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171 results on '"Jin, Junwei"'

19. Weighted Competitive-Collaborative Representation Based Classifier for Imbalanced Data Classification

Author

Li, Yanting, Wang, Shuai, Jin, Junwei, Philip Chen, C. L., Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Fang, Lu, editor, Povey, Daniel, editor, Zhai, Guangtao, editor, Mei, Tao, editor, and Wang, Ruiping, editor

Published
2022
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29. SP1 transcriptionally activates HTR2B to aggravate traumatic spinal cord injury by shifting microglial M1/M2 polarization.

Author

Xu, Qifei, Kong, Fanguo, Zhao, Guanghui, Jin, Junwei, Feng, Shengkai, and Li, Ming

Subjects
PROTEIN metabolism, BIOLOGICAL models, APOPTOSIS, SPINAL cord injuries, TRANSCRIPTION factors, REVERSE transcriptase polymerase chain reaction, DESCRIPTIVE statistics, MICE, MESSENGER RNA, ANIMAL experimentation, LIPOPOLYSACCHARIDES, OXIDOREDUCTASES, WESTERN immunoblotting, INFLAMMATION, CELL survival, STAINS & staining (Microscopy), CELL receptors, CELLS, INTERLEUKINS, TUMOR necrosis factors, PHENOTYPES, DISEASE complications
Abstract

Background: Spinal cord injury (SCI) can result in structural and functional damage to the spinal cord, which may lead to loss of limb movement and sensation, loss of bowel and bladder control, and other complications. Previous studies have revealed the critical influence of trans-acting transcription factor 1 (SP1) in neurological pathologies, however, its role and mechanism in SCI have not been fully studied. Methods: The study was performed using mouse microglia BV2 stimulated using lipopolysaccharide (LPS) and male adult mice subjected to spinal hitting. Western blotting was performed to detect protein expression of SP1, 5-hydroxytryptamine (serotonin) receptor 2B (HTR2B), BCL2-associated x protein (Bax), B-cell lymphoma-2 (Bcl-2), inducible nitric oxide synthase (iNOS), clusters of differentiation 86 (CD86), Arginase 1 (Arg-1) and clusters of differentiation 206 (CD206). Cell viability and apoptosis were analyzed by MTT assay and TUNEL assay. mRNA levels of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-4 (IL-4) and tumor necrosis factor-β (TNF-β) were quantified by quantitative real-time polymerase chain reaction. The association of SP1 and HTR2B was identified by chromatin immunoprecipitation assay and dual-luciferase reporter assay. HE staining assay was performed to analyze the pathological conditions of spinal cord tissues. Results: LPS treatment induced cell apoptosis and inhibited microglia polarization from M1 to M2 phenotype, accompanied by an increase of Bax protein expression and a decrease of Bcl-2 protein expression, however, these effects were relieved after SP1 silencing. Mechanism assays revealed that SP1 transcriptionally activated HTR2B in BV2 cells, and HTR2B knockdown rescued LPS-induced effects on BV2 cell apoptosis and microglial M1/M2 polarization. Moreover, SP1 absence inhibited BV2 cell apoptosis and promoted microglia polarization from M1 to M2 phenotype by decreasing HTR2B expression. SCI mouse model assay further showed that SP1 downregulation could attenuate spinal hitting-induced promoting effects on cell apoptosis of spinal cord tissues and microglial M1 polarization. Conclusion: SP1 transcriptionally activated HTR2B to aggravate traumatic SCI by shifting microglial M1/M2 polarization. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Pteris vittata plantation decrease colloidal phosphorus contents by reducing degree of phosphorus saturation in manure amended soils

Author

Sangar Khan, Miaomiao He, Paul J. Milham, Jin Junwei, Kamel Mohamed Eltohamy, Xinqiang Liang, Fayong Li, and Yasir Hamid

Subjects
Cambisol, Environmental Engineering, biology, Phosphorus, chemistry.chemical_element, Pteris, General Medicine, Management, Monitoring, Policy and Law, engineering.material, biology.organism_classification, Manure, Soil, Nutrient, chemistry, Environmental chemistry, Pteris vittata, Soil water, engineering, Anthrosol, Fertilizer, Waste Management and Disposal, Ecosystem
Abstract

The agricultural use of manure fertilizer increases the phosphorus (P) saturation of soils and the risk of colloidal P (Pcoll) release to aquatic ecosystems. Two experiments were conducted to identify whether Pteris vittata plantation can decrease Pcoll contents in two soils (Cambisol and Anthrosol) amended with various manure P rates (0, 10, 25, and 50 mg P kg−1 of soil). The total Pcoll contents in manured soil without P. vittata were 1.14–3.37 mg kg−1 (Cambisol), and 0.01–2.83 mg kg−1 (Anthrosol) across manure-P rates. The corresponding values with P. vittata were 0.97–2.33 mg kg−1 (Cambisol) and 0.005–1.6 mg kg−1 (Anthrosol). Experimentally determined colloidal minerals (Fe, Al, Ca), colloidal total organic carbon, Mehlich−3 nutrients (Fe, Al, and Ca), and the degree of P saturation were good predictors of Pcoll concentrations in both soils with and without P. vittata plantation. In unplanted soils, P adsorption decreased and the degree of P saturation increased which released more Pcoll. However, P. vittata plantation decreased the Pcoll release and P loss risk due to the increase of P adsorption and reduced DPS in both soils. The P fractions (NaOH, NH4F, and HCl–P) contributed to increase the P pool in planted soils which enhanced the bioavailability of Pcoll and increased the P. vittata biomass. It suggested that P. vittata plantation was an effective approach to reduce Pcoll release from manure amended soils.

Published
2021

50. A Framework for Interpreting Lateral Swelling Pressure in Unsaturated Expansive Soils

Author

Jin Junwei, Li Mingyu, Yunlong Liu, and Wei Yanqing

Subjects
021110 strategic, defence & security studies, Article Subject, Expansive clay, 0211 other engineering and technologies, Foundation (engineering), Swelling pressure, 02 engineering and technology, Engineering (General). Civil engineering (General), Key factors, Geotechnical engineering, Boundary value problem, TA1-2040, Pile, Civil infrastructure, Soil mechanics, Geology, 021101 geological & geomatics engineering, Civil and Structural Engineering
Abstract

Lateral swelling pressure (LSP) develops when expansive soil volume increment associated with water infiltration is restrained in a confined domain, for example, due to construction of civil infrastructure. In this paper, initially a flowchart is developed to highlight various key factors that influence the LSP mobilization according to lab and field studies collected from previous literature studies. Then extending unsaturated soil mechanics, a theoretical framework is proposed for illustrating the LSP mobilization in the field against retaining structures and pile foundations under different boundary conditions, respectively. An example problem for a basement wall and a pile foundation constructed in a typical expansive soil from Regina, Canada, is presented to illustrate the proposed theoretical framework. The framework and corresponding analysis presented in this paper can facilitate to provide rational designs of geotechnical infrastructures in expansive soils.

Published
2021

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