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Your search keyword '"Jia-Bi Liang"' showing total 3 results
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3 results on '"Jia-Bi Liang"'

1. A novel DNA damage repair-related signature for predicting prognositc and treatment response in non-small lung cancer

Author

Ling Li, Bao-jia Zou, Juan-zhi Zhao, Jia-bi Liang, Zi-yue She, Wen-ying Zhou, Si-xiao Lin, Lin Tian, Wen-ji Luo, and Fa-zhong He

Subjects
non-small lung cancer (NSCLC), tumor microenvironment, DNA damage repair-based prognostic signature, NSCLC classification, biomarker, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

DNA damage repair (DDR) is essential for maintaining genome integrity and modulating cancer risk, progression, and therapeutic response. DDR defects are common among non-small lung cancer (NSCLC), resulting in new challenge and promise for NSCLC treatment. Thus, a thorough understanding of the molecular characteristics of DDR in NSCLC is helpful for NSCLC treatment and management. Here, we systematically analyzed the relationship between DDR alterations and NSCLC prognosis, and successfully established and validated a six-DDR gene prognostic model via LASSO Cox regression analysis based on the expression of prognostic related DDR genes, CDC25C, NEIL3, H2AFX, NBN, XRCC5, RAD1. According to this model, NSCLC patients were classified into high-risk subtype and low-risk subtype, each of which has significant differences between the two subtypes in clinical features, molecular features, immune cell components, gene mutations, DDR pathway activation status and clinical outcomes. The high-risk patients was characterized with worse prognosis, lower proportion and number of DDR mutations, unique immune profile and responsive to immunetherapy. And the low-risk patients tend to have superior survival, while being less responsive to immunotherapy and more sensitive to treatment with DNA-damaging chemotherapy drugs. Overall, this molecular classification based on DDR expression profile enables hierarchical management of patients and personalized clinical treatment, and provides potential therapeutic targets for NSCLC.

Published
2022
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3. Impact of a pharmacist-led education and follow-up service on anticoagulation control and safety outcomes at a tertiary hospital in China: a randomised controlled trial

Author

Henry Hoi-Yee Tong, Lin Tian, Alexandre Chan, Hui-Min Wu, Jia-Bi Liang, Cheng-Kin Lao, and Ying-Ying Yang

Subjects
Adult, Male, medicine.medical_specialty, China, 020205 medical informatics, Pharmacist, Warfarin therapy, Pharmaceutical Science, 02 engineering and technology, Pharmacy, 030204 cardiovascular system & hematology, Target range, Pharmacists, law.invention, Tertiary Care Centers, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Patient Education as Topic, law, Internal medicine, Statistical significance, 0202 electrical engineering, electronic engineering, information engineering, medicine, Humans, International Normalized Ratio, Prospective Studies, Aged, business.industry, Health Policy, Public Health, Environmental and Occupational Health, Warfarin, On warfarin, Anticoagulants, Middle Aged, Usual care, Female, business, Pharmacy Service, Hospital, medicine.drug, Follow-Up Studies
Abstract

Objectives This study was designed to evaluate the impact of a pharmacist-led anticoagulation service on international normalised ratio (INR) control and other outcomes among patients receiving warfarin therapy at a tertiary hospital in Zhuhai, China. Methods In this randomised controlled trial, adult patients who were newly initiated on warfarin with intended treatment duration of at least 3 months were recruited. Participants were randomly allocated to receive the pharmacist-led education and follow-up service (PEFS) or usual care (UC). Anticoagulation control was calculated as the proportions of time within the target INR range (TTR) and time within the expanded target range (TER). Key findings A total of 152 participants (77 in the PEFS group and 75 in the UC group) were included. Within 180 days after hospital discharge, the PEFS group spent more TER than the UC group (54.4% versus 42.0%; P = 0.024), whereas the difference in TTR did not reach statistical significance (35.9% versus 29.5%; P = 0.203). No major bleeding events were observed, and the cumulative incidences of major thromboembolic events (6.5% versus 9.3%) and mortality (1.3% versus 1.3%) were similar between the two groups (P> 0.05). At 30 days postdischarge, the PEFS group had better warfarin knowledge by answering 57.5% of questions correctly, compared with the UC group (43.0%) (P = 0.003). Conclusions The PEFS markedly enhanced anticoagulation control and warfarin knowledge but there was room for improvement. The expansion of pharmacists’ clinical role and the development of more effective education and follow-up strategies are warranted to optimise anticoagulation management services in China.

Published
2019

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