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2. Design Optimization of a Small-animal SPECT System Using LGSO Continuous Crystal and a Micro Parallel-hole Collimator

Author

Kim, Joong Hyun, Ito, Mikiko, Kim, Soo Mee, Hong, Seong Jong, and Lee, Jae Sung

Subjects
Physics - Medical Physics, Physics - Instrumentation and Detectors
Abstract

The aim of this study was to optimize the design of a monolithic LGSO scintillation crystal and micro parallel-hole collimator for the development of a small-animal single photon emission computed tomography (SPECT) system with compact size, low-cost and reasonable performance through Monte Carlo simulation. L0.9GSO crystals with surface area of 50 mm X 50 mm were investigated for the design optimization. The intrinsic detection efficiency, intrinsic spatial resolution, and intrinsic energy resolution of crystals were estimated for different crystal thicknesses and photon energies (using I-125 and Tc-99m sources). Two kinds of surface treatments (providing polished and rough surfaces) were compared by optical photon simulation. The standard deviation of the angle between a micro-facet and the mean surface was set to 0.1 and 6.0 for polished and rough surfaces, respectively. For comparison, the intrinsic performance of NaI(Tl) was also investigated. A multi-photomultiplier tube was designed with 16 X 16 anode pixels having size of 2.8 mm X 2.8 mm and pitch of 3.04 mm, and a 1.5 mm thickness glass window. The length of the micro collimator was also optimized. Finally, the performance of the SPECT system was assessed and an ultra-micro hot spot phantom image was obtained in simulation. The 1-mm-thick LGSO was sufficient to detect most incident photons from I-125 but a thickness of 3 mm was required for Tc-99m imaging. Polished crystal yielded better intrinsic spatial resolution (~540 {\mu}m) and lower light output than rough crystal. Energy resolutions of I-125 and Tc-99m were ~36.9% and ~19.1%. With the optimized collimator length, spatial resolution of ~1 mm and sensitivity of ~100 cps/MBq were achieved with a four-head SPECT system. A hot rod with a diameter of 1.0 mm was resolved in the SPECT image of ultra-micro hot spot phantom., Comment: 19 pages of text, 2 tables, and 7 figures

Published
2015

5. Performance Evaluation of a Mobile Digital Tomosynthesis System Using a Moving CNT-Based Tube Array for Extremity Scans

Author

Ito, Mikiko, Han, Dahea, Kim, Tae-Hyung, Kim, Young-Tae, Lee, Sungeun, Soh, Jeongtae, Jung, Young-Jun, and Lee, Byungkee

Abstract

Digital tomosynthesis (DTS) can enhance diagnostic accuracy by providing 3-D volume images with a remarkably low-X-ray dose. The aim of this study is to provide an initial assessment of the image quality and the X-ray dose for a mobile DTS system employing a moving carbon-nanotube (CNT)-based digital X-ray source array and a fixed detector for extremity scans. This design allows to reduce the source-to-detector distance (SDD) to only 400 mm, thereby enabling a compact and highly mobile system. We first measured the entrance surface dose (ESD), which is the sum of the X-ray dose irradiated from individual projections using a dosimeter placed at the center of the X-ray detector. The ESDs obtained for hand, foot, and knee scan configurations were 0.15, 0.22, and 0.43 mGy, respectively, which were comparable to those obtained from 2-D radiography exposures. For the evaluation of its reconstructed image quality, the in-plane modulation transfer function (MTF), Z-resolution, geometry distortion, and image homogeneity were assessed by utilizing a wire-phantom, sphere-phantom, and PMMA phantoms. The reconstructed images of hand, ankle and knee phantoms were evaluated qualitatively. The results of the evaluation demonstrate the successful development of the mobile DTS system proposed in this article.

Published
2024
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6. Duloxetine improves chronic orofacial pain and comorbid depressive symptoms in association with reduction of serotonin transporter protein through upregulation of ubiquitinated serotonin transporter protein

Author

Nakamura, Mariko, primary, Yoshimi, Akira, additional, Tokura, Tatsuya, additional, Kimura, Hiroyuki, additional, Kishi, Shinichi, additional, Miyauchi, Tomoya, additional, Iwamoto, Kunihiro, additional, Ito, Mikiko, additional, Sato-Boku, Aiji, additional, Mouri, Akihiro, additional, Nabeshima, Toshitaka, additional, Ozaki, Norio, additional, and Noda, Yukihiro, additional

Published
2024
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13. Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorder

Author

Sakurai, Masashi, Yamamoto, Yasuko, Kanayama, Noriyo, Hasegawa, Masaya, Mouri, Akihiro, Takemura, Masao, Matsunami, Hidetoshi, Miyauchi, Tomoya, Tokura, Tatsuya, Kimura, Hiroyuki, Ito, Mikiko, Umemura, Eri, (Boku), Aiji Sato, Nagashima, Wataru, Tonoike, Takashi, Kurita, Kenichi, Ozaki, Norio, Nabeshima, Toshitaka, and Saito, Kuniaki

Published
2020
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18. Failure modes and effects analysis study for accelerator‐based Boron Neutron Capture Therapy

Author

Takemori, Mihiro, primary, Nakamura, Satoshi, additional, Sofue, Toshimitsu, additional, Ito, Mikiko, additional, Goka, Tomonori, additional, Miura, Yuki, additional, Iijima, Kotaro, additional, Chiba, Takahito, additional, Nakayama, Hiroki, additional, Nakaichi, Tetsu, additional, Mikasa, Shohei, additional, Takano, Yuki, additional, Kon, Mitsuhiro, additional, Shuto, Yasunori, additional, Urago, Yuka, additional, Nishitani, Masato, additional, Kashihara, Tairo, additional, Takahashi, Kana, additional, Murakami, Naoya, additional, Nishio, Teiji, additional, Okamoto, Hiroyuki, additional, Chang, Weishan, additional, and Igaki, Hiroshi, additional

Published
2022
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22. Association between effect of duloxetine on chronic orofacial pain and expression of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia

Author

Mariko, Nakamura, primary, Yoshimi, Akira, additional, Mouri, Akihiro, additional, Tokura, Tatsuya, additional, Kimura, Hiroyuki, additional, Kishi, Shinichi, additional, Miyauchi, Tomoya, additional, Iwamoto, Kunihiro, additional, Ito, Mikiko, additional, Sato, Aiji, additional, Ozaki, Norio, additional, Nabeshima, Toshitaka, additional, and Noda, Yukihiro, additional

Published
2022
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23. SAFIR-I: Design and Performance of a High-Rate Preclinical PET Insert for MRI

Author

Bebié, Pascal, Becker, Robert, Commichau, Volker, Debus, Jan, Dissertori, Günther, Djambazov, Lubomir, Eleftheriou, Afroditi, Fischer, Jannis, Fischer, Peter, Ito, Mikiko, Khateri, Parisa, Lustermann, Werner, Ritzer, Christian, Ritzert, Michael, Röser, Ulf, Tsoumpas, Charalampos, Warnock, Geoffrey, Weber, Bruno, Wyss, Matthias T., and Zagozdzinska-Bochenek, Agnieszka

Subjects
Photons, high frame rates, Phantoms, Imaging, Chemical technology, MathematicsofComputing_GENERAL, Equipment Design, TP1-1185, dynamic PET/MR imaging, PET detector, Magnetic Resonance Imaging, Article, Rats, preclinical PET/MRI, Kinetics, Mice, TheoryofComputation_MATHEMATICALLOGICANDFORMALLANGUAGES, 5 s time frames, Positron-Emission Tomography, Animals, PET insert, temporal resolution, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), MRI
Abstract

(1) Background: Small Animal Fast Insert for MRI detector I (SAFIR-I) is a preclinical Positron Emission Tomography (PET) insert for the Bruker BioSpec 70/30 Ultra Shield Refrigerated (USR) preclinical 7T Magnetic Resonance Imaging (MRI) system. It is designed explicitly for high-rate kinetic studies in mice and rats with injected activities reaching 500MBq, enabling truly simultaneous quantitative PET and Magnetic Resonance (MR) imaging with time frames of a few seconds in length. (2) Methods: SAFIR-I has an axial field of view of 54.2mm and an inner diameter of 114mm. It employs Lutetium Yttrium OxyorthoSilicate (LYSO) crystals and Multi Pixel Photon Counter (MPPC) arrays. The Position-Energy-Timing Application Specific Integrated Circuit, version 6, Single Ended (PETA6SE) digitizes the MPPC signals and provides time stamps and energy information. (3) Results: SAFIR-I is MR-compatible. The system’s Coincidence Resolving Time (CRT) and energy resolution are between separate-uncertainty 209.0(3)ps and separate-uncertainty 12.41(02) Full Width at Half Maximum (FWHM) at low activity and separate-uncertainty 326.89(12)ps and separate-uncertainty 20.630(011) FWHM at 550MBq, respectively. The peak sensitivity is ∼1.6. The excellent performance facilitated the successful execution of first in vivo rat studies beyond 300MBq. Based on features visible in the acquired images, we estimate the spatial resolution to be ∼2mm in the center of the Field Of View (FOV). (4) Conclusion: The SAFIR-I PET insert provides excellent performance, permitting simultaneous in vivo small animal PET/MR image acquisitions with time frames of a few seconds in length at activities of up to 500MBq.

Published
2021

24. Failure modes and effects analysis study for accelerator‐based Boron Neutron Capture Therapy.

Author

Takemori, Mihiro, Nakamura, Satoshi, Sofue, Toshimitsu, Ito, Mikiko, Goka, Tomonori, Miura, Yuki, Iijima, Kotaro, Chiba, Takahito, Nakayama, Hiroki, Nakaichi, Tetsu, Mikasa, Shohei, Takano, Yuki, Kon, Mitsuhiro, Shuto, Yasunori, Urago, Yuka, Nishitani, Masato, Kashihara, Tairo, Takahashi, Kana, Murakami, Naoya, and Nishio, Teiji

Subjects
BORON-neutron capture therapy, FAILURE mode & effects analysis, PHYSICIANS, QUALITY control, RADIOLOGIC technologists
Abstract

Background: Boron Neutron Capture Therapy (BNCT) has recently been used in clinical oncology thanks to recent developments of accelerator‐based BNCT systems. Although there are some specific processes for BNCT, they have not yet been discussed in detail. Purpose: The aim of this study is to provide comprehensive data on the risk of accelerator‐based BNCT system to institutions planning to implement an accelerator‐based BNCT system. Methods: In this study, failure mode and effects analysis (FMEA) was performed based on a treatment process map prepared for the accelerator‐based BNCT system. A multidisciplinary team consisting of a medical doctor (MD), a registered nurse (RN), two medical physicists (MP), and three radiologic technologists (RT) identified the failure modes (FMs). Occurrence (O), severity (S), and detectability (D) were scored on a scale of 10, respectively. For each failure mode (FM), risk priority number (RPN) was calculated by multiplying the values of O, S, and D, and it was then categorized as high risk, very high risk, and other. Additionally, FMs were statistically compared in terms of countermeasures, associated occupations, and whether or not they were the patient‐derived. Results: The identified FMs for BNCT were 165 in which 30 and 17 FMs were classified as high risk and very high risk, respectively. Additionally, 71 FMs were accelerator‐based BNCT‐specific FMs in which 18 and 5 FMs were classified as high risk and very high risk, respectively. The FMs for which countermeasures were "Education" or "Confirmation" were statistically significantly higher for S than the others (p = 0.019). As the number of BNCT facilities is expected to increase, staff education is even more important. Comparing patient‐derived and other FMs, O tended to be higher in patient‐derived FMs. This could be because the non‐patient‐derived FMs included events that could be controlled by software, whereas the patient‐derived FMs were impossible to prevent and might also depend on the patient's condition. Alternatively, there were non‐patient‐derived FMs with higher D, which were difficult to detect mechanically and were classified as more than high risk. In O, significantly higher values (p = 0.096) were found for FMs from MD and RN associated with much patient intervention compared to FMs from MP and RT less patient intervention. Comparing conventional radiotherapy and accelerator‐based BNCT, although there were events with comparable risk in same FMs, there were also events with different risk in same FMs. They could be related to differences in the physical characteristics of the two modalities. Conclusions: This study is the first report for conducting a risk analysis for BNCT using FMEA. Thus, this study provides comprehensive data needed for quality assurance/quality control (QA/QC) in the treatment process for facilities considering the implementation of accelerator‐based BNCT in the future. Because many BNCT‐specific risks were discussed, it is important to understand the characteristics of BNCT and to take adequate measures in advance. If the effects of all FMs and countermeasures are discussed by multidisciplinary team, it will be possible to take countermeasures against individual FMs from many perspectives and provide BNCT more safely and effectively. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Duloxetine attenuates pain in association with downregulation of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia

Author

Nakamura, Mariko, primary, Yoshimi, Akira, additional, Mouri, Akihiro, additional, Tokura, Tatsuya, additional, Kimura, Hiroyuki, additional, Kishi, Shinichi, additional, Miyauchi, Tomoya, additional, Iwamoto, Kunihiro, additional, Ito, Mikiko, additional, Sato‐Boku, Aiji, additional, Ozaki, Norio, additional, Nabeshima, Toshitaka, additional, and Noda, Yukihiro, additional

Published
2021
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28. ヒト腎臓におけるリン代謝機構を理解するためのオポッサム腎NaPi-IIc (Na+依存性Piトランスポーター)の解析

Author

Fujii, Toru, Shiozaki, Yuji, Segawa, Hiroko, Nishiguchi, Shiori, Hanazaki, Ai, Noguchi, Miwa, Kirino, Ruri, Sasaki, Sumire, Tanifuji, Kazuya, Koike, Megumi, Yokoyama, Mizuki, Arima, Yuki, Kaneko, Ichiro, Tatsumi, Sawako, Ito, Mikiko, and Miyamoto, Ken-ichi

Subjects
Hereditary hypophosphatemic rickets with hypercalciuria, Proximal tubule, Phosphate, Transporter
Abstract

Background The role of Na+- dependent inorganic phosphate (Pi) transporters in the human kidney is not fully clarified. Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is caused by loss-of-function mutations in the IIc Na+- dependent Pi transporter (NPT2c/Npt2c/NaPi-IIc) gene. Another Na+- dependent type II transporter, (NPT2A/Npt2a/NaPi-IIa), is also important for renal Pi reabsorption in humans. In mice, Npt2c deletion does not lead to hypophosphatemia and rickets because Npt2a compensates for the impaired Pi reabsorption. To clarify the differences between mouse and human, we investigated the relation between NaPi-IIa and NaPi-IIc functions in opossum kidney (OK) cells. Methods We cloned NaPi-IIc from OK cells and created opossum NaPi-IIc (oNaPi-IIc) antibodies. We used oNaPi-IIc small interference (si)RNA and investigated the role of NaPi-IIc in Pi transport in OK cells. Results We cloned opossum kidney NaPi-IIc cDNAs encoding 622 amino acid proteins (variant1) and examined their pH- and sodium-dependency. The antibodies reacted specifically with 75-kDa and 150-kDa protein bands, and the siRNA of NaPi-IIc markedly suppressed endogenous oNaPi-IIc in OK cells. Treatment with siRNA significantly suppressed the expression of NaPi-4 (NaPi-IIa) protein and mRNA. oNaPi-IIc siRNA also suppressed Na+/H+ exchanger regulatory factor 1 expression in OK cells. Conclusion These findings suggest that NaPi-IIc is important for the expression of NaPi-IIa (NaPi-4) protein in OK cells. Suppression of Npt2c may downregulate Npt2a function in HHRH patients.

Published
2018

31. Initial Characterization of the SAFIR Prototype PET-MR Scanner

Author

Ritzer, Christian, primary, Becker, Robert, additional, Buck, Alfred, additional, Commichau, Volker, additional, Debus, Jan, additional, Djambazov, Lubomir, additional, Eleftheriou, Afroditi, additional, Fischer, Jannis, additional, Fischer, Peter, additional, Ito, Mikiko, additional, Khateri, Parisa, additional, Lustermann, Werner, additional, Ritzert, Michael, additional, Roser, Ulf, additional, Rudin, Markus, additional, Sacco, Ilaria, additional, Tsoumpas, Charalampos, additional, Warnock, Geoffrey, additional, Wyss, Matthias, additional, Zagozdzinska-Bochenek, Agnieszka, additional, Weber, Bruno, additional, and Dissertori, Gunther, additional

Published
2020
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34. Duloxetine attenuates pain in association with downregulation of platelet serotonin transporter in patients with burning mouth syndrome and atypical odontalgia.

Author

Nakamura, Mariko, Yoshimi, Akira, Mouri, Akihiro, Tokura, Tatsuya, Kimura, Hiroyuki, Kishi, Shinichi, Miyauchi, Tomoya, Iwamoto, Kunihiro, Ito, Mikiko, Sato‐Boku, Aiji, Ozaki, Norio, Nabeshima, Toshitaka, and Noda, Yukihiro

Subjects
BURNING mouth syndrome, SEROTONIN transporters, TOOTHACHE, DULOXETINE, HELLP syndrome, BLOOD platelets, MOUTH
Abstract

Objective: The aim of this study was evaluation of the association between severity of pain and expression of total or ubiquitinated serotonin transporter (SERT) protein in patients with burning mouth syndrome and atypical odontalgia (BMS/AO), who were treated by duloxetine. Methods: Patients with BMS/AO were assessed for severity of pain using the visual analog scale (VAS), and expression of total and ubiquitinated SERT protein in platelets before (baseline) and 12 weeks after duloxetine‐treatment. Results: The expression of total and ubiquitinated SERT protein at baseline in all patients (n = 33) were higher and lower, respectively, compared to those in healthy controls. 12 weeks after duloxetine‐treatment, there was no difference in the total SERT protein levels between patients (n = 21) and healthy controls. In the 16 patients who could be measured, mean VAS scores and total SERT protein levels were significantly decreased after the treatment, compared to those at baseline. There was tendency for a positive correlation between total SERT protein levels and VAS scores in these patients. Conclusions: Our findings indicate that duloxetine relieves pain in association with downregulation of platelet SERT expression in patients with BMS/AO. [ABSTRACT FROM AUTHOR]

Published
2022
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35. Potential of the Japanese Version of PainDETECT questionnaire for Patients with Chronic Orofacial Pain and Psychiatric Comorbidities: A preliminary study

Author

(Boku), Aiji Sato, primary, Kimura, Hiroyuki, additional, Tokura, Tatsuya, additional, Nagashima, Wataru, additional, Kobayashi, Yuka, additional, Umemura, Eri, additional, Miyauchi, Tomoya, additional, Ito, Mikiko, additional, Kishi, Shinichi, additional, Ogi, Nobumi, additional, Tonoike, Takashi, additional, Ozaki, Norio, additional, Kurita, Kenichi, additional, Nakano, Yumi, additional, and Okuda, Masahiro, additional

Published
2020
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39. Effect of antidepressant treatment on plasma levels of neuroinflammation‐associated molecules in patients with somatic symptom disorder with predominant pain around the orofacial region

Author

Miyauchi, Tomoya, primary, Tokura, Tatsuya, additional, Kimura, Hiroyuki, additional, Ito, Mikiko, additional, Umemura, Eri, additional, Sato (Boku), Aiji, additional, Nagashima, Wataru, additional, Tonoike, Takashi, additional, Yamamoto, Yasuko, additional, Saito, Kuniaki, additional, Kurita, Kenichi, additional, and Ozaki, Norio, additional

Published
2019
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40. フクロネズミ腎近位尿細管細胞におけるナトリウム依存性リン酸トランスポーターNaPi-IIcと細胞内vacuole形成の関連

Author

Shiozaki, Yuji, Segawa, Hiroko, Ohnishi, Saori, Ohi, Akiko, Ito, Mikiko, Kaneko, Ichiro, Kido, Shinsuke, Tatsumi, Sawako, and Miyamoto, Ken-ichi

Subjects
vacuole, proximal tubule, proliferation, SLC34A3, opossum kidney cells
Abstract

NaPi-IIc/SLC34A3 is a sodium-dependent inorganic phosphate (Pi) transporter in the renal proximal tubules and its mutations cause hereditary hypophosphatemic rickets with hypercalciuria (HHRH). In the present study, we created a specific antibody for opossum SLC34A3, NaPi-IIc (oNaPi-IIc), and analyzed its localization and regulation in opossum kidney cells (a tissue culture model of proximal tubular cells). Immunoreactive oNaPi-IIc protein levels increased during the proliferative phase and decreased during differentiation. Moreover, stimulating cell growth upregulated oNaPi-IIc protein levels, whereas suppressing cell proliferation downregulated oNaPi-IIc protein levels. Immunocytochemistry revealed that endogenous and exogenous oNaPi-IIc proteins localized at the protrusion of the plasma membrane, which is a phosphatidylinositol 4,5-bisphosphate (PIP2) rich-membrane, and at the intracellular vacuolar membrane. Exogenous NaPi-IIc also induced cellular vacuoles and localized in the plasma membrane. The ability to form vacuoles is specific to electroneutral NaPi-IIc, and not electrogenic NaPi-IIa or NaPi-IIb. In addition, mutations of NaPi-IIc (S138F and R468W) in HHRH did not cause cellular PIP2-rich vacuoles. In conclusion, our data anticipate that NaPi-IIc may regulate PIP2 production at the plasma membrane and cellular vesicle formation.

Published
2015

41. High-fat diets provoke phosphorus absorption from the small intestine in rats

Author

Kawamoto, Keisuke, Sakuma, Masae, Tanaka, Sarasa, Masuda, Masashi, Nakao-Muraoka, Mari, Niida, Yuki, Nakamatsu, Yurino, Ito, Mikiko, Taketani, Yutaka, Arai, Hidekazu, Kawamoto, Keisuke, Sakuma, Masae, Tanaka, Sarasa, Masuda, Masashi, Nakao-Muraoka, Mari, Niida, Yuki, Nakamatsu, Yurino, Ito, Mikiko, Taketani, Yutaka, and Arai, Hidekazu

Abstract

Objective: Dietary carbohydrate/fat ratio may affect phosphorus metabolism because both calcium and phosphorus are regulated by similar metabolic mechanisms, and a high-fat diet (HF) induces deleterious effects on the absorption of dietary calcium. We hypothesized that the HF induces an increase in phosphorus absorption; therefore, this study aimed to evaluate the effects of differences in the quantity and quality of dietary fat on phosphorus metabolism over the short and long term. Research Methods & Procedures: Eighteen 8-week-old Sprague-Dawley male rats were fed an isocaloric diet containing varied carbohydrate/fat energy ratio and sources of fat (control diet [Control], HF, and high saturated-fat diet [HF-SFA]). At 3 days and 7 weeks after the allocation and initiation of the test diets, feces and urine were collected and used for phosphorus and calcium measurement. Results: The fecal phosphorous concentration (F-Pi) was lower in the HF-SFA group than in the other two groups; however, the urine phosphorus concentration (U-Pi) was significantly higher in the HF-SFA group than the other two groups when the rats were fed over the short (p<0.01) and long term (p<0.01 vs Control group, p<0.05 vs HF group). There were no significant differences in type-IIa sodium-phosphate cotransporter (NaPi-2a) and type-IIc sodium-phosphate cotransporter (NaPi-2c) mRNA expression, which are renal phosphate transport-related genes; however, the expression of type-IIb sodium-phosphate cotransporter (NaPi-2b) and type-III sodium-phosphate cotransporter (Pit-1) mRNA in the duodenum was higher in the HF and HF-SFA groups than in the Control group (p<0.05), although there were no significant differences in these in the jejunum. Conclusions: Our results indicated that HF, particularly HF-SFA, increases intestinal phosphate absorption compared with Control.

Published
2019

45. Dual Ring Prototype Electronic System for the Small Animal Fast Insert for MRI

Author

Becker, Robert, primary, Buck, Alfred, additional, Commichau, Volker, additional, Di Calafiori, Diogo, additional, Dissertori, Gunther, additional, Djambazov, Lubomir, additional, Eleftheriou, Afroditi, additional, Fischer, Peter, additional, Ito, Mikiko, additional, Khateri, Parisa, additional, Lustermann, Werner, additional, Oliver, Josep F., additional, Ritzer, Christian, additional, Ritzert, Michael, additional, Roser, Ulf, additional, Rudin, Markus, additional, Sacco, Ilaria, additional, Solevi, Paola, additional, Tsoumpas, Charalampos, additional, Warnock, Geoffrey, additional, Weber, Bruno, additional, Wyss, Matthias, additional, and Zagozdzinska-Bochenck, Agnieszka, additional

Published
2018
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46. Analysis of opossum kidney NaPi-IIc sodium-dependent phosphate transporter to understand Pi handling in human kidney

Author

Fujii, Toru, primary, Shiozaki, Yuji, additional, Segawa, Hiroko, additional, Nishiguchi, Shiori, additional, Hanazaki, Ai, additional, Noguchi, Miwa, additional, Kirino, Ruri, additional, Sasaki, Sumire, additional, Tanifuji, Kazuya, additional, Koike, Megumi, additional, Yokoyama, Mizuki, additional, Arima, Yuki, additional, Kaneko, Ichiro, additional, Tatsumi, Sawako, additional, Ito, Mikiko, additional, and Miyamoto, Ken-ichi, additional

Published
2018
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47. Performance Measurements of the SAFIR Prototype Detector With the STiC ASIC Readout

Author

Ahnen, Max, primary, Becker, Robert, additional, Buck, Alfred, additional, Casella, Chiara, additional, Commichau, Volker, additional, Calafiori, Diogo di, additional, Dissertori, Gunther, additional, Eleftheriou, Afroditi, additional, Fischer, Jannis, additional, Howard, Alexander S., additional, Ito, Mikiko, additional, Khateri, Parisa, additional, Kim, Jisoo, additional, Lustermann, Werner, additional, Ritzer, Christian, additional, Roser, Ulf, additional, Rudin, Markus, additional, Solevi, Paola, additional, Tsoumpas, Charalampos, additional, Warnock, Geoffrey, additional, Weber, Bruno, additional, Wyss, Matthias, additional, and Zagozdzinska-Bochenek, Agnieszka, additional

Published
2018
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48. Hypophosphatemia occurs with insulin administration during refeeding by total parenteral nutrition in rats

Author

Kawamura, Hiromi, Tanaka, Sarasa, Uenami, Yuri, Tani, Mariko, Ishitani, Midori, Morii, Saeko, Sakaue, Motoyoshi, Ito, Mikiko, Kawamura, Hiromi, Tanaka, Sarasa, Uenami, Yuri, Tani, Mariko, Ishitani, Midori, Morii, Saeko, Sakaue, Motoyoshi, and Ito, Mikiko

Abstract

Refeeding syndrome (RFS) is characterized by the metabolic and clinical changes that occur following aggressive nutritional supplementation in malnourished patients. Hypophosphatemia is the hallmark of RFS and is key to its prevention and treatment in clinical practice. However, the mechanism of hypophosphatemia during RFS is unclear because of the lack of an animal model. In this study,we developed a rat RFS model as a first step to clarifying the molecular mechanism. After establishing the parenteral route, rats were fasted for 5 days and refeeding was started using total parenteral nutrition. The animals were infused with a high calorie solution with or without insulin administration. Results showed that plasma phosphate levels did not decrease in rats infused with the high calorie solution alone ; in contrast, a 20% reduction compared to baseline was observed in rats administered insulin. In addition, rats infused with the high calorie solution containing added phosphate did not present with hypophosphatemia. Thus, we developed a rat RFS model with hypophosphatemia by tube feeding and insulin administration, and demonstrated the importance of phosphate in preventing refeeding hypophosphatemia.

Published
2018

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