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Your search keyword '"Jackling, Felicity C."' showing total 7 results
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7 results on '"Jackling, Felicity C."'

1. Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2 mutation carriers

Author

Joyce, Rachel, Pascual, Rosa, Heitink, Luuk, Capaldo, Bianca D., Vaillant, François, Christie, Michael, Tsai, Minhsuang, Surgenor, Elliot, Anttila, Casey J. A., Rajasekhar, Pradeep, Jackling, Felicity C., Trussart, Marie, Milevskiy, Michael J. G., Song, Xiaoyu, Li, Mengbo, Teh, Charis E., Gray, Daniel H. D., Smyth, Gordon K., Chen, Yunshun, Lindeman, Geoffrey J., and Visvader, Jane E.

Published
2024
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2. Ehf controls mammary alveolar lineage differentiation and is a putative suppressor of breast tumorigenesis

Author

Nightingale, Rebecca, Reehorst, Camilla M., Vukelic, Natalia, Papadopoulos, Nikolaos, Liao, Yang, Guleria, Shalini, Bell, Caroline, Vaillant, François, Paul, Sudip, Luk, Ian Y., Dhillon, Amardeep S., Jenkins, Laura J., Morrow, Riley J., Jackling, Felicity C., Chand, Ashwini L., Chisanga, David, Chen, Yunshun, Williams, David S., Anderson, Robin L., Ellis, Sarah, Meikle, Peter J., Shi, Wei, Visvader, Jane E., Pal, Bhupinder, and Mariadason, John M.

Published
2024
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3. Identification of aberrant luminal progenitors and mTORC1 as a potential breast cancer prevention target in BRCA2mutation carriers

Author

Joyce, Rachel, Pascual, Rosa, Heitink, Luuk, Capaldo, Bianca D., Vaillant, François, Christie, Michael, Tsai, Minhsuang, Surgenor, Elliot, Anttila, Casey J. A., Rajasekhar, Pradeep, Jackling, Felicity C., Trussart, Marie, Milevskiy, Michael J. G., Song, Xiaoyu, Li, Mengbo, Teh, Charis E., Gray, Daniel H. D., Smyth, Gordon K., Chen, Yunshun, Lindeman, Geoffrey J., and Visvader, Jane E.

Abstract

Inheritance of a BRCA2pathogenic variant conveys a substantial life-time risk of breast cancer. Identification of the cell(s)-of-origin of BRCA2-mutant breast cancer and targetable perturbations that contribute to transformation remains an unmet need for these individuals who frequently undergo prophylactic mastectomy. Using preneoplastic specimens from age-matched, premenopausal females, here we show broad dysregulation across the luminal compartment in BRCA2mut/+tissue, including expansion of aberrant ERBB3loluminal progenitor and mature cells, and the presence of atypical oestrogen receptor (ER)-positive lesions. Transcriptional profiling and functional assays revealed perturbed proteostasis and translation in ERBB3loprogenitors in BRCA2mut/+breast tissue, independent of ageing. Similar molecular perturbations marked tumours bearing BRCA2-truncating mutations. ERBB3loprogenitors could generate both ER+and ER−cells, potentially serving as cells-of-origin for ER-positive or triple-negative cancers. Short-term treatment with an mTORC1 inhibitor substantially curtailed tumorigenesis in a preclinical model of BRCA2-deficient breast cancer, thus uncovering a potential prevention strategy for BRCA2mutation carriers.

Published
2024
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5. Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging

Author

Rios, Anne C., primary, Capaldo, Bianca D., additional, Vaillant, François, additional, Pal, Bhupinder, additional, van Ineveld, Ravian, additional, Dawson, Caleb A., additional, Chen, Yunshun, additional, Nolan, Emma, additional, Fu, Nai Yang, additional, Jackling, Felicity C., additional, Devi, Sapna, additional, Clouston, David, additional, Whitehead, Lachlan, additional, Smyth, Gordon K., additional, Mueller, Scott N., additional, Lindeman, Geoffrey J., additional, and Visvader, Jane E., additional

Published
2019
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6. Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence

Author

Fu, Nai Yang, primary, Pal, Bhupinder, additional, Chen, Yunshun, additional, Jackling, Felicity C., additional, Milevskiy, Michael, additional, Vaillant, François, additional, Capaldo, Bianca D., additional, Guo, Fusheng, additional, Liu, Kevin H., additional, Rios, Anne C., additional, Lim, Nicholas, additional, Kueh, Andrew J., additional, Virshup, David M., additional, Herold, Marco J., additional, Tucker, Haley O., additional, Smyth, Gordon K., additional, Lindeman, Geoffrey J., additional, and Visvader, Jane E., additional

Published
2018
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7. Construction of developmental lineage relationships in the mouse mammary gland by single-cell RNA profiling

Author

Pal, Bhupinder, primary, Chen, Yunshun, additional, Vaillant, François, additional, Jamieson, Paul, additional, Gordon, Lavinia, additional, Rios, Anne C., additional, Wilcox, Stephen, additional, Fu, Naiyang, additional, Liu, Kevin He, additional, Jackling, Felicity C., additional, Davis, Melissa J., additional, Lindeman, Geoffrey J., additional, Smyth, Gordon K., additional, and Visvader, Jane E., additional

Published
2017
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