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6. Long-Term Efficacy of Evolocumab in Patients With or Without Multivessel Coronary Disease

Author

McClintick, Daniel J., primary, O’Donoghue, Michelle L., additional, De Ferrari, Gaetano M., additional, Ferreira, Jorge, additional, Ran, Xinhui, additional, Im, KyungAh, additional, López, J. Antonio G., additional, Elliott-Davey, Mary, additional, Wang, Bei, additional, Monsalvo, Maria Laura, additional, Atar, Dan, additional, Keech, Anthony, additional, Giugliano, Robert P., additional, and Sabatine, Marc S., additional

Published
2024
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8. Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study

Author

Mautalén, Carlos Alfredo, Man, Zulema, Zanchetta, Jose Ruben, Magaril, Clelia Haydee, Sambrook, Philip, Reginster, Jean-Yves, Geusens, Piet, Goemaere, Stefan, Albergaria, Ben Hur, Zerbini, Cristiano Augusto de Freitas, Castro, Marise Lazaretti, Gregorio, Luiz Henrique, Stoilov, Rumen, Borissova, Anna-Maria I, Hristozov, Kiril Hristov, Temelkova, Nataliya L, Daskalova, Ivona Kirilova, Kuzmanova, Stefka Ivanova, Yaneva-Bichovska, Daniela, Batalov, Anastas Zgurov, Riedemann, Pablo, Rodriguez Portales, José Adolfo, Tang, Hai, Zhu, hanmin, Zhang, Zhenlin, Chao, Aijun, Hu, Yali, Liu, Zhiming, Lu, Juming, Qiu, Mingcai, Gao, Xin, Zhang, Shaofen, Xu, Ling, Xia, Weibo, Liao, Eryuan, Yang, Wenying, Wu, Wen, Dai, Kerong, Hu, Renming, Jaller, Juan Jose, Cabal, Francisco, Molina, José Fernando, Cure Cure, Carlos A, Yupanqui-Lozno, Hernan, Chalem, Philippe, Londono, John, Abello, Mauricio, Tobias, Edgardo D, Otero, William, Nikolic, Tatjana, Miskic, Blazenka, Stepan, Jan, Vyskocil, Vaclav, Novosad, Libor, Slesinger, Jan, Novosad, Pavel, Vlckova, Erika, Bortlik, Ladislav, Dokoupilova, Eva, Hala, Tomas, Jensen, Jens-Erik Beck, Brixen, Kim Torsten, Langdahl, Bente Lomholt, Schwarz, Peter, Eskildsen, Peter Claes, Eiken, Pia Agnete, Hermann, Anne Pernille, Gram, Jeppe, Schou, Maiken Brix, Alexandersen, Peter, Nedergaard, Bettina, Mejía, Dolores Magdalena, Estrella De Henriquez, Lourdes, Páez, Norka, Velazco, Casimiro, Valter, Ivo, Vahula, Kadri-Liina, Kull, Ingrid, Maasalu, Katre, Chapurlat, Roland, Fardellone, Patrice, Benhamou, Claude Laurent, Roux, Christian, Weryha, Georges, Herkt, Volkmar, Martz, Rene, Nischik, Ruth, Spieler, Wolfgang, Contzen, Christel, Felsenberg, Dieter, Frieling, Isolde, Frahm, Eike, Briones, Henry, Sandoval, Boris, Barrios, Patricia, García, Abraham, Avendaño, Carlos, González, Magdalena, Guerra, Jeremías, Tuna, Maria, Díaz, Olga Marina, Samayoa, Eduardo, López, Edgar, Barrera, José Raúl, Palencia, Mainor, Cifuentes, Mayra, Alvarado, Georgina, López, Miriam, Chavez, Nilmo, Haase, Franklin, Rivera, Ruddy, González, Claudio, Tan, Kathryn, Leung, Ping Chung, Mandalam, Sheshadri, Pitale, Shailesh Umakant, Bantwal, Ganapathi, Ammini, Ariachery Chinamma, Shaikh, Shehla Sajid Akhta, Kanakatte Mylariah, Prasanna Kumar, Dharmalingam, Mala, Mukhopadhyay, Satinath, Jain, Arpit, Singh, Parminder, Shetty, Naresh, Sathyanarayana, Srikanta Shamanna, Shah, Nalini, Chadha, Manoj Dharam, Bhandankar, Rajendra, Velayutham, Kumaravel, Marwah, Sudha, John, Mathew, Sahay, Rakesh Kumar, Adami, Silvano, Nuti, Ranuccio, Bianchi, Gerolamo, Brandi, Maria Luisa, Minisola, Salvatore, Fiore, Carmelo Erio, Rubinacci, Alessandro, Miyajima, Hisayuki, Yamane, Hiroo, Nakatani, Yuji, Okamoto, Sumiaki, Kuroda, Koji, Fujimori, Motoaki, Itabashi, Akira, Katayama, Kuniaki, Nakajo, Satoru, Somekawa, Yoshiaki, Ohsawa, Yoshimitsu, Tajima, Wataru, Mizuno, Katsunori, Mori, Shigeru, Kanabuchi, Takato, Hashizume, Hiroyuki, Oka, Nobuyuki, Hamada, Kazutoshi, Yamaguchi, Motoi, Hirahara, Fumiki, Atobe, Masaaki, Ohtake, Yoshiharu, Ichikawa, Shuichi, Onishi, Tomoyuki, Matsumoto, Kou, Nakamura, Tetsuro, Shirasawa, Eishi, Katayama, Ko, Takahashi, Mitsugu, Oguma, Tadanori, Matsui, Hideo, Katoh, Yoshiharu, Shigenobu, Keiichi, Onishi, Tsutomu, Shibukawa, Masato, Ikeda, Satoshi, Osaka, Kazuhiro, Kanda, Ryosuke, Inobe, Yoshito, Shigenobu, Masaharu, Hasegawa, Morimasa, Yamaji, Tetsuo, Miyazaki, Yu, Ito, Takayasu, Nakamura, Eisuke, Nagai, Shinji, Lim, Sung-Kil, Chung, Yoon-Sok, Shin, Chan-Soo, Min, Yong-Ki, Kim, Ghi Su, Yoon, Hyun Koo, Kang, Moo-Il, Yang, Kyu-Hyun, Park, Hyoung Moo, Kim, In Joo, Chung, Dong Jin, Chung, Ho Yeon, Jaundzeikare, Sandra, Andersone, Dace, Medne, Agita, Yaghi, Yasser, Alekna, Vidmantas, Kasiulevicius, Vytautas, Purtokaite - Labutiniene, Irina, Krasauskiene, Aurelija, Varanaviciene, Jurate, Basijokiene, Vida, Abraitiene, Agne, Radzeviciene, Lina, Walliser, Jesus, García Hernández, Pedro Alberto, Araujo, Maria Frida, Avila Armengol, Hilario Ernesto, De la Peña, Pilar, Tamayo, Juan, Zazueta, Beatriz, Cons, Fidencio, Gilchrist, Nigel Leslie, Reid, Ian Reginald, Leikis, Robert, Jones, Peter, Singh, Joe Gragrath Pradeep, Halse, Johan Inge, Syversen, Unni, Høivik, Hans Olav, Øfjord, Erik Snorre, Gulseth, Hans Christian, Elle, Sigbjørn, Norheim, Paal Dag, Calvo Quiroz, Armando A., Cesar Augusto, Pastor A., León Portocarrero, Manuel Gustavo, Vidal Neira, Luis Fernando, Chavez, Jose, Garro Barrera, Boris, Kuroiwa Sampei, Rita, Luis Fernando, Bellatín V., Oquelis Cabredo, Rogger, Castillo, Sonia, Morales, Agustin Miguel G, Tan, Perry Pua, Leagogo, Liberato Antonio C, Jr., Wang, Edward HM, Li-Yu, Julie T, Sawicki, Andrzej Z, Stasiuk, Barbara, Kania, Grzegorz, Lorenc, Roman, Sidorowicz-Bialynicka, Anna, Szczepanski, Leszek, Franek, Edward, Filip, Rafal, Sekula, Jan, Blicharski, Tomasz, Leszczynski, Piotr, Sewerynek, Ewa, Miazgowski, Tomasz, Milewicz, Andrzej, Dabrowska, Magda, Romaszko, Jerzy, Pluskiewicz, Wojciech, Wojnowski, Lukasz, Codreanu, Catalin, Bolosiu, Horatiu, Ionescu, Ruxandra, Zosin, Ioana, Macovei, Liviu, Bojinca, Mihai, Radulescu, Florin, Pop, Simona, Sarbu, Adrian, Benevolenskaya, Lidia I, Nasonov, Evgeny L, Rozhinskaya, Lyudmila Ya, Oganov, Raphael G, Rodionova, Svetlana S, Shlyakhto, Eugeny Vladimirovich, Trofimov, Vasiliy, Zotkin, Eugeny G, Zazerskaya, Irina E, Grineva, Elena N, Ershova, Olga, Lesnyak, Olga, Ostroumova, Olga D, Malichenko, Svetlana B, Pikhlak, Eduard G, Pilyaev, Valery G, Raskina, Tatiana, Zonova, Elena V, Shirinsky, Valery S, Dimic, Aleksandar N, Cobeljic, Goran, Vujovic, Svetlana, Ellis, Graham Charlston, Lipschitz, Stanley, De Villiers, Tobias Johannes, De Weerd, Albert Jan, Vally, Tasneem, Trinder, Yvonne, Coetsee, Jacobus Ludewikus, Davis, Charles Pierre, Nayiager, Savithree, Hough, Frans Stephanus, Oelofse, Louis F, van der Walt, Eugene, Lombaard, Johannes Jurgens, Blignaut, Suzanne, Govind, Uttam, Fouche, Leon Frederik, Kruger, Dawid Stephanus, Dalmeyer, Johannes Paul, Ferreira, Mada M, Escudero-Contreras, Alejandro, Muñoz Torres, Manuel, Hawkins Carranza, Federico, Perez Castrillon, Jose Luis, García Meijide, Juan Antonio, Jodar Gimeno, Esteban, Palacios Gil-Antuñana, Santiago, de Teresa Parreno, Luis, Martín Mola, Emilio, Alvarez Sanchez, Carmen, Lippuner, Kurt, Tsai, Keh-Sung, Tu, Shih-Te, Chen, Jung-Fu, Lee, Oscar Kuang-Sheng, Hsu, Wen-Wei, Grygorieva, Natalia Viktorivna, Povoroznyuk, Vladyslav Volodymyrovych, Korzh, Mykola Oleksiiovych, Loskutov, Oleksandr Levgeniiovych, Chukov, Andriy Borysovych, Sarmiento, Rex, Thomas, Hawys, Donnachie, Hugh, Pavel-Knox, Irina, Shaw, Hilary, Hassanin, Hana, Abdulhakim, Essam Eldin Ahmed, Savani, Naren, Bachmann, Gloria A, Barrett-Connor, Elizabeth, Binkley, Neil C, Bone, Henry G, Brandon, Donald M, Checketts, Darin David, Fraser, Neil J, Watts, Nelson B, Geller, Steven A, Gimbel, Joseph S, Greenwald, Maria White, Holt, Peter A, Johnston, Cyrus Conrad, Fang, Chien, Kiel, Douglas P, Klashman, David J, Lewiecki, E. Michael, Lowenstein, Mitchell B, McClung, Michael Roy, Nattrass, Susan M, Odio, Alberto, Levengood, Julie, Romaguera, Josefina, Saag, Kenneth G, Sebai, Mohamed Bassam, Snyder, Brian, Kutner, Mark Eliot, Streja, Dan, Schwartz, Elliott P, Christiansen, Mark G, McClung, Michael R, O'Donoghue, Michelle L, Papapoulos, Socrates E, Bone, Henry, Langdahl, Bente, Reid, Ian R, Cavallari, Ilaria, Bonaca, Marc P, Wiviott, Stephen D, de Villiers, Tobias, Ling, Xu, Nakamura, Toshitaka, Rodriguez-Portales, Jose Adolfo, Zanchetta, José, Zerbini, Cristiano A F, Park, Jeong-Gun, Im, KyungAh, Cange, Abby, Grip, Laura T, Heyden, Norman, DaSilva, Carolyn, Cohn, Dosinda, Massaad, Rachid, Scott, Boyd B, Verbruggen, Nadia, Gurner, Deborah, Miller, Deborah L, Blair, Micki L, Polis, Adam B, Stoch, S Aubrey, Santora, Arthur, Lombardi, Antonio, Leung, Albert T, Kaufman, Keith D, and Sabatine, Marc S

Published
2019
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11. Ticagrelor for Secondary Prevention of Atherothrombotic Events in Patients With Multivessel Coronary Disease

Author

Bansilal, Sameer, Bonaca, Marc P., Cornel, Jan H., Storey, Robert F., Bhatt, Deepak L., Steg, Ph. Gabriel, Im, Kyungah, Murphy, Sabina A., Angiolillo, Dominick J., Kiss, Robert G., Parkhomenko, Alexander N., Lopez-Sendon, Jose, Isaza, Daniel, Goudev, Assen, Kontny, Frederic, Held, Peter, Jensen, Eva C., Braunwald, Eugene, Sabatine, Marc S., and Oude Ophuis, A.J.

Published
2018
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12. Abstract 16139: A Targeted Proteomic Approach to Identify Circulating Biomarkers of Heart Failure Risk in Patients With Type 2 Diabetes Mellitus in DECLARE-TIMI 58

Author

Berg, David, Wiviott, Stephen D, RAZ, Itamar, Kamanu, Frederick, Im, KyungAh, Cahn, Avivit, Mosenzon, ofri, Bhatt, Deepak L, Jarolim, Petr, Leiter, Lawrence A, McGuire, Darren K, WILDING, JOHN, Huo, Yong, Lopez-sendon, Jose L, Ardissino, Diego, Gause-nilsson, Ingrid A, Sabatine, Marc S, and Morrow, David A

Published
2020
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15. REDUCTION IN TOTAL CARDIOVASCULAR EVENTS WITH THE PCSK9 INHIBITOR EVOLOCUMAB IN PATIENTS WITH CARDIOVASCULAR DISEASE IN THE COMBINED FOURIER AND FOURIER OPEN-LABEL EXTENSION (OLE) STUDIES

Author

Murphy, Sabina, primary, O'Donoghue, Michelle L., additional, Wiviott, Stephen, additional, Atar, Dan, additional, Keech, Anthony C., additional, Kuder, Julia, additional, Im, KyungAh, additional, Flores-Arredondo, Jose, additional, Antonio, J., additional, Lopez, G., additional, Elliott, Mary, additional, Wang, Bei, additional, Monsalvo, Maria Laura, additional, Abbasi, Siddique A., additional, Giugliano, Robert P., additional, and Sabatine, Marc Steven, additional

Published
2023
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16. Association Between Achieved Low-Density Lipoprotein Cholesterol Levels and Long-Term Cardiovascular and Safety Outcomes: An Analysis of FOURIER-OLE

Author

Gaba, Prakriti, primary, O’Donoghue, Michelle L., additional, Park, Jeong-Gun, additional, Wiviott, Stephen D., additional, Atar, Dan, additional, Kuder, Julia F., additional, Im, KyungAh, additional, Murphy, Sabina A., additional, De Ferrari, Gaetano M., additional, Gaciong, Zbigniew A., additional, Toth, Kalman, additional, Gouni-Berthold, Ioanna, additional, Lopez-Miranda, Jose, additional, Schiele, François, additional, Mach, François, additional, Flores-Arredondo, Jose H., additional, López, J. Antonio G., additional, Elliott-Davey, Mary, additional, Wang, Bei, additional, Monsalvo, Maria Laura, additional, Abbasi, Siddique, additional, Giugliano, Robert P., additional, and Sabatine, Marc S., additional

Published
2023
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19. Comparison of the Effects of Glucagon-Like Peptide Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors for Prevention of Major Adverse Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis of Cardiovascular Outcomes Trials

Author

Zelniker, Thomas A., Wiviott, Stephen D., Raz, Itamar, Im, KyungAh, Goodrich, Erica L., Furtado, Remo H.M., Bonaca, Marc P., Mosenzon, Ofri, Kato, Eri T., Cahn, Avivit, Bhatt, Deepak L., Leiter, Lawrence A., McGuire, Darren K., Wilding, John P.H., and Sabatine, Marc S.

Published
2019
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22. Long-Term Evolocumab in Patients With Established Atherosclerotic Cardiovascular Disease

Author

O’Donoghue, Michelle L., primary, Giugliano, Robert P., additional, Wiviott, Stephen D., additional, Atar, Dan, additional, Keech, Anthony, additional, Kuder, Julia F., additional, Im, KyungAh, additional, Murphy, Sabina A., additional, Flores-Arredondo, Jose H., additional, López, J. Antonio G., additional, Elliott-Davey, Mary, additional, Wang, Bei, additional, Monsalvo, Maria Laura, additional, Abbasi, Siddique, additional, and Sabatine, Marc S., additional

Published
2022
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23. Abstract 15100: Reduction in Total Cardiovascular Events With the PCSK9 Inhibitor Evolocumab in Patients With Cardiovascular Disease in the FOURIER Trial

Author

Murphy, Sabina A, Pedersen, Terje R, Gaciong, Zbigniew A, Ceska, Richard, Ezhov, Marat V, Connolly, Derek, Kraydashenko, Oleg, Jukema, J. Wouter, Toth, Kalman, Tikkanen, Matti J, Im, Kyungah, Wiviott, Stephen D, Kurtz, Christopher, Honarpour, Narimon, Giugliano, Robert P, Keech, Anthony C, Sever, Peter S, and Sabatine, Marc S

Published
2017

24. Re‐adjudication of the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) with study‐level meta‐analysis of hospitalization for heart failure from cardiovascular outcomes trials with dipeptidyl peptidase‐4 (DPP‐4) inhibitors

Author

Scirica, Benjamin M., primary, Im, KyungAh, additional, Murphy, Sabina A., additional, Kuder, Julia F., additional, Rodriguez, Dolly A., additional, Lopes, Renato D., additional, Green, Jennifer B., additional, Ruff, Christian T., additional, and Sabatine, Marc S., additional

Published
2022
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30. Ischaemic risk and efficacy of ticagrelor in relation to time from P2Y12 inhibitor withdrawal in patients with prior myocardial infarction: insights from PEGASUS-TIMI 54

Author

Bonaca, Marc P., Bhatt, Deepak L., Steg, P. Gabriel, Storey, Robert F., Cohen, Marc, Im, Kyungah, Oude Ophuis, Ton, Budaj, Andrej, Goto, Shinya, López-Sendón, José, Diaz, Rafael, Dalby, Anthony, Van de Werf, Frans, Ardissino, Diego, Montalescot, Gilles, Aylward, Philip, Magnani, Giulia, Jensen, Eva C., Held, Peter, Braunwald, Eugene, and Sabatine, Marc S.

Published
2016
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31. Efficacy and safety of ticagrelor for long-term secondary prevention of atherothrombotic events in relation to renal function: insights from the PEGASUS-TIMI 54 trial

Author

Magnani, Giulia, Storey, Robert F., Steg, Gabriel, Bhatt, Deepak L., Cohen, Marc, Kuder, Julia, Im, Kyungah, Aylward, Philip, Ardissino, Diego, Isaza, Daniel, Parkhomenko, Alexander, Goudev, Assen R., Dellborg, Mikael, Kontny, Frederic, Corbalan, Ramon, Medina, Felix, Jensen, Eva C., Held, Peter, Braunwald, Eugene, Sabatine, Marc S., and Bonaca, Marc P.

Published
2016
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33. Long‐Term Ticagrelor in Patients With Prior Coronary Stenting in the PEGASUS‐TIMI 54 Trial

Author

Bergmark, Brian A., primary, Bhatt, Deepak L., additional, Steg, P. Gabriel, additional, Budaj, Andrzej, additional, Storey, Robert F., additional, Gurmu, Yared, additional, Kuder, Julia F., additional, Im, KyungAh, additional, Magnani, Giulia, additional, Oude Ophuis, Ton, additional, Hamm, Christian, additional, Špinar, Jindřich, additional, Kiss, Robert G., additional, Van de Werf, Frans J., additional, Montalescot, Gilles, additional, Johanson, Per, additional, Braunwald, Eugene, additional, Sabatine, Marc S., additional, and Bonaca, Marc P., additional

Published
2021
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35. Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes

Author

Cannon, Christopher P., Blazing, Michael A., Giugliano, Robert P., McCagg, Amy, White, Jennifer A., Theroux, Pierre, Darius, Harald, Lewis, Basil S., Ophuis, Ton Oude, Jukema, J. Wouter, De Ferrari, Gaetano M., Ruzyllo, Witold, De Lucca, Paul, Im, KyungAh, Bohula, Erin A., Reist, Craig, Wiviott, Stephen D., Tershakovec, Andrew M., Musliner, Thomas A., Braunwald, Eugene, and Califf, Robert M.

Published
2015
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36. Long-Term Use of Ticagrelor in Patients with Prior Myocardial Infarction

Author

Bonaca, Marc P., Bhatt, Deepak L., Cohen, Marc, Steg, Philippe Gabriel, Storey, Robert F., Jensen, Eva C., Magnani, Giulia, Bansilal, Sameer, Fish, M. Polly, Im, Kyungah, Bengtsson, Olof, Ophuis, Ton Oude, Budaj, Andrzej, Theroux, Pierre, Ruda, Mikhail, Hamm, Christian, Goto, Shinya, Spinar, Jindrich, Nicolau, José Carlos, Kiss, Robert G., Murphy, Sabina A., Wiviott, Stephen D., Held, Peter, Braunwald, Eugene, and Sabatine, Marc S.

Published
2015
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37. Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Moderate or Severe Renal Impairment: Observations From the SAVOR-TIMI 53 Trial

Author

Udell, Jacob A., Bhatt, Deepak L., Braunwald, Eugene, Cavender, Matthew A., Mosenzon, Ofri, Steg, Ph. Gabriel, Davidson, Jaime A., Nicolau, Jose C., Corbalan, Ramon, Hirshberg, Boaz, Frederich, Robert, Im, KyungAh, Umez-Eronini, Amarachi A., He, Ping, McGuire, Darren K., Leiter, Lawrence A., Raz, Itamar, and Scirica, Benjamin M.

Published
2015
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40. Effect of Dapagliflozin on Cardiovascular Outcomes According to Baseline Kidney Function and Albuminuria Status in Patients With Type 2 Diabetes

Author

Zelniker, Thomas A., primary, Raz, Itamar, additional, Mosenzon, Ofri, additional, Dwyer, Jamie P., additional, Heerspink, Hiddo H. J. L., additional, Cahn, Avivit, additional, Goodrich, Erica L., additional, Im, Kyungah, additional, Bhatt, Deepak L., additional, Leiter, Lawrence A., additional, McGuire, Darren K., additional, Wilding, John P. H., additional, Gause-Nilsson, Ingrid, additional, Langkilde, Anna Maria, additional, Sabatine, Marc S., additional, and Wiviott, Stephen D., additional

Published
2021
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41. Sex, Permanent Drug Discontinuation, and Study Retention in Clinical Trials

Author

Lau, Emily S., primary, Braunwald, Eugene, additional, Morrow, David A., additional, Giugliano, Robert P., additional, Antman, Elliott M., additional, Gibson, C. Michael, additional, Scirica, Benjamin M., additional, Bohula, Erin A., additional, Wiviott, Stephen D., additional, Bhatt, Deepak L., additional, Bonaca, Marc P., additional, Cannon, Christopher P., additional, Im, KyungAh, additional, Guo, Jianping, additional, Sabatine, Marc S., additional, and O’Donoghue, Michelle L., additional

Published
2021
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42. Predictors, Type, and Impact of Bleeding on the Net Clinical Benefit of Long‐Term Ticagrelor in Stable Patients With Prior Myocardial Infarction

Author

Magnani, Giulia, primary, Ardissino, Diego, additional, Im, KyungAh, additional, Budaj, Andrzej, additional, Storey, Robert F., additional, Steg, P. Gabriel, additional, Bhatt, Deepak L., additional, Cohen, Marc, additional, Oude Ophius, Ton, additional, Goudev, Assen, additional, Parkhomenko, Alexander, additional, Kamensky, Gabriel, additional, Angiolillo, Dominick J., additional, López‐Sendón, José, additional, Johanson, Per, additional, Braunwald, Eugene, additional, Sabatine, Marc S., additional, and Bonaca, Marc P., additional

Published
2021
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44. Cognition After Lowering LDL-Cholesterol With Evolocumab

Author

Gencer, Baris, primary, Mach, François, additional, Guo, Jianping, additional, Im, KyungAh, additional, Ruzza, Andrea, additional, Wang, Huei, additional, Kurtz, Christopher E., additional, Pedersen, Terje Rolf, additional, Keech, Anthony C., additional, Ott, Brian R., additional, Sabatine, Marc S., additional, and Giugliano, Robert P., additional

Published
2020
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45. SEX AND PERMANENT DRUG DISCONTINUATION IN CLINICAL TRIALS: INSIGHTS FROM THE TIMI TRIALS

Author

Lau, Emily, primary, Braunwald, Eugene, additional, Morrow, David A., additional, Giugliano, Robert, additional, Antman, Elliott M., additional, Gibson, C. Michael, additional, Scirica, Benjamin M., additional, Bohula, Erin Ann, additional, Bhatt, Deepak, additional, Cannon, Christopher P., additional, Im, KyungAh, additional, Guo, Jianping, additional, Sabatine, Marc Steven, additional, and O’Donoghue, Michelle, additional

Published
2020
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48. Long-term ticagrelor for secondary prevention in patients with prior myocardial infarction and no history of coronary stenting: insights from PEGASUS-TIMI 54

Author

Furtado, Remo H M, primary, Nicolau, Jose C, additional, Magnani, Giulia, additional, Im, Kyungah, additional, Bhatt, Deepak L, additional, Storey, Robert F, additional, Steg, P Gabriel, additional, Spinar, Jindrich, additional, Budaj, Andrzej, additional, Kontny, Frederic, additional, Corbalan, Ramon, additional, Kiss, Robert G, additional, Abola, Maria Teresa, additional, Johanson, Per, additional, Jensen, Eva C, additional, Braunwald, Eugene, additional, Sabatine, Marc S, additional, and Bonaca, Marc P, additional

Published
2019
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49. Odanacatib for the treatment of postmenopausal osteoporosis: results of the LOFT multicentre, randomised, double-blind, placebo-controlled trial and LOFT Extension study

Author

McClung, Michael R, primary, O'Donoghue, Michelle L, additional, Papapoulos, Socrates E, additional, Bone, Henry, additional, Langdahl, Bente, additional, Saag, Kenneth G, additional, Reid, Ian R, additional, Kiel, Douglas P, additional, Cavallari, Ilaria, additional, Bonaca, Marc P, additional, Wiviott, Stephen D, additional, de Villiers, Tobias, additional, Ling, Xu, additional, Lippuner, Kurt, additional, Nakamura, Toshitaka, additional, Reginster, Jean-Yves, additional, Rodriguez-Portales, Jose Adolfo, additional, Roux, Christian, additional, Zanchetta, José, additional, Zerbini, Cristiano A F, additional, Park, Jeong-Gun, additional, Im, KyungAh, additional, Cange, Abby, additional, Grip, Laura T, additional, Heyden, Norman, additional, DaSilva, Carolyn, additional, Cohn, Dosinda, additional, Massaad, Rachid, additional, Scott, Boyd B, additional, Verbruggen, Nadia, additional, Gurner, Deborah, additional, Miller, Deborah L, additional, Blair, Micki L, additional, Polis, Adam B, additional, Stoch, S Aubrey, additional, Santora, Arthur, additional, Lombardi, Antonio, additional, Leung, Albert T, additional, Kaufman, Keith D, additional, Sabatine, Marc S, additional, Mautalén, Carlos Alfredo, additional, Man, Zulema, additional, Zanchetta, Jose Ruben, additional, Magaril, Clelia Haydee, additional, Sambrook, Philip, additional, Geusens, Piet, additional, Goemaere, Stefan, additional, Albergaria, Ben Hur, additional, Zerbini, Cristiano Augusto de Freitas, additional, Castro, Marise Lazaretti, additional, Gregorio, Luiz Henrique, additional, Stoilov, Rumen, additional, Borissova, Anna-Maria I, additional, Hristozov, Kiril Hristov, additional, Temelkova, Nataliya L, additional, Daskalova, Ivona Kirilova, additional, Kuzmanova, Stefka Ivanova, additional, Yaneva-Bichovska, Daniela, additional, Batalov, Anastas Zgurov, additional, Riedemann, Pablo, additional, Rodriguez Portales, José Adolfo, additional, Tang, Hai, additional, Zhu, hanmin, additional, Zhang, Zhenlin, additional, Chao, Aijun, additional, Hu, Yali, additional, Liu, Zhiming, additional, Lu, Juming, additional, Qiu, Mingcai, additional, Gao, Xin, additional, Zhang, Shaofen, additional, Xu, Ling, additional, Xia, Weibo, additional, Liao, Eryuan, additional, Yang, Wenying, additional, Wu, Wen, additional, Dai, Kerong, additional, Hu, Renming, additional, Jaller, Juan Jose, additional, Cabal, Francisco, additional, Molina, José Fernando, additional, Cure Cure, Carlos A, additional, Yupanqui-Lozno, Hernan, additional, Chalem, Philippe, additional, Londono, John, additional, Abello, Mauricio, additional, Tobias, Edgardo D, additional, Otero, William, additional, Nikolic, Tatjana, additional, Miskic, Blazenka, additional, Stepan, Jan, additional, Vyskocil, Vaclav, additional, Novosad, Libor, additional, Slesinger, Jan, additional, Novosad, Pavel, additional, Vlckova, Erika, additional, Bortlik, Ladislav, additional, Dokoupilova, Eva, additional, Hala, Tomas, additional, Jensen, Jens-Erik 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Published
2019
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50. Lipoprotein(a), PCSK9 Inhibition, and Cardiovascular Risk

Author

O'Donoghue, Michelle L., Fazio, Sergio, Giugliano, Robert P., Stroes, Erik S. G., Kanevsky, Estella, Gouni-Berthold, Ioanna, Im, KyungAh, Lira Pineda, Armando, Wasserman, Scott M., Češka, Richard, Ezhov, Marat V., Jukema, J. Wouter, Jensen, Henrik K., Tokgözoğlu, S. Lale, Mach, François, Huber, Kurt, Sever, Peter S., Keech, Anthony C., Pedersen, Terje R., Sabatine, Marc S., Experimental Vascular Medicine, Vascular Medicine, and ACS - Atherosclerosis & ischemic syndromes

Abstract

BACKGROUND: Lipoprotein(a) [Lp(a)] may play a causal role in atherosclerosis. PCSK9 (proprotein convertase subtilisin/kexin 9) inhibitors have been shown to significantly reduce plasma Lp(a) concentration. However, the relationship between Lp(a) levels, PCSK9 inhibition, and cardiovascular risk reduction remains undefined. METHODS: Lp(a) was measured in 25 096 patients in the FOURIER trial (Further Cardiovascular Outcomes Research with PCSK9 Inhibition in Subjects with Elevated Risk), a randomized trial of evolocumab versus placebo in patients with established atherosclerotic cardiovascular disease (median follow-up, 2.2 years). Cox models were used to assess the independent prognostic value of Lp(a) and the efficacy of evolocumab for coronary risk reduction by baseline Lp(a) concentration. RESULTS: The median (interquartile range) baseline Lp(a) concentration was 37 (13-165) nmol/L. In the placebo arm, patients with baseline Lp(a) in the highest quartile had a higher risk of coronary heart disease death, myocardial infarction, or urgent revascularization (adjusted hazard ratio quartile 4: quartile 1, 1.22; 95% CI, 1.01-1.48) independent of low-density lipoprotein cholesterol. At 48 weeks, evolocumab significantly reduced Lp(a) by a median (interquartile range) of 26.9% (6.2%-46.7%). The percent change in Lp(a) and low-density lipoprotein cholesterol at 48 weeks in patients taking evolocumab was moderately positively correlated ( r=0.37; 95% CI, 0.36-0.39; Pmedian, and by 7% (hazard ratio, 0.93; 95% CI, 0.80-1.08; P interaction=0.07) in those ≤median. Coupled with the higher baseline risk, the absolute risk reductions, and number needed to treat over 3 years were 2.49% and 40 versus 0.95% and 105, respectively. CONCLUSIONS: Higher levels of Lp(a) are associated with an increased risk of cardiovascular events in patients with established cardiovascular disease irrespective of low-density lipoprotein cholesterol. Evolocumab significantly reduced Lp(a) levels, and patients with higher baseline Lp(a) levels experienced greater absolute reductions in Lp(a) and tended to derive greater coronary benefit from PCSK9 inhibition. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov . Unique identifier: NCT01764633.

Published
2019

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