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Your search keyword '"Ichihashi, Masamitsu"' showing total 31 results
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31 results on '"Ichihashi, Masamitsu"'

6. SOCS7-Derived BC-Box Motif Peptide Mediated Cholinergic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells

Author

Kanno, Hiroshi, primary, Matsumoto, Shutaro, additional, Yoshizumi, Tetsuya, additional, Nakahara, Kimihiro, additional, Shinonaga, Masamichi, additional, Kubo, Atsuhiko, additional, Fujii, Satoshi, additional, Ishizuka, Yasuyuki, additional, Tanaka, Masaki, additional, Ichihashi, Masamitsu, additional, and Murata, Hidetoshi, additional

Published
2023
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9. Aging of the Vascular System and Neural Diseases

Author

Watanabe, Chisato, primary, Imaizumi, Tsutomu, additional, Kawai, Hiromi, additional, Suda, Kazuma, additional, Honma, Yoichi, additional, Ichihashi, Masamitsu, additional, Ema, Masatsugu, additional, and Mizutani, Ken-ichi, additional

Published
2020
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10. Dermal Fibroblasts Internalize Phosphatidylserine-Exposed Secretory Melanosome Clusters and Apoptotic Melanocytes

Author

Ando, Hideya, primary, Yoshimoto, Satoshi, additional, Yoshida, Moemi, additional, Shimoda, Nene, additional, Tadokoro, Ryosuke, additional, Kohda, Haruka, additional, Ishikawa, Mami, additional, Nishikata, Takahito, additional, Katayama, Bunpei, additional, Ozawa, Toshiyuki, additional, Tsuruta, Daisuke, additional, Mizutani, Ken-ichi, additional, Yagi, Masayuki, additional, and Ichihashi, Masamitsu, additional

Published
2020
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19. Preface

Author

Ando, Hideya, primary, Ichihashi, Masamitsu, additional, and Morita, Akimichi, additional

Published
2019
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27. Preface

Author

Ishikawa, Osamu, primary, Kawada, Akira, additional, Ichihashi, Masamitsu, additional, and Morita, Akimichi, additional

Published
2016
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29. Photocatalysis in the Skin Related to UVA Photoaging

Author

Yoshimoto, Satoshi, Ichihashi, Masamitsu, and Yoshida, Moemi

Subjects
Science / Chemistry
Abstract

Skin aging is classified into chronological aging and photoaging, involving ultraviolet radiation (UV), visible light, and others. UVA and UVA-photosensitizers (involving photocatalysis) contribute to the production of chronically induced skin damage that results in photoaging, especially wrinkles that are associated with histopathological actinic elastosis in the dermis. Hydrogen peroxide produced by the photosensitization involving photocatalysis, such as flavin, has been proposed as a risk factor for photoaging. It was also revealed that hydrogen peroxide production by UVA is amplified through the following reactions. The photosensitization of type I and type II by riboflavin as an initiator oxidizes coexisted amino acids and vitamins. The oxidized amino acids and vitamins produce reactive oxygen species (ROS), including hydrogen peroxide, through secondary UVA-photosensitization. Finally, we proposed a screening method for detecting the effects of antioxidants on UVA-photosensitization. In our previous study, histidine and other antioxidants did not inhibit UVA-photosensitized by riboflavin, even though they have been reported to scavenge singlet oxygen and superoxide. In contrast, we demonstrated that ergothioneine suppressed the production of hydrogen peroxide by UVA-photosensitization. The purpose of this report is to provide new findings for the prevention of photoaging by discussing the characteristics of UVA-photocatalysts in the skin.

Published
2020

30. Riboflavin Plays a Pivotal Role in the UVA-Induced Cytotoxicity of Fibroblasts as a Key Molecule in the Production of H 2 O 2 by UVA Radiation in Collaboration with Amino Acids and Vitamins.

Author

Yoshimoto S, Kohara N, Sato N, Ando H, and Ichihashi M

Subjects
Amino Acids metabolism, Cell Survival drug effects, Cell Survival radiation effects, Cells, Cultured, Culture Media metabolism, Culture Media pharmacology, Fibroblasts cytology, Foreskin cytology, Humans, Infant, Newborn, Male, Oxidation-Reduction drug effects, Oxidation-Reduction radiation effects, Oxidative Stress drug effects, Oxidative Stress radiation effects, Photosensitizing Agents metabolism, Photosensitizing Agents pharmacology, Riboflavin metabolism, Vitamins metabolism, Amino Acids pharmacology, Fibroblasts drug effects, Fibroblasts radiation effects, Hydrogen Peroxide metabolism, Riboflavin pharmacology, Ultraviolet Rays, Vitamins pharmacology
Abstract

To investigate environmental factors that contribute to ultraviolet A (UVA)-induced oxidative stress, which accelerates the senescence and toxicity of skin cells, we irradiated human fibroblasts cultured in commonly used essential media with UVA and evaluated their viability and production of reactive oxygen species. The viability of fibroblasts exposed to a single dose of 3.6 J/cm 2 UVA was not reduced when cultured in Hanks balanced salt solution, but it was significantly decreased when cultured in Dulbecco's modified Eagle's medium (DMEM), which contains various amino acids and vitamins. Furthermore, cell viability was not reduced when fibroblasts were cultured in DMEM and treated with a hydrogen peroxide (H₂O₂) scavenger such as glutathione or catalase added after UVA irradiation. In addition, we confirmed that the production of H 2 O 2 was dramatically increased by UVA photosensitization when riboflavin (R) coexisted with amino acids such as tryptophan (T), and found that R with folic acid (F) produced high levels of H 2 O 2 after UVA irradiation. Furthermore, we noticed that R and F or R and T have different photosensitization mechanisms since NaN 3 , which is a singlet oxygen quencher, suppressed only R and T photosensitization. Lastly, we examined the effects of antioxidants (L-ascorbic acid, trolox, L-cysteine, and L-histidine), which are singlet oxygen or superoxide or H₂O₂ scavengers, on R and F or on R and T photosensitization, and found that 1 mM ascorbic acid, Trolox, and L-histidine were strongly photosensitized with R, and produced significant levels of H₂O₂ during UVA exposure. However, 1 mM L-cysteine dramatically suppressed H₂O₂ production by UVA photosensitization. These data suggest that a low concentration of R-derived photosensitization is elicited by different mechanisms depending on the coexisting vitamins and amino acids, and regulates cellular oxidative stress by producing H₂O₂ during UVA exposure., Competing Interests: The authors declare no conflict of interest.

Published
2020
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31. Age-related diseases of the skin and anti-aging medicine.

Author

Yonei Y, Ichihashi M, and Takabe W

Subjects
DNA Damage, Humans, Oxidation-Reduction, Skin metabolism, Collagen metabolism, Oxidative Stress, Skin Aging physiology
Abstract

In the anti-aging medicine, we recommend to assess the skin aging by five categories: wrinkle age, spot age, yellow tint age, elasticity age, and moisture age. Photo-aging (oxidative stress) and glycative stress are major causes of age-related deterioration in the skin. Gly- cative stress finally causes skin accumulation of advanced glycation end products(AGEs), inducing yellow tint, and cross linkage between collagen fibers inducing less elastic skin. Oxidative stress causes skin dark spots through the various processes; excess pigment forma- tion and DNA damages. It also causes wrinkle formation associated with matrix metallopro- teinase(MMP) activation and degeneration of collagen and elastin fibers. Study of oxidative and glycative stress may help identify new anti-aging treatments so that we can achieve the skin rejuvenation.

Published
2016

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