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A Schiff base compound derived from naphthalene has been synthesized and characterized as an Al3+-selective fluorescent probe. The chemosensor ( L) exhibits high selectively for Al3+ in aqueous solution, even in the presence of biologically relevant cations such as Na+, K+, Ca2+, Mg2+, Pb2+ and several transition metal ions. There was no observed interference from anions like Br−, Cl−, HSO3−, SO32−, S2O32−, NO2−, CO32− and AC−. The lowest detection limit for the chemosensor L was found to be 1.89 × 10−8 M with a linear response towards Al3+ over a concentration range of 5 × 10−6 to 4 × 10−5 M. Furthermore, the proposed chemosensor has been used for imaging of Al3+ in two different types of cells with satisfying results, which further demonstrates its value for practical application in biological systems. [ABSTRACT FROM AUTHOR]

In this study, we aimed to demonstrate the antidiabetic potential of (E)-N-(4-(3-(5-bromo-4-hydroxy-2-methoxyphenyl)acryloyl) phenyl)-4- tert -butylbenzamide (SN158) through peroxisome proliferator-activated receptor (PPAR)-α/γ dual activation. SN158 interacted with both PPARα and PPARγ, and increased their transcriptional activities. Simultaneously, SN158 treatment led to an increase in adipogenic differentiation of 3T3-L1 preadipocytes and fatty acid oxidation in hepatocytes. In addition, glucose uptake in myotubes was significantly increased by SN158 treatment. Finally, SN158 significantly lowered the plasma levels of glucose, triglycerides, and free fatty acids in ob/ob mice without severe weight gain and hepatomegaly. These results suggest that SN158 can be useful as a potential therapeutic agent against type 2 diabetes and related metabolic disorders by alleviating glucose and lipid abnormalities. [ABSTRACT FROM AUTHOR]