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1. Conclusion: The Case for Clotilda

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

3. Foreword

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

4. Cover

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

5. List of Figures

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

6. Acknowledgments

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

8. Glossary

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

10. References Cited

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

12. Chapter 7. Shipwreck Archaeology

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

13. Index

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

14. Chapter 1. Maritime Mobile, 1519-1860

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

15. Introduction: Clotilda's Final Voyage

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

16. Chapter 3. A Graveyard of Ships

Author

Hathorn, Stacye, Jones, Lisa D., DeCaro, Alexander, Grinnan, Joseph, Lent, Kyle, Marx, Deborah E., and Delgado, James P.

Published
2023

18. Program Directors Survey on the Impact of the COVID-19 Pandemic on Cardiology Fellowship Training

Author

Cullen, Michael W, Damp, Julie B, Soukoulis, Victor, Keating, Friederike K, Abudayyeh, Islam, Yang, Eric H, Kondapaneni, Meera, Polk, Donna M, Rose-Jones, Lisa J, Theriot, Paul, and Weissman, Gaby

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Emerging Infectious Diseases, Coronaviruses Disparities and At-Risk Populations, Coronaviruses, Infectious Diseases, Cardiovascular, Quality Education
Published
2024

23. Development of Spheroid-FPOP: An In-Cell Protein Footprinting Method for 3D Tumor Spheroids.

Author

Shortt, Raquel, Wang, Yijia, Hummon, Amanda, and Jones, Lisa

Subjects
Humans, Protein Footprinting, Proteins, Mass Spectrometry, Oxidation-Reduction, Neoplasms, Antineoplastic Agents, Spheroids, Cellular, Tumor Microenvironment
Abstract

Many cancer drugs fail at treating solid epithelial tumors with hypoxia and insufficient drug penetration thought to be contributing factors to the observed chemoresistance. Owing to this, it is imperative to evaluate potential cancer drugs in conditions as close to in vivo as possible, which is not always done. To address this, we developed a mass spectrometry-based protein footprinting method for exploring the impact of hypoxia on protein in 3D colorectal cancer cells. Our group has previously extended the protein footprinting method fast photochemical oxidation of proteins (FPOP) for live cell analysis (IC-FPOP); however, this is the first application of IC-FPOP in a 3D cancer model. In this study, we perform IC-FPOP on intact spheroids (Spheroid-FPOP) using a modified version of the static platform incubator with an XY movable stage (PIXY) FPOP platform. We detected modification in each of three spheroid layers, even the hypoxic core. Pathway analysis revealed protein modifications in over 10 distinct protein pathways, including some involved in protein ubiquitination; a process modulated in cancer pathologies. These results demonstrate the feasibility of Spheroid-FPOP to be utilized as a tool to interrogate protein interactions within a native tumor microenvironment.

Published
2023

24. Measuring Online Prosocial Behaviors in Primary School Children: Psychometric Properties of the Online Civility Scale

Author

Beseler, Cheryl L., Jones, Lisa M., and Mitchell, Kimberly J.

Abstract

Children are online at increasing frequency, for longer periods of time, and at younger ages than ever before. Schools in the USA are engaged in providing online citizenship education to students; however, there are few evaluations of how well programs work or tools to measure program effectiveness. The current study provides psychometric information on one tool, the eight-item online civility scale (OCS), administered as part of an evaluation of the Be Internet Awesome (BIA), digital citizenship curriculum. The OCS was administered securely online to children in grades 4th, 5th, and 6th, to evaluate whether the BIA program improved their online citizenship skills. Psychometric analysis of the OCS was conducted for 824 youth who responded to both the pretest and posttest measures. Item constructs were validated in structural equation models with self-reported online behaviors. The eight items formed a cohesive construct, explaining 60% of the variance in online civility. The item response theory models showed that the items covered a range of the underlying trait. Differential item functioning (DIF) was observed by gender. The difficulty parameter did not show DIF across time (p = 0.11), but the discrimination parameter did (p = 0.002). The OCS construct was significantly and strongly associated with each of the validating variables in the expected directions. The OCS demonstrated excellent psychometric properties and could be a useful evaluation tool in programs designed to promote prosocial online behaviors in children. The scale behaves differently by gender and may discriminate differently across time points after an intervention.

Published
2023
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26. MetaCon: Unified Predictive Segments System with Trillion Concept Meta-Learning

Author

Li, Keqian, Hu, Yifan, Palanisamy, Logan, Jones, Lisa, Gupta, Akshay, Grigsby, Jason, Selinger, Ili, Gillingham, Matt, and Tan, Fei

Subjects
Computer Science - Artificial Intelligence, Computer Science - Machine Learning
Abstract

Accurate understanding of users in terms of predicative segments play an essential role in the day to day operation of modern internet enterprises. Nevertheless, there are significant challenges that limit the quality of data, especially on long tail predictive tasks. In this work, we present MetaCon, our unified predicative segments system with scalable, trillion concepts meta learning that addresses these challenges. It builds on top of a flat concept representation that summarizes entities' heterogeneous digital footprint, jointly considers the entire spectrum of predicative tasks as a single learning task, and leverages principled meta learning approach with efficient first order meta-optimization procedure under a provable performance guarantee in order to solve the learning task. Experiments on both proprietary production datasets and public structured learning tasks demonstrate that MetaCon can lead to substantial improvements over state of the art recommendation and ranking approaches.

Published
2022

29. Reading the score : music novels and the alternative world of words

Author

Owen-Jones, Lisa

Abstract

The aim of this thesis is to write a 'music novel' for children and by doing so examine some of the many ways words and music play a role in storytelling. A music novel can be studied critically and to write one is ultimately a creative act. Academic scholarship on literary representations of music has so far been primarily focused on attending to the presence and representation of Western classical music in adult literary texts. Eminent leaders in the field include Delia da Sousa Correa, Emily Petermann, and Werner Wolf. Research into music in children's fiction has not been undertaken to such an extent. This thesis takes a first step towards readdressing this gap in knowledge, taking as examples children's novels by Aimee Lucido (In the Key of Code, 2019), Philip Reeve (Railhead, 2015), and Lewis Carroll (Alice's Adventures in Wonderland, 1865); and a more recent, contemporary adult novel by Matthew Herbert (The Music - A novel through sound, 2018). My detailed analysis centres on how music contributes to the construction and development of these works, as well as music that has made use of fiction as a compositional device in György Ligeti's Nonsense Madrigals (1988-93). The theoretical framing of my study draws on work by Roland Barthes, John Cage, Jean-Jacques Nattiez, and Patricia Waugh. Underdog, my music novel aimed at readers aged eight years and over, is my creative response to the questions this thesis raises. The two soundscapes that accompany the novel are musical paratexts born from Underdog that help unite the words with the music beyond the printed page. I provide a critical reflection on the inspirations behind Underdog which serves as a bridge into critical case studies that investigate what happens when one art form (music) has infiltrated the other (fiction) as part of what Jean-Jacques Nattiez calls the poietic process. My study demonstrates that the literary techniques used in fiction to imitate music, regardless of genre, are shared. These traits include references to pop and classical music embedded in the text, imitation of motifs and numerical musical patterns associated with a particular piece of music, and individual pieces of music that underpin the construction of a literary work.

Published
2022

30. Exome sequencing in bipolar disorder identifies AKAP11 as a risk gene shared with schizophrenia

Author

Palmer, Duncan S, Howrigan, Daniel P, Chapman, Sinéad B, Adolfsson, Rolf, Bass, Nick, Blackwood, Douglas, Boks, Marco PM, Chen, Chia-Yen, Churchhouse, Claire, Corvin, Aiden P, Craddock, Nicholas, Curtis, David, Di Florio, Arianna, Dickerson, Faith, Freimer, Nelson B, Goes, Fernando S, Jia, Xiaoming, Jones, Ian, Jones, Lisa, Jonsson, Lina, Kahn, Rene S, Landén, Mikael, Locke, Adam E, McIntosh, Andrew M, McQuillin, Andrew, Morris, Derek W, O’Donovan, Michael C, Ophoff, Roel A, Owen, Michael J, Pedersen, Nancy L, Posthuma, Danielle, Reif, Andreas, Risch, Neil, Schaefer, Catherine, Scott, Laura, Singh, Tarjinder, Smoller, Jordan W, Solomonson, Matthew, Clair, David St, Stahl, Eli A, Vreeker, Annabel, Walters, James TR, Wang, Weiqing, Watts, Nicholas A, Yolken, Robert, Zandi, Peter P, and Neale, Benjamin M

Subjects
Biotechnology, Human Genome, Clinical Research, Serious Mental Illness, Schizophrenia, Brain Disorders, Bipolar Disorder, Mental Health, Genetics, 2.1 Biological and endogenous factors, Aetiology, Mental health, A Kinase Anchor Proteins, Exome, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Exome Sequencing, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

We report results from the Bipolar Exome (BipEx) collaboration analysis of whole-exome sequencing of 13,933 patients with bipolar disorder (BD) matched with 14,422 controls. We find an excess of ultra-rare protein-truncating variants (PTVs) in patients with BD among genes under strong evolutionary constraint in both major BD subtypes. We find enrichment of ultra-rare PTVs within genes implicated from a recent schizophrenia exome meta-analysis (SCHEMA; 24,248 cases and 97,322 controls) and among binding targets of CHD8. Genes implicated from genome-wide association studies (GWASs) of BD, however, are not significantly enriched for ultra-rare PTVs. Combining gene-level results with SCHEMA, AKAP11 emerges as a definitive risk gene (odds ratio (OR) = 7.06, P = 2.83 × 10-9). At the protein level, AKAP-11 interacts with GSK3B, the hypothesized target of lithium, a primary treatment for BD. Our results lend support to BD's polygenicity, demonstrating a role for rare coding variation as a significant risk factor in BD etiology.

Published
2022

31. Evaluating the Impact of a Youth-Led Sexual Violence Prevention Program: Youth Leadership Retreat Outcomes

Author

Edwards, Katie M., Banyard, Victoria L., Waterman, Emily A., Mitchell, Kimberly J., Jones, Lisa M., Kollar, Laura M. Mercer, Hopfauf, Skyler, and Simon, Briana

Abstract

Involving youth in developing and implementing prevention programs to reduce sexual violence (SV) has the potential to improve prevention outcomes. However, there has been little focus on youth-led SV prevention programs, and limited evaluation research to help guide efforts. The current study examined the effectiveness of Youth Voices in Prevention (Youth VIP) leadership retreats on SV victimization and perpetration, forms of violence related to SV (e.g., bullying), SV bystander behaviors and readiness, and perceptions of norms related to SV prevention. Results identified mixed findings for program impact, with variations in outcomes that can help guide future youth-led prevention program initiatives. Youth attending a large "kick-off" leadership retreat (that was less youth-led that subsequent smaller retreats) later reported more bystander behaviors, but also reported increased perpetration and victimization, compared to non-attending youth. However, youth attending smaller, more focused leadership retreats held during the school year, reported reductions in sexual harassment perpetration and improved bystander behaviors and attitudes compared to non-attending youth. Evaluation of moderator variables suggests that program impact was generally stronger for younger participants, sexual minority youth, and non-White youth (which were largely Native American youth in this sample). Findings suggest promise for youth-led prevention work but also highlight the need for testing the impact of different training structures and modalities.

Published
2022
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32. Voices of Youth and Emerging Adults on Suicide Prevention: Experiences and Expectations

Author

Banyard, Victoria, Mitchell, Kimberly J., Jones, Lisa M., and Ybarra, Michele L.

Abstract

Self-directed violence (SDV) is a significant public health issue for adolescents and emerging adults, and yet youth exposure to prevention messaging and youth perspectives on SDV prevention needs are understudied. The current study sought to better understand the ways in which a national sample of youth and emerging adults were exposed to suicide prevention programs or conversations. A sample of 1031 young people ages 13-23 were recruited nationally through social media. Survey questions asked about SDV prevention exposure. Open-ended questions asked youth to suggest additional information they desired about SDV. A majority of participants (87%) reported that they had received prevention exposure from at least one source (i.e., family, online, attending a talk, or formal program) with few differences by demographic characteristics. However, sexual and gender minority (SGM) youth reported accessing more SDV prevention information online compared to other youth. Overall, youth had many ideas about what additional information they needed, including how to help someone at risk for SDV and how to access information about mental health. While the majority of youth are receiving some SDV prevention messages, there is variation in how they get this information, and survey participants still felt they were missing important information. Findings highlight the need to resource more comprehensive SDV prevention for youth and young adults.

Published
2022
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33. The Contributing Role of Family, School, and Peer Supportive Relationships in Protecting the Mental Wellbeing of Children and Adolescents

Author

Butler, Nadia, Quigg, Zara, Bates, Rebecca, Jones, Lisa, Ashworth, Emma, Gowland, Steve, and Jones, Margaret

Abstract

Globally, mental disorders are the leading cause of disability in children and adolescents. Previous research has demonstrated that supportive relationships are a key protective factor against poor mental health in children, particularly amongst those who have experienced adversity. However, fewer studies have examined the relative impact of different types of supportive relationships. The current study examined the association between level of family adult support, school adult support, and school peer support and mental wellbeing in a sample of children (age 8-15 years, N = 2,074) from schools in the UK. All three sources of support were independently associated with mental wellbeing. Analyses demonstrated a graded relationship between the number of sources of support and the odds of low mental wellbeing (LMWB), reflecting a cumulative protective effect. While all three sources of support were best, it was not vital, and analyses demonstrated a protective effect of school sources of support on LMWB amongst children with low family support. Peer support was found to be particularly important, with prevalence of LMWB similar amongst children who had high peer support (but low family and school adult support), and those who had high family and school adult support, (but low peer support), indicating that high peer support has an equivalent impact of two other protective factors. Findings from the study highlight the crucial context schools provide in fostering positive peer relationships and supportive teacher--student relationships to promote mental health and resilience for all children, including both those with and without supportive home environments.

Published
2022
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34. Characterisation of age and polarity at onset in bipolar disorder.

Author

Kalman, Janos L, Olde Loohuis, Loes M, Vreeker, Annabel, McQuillin, Andrew, Stahl, Eli A, Ruderfer, Douglas, Grigoroiu-Serbanescu, Maria, Panagiotaropoulou, Georgia, Ripke, Stephan, Bigdeli, Tim B, Stein, Frederike, Meller, Tina, Meinert, Susanne, Pelin, Helena, Streit, Fabian, Papiol, Sergi, Adams, Mark J, Adolfsson, Rolf, Adorjan, Kristina, Agartz, Ingrid, Aminoff, Sofie R, Anderson-Schmidt, Heike, Andreassen, Ole A, Ardau, Raffaella, Aubry, Jean-Michel, Balaban, Ceylan, Bass, Nicholas, Baune, Bernhard T, Bellivier, Frank, Benabarre, Antoni, Bengesser, Susanne, Berrettini, Wade H, Boks, Marco P, Bromet, Evelyn J, Brosch, Katharina, Budde, Monika, Byerley, William, Cervantes, Pablo, Chillotti, Catina, Cichon, Sven, Clark, Scott R, Comes, Ashley L, Corvin, Aiden, Coryell, William, Craddock, Nick, Craig, David W, Croarkin, Paul E, Cruceanu, Cristiana, Czerski, Piotr M, Dalkner, Nina, Dannlowski, Udo, Degenhardt, Franziska, Del Zompo, Maria, DePaulo, J Raymond, Djurovic, Srdjan, Edenberg, Howard J, Eissa, Mariam Al, Elvsåshagen, Torbjørn, Etain, Bruno, Fanous, Ayman H, Fellendorf, Frederike, Fiorentino, Alessia, Forstner, Andreas J, Frye, Mark A, Fullerton, Janice M, Gade, Katrin, Garnham, Julie, Gershon, Elliot, Gill, Michael, Goes, Fernando S, Gordon-Smith, Katherine, Grof, Paul, Guzman-Parra, Jose, Hahn, Tim, Hasler, Roland, Heilbronner, Maria, Heilbronner, Urs, Jamain, Stephane, Jimenez, Esther, Jones, Ian, Jones, Lisa, Jonsson, Lina, Kahn, Rene S, Kelsoe, John R, Kennedy, James L, Kircher, Tilo, Kirov, George, Kittel-Schneider, Sarah, Klöhn-Saghatolislam, Farah, Knowles, James A, Kranz, Thorsten M, Lagerberg, Trine Vik, Landen, Mikael, Lawson, William B, Leboyer, Marion, Li, Qingqin S, Maj, Mario, Malaspina, Dolores, Manchia, Mirko, and Mayoral, Fermin

Subjects
Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group, International Consortium on Lithium Genetics, Colombia-US Cross Disorder Collaboration in Psychiatric Genetics, Humans, Bipolar Disorder, Depressive Disorder, Major, Age of Onset, Multifactorial Inheritance, Genome-Wide Association Study, Autism Spectrum Disorder, Bipolar disorder, GWAS, age at onset, polarity at onset, polygenic score, Genetics, Mental Health, Prevention, Brain Disorders, Serious Mental Illness, 2.1 Biological and endogenous factors, Aetiology, Mental health, Good Health and Well Being, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry
Abstract

BackgroundStudying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.AimsTo examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.MethodGenome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.ResultsEarlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = -0.34 years, s.e. = 0.08), major depression (β = -0.34 years, s.e. = 0.08), schizophrenia (β = -0.39 years, s.e. = 0.08), and educational attainment (β = -0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.ConclusionsAAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.

Published
2021

35. Patient-Level Pooled Analysis of Endovascular Ultrasound Renal Denervation or a Sham Procedure 6 Months After Medication Escalation: The RADIANCE Clinical Trial Program

Author

Azizi, Michel, Sharp, Andrew S.P., Fisher, Naomi D.L., Weber, Michael A., Lobo, Melvin D., Daemen, Joost, Lurz, Philipp, Mahfoud, Felix, Schmieder, Roland E., Basile, Jan, Bloch, Michael J., Saxena, Manish, Wang, Yale, Sanghvi, Kintur, Jenkins, J. Stephen, Devireddy, Chandan, Rader, Florian, Gosse, Philippe, Claude, Lisa, Augustin, Dimitri A., McClure, Candace K., Kirtane, Ajay J., Wang, Yale, Skeik, Nedaa, Bae, Richard, McMeans, Amy, Goldman, JoAnne, Peterson, Rose, Stephen Jenkins, James, Tutor, Isabelle, Harrison, Michael, Penning, Angel, Devireddy, Chandan, Lea, Janice, Fiebach, Amanda, Merlin, Claudia, Rader, Florian, Dohad, Suhail, Tran, Anne, Bhatia, Kirin, Fisher, Naomi D.L., Sobieszczyk, Piotr, Halliday, Ian, Munson, Tay, Lindsey, Jason, Laster, Steven, Bunte, Mathew, Hart, Anthony, King, Dana, Hall, Jamie, Sanghvi, Kintur, Krathen, Courtney, Lewis, Luot, Willitts, Ashley, Todoran, Thomas, Basile, Jan, Awkar, Anthony, Palmer, Casey, Tecklenburg, Anna, Schindler, John, Pacella, John, Muldoon, Matthew, Albright, MaryJo, Nicholson, Tracy, Flack, John, Chami, Youseff, Hafiz, Abdul Moiz, Starkey, Emily, Adams, Kristal, Bernardo, Nelson, Veis, Judith, Hashim, Hayder, Singh, Suman, Whitman, Donna, Stouffer, Rick, Hinderliter, Alan, Allen, Meghan, Scholl, Tatum, Fong, Pete, Gainer, James, Crook, Sherron, Hatchcock, Ellen, Cohen, Debbie, Giri, Jay, Kobayashi, Taisei, Neubauer, Robin, Naidu, Suveeksha, Kirtane, Ajay J., Radhakrishnan, Jai, Batres, Candido, Edwards, Suzanne, Khuddus, Matheen, Zentko, Suzanne, Touchton, Abby, Roberson, Marti, Bloch, Michael J., Akinapelli, Abhilash, English, Lisa, Neumann, Bridget, Mendelsohn, Farrel, Brantley, Hutton, Cawthon, Thomas, DeRamus, Susan, Wade, Wesley, Fishman, Robert, Tuohy, Edward, LeBlanc, Jessica, McCurry, Tina, Krishnaswamy, Amar, Laffin, Luke, Bajzer, Christopher, Boros, Marilyn, Branche, Monica, Abraham, Josephine, Abraham, Anu, Stijleman, Inge, Hsi, David, Martin, Scott, Portnay, Edward, Fiebach, Maryann, Garavito, Carolina, Adams, Todd, Teklinski, Andrew, Leech, Adam, Drilling, Patrick, Tulik, Lynda, Benzuly, Keith, Paparello, James, Fintel, Dan, Ramirez, Haydee, Kats, Lauren, Huang, Paul, Biswas, Santanu, Risher, Serena, Pratt, Kristina, Ibebuogu, Uzoma, Johnson, Karen, Cushman, William, Jones, Lisa, Jackson, Leigh, Landers, David, Pasala, Tilak, Salazer, Thomas, Canino, Peter, Arakelian, Patricia, Yang, Yi-Ming, Khaliq, Asma, Weinberg, Mitchell, Abetu, Yihenew, Gulliver, Alana, Reilly, J.P., Garasic, Joseph, Chugh, Atul, Bertolet, Barry, Go, Brian, Gallapudi, Raghava, Cohn, Joel, Rogers, Kevin, Saxena, Manish, Mathur, Anthony, Jain, Ajay, Balawon, Armida, Zongo, Oliver, Topham, Christine, Sharp, Andrew, Anderson, Richard, Thompson, Elizabeth, Spiro, Nikki, Hodges, Elizabeth, Holder, Jaqueline, Ellam, Timothy, Bagnall, Alan, Jackson, Ralph, Bridgett, Victoria, Wilson, Peter, Das, Neelanjan, Doulton, Timothy, Loader, David, Hector, Gemma, Levy, Terry, Bent, Clare, Kodoth, Vivek, Horler, Stephanie, Nix, Sara, Robinson, Nicholas, Al-Janabi, Firas, Sayer, Jeremy, Ganesh Iyer, Sudha, Redman, Emily, Ramirez, Jonaifah, Padmanabhan, Sandosh, Sharif, Faisal, Alhmoudi, Aishah, Lunardi, Mattia, Coen, Eileen, Glynn, Nicola, Mahfoud, Felix, Lauder, Lucas, Kulenthiran, Saarraaken, Koch, Christina, Wachter, Angelika, Schmieder, Roland, Schmid, Axel, Kannenkeril, Dennis, Heinritz, Ulrike, Endres-Frohlich, Kerstin, Lurz, Philipp, Rommel, Karl, Fengler, Petzold, Martin, Büttner, Margit, Weil, Joachim, Agdirlioglu, Tolga, Köllner, Tanja, Stephan, Jeannine, Dagkonakis, Nikolaos, Hamann, Frank, Ettl, Ute, Petzsche, Ulrike, Reimer, Peter, Hausberg, Martin, Hinrichs, Ralf, Di Ponio-Voit, Isabella, Lutz, Matthias, Gosse, Philippe, Cremer, Antoine, Papadopoulos, Panteleimon, Gaudissard, Julie, Maire, Florent, Azizi, Michel, Sapoval, Marc, Livrozet, Marine, Regrag, Asma, Paquet, Valerie, Delsart, Pascal, Hennicaux, Justin, Sommeville, Coralie, Bertrand, Fabien, Daemen, Joost, Lafeber, Melvin, Zeijen, Victor, Ruiter, Amo, Huijskens, Elisabeth, van Ramshorst, Jan, Xaplanteris, Panagiotis, Briki, Rachid, de Hemptinne, Quentin, Pascal, Severine, Renard, Katty, Ferdinande, Bert, Iglesias, Juan F., Ehert, Georg, Gallego, Laetitia, Dobretz, Kevin, Bottone, Sylviane, Sanghvi, Kintur, Costello, Josh, Krathan, Courtney, Lewis, Luot, McElvarr, Andrew, Reilly, John, Jenkins, Stephen, Cash, Michael, Williams, Shannon, Jarvis, Maria, Fong, Pete, Laffer, Cheryl, Gainer, James, Robbins, Mark, Crook, Sherron, Maddel, Sarita, Hsi, David, Martin, Scott, Portnay, Edward, Ducey, Maryanne, Rose, Suzanne, DelMastro, Elizabeth, Bangalore, Sripal, Williams, Stephen, Cabos, Stanley, Rodriguez Alvarez, Carolina, Todoran, Thomas, Basile, Jan, Powers, Eric, Hodskins, Emily, Paladugu, Vijay, Tecklenburg, Anna, Devireddy, Chandan, Lea, Janice, Wells, Bryan, Fiebach, Amanda, Merlin, Claudia, Rader, Florian, Dohad, Suhail, Kim, Hyun-Min, Rashid, Mohammad, Abraham, Josephine, Owan, Theophilus, Abraham, Anu, Lavasani, Iran, Neilson, Hailey, Calhoun, David, McElderry, Thomas, Maddox, William, Oparil, Suzanne, Kinder, Sheila, Kirtane, Ajay J., Radhakrishnan, Jai, Batres, Candido, Edwards, Suzanne, Garasic, Joseph, Drachman, Doug, Zusman, Randy, Rosenfield, Kenneth, Do, Danny, Khuddus, Matheen, Zentko, Suzanne, O’Meara, James, Barb, Ilie, Foster, Abby, Boyette, Alice, Wang, Yale, Jay, Desmond, Skeik, Nedaa, Schwartz, Robert, Peterson, Rose, Goldman, Jo Anne, Goldman, Jessie, Ledley, Gary, Katof, Nancy, Potluri, Srinivasa, Biedermann, Scott, Ward, Jacquelyn, White, Megan, Fisher, Naomi D.L., Mauri, Laura, Sobieszczky, Piotr, Smith, Alex, Aseltine, Laura, Stouffer, Rick, Hinderliter, Alan, Pauley, Eric, Wade, Tyrone, Zidar, David, Shishehbor, Mehdi, Effron, Barry, Costa, Marco, Semenec, Terence, Bloch, Michael J., Roongsritong, Chanwit, Nelson, Priscilla, Neumann, Bridget, Cohen, Debbie, Giri, Jay, Neubauer, Robin, Vo, Thu, Chugh, Atul R., Huang, Pei-Hsiu, Jose, Powell, Flack, John, Fishman, Robert, Jones, Michael, Adams, Todd, Bajzer, Christopher, Saxena, Manish, Lobo, Melvin D., Mathur, Anthony, Jain, Ajay, Balawon, Armida, Zongo, Olivier, Levy, Terry, Bent, Clare, Beckett, David, Lakeman, Nicki, Kennard, Sarah, Sharp, Andrew, D’Souza, Richard J., Statton, Sarah, Wilkes, Lindsay, Anning, Christine, Sayer, Jeremy, Ganesh Iyer, Sudha, Robinson, Nicholas, Sevillano, Annaliza, Ocampo, Madelaine, Gerber, Robert, Faris, Mohamad, John Marshall, Andrew, Sinclair, Janet, Pepper, Hayley, Davies, Justin, Chapman, Neil, Burak, Paula, Carvelli, Paula, Jadhav, Sachin, Quinn, Jane, Christian Rump, Lars, Stegbauer, Johannes, Schimmöller, Lars, Potthoff, Sebastian, Schmid, Claudia, Roeder, Sylvia, Weil, Joachim, Hafer, Lukas, Agdirlioglu, Tolga, Köllner, Tanja, Mahfoud, Felix, Böhm, Michael, Ewen, Sebastian, Kulenthiran, Saarraaken, Wachter, Angelika, Koch, Christina, Lurz, Philipp, Fengler, Karl, Rommel, Karl-Philipp, Trautmann, Kai, Petzold, Martin, Schmieder, Roland E., Ott, Christian, Schmid, Axel, Uder, Michael, Heinritz, Ulrike, Fröhlich-Endres, Kerstin, Genth-Zotz, Sabine, Kämpfner, Denise, Grawe, Armin, Höhne, Johannes, Kaesberger, Bärbel, von zur Mühlen, Constantin, Wolf, Dennis, Welzel, Markus, Gosse, Philippe, Cremer, Antoine, Trillaud, Hervé, Papadopoulos, Panteleimon, Maire, Florent, Gaudissard, Julie, Azizi, Michel, Sapoval, Marc, Cornu, Erika, Fouassier, David, Livrozet, Marine, Lorthioir, Aurélien, Paquet, Valérie, Pathak, Atul, Honton, Benjamin, Cottin, Marianne, Petit, Frédéric, Lantelme, Pierre, Berge, Constance, Courand, Pierre-Yves, Langevin, Fatou, Delsart, Pascal, Longere, Benjamin, Ledieu, Guillaume, Pontana, François, Sommeville, Coralie, Bertrand, Fabien, Daemen, Joost, Feyz, Lida, Zeijen, Victor, Ruiter, Arno, Huyskens, Elisabeth, Blankestijn, Peter, Voskuil, Michiel, Rittersma, Zwaantina, Dolmans, Helma, Kroon, A.A., van Zwam, W.H., Vranken, Jeannique, de Haan, Claudia, Persu, Alexandre, Renkin, Jean, Maes, Frédéric, Beauloye, Christophe, Lengelé, Jean-Philippe, Huyberechts, Dominique, Bouvier, Anne, Witkowski, Adam, Januszewicz, Andrzej, Kądziela, Jacek, Prejbisj, Aleksander, Hering, Dagmara, Ciecwierz, Dariusz, Jaguszewski, Milosz J., Owczuk, Radoslaw, Ciecwierz, Dariusz, Jaguszewski, Milosz J., Wang, Yale, Jay, Desmond, Skeik, Nedaa, Schwartz, Robert, Rader, Florian, Dohad, Suhail, Victor, Ronald, Sanghvi, Kintur, Costello, Josh, Walsh, Courtney, Abraham, Josephine, Owan, Theophilus, Abraham, Anu, Fisher, Naomi D.L., Mauri, Laura, Sobieszczky, Piotr, Williams, Jonathan, Bloch, Michael J., Roongsritong, Chanwit, Todoran, Thomas, Basile, Jan, Powers, Eric, Hodskins, Emily, Fong, Pete, Laffer, Cheryl, Gainer, James, Robbins, Mark, Reilly, John, Cash, Michael, Goldman, Jessie, Aggarwal, Sandeep, Ledley, Gary, Hsi, David, Martin, Scott, Portnay, Edward, Calhoun, David, McElderry, Thomas, Maddox, William, Oparil, Suzanne, Huang, Pei-Hsiu, Jose, Powell, Khuddus, Matheen, Zentko, Suzanne, O’Meara, James, Barb, Ilie, Garasic, Joseph, Drachman, Doug, Zusman, Randy, Rosenfield, Kenneth, Devireddy, Chandan, Lea, Janice, Wells, Bryan, Stouffer, Rick, Hinderliter, Alan, Pauley, Eric, Potluri, Srinivasa, Biedermann, Scott, Bangalore, Sripal, Williams, Stephen, Zidar, David, Shishehbor, Mehdi, Effron, Barry, Costa, Marco, Kirtane, Ajay J., Radhakrishnan, Jai, Lobo, Melvin D., Mathur, Anthony, Jain, Ajay, Sayer, Jeremy, Ganesh Iyer, Sudha, Robinson, Nicholas, Ali Edroos, Sadat, Levy, Terry, Patel, Amit, Beckett, David, Bent, Clare, Davies, Justin, Chapman, Neil, Shun Shin, Matthew, Howard, James, Sharp, Andrew S.P., Joseph, Anil, D’Souza, Richard, Gerber, Robert, Faris, Mohamad, John Marshall, Andrew, Elorz, Cristina, Lurz, Philipp, Höllriegel, Robert, Fengler, Karl, Rommel, Karl-Philipp, Mahfoud, Felix, Böhm, Michael, Ewen, Sebastian, Lucic, Jelena, Schmieder, Roland E., Ott, Christian, Schmid, Axel, Uder, Michael, Rump, Christian, Stegbauer, Johannes, Kröpil, Patric, Azizi, Michel, Sapoval, Marc, Cornu, Erika, Fouassier, David, Gosse, Philippe, Cremer, Antoine, Trillaud, Hervé, Papadopoulos, Panteleimon, Pathak, Atul, Honton, Benjamin, Lantelme, Pierre, Berge, Constance, Courand, Pierre-Yves, Daemen, Joost, Feyz, Lida, Blankestijn, Peter, Voskuil, Michiel, Rittersma, Zwaantina, Kroon, A.A., van Zwam, W.H., Persu, Alexandre, and Renkin, Jean

Published
2024
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40. The role of shifting baseline syndrome in conservation : linked local ecological knowledge and biological datasets

Author

Jones, Lisa (Lizzie) P.

Subjects
Local Ecological Knowledge, Shifting Baseline Syndrome, Generational Amnesia, Personal Amnesia, Shifting Baselines
Abstract

Local ecological knowledge (LEK) is increasingly recognised as an important source of information for conservation, especially when long-term scientific datasets are inaccessible or non-existent. However, local knowledge and perceptions of environmental change are fundamentally personal and subjective, due to a variety of social and psychological factors. Cognitive biases and phenomena, such as Shifting Baseline Syndrome (SBS) can threaten the exclusion of valuable anecdotal knowledge in conservation research, practice and policy. Under SBS, perceived environmental baselines used to measure change may not accurately represent the true ecological 'starting point', potentially leading to the consistent downgrading of perceived 'normal' conditions with every sequential generation. SBS is therefore considered an increasingly critical issue in the face of accelerating global change, as people are unable to perceive the true extent of ecological degradation, yet very little empirical evidence for SBS exists. This thesis provides a thorough review of the SBS literature (Chapter 1), regarding current evidence for SBS and the causes, consequences, and proposed combat methods of SBS in the context of conservation management, participation, education and environmental policy. The review aims to define key terminology from a multidisciplinary perspective and distinguish SBS from other similar phenomena, combining the fields of social science, psychology, and ecology to reveal key gaps in the SBS literature. Tackling a key research gap identified by the literature review, this thesis provides early empirical evidence for SBS in the context of garden bird population change in the UK (Chapter 3). Following the widely accepted criteria for defining evidence of SBS, social perceptions of local ecological change were statistically compared to long-term biological data to create a measure of paired 'agreement'. Variation in paired agreement was used to identify evidence of both generational and personal amnesia, the two mechanisms thought to drive evidence of SBS. This thesis also offers the first evidence of negative impacts of SBS on public perceptions of conservation priority for species in decline, confirming previous hypotheses regarding the detrimental effects of SBS on conservation support. In investigating differences in evidence of SBS between the UK and Finland, evidence of the impacts of data range restriction and reduced sample size were identified. Data range restriction (hereafter 'range restriction') is a statistical phenomenon, characterised by weakened statistical relationships due to limited variation in the dataset as the observed sample data do not represent the full data range of interest. The effects of data range restriction are explored using comparative modelling of variance in experience of biological change across three unrestricted and range restricted samples. The chapter concludes that range restricted sample size increases of up to 45% to achieve power equivalent to an unrestricted dataset. Combining data in the UK and Finland, areas of agreement and disagreement between perceptions and the biological data are explored across multiple bird species, time points and population parameters (relative abundance and population trends). Patterns in agreement between data sources were identified, revealing situations where the effects of underlying socio-psychological phenomena may be more prominent and where collecting species relative abundance may be more effective than collecting species trends and vice versa. This study indicated that agreement was more likely to vary between species, countries and participants when collecting species relative abundance, and when asking for personal perceptions of species relative abundance, agreement tended to be higher for male participants, those recognised a greater number of species from those who reported a greater number of years birding experience. By contrast, trend agreement varied only between species, indicating that for poorly known species, research on long-term trends may be a more reliable measure of species status than relative abundance. Finally, Chapter 7 provides one of very few studies to investigate the potential implications of SBS on conservation target-setting and decision-making. Previous hypotheses and evidence for SBS in this area are conflicted. There has been speculation as to the presence and impacts of SBS within conservation management since Daniel Pauly's seminal paper on SBS in 1995, however, recent studies have not found evidence for the syndrome. In this study, paired tests investigated experience-related differences in personal perceptions of current, maximum and target abundance (as pairs or territories), long-term trends, and perceived conservation priority for six bird species on participant's local bird or nature reserves. No significant effect of experience was found for all species and power analysis indicated that even if SBS was statistically detectible with a larger sample, the practical implications of the syndrome would be minimal due to small effect sizes, suggesting that SBS may not be as significant a threat in conservation management as first thought.

Published
2021

41. Sentinel Surveillance System Implementation and Evaluation for SARS-CoV-2 Genomic Data, Washington, USA, 2020-2021

Author

Oltean, Hanna N., Allen, Krisandra J., Frisbie, Lauren, Lunn, Stephanie M., Torres, Laura Marcela, Manahan, Lillian, Painter, Ian, Russel, Denny, Singh, Avi, Aric, JohnAric MoonDance, Grant, Kristin, Peter, Cara, Cao, Rebecca, Garcia, Katelynn, Mackellar, Drew, Jones, Lisa, Halstead, Holly, Gray, Hannah, Melly, Geoff, Nickerson, Deborah, Starita, Lea, Frazar, Chris, Greninger, Alexander L., Roychoudhury, Pavitra, Mathias, Patrick C., Kalnoski, Michael H., Ting, Chao-Nan, Lykken, Marisa, and Rice, Tana

Subjects
Washington -- Health aspects, Epidemics -- Statistics -- Genetic aspects, Sentinel health events -- Methods, Data entry -- Methods, Health
Abstract

Virus genome data can provide useful information for public health practice, particularly when combined with epidemiologic data in real time. Goals of genomic surveillance can include monitoring circulating and emerging [...]

Published
2023
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42. Lipid intensive drug therapy for sepsis pilot: A Bayesian phase I clinical trial

Author

Guirgis, Faheem W, Black, Lauren Page, DeVos, Elizabeth, Henson, Morgan, Ferreira, Jason, Miller, Taylor, Rosenthal, Martin, Leeuwenburgh, Christiaan, Kalynych, Colleen, Moldawer, Lyle, Jones, Lisa, Crandall, Marie, Reddy, Srinivasa T, Gao, Hanzhi, Wu, Sam, and Moore, Frederick

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Neurosciences, Infectious Diseases, Clinical Research, Sepsis, Hematology, Clinical Trials and Supportive Activities, Patient Safety, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Inflammatory and immune system, Infection, cholesterol, lipid emulsion, lipids, organ failure, parenteral nutrition, sepsis, septic shock
Abstract

ObjectivesCholesterol may be protective in sepsis. Patients with early sepsis may have critically low cholesterol levels that are associated with poor outcomes. The study objective was to test the safety of a fish oil-containing lipid injectable emulsion for stabilizing early cholesterol levels in sepsis.MethodsPhase I Bayesian optimal interval design trial of adult patients with septic shock (Sequential Organ Failure Assessment score ≥4 or vasopressor dependence). Using sequential dose escalation, participants received 2 doses of 1.0 to 1.6 g/kg of lipid emulsion (Smoflipid 20% lipid emulsion) within 48 hours of enrollment. Cholesterol levels, function, and organ failure were assessed serially during the first 7 days of hospital admission.Measurements and main resultsA total of 10 patients with septic shock were enrolled. One patient withdrew for social reasons. Another patient had an unrelated medical complication and received 1 drug dose. Of 9 patients, mean age was 58 years (SD 16), median Sequential Organ Failure Assessment was 8, and 28-day mortality was 30%. No serious adverse events related to lipid infusion occurred. The six occurrences of non-serious adverse events possibly related to lipid infusion included hyperglycemia (1), elevated triglycerides (3), anemia (1), and vascular access redness/pain (1) for all doses. The mean change in total cholesterol levels from enrollment was -7 (SD 16.6) at 48 hours and 14 (SD 25.2) at 7 days.ConclusionsFish oil-containing lipid emulsion administration during early septic shock was safe. Further studies are needed to assess effects on cholesterol levels, function, and organ failure.Clinical trial registrationNCT03405870.

Published
2020

43. Black Fish in a White Pond: Identity Development of African American Students in Predominately White Suburban Schools

Author

Jones, Lisa A.

Abstract

The issues that African American students face daily in suburban schools are different from what their White counterparts as well as other African American students living in urban areas face. Such issues are grounded in the cultural and social identity development of individuals. Not only do African American students have to learn to deal with the pitfalls of school but they must navigate the murky waters of identity development at the same time. This notion is underscored by Tatum (1997), who pointed out that "the search for personal identity that intensifies in adolescence can involve several dimensions of an adolescent's life: vocational plans, religious beliefs, values, and preferences, political affiliations and beliefs, gender roles, and ethnic identities." This article briefly explores the sociopolitical context of school as it applies to the cultural identity development of African American students and their education in predominately White, middle-class, suburban schools. Topics of discussion include: (1) cultural and social identity development; (2) sociopolitical context of schooling and multicultural education; (3) minority students and the classroom; and (4) addressing the needs of students of color, particularly African Americans, in predominately White, middle-class, suburban schools.

Published
2018

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