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17 results on '"Jeong, Dongjin"'

9. Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

Author

Jeong, Dongjin, primary, Kim, Hye Sung, additional, Kim, Hye Young, additional, Kang, Min Jueng, additional, Jung, Hyeryeon, additional, Oh, Yumi, additional, Kim, Donghyun, additional, Koh, Jaemoon, additional, Cho, Sung-Yup, additional, Jeon, Yoon Kyung, additional, Lee, Eun Bong, additional, Lee, Seung Hyo, additional, Shin, Eui-Cheol, additional, Kim, Ho Min, additional, Yi, Eugene C, additional, and Chung, Doo Hyun, additional

Published
2021
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11. Author response: Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2

Author

Jeong, Dongjin, primary, Kim, Hye Sung, additional, Kim, Hye Young, additional, Kang, Min Jueng, additional, Jung, Hyeryeon, additional, Oh, Yumi, additional, Kim, Donghyun, additional, Koh, Jaemoon, additional, Cho, Sung-Yup, additional, Jeon, Yoon Kyung, additional, Lee, Eun Bong, additional, Lee, Seung Hyo, additional, Shin, Eui-Cheol, additional, Kim, Ho Min, additional, Yi, Eugene C, additional, and Chung, Doo Hyun, additional

Published
2019
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15. Estimation of the Effect of Self-Driving and En Route Preparation in Urban Parcel Delivery: The Case in Seoul

Author

Lee, Keyju, Jeong, Dongjin, and Chae, Junjae

Abstract

Self-driving technology is on the verge of commercialization and is expected to be utilized in delivery services. At the same time, low efficiency and physical limitations of last mile robots (especially for non-standardized cargo, stairs, etc.) are being pointed out. In addition, as leading overseas companies design robots to complete delivery through interaction with the recipient, it may be difficult to implement the robots in delivery environments like South Korea, where most parcels are not delivered face-to-face. Therefore, this study considers a parcel delivery model in which a person, not a robot, is on-board an autonomous truck for door-to-door deliveries. This study takes three expected effects of a self-driving vehicle into consideration: (i) reduced travel time, owing to alleviation of traffic congestion; (ii) reduced service time, owing to relaxed parking restrictions; and (iii) benefits from en route preparation (planning and collecting in advance of arrival) that can be realized when a person is not required in the driver’s seat. The findings from a case study conducted in Seoul indicate that advanced self-driving capabilities and en route preparation can potentially lead to a doubling of the delivery capacity at a terminal, along with a reduction of over 40% in operating costs per box. As suggested in this study, the en route preparation activities are verified to bring benefits.

Published
2024
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17. Sodium chloride inhibits IFN‐γ, but not IL‐4, production by invariant NKT cells.

Author

Jeong, Dongjin, Kim, Hye Young, and Chung, Doo Hyun

Subjects
SALT, KNOCKOUT mice, T cells, CELLS, CELL physiology
Abstract

Abstract: Invariant NKT (iNKT) cells are a distinct subset of T cells that exert Janus‐like functions in vivo by producing IFN‐γ and IL‐4. Sodium chloride modulates the functions of various immune cells, including conventional CD4+ T cells and macrophages. However, it is not known whether sodium chloride affects iNKT cell function, so we addressed this issue. Sodium chloride inhibited IFN‐γ, but not IL‐4, production by iNKT cells upon TCR or TCR‐independent (IL‐12 and IL‐18) stimulation in a dose‐dependent manner. Consistently, sodium chloride reduced the expression level of tbx21, but not gata‐3, in iNKT cells stimulated with TCR engagement or IL‐12 + IL‐18. Sodium chloride increased phosphorylated p38 expression in iNKT cells and inhibitors of p38, NFAT5, SGK1, and TCF‐1 restored IFN‐γ production by iNKT cells stimulated with sodium chloride and TCR engagement. Furthermore, adoptive transfer of iNKT cells pretreated with sodium chloride restored antibody‐induced joint inflammation to a lesser extent than for untreated iNKT cells in Jα18 knockout mice. These findings suggest that sodium chloride inhibits IFN‐γ production by iNKT cells in TCR‐dependent and TCR‐independent manners, which is dependent on p38, NFAT5, SGK1, and TCF‐1. These findings highlight the functional role of sodium chloride in iNKT cell‐mediated inflammatory diseases. [ABSTRACT FROM AUTHOR]

Published
2018
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