxins with tumor target domain could provide a simple yet effective way to delivery of peptide or protein drugs.

internationally. With frequent appearances at fashion’s world, cities’ fashion weeks, museum exhibitions and retail, Chinese designers have started to gain international recognition. Although all the fashion designers stressed that the key to their brands success in China is design and quality, there is a significant difference between the brands’ orientations: market or design, which is embodied by the brands’ positioning strategies, approach to design, retail operation and international outlook. This research on Chinese fashion designer brands would extend our current understanding of fashion branding in China. At the same time, these designer brands provide exemplary branding strategies that suit the Chinese fashion market.

In this paper, the (2[Formula: see text]+[Formula: see text]1)-dimensional CDGKS equation is studied and its diverse soliton solutions consisting of line soliton, periodic soliton and lump soliton with different parameters are derived based on the Hirota bilinear method and long-wave limit method. Based on exact solution formulae with different parameters, the interaction between line soliton and periodic soliton, the interaction between line soliton and lump soliton, as well as the interaction between periodic soliton and lump soliton are illustrated. According to the dynamical behaviors, it can be found that the effects of different parameters are on the propagation direction and shapes. Novel soliton interaction phenomena are also observed.

Bone cancer pain is a challenge for its not completely clarified mechanism and broad clinical morbidity. Therefore, novel and more effective drugs are urgent needed for improvement of patients' quality of life. Glutamate receptors have been associated with the development of the central sensitization of chronic pain. Inhibition of N-methyl-d-aspartate (NMDA) and metabotropic glutamate (mGlu) receptors can effectively attenuate bone cancer pain, respectively. Herein, our results indicated that levo-Corydalmine (l-CDL), a compound from Corydalis yanhusuo W.T. Wang, which has been used in traditional Chinese medicine for pain relief could effectively attenuate bone cancer pain induced by tibia bone cavity tumor cell implantation (TCI) through simultaneously inhibiting the NMDA and mGlu1/5 receptors in rat spinal cord without notable side effects. Both intragastric and intrathecal administration of l-CDL significantly alleviated the mechanical hypersensitivity induced by TCI in rats, and the analgesic effect of l-CDL could be reversed by intrathecal administration of NMDA receptor agonist NMDA and mGlu1/5 receptor agonist DHPG but not AMPA receptor agonist AMPA. l-CDL could also selectively suppress NMDA and DHPG induced rapid rise in Ca

Ten novel artemisinin derivatives containing sulfur atoms were designed and synthesized and their structures were confirmed by 1 H NMR, 13 C NMR and HRMS technologies in this study. All compounds were reported for the first time. The in vitro cytotoxicity against PC-3, SGC-7901, A549 and MDA-MB-435s cancer cell lines was evaluated by MTT assay. Compounds 4a and 4f displayed potent antitumor activity against PC-3, SGC-7901 and A549 cells with IC 50 ranging from 1.6 to 30.5 μM, which values are compared to that of 5-FU (IC 50 from 6.8 to 42.5 μM). Compounds 4a and 4f showed high specificity towards human lung cancer A549 cells compared to normal human hepatic L-02 cells with selectivity index of 16.1 and 50.1 respectively. Our promising findings indicated that the compounds 4a and 4f could stand as potential lead compounds for further investigation.

Aim: We investigated the effects of TORC1/2 kinase inhibitors on colorectal cancer (CRC) cell lines. Materials & methods: Using selective TORC1/2 inhibitors, rapamycin and PP242, we assessed their effect on the growth of CRC cells in vitro and tumor growth in vivo. Results: Rapamycin and PP242 inhibit proliferation and induce apoptosis of CRC cells. They also enhance proapoptotic effect of conventional chemo drug doxorubicin in CRC cells in vitro. When combined with doxorubicin, rapamycin and PP242 almost completely inhibit tumor growth in vivo. Rapamycin and PP242 inhibit phosphorylation of Akt, ribosomal S6 kinase, 4EBP1 and mTOR. Conclusion: Our study suggests rapamycin and PP242 may be a useful therapeutic agent and inhibiting mTOR signaling pathway represents a new targeted therapy for CRC.

Çinlilerin `T'o-pa` diye adlandırdıkları ve Divan-ı Lügâti't-Türk'te bir Türk kavmi olarak geçen Tabgaçların kökenleri ve dilleri konusunda günümüze kadar bir fikir birliğine varılamamıştır. Öne sürülen fikirler temel olarak kökenlerinin ve dillerinin Türk ya da Moğol olduğu yönündedir. Haklarındaki birçok belirsizliğe rağmen, kesin olan tek şey çok sayıda boydan müteşekkil bir `boylar birliği` olan Tabgaçların kuruluşunda sekiz boyun mevcut bulunup, hâkim olunan topraklar genişledikçe bu boyların sayısının artmış olmasıdır. Konfederasyonda menşei tespit edilen kavimler arasında Hunlar, Hsien-piler, T'u-yü-hunlar, Kao-ch'elar, Juan-juanlar, Wu-huanlar ve Yüeh-chihler bulunmaktadır.Tabgaç tarihinin ana kaynağı olan Wei-shu'da nesilleri efsanevi Sarı İmparator'a dayandırılan Tabgaçların ana yurtları Amur ile Argun Nehri arasındaki bölgedir. II. yüzyılda Hunlardan boşalan İç Moğolistan topraklarına yerleşen, daha sonra güneye doğru inmeye başlayan Tabgaçlar 315 yılında Tai Devleti'ni, 386 yılında da Kuzey Wei Hanedanlığı'nı kurdular. Resmi Çin hanedanlıklarından biri sayılan Kuzey Wei Hanedanlığı zamanında Tabgaçlar On Altı Devlet dönemine son vererek tüm Kuzey ve Merkezî Çin'i kendi hâkimiyetleri altında yeniden birleştirdiler. Bu dönemde idarî anlamda birçok yenilik yapıldı ve Budizm Çin topraklarında yayıldı. 534 yılında ikiye ayrılan Kuzey Wei Hanedanlığı zamanında her ne kadar Çinlileşme yönünde büyük reformlar yapılmış olsa da, yine de geleneksel hayatlarına devam edenler sayesinde göçebe kültürü kendilerinden sonra kurulan hanedanlıklara aktarmayı başardılar. Dolayısıyla Chin Hanedanlığı ile T'ang Hanedanlığı arasındaki dönemde hem İslamiyetten Önceki Türk Tarihi hem de Eski Çin Tarihi açısından önemli bir köprü vazifesi gördüler.Anahtar Kelimeler: Tabgaç, T'o-pa, Kuzey Wei Hanedanlığı, Hsien-pi There is no an agreement at the present on the origin and the language of Tabgatchs called as `T'o-pa` by Chinese and also considered as a Turkish tribe in Divan-ı Lügâti't-Türk. The given ideas are fundamentally the way in which their origin and language were thought to be Turkish or Mongolian. Although uncertainties are ubiquitous in Tabgatchs' history, one thing is almost certain: they were 'a confederation' which composed of many tribes and there were just eight tribes at the time of their foundation, while their territory became larger and increased in number of these clans. Hun, Hsien-pi, T'u-yü-hun, Kao-ch'e, Juan-juan, Wu-huan and Yüeh-chih clans were among them which were recognized in this confederation. The lineage of Tabgatchs was based on the legendary of Yellow Emperor in the Wei-shu which is the main resource of Tabgatchs' history. Their homeland was the area that lay between Amur River and Argun River. Tabgatchs, who settled in Inner Mongolia at first in the 2rd century and later on moved to south, founded Tai State in 315 and then Northern Wei Dynasty in 386. At the time of Northern Wei Dynasty entitled to one of the legitimate Chinese dynasties, Tabgatchs ended up Sixteen States era and reunified whole North and Central China under their own rule. In this period, many administrative renewals were made and Buddhism was spread to the Chinese territories. Although several great reforms took place with the purpose of sinicization during the Northern Wei Dynasty which separated to east and west in 534, still by virtue of those whom continued their traditional life, they succeeded in through the nomadic culture to the dynasties after themselves. Thus, in the period between Chin and T'ang Dynasties, they served as a bridge in terms of both Turkish History before Islam and Ancient Chinese History. Key Words: Tabgatch, T'o-pa, Northern Wei Dynasty, Hsien-pi 192