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28 results on '"Iannone, Lynne"'

3. Spirometry, Static Lung Volumes, and Diffusing Capacity.

Author

Vaz Fragoso, Carlos A, Cain, Hilary C, Casaburi, Richard, Lee, Patty J, Iannone, Lynne, Leo-Summers, Linda S, and Van Ness, Peter H

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Lung, Adult, Aged, Airway Obstruction, Female, Functional Residual Capacity, Humans, Least-Squares Analysis, Linear Models, Male, Middle Aged, Multivariate Analysis, Pulmonary Diffusing Capacity, Residual Volume, Retrospective Studies, Spirometry, Total Lung Capacity, spirometry, Global Lung Initiative, static lung volumes, restriction, hyperinflation, air trapping, diffusing capacity, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Respiratory System, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundSpirometric Z-scores from the Global Lung Initiative (GLI) rigorously account for age-related changes in lung function and are thus age-appropriate when establishing spirometric impairments, including a restrictive pattern and air-flow obstruction. However, GLI-defined spirometric impairments have not yet been evaluated regarding associations with static lung volumes (total lung capacity [TLC], functional residual capacity [FRC], and residual volume [RV]) and gas exchange (diffusing capacity).MethodsWe performed a retrospective review of pulmonary function tests in subjects ≥40 y old (mean age 64.6 y), including pre-bronchodilator measures for: spirometry (n = 2,586), static lung volumes by helium dilution with inspiratory capacity maneuver (n = 2,586), and hemoglobin-adjusted single-breath diffusing capacity (n = 2,508). Using multivariable linear regression, adjusted least-squares means (adjLSMeans) were calculated for TLC, FRC, RV, and hemoglobin-adjusted single-breath diffusing capacity. The adjLSMeans were expressed with and without height-cubed standardization and stratified by GLI-defined spirometry, including normal (n = 1,251), restrictive pattern (n = 663), and air-flow obstruction (mild, [n = 128]; moderate, [n = 150]; and severe, [n = 394]).ResultsRelative to normal spirometry, restrictive-pattern had lower adjLSMeans for TLC, FRC, RV, and hemoglobin-adjusted single-breath diffusing capacity (P ≤ .001). Conversely, relative to normal spirometry, mild, moderate, and severe air-flow obstruction had higher adjLSMeans for FRC and RV (P < .001). However, only mild and moderate air-flow obstruction had higher adjLSMeans for TLC (P < .001), while only moderate and severe air-flow obstruction had higher adjLSMeans for RV/TLC (P < .001) and lower adjLSMeans for hemoglobin-adjusted single-breath diffusing capacity (P < .001). Notably, TLC (calculated as FRC + inspiratory capacity) was not increased in severe air-flow obstruction (P ≥ .11) because inspiratory capacity decreased with increasing air-flow obstruction (P < .001), thus opposing the increased FRC (P < .001). Finally, P values were similar whether adjLSMeans were height-cubed standardized.ConclusionsA GLI-defined spirometric restrictive pattern is strongly associated with a restrictive ventilatory defect (decreased TLC, FRC, and RV), while GLI-defined spirometric air-flow obstruction is strongly associated with hyperinflation (increased FRC) and air trapping (increased RV and RV/TLC). Both spirometric impairments were strongly associated with impaired gas exchange (decreased hemoglobin-adjusted single-breath diffusing capacity).

Published
2017

8. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study

Author

Gill, Thomas, Fragoso, Carlos, Fielding, Roger, Hauser, Michelle E., Pahor, Marco, Guralnik, Jack M., Leeuwenburgh, Christiaan, Caudle, Connie, Crump, Lauren, Holmes, Latonia, Lee, Jocelyn, Lu, Ching-ju, Miller, Michael E., Espeland, Mark A., Ambrosius, Walter T., Applegate, William, Beavers, Daniel P., Byington, Robert P., Cook, Delilah, Furberg, Curt D., Harvin, Lea N., Henkin, Leora, Hepler, Med John, Hsu, Fang-Chi, Lovato, Laura, Roberson, Wesley, Rushing, Julia, Rushing, Scott, Stowe, Cynthia L., Walkup, Michael P., Hire, Don, Rejeski, W. Jack, Katula, Jeffrey A., Brubaker, Peter H., Mihalko, Shannon L., Jennings, Janine M., Hadley, Evan C., Romashkan, Sergei, Patel, Kushang V., Bonds, Denise, McDermott, Mary M., Spring, Bonnie, Hauser, Joshua, Kerwin, Diana, Domanchuk, Kathryn, Graff, Rex, Rego, Alvito, Church, Timothy S., Blair, Steven N., Myers, Valerie H., Monce, Ron, Britt, Nathan E., Harris, Melissa Nauta, McGucken, Ami Parks, Rodarte, Ruben, Millet, Heidi K., Tudor-Locke, Catrine, Butitta, Ben P., Donatto, Sheletta G., Cocreham, Shannon H., King, Abby C., Castro, Cynthia M., Haskell, William L., Stafford, Randall S., Pruitt, Leslie A., Berra, Kathy, Yank, Veronica, Fielding, Roger A., Nelson, Miriam E., Folta, Sara C., Phillips, Edward M., Liu, Christine K., McDavitt, Erica C., Reid, Kieran F., Kirn, Dylan R., Pasha, Evan P., Kim, Won S., Beard, Vince E., Tsiroyannis, Eleni X., Hau, Cynthia, Manini, Todd M., Anton, Stephen D., Nayfield, Susan, Buford, Thomas W., Marsiske, Michael, Sandesara, Bhanuprasad D., Knaggs, Jeffrey D., Lorow, Megan S., Marena, William C., Korytov, Irina, Morris, Holly L., Fitch, Margo, Singletary, Floris F., Causer, Jackie, Radcliff, Katie A., Newman, Anne B., Studenski, Stephanie A., Goodpaster, Bret H., Glynn, Nancy W., Lopez, Oscar, Nadkarni, Neelesh K., Williams, Kathy, Newman, Mark A., Grove, George, Bonk, Janet T., Rush, Jennifer, Kost, Piera, Ives, Diane G., Kritchevsky, Stephen B., Marsh, Anthony P., Brinkley, Tina E., Demons, Jamehl S., Sink, Kaycee M., Kennedy, Kimberly, Shertzer-Skinner, Rachel, Wrights, Abbie, Fries, Rose, Barr, Deborah, Gill, Thomas M., Axtell, Robert S., Kashaf, Susan S., de Rekeneire, Nathalie, McGloin, Joanne M., Wu, Karen C., Shepard, Denise M., Fennelly, Barbara, Iannone, Lynne P., Mautner, Raeleen, Barnett, Theresa Sweeney, Halpin, Sean N., Brennan, Matthew J., Bugaj, Julie A., Zenoni, Maria A., Mignosa, Bridget M., Williamson, Jeff, Hendrie, Hugh C., Rapp, Stephen R., Verghese, Joe, Woolard, Nancy, Espeland, Mark, Jennings, Janine, Wilson, Valerie K., Pepine, Carl J., Ariet, Mario, Handberg, Eileen, Deluca, Daniel, Hill, James, Szady, Anita, Chupp, Geoffrey L., Flynn, Gail M., Hankinson, John L., Vaz Fragoso, Carlos A., Groessl, Erik J., Kaplan, Robert M., Aubertin-Leheudre, Mylène, Anton, Stephen, Newman, Ann, Church, Tim, Conroy, David, and Botoseneanu, Anda

Published
2017
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22. Diagnosing and Treating Sleep Apnea in Patients With Acute Cerebrovascular Disease

Author

Bravata, Dawn M., primary, Sico, Jason, additional, Vaz Fragoso, Carlos A., additional, Miech, Edward J., additional, Matthias, Marianne S., additional, Lampert, Rachel, additional, Williams, Linda S., additional, Concato, John, additional, Ivan, Cristina S., additional, Fleck, J. D., additional, Tobias, Lauren, additional, Austin, Charles, additional, Ferguson, Jared, additional, Radulescu, Radu, additional, Iannone, Lynne, additional, Ofner, Susan, additional, Taylor, Stanley, additional, Qin, Li, additional, Won, Christine, additional, and Yaggi, H. Klar, additional

Published
2018
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24. Association of Accelerometry‐Measured Physical Activity and Cardiovascular Events in Mobility‐Limited Older Adults: The LIFE (Lifestyle Interventions and Independence for Elders) Study

Author

Cochrane, Shannon K., primary, Chen, Shyh‐Huei, additional, Fitzgerald, Jodi D., additional, Dodson, John A., additional, Fielding, Roger A., additional, King, Abby C., additional, McDermott, Mary M., additional, Manini, Todd M., additional, Marsh, Anthony P., additional, Newman, Anne B., additional, Pahor, Marco, additional, Tudor‐Locke, Catrine, additional, Ambrosius, Walter T., additional, Buford, Thomas W., additional, Espeland, Mark A., additional, Applegate, William, additional, Beavers, Daniel P., additional, Byington, Robert P., additional, Cook, Delilah, additional, Furberg, Curt D., additional, Harvin, Lea N., additional, Henkin, Leora, additional, Hepler, John, additional, Hsu, Fang‐Chi, additional, Lovato, Laura, additional, Roberson, Wesley, additional, Rushing, Julia, additional, Rushing, Scott, additional, Stowe, Cynthia L., additional, Walkup, Michael P., additional, Hire, Don, additional, Rejeski, W. Jack, additional, Katula, Jeffrey A., additional, Brubaker, Peter H., additional, Mihalko, Shannon L., additional, Jennings, Janine M., additional, Pierce, June J., additional, Romashkan, Sergei, additional, Patel, Kushang V., additional, Bonds, Denise, additional, Spring, Bonnie, additional, Hauser, Joshua, additional, Kerwin, Diana, additional, Domanchuk, Kathryn, additional, Graff, Rex, additional, Rego, Alvito, additional, Blair, Steven N., additional, Myers, Valerie H., additional, Monce, Ron, additional, Britt, Nathan E., additional, Harris, Melissa Nauta, additional, McGucken, Ami Parks, additional, Rodarte, Ruben, additional, Millet, Heidi K., additional, Butitta, Ben P., additional, Donatto, Sheletta G., additional, Cocreham, Shannon H., additional, Castro, Cynthia M., additional, Haskell, William L., additional, Stafford, Randall S., additional, Pruitt, Leslie A., additional, Berra, Kathy, additional, Yank, Veronica, additional, Anton, Stephen D., additional, Nayfield, Susan, additional, Marsiske, Michael, additional, Sandesara, Bhanuprasad D., additional, Knaggs, Jeffrey D., additional, Lorow, Megan S., additional, Marena, William C., additional, Korytov, Irina, additional, Morris, Holly L., additional, Fitch, Margo, additional, Singletary, Floris F., additional, Causer, Jackie, additional, Radcliff, Katie A., additional, Studenski, Stephanie A., additional, Goodpaster, Bret H., additional, Glynn, Nancy W., additional, Lopez, Oscar, additional, Nadkarni, Neelesh K., additional, Williams, Kathy, additional, Newman, Mark A., additional, Grove, George, additional, Bonk, Janet T., additional, Rush, Jennifer, additional, Kost, Piera, additional, Ives, Diane G., additional, Brinkley, Tina E., additional, Demons, Jamehl S., additional, Sink, Kaycee M., additional, Kennedy, Kimberly, additional, Shertzer‐Skinner, Rachel, additional, Wrights, Abbie, additional, Fries, Rose, additional, Barr, Deborah, additional, Axtell, Robert S., additional, Kashaf, Susan S., additional, de Rekeneire, Nathalie, additional, McGloin, Joanne M., additional, Wu, Karen C., additional, Shepard, Denise M., additional, Fennelly, Barbara, additional, Iannone, Lynne P., additional, Mautner, Raeleen, additional, Barnett, Theresa Sweeney, additional, Halpin, Sean N., additional, Brennan, Matthew J., additional, Bugaj, Julie A., additional, Zenoni, Maria A., additional, Mignosa, Bridget M., additional, Hendrie, Hugh C., additional, Rapp, Stephen R., additional, Verghese, Joe, additional, Woolard, Nancy, additional, Espeland, Mark, additional, Jennings, Janine, additional, Wilson, Valerie K., additional, Handberg, Eileen, additional, Flynn, Gail M., additional, Gill, Thomas M., additional, Hankinson, John L., additional, Vaz Fragoso, Carlos A., additional, and Kaplan, Robert M., additional

Published
2017
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25. Dynapenia and Metabolic Health in Obese and Nonobese Adults Aged 70 Years and Older: The LIFE Study

Author

Aubertin-Leheudre, Mylène, primary, Anton, Stephen, additional, Beavers, Daniel P., additional, Manini, Todd M., additional, Fielding, Roger, additional, Newman, Ann, additional, Church, Tim, additional, Kritchevsky, Stephen B., additional, Conroy, David, additional, McDermott, Mary M., additional, Botoseneanu, Anda, additional, Hauser, Michelle E., additional, Pahor, Marco, additional, Gill, Thomas, additional, Fragoso, Carlos, additional, Guralnik, Jack M., additional, Leeuwenburgh, Christiaan, additional, Caudle, Connie, additional, Crump, Lauren, additional, Holmes, Latonia, additional, Lee, Jocelyn, additional, Lu, Ching-ju, additional, Miller, Michael E., additional, Espeland, Mark A., additional, Ambrosius, Walter T., additional, Applegate, William, additional, Byington, Robert P., additional, Cook, Delilah, additional, Furberg, Curt D., additional, Harvin, Lea N., additional, Henkin, Leora, additional, Hepler, Med John, additional, Hsu, Fang-Chi, additional, Lovato, Laura, additional, Roberson, Wesley, additional, Rushing, Julia, additional, Rushing, Scott, additional, Stowe, Cynthia L., additional, Walkup, Michael P., additional, Hire, Don, additional, Rejeski, W. Jack, additional, Katula, Jeffrey A., additional, Brubaker, Peter H., additional, Mihalko, Shannon L., additional, Jennings, Janine M., additional, Hadley, Evan C., additional, Romashkan, Sergei, additional, Patel, Kushang V., additional, Bonds, Denise, additional, Spring, Bonnie, additional, Hauser, Joshua, additional, Kerwin, Diana, additional, Domanchuk, Kathryn, additional, Graff, Rex, additional, Rego, Alvito, additional, Church, Timothy S., additional, Blair, Steven N., additional, Myers, Valerie H., additional, Monce, Ron, additional, Britt, Nathan E., additional, Harris, Melissa Nauta, additional, McGucken, Ami Parks, additional, Rodarte, Ruben, additional, Millet, Heidi K., additional, Tudor-Locke, Catrine, additional, Butitta, Ben P., additional, Donatto, Sheletta G., additional, Cocreham, Shannon H., additional, King, Abby C., additional, Castro, Cynthia M., additional, Haskell, William L., additional, Stafford, Randall S., additional, Pruitt, Leslie A., additional, Berra, Kathy, additional, Yank, Veronica, additional, Fielding, Roger A., additional, Nelson, Miriam E., additional, Folta, Sara C., additional, Phillips, Edward M., additional, Liu, Christine K., additional, McDavitt, Erica C., additional, Reid, Kieran F., additional, Kirn, Dylan R., additional, Pasha, Evan P., additional, Kim, Won S., additional, Beard, Vince E., additional, Tsiroyannis, Eleni X., additional, Hau, Cynthia, additional, Anton, Stephen D., additional, Nayfield, Susan, additional, Buford, Thomas W., additional, Marsiske, Michael, additional, Sandesara, Bhanuprasad D., additional, Knaggs, Jeffrey D., additional, Lorow, Megan S., additional, Marena, William C., additional, Korytov, Irina, additional, Morris, Holly L., additional, Fitch, Margo, additional, Singletary, Floris F., additional, Causer, Jackie, additional, Radcliff, Katie A., additional, Newman, Anne B., additional, Studenski, Stephanie A., additional, Goodpaster, Bret H., additional, Glynn, Nancy W., additional, Lopez, Oscar, additional, Nadkarni, Neelesh K., additional, Williams, Kathy, additional, Newman, Mark A., additional, Grove, George, additional, Bonk, Janet T., additional, Rush, Jennifer, additional, Kost, Piera, additional, Ives, Diane G., additional, Marsh, Anthony P., additional, Brinkley, Tina E., additional, Demons, Jamehl S., additional, Sink, Kaycee M., additional, Kennedy, Kimberly, additional, Shertzer-Skinner, Rachel, additional, Wrights, Abbie, additional, Fries, Rose, additional, Barr, Deborah, additional, Gill, Thomas M., additional, Axtell, Robert S., additional, Kashaf, Susan S., additional, de Rekeneire, Nathalie, additional, McGloin, Joanne M., additional, Wu, Karen C., additional, Shepard, Denise M., additional, Fennelly, Barbara, additional, Iannone, Lynne P., additional, Mautner, Raeleen, additional, Barnett, Theresa Sweeney, additional, Halpin, Sean N., additional, Brennan, Matthew J., additional, Bugaj, Julie A., additional, Zenoni, Maria A., additional, Mignosa, Bridget M., additional, Williamson, Jeff, additional, Hendrie, Hugh C., additional, Rapp, Stephen R., additional, Verghese, Joe, additional, Woolard, Nancy, additional, Espeland, Mark, additional, Jennings, Janine, additional, Wilson, Valerie K., additional, Pepine, Carl J., additional, Ariet, Mario, additional, Handberg, Eileen, additional, Deluca, Daniel, additional, Hill, James, additional, Szady, Anita, additional, Chupp, Geoffrey L., additional, Flynn, Gail M., additional, Hankinson, John L., additional, Vaz Fragoso, Carlos A., additional, Groessl, Erik J., additional, and Kaplan, Robert M., additional

Published
2017
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27. Predictors of Change in Physical Function in Older Adults in Response to Long-Term, Structured Physical Activity: The LIFE Study

Author

Layne, Andrew S., primary, Hsu, Fang-Chi, additional, Blair, Steven N., additional, Chen, Shyh-Huei, additional, Dungan, Jennifer, additional, Fielding, Roger A., additional, Glynn, Nancy W., additional, Hajduk, Alexandra M., additional, King, Abby C., additional, Manini, Todd M., additional, Marsh, Anthony P., additional, Pahor, Marco, additional, Pellegrini, Christine A., additional, Buford, Thomas W., additional, Guralnik, Jack M., additional, Leeuwenburgh, Christiaan, additional, Caudle, Connie, additional, Crump, Lauren, additional, Holmes, Latonia, additional, Lee, Jocelyn, additional, Lu, Ching-ju, additional, Miller, Michael E., additional, Espeland, Mark A., additional, Ambrosius, Walter T., additional, Applegate, William, additional, Beavers, Daniel P., additional, Byington, Robert P., additional, Cook, Delilah, additional, Furberg, Curt D., additional, Harvin, Lea N., additional, Henkin, Leora, additional, Hepler, John, additional, Lovato, Laura, additional, Roberson, Wesley, additional, Rushing, Julia, additional, Rushing, Scott, additional, Stowe, Cynthia L., additional, Walkup, Michael P., additional, Hire, Don, additional, Rejeski, W. Jack, additional, Katula, Jeffrey A., additional, Brubaker, Peter H., additional, Mihalko, Shannon L., additional, Jennings, Janine M., additional, Hadley, Evan C., additional, Romashkan, Sergei, additional, Patel, Kushang V., additional, Bonds, Denise, additional, McDermott, Mary M., additional, Spring, Bonnie, additional, Hauser, Joshua, additional, Kerwin, Diana, additional, Domanchuk, Kathryn, additional, Graff, Rex, additional, Rego, Alvito, additional, Church, Timothy S., additional, Myers, Valerie H., additional, Monce, Ron, additional, Britt, Nathan E., additional, Harris, Melissa Nauta, additional, McGucken, Ami Parks, additional, Rodarte, Ruben, additional, Millet, Heidi K., additional, Tudor-Locke, Catrine, additional, Butitta, Ben P., additional, Donatto, Sheletta G., additional, Cocreham, Shannon H., additional, Castro, Cynthia M., additional, Haskell, William L., additional, Stafford, Randall S., additional, Pruitt, Leslie A., additional, Berra, Kathy, additional, Yank, Veronica, additional, Nelson, Miriam E., additional, Folta, Sara C., additional, Phillips, Edward M., additional, Liu, Christine K., additional, McDavitt, Erica C., additional, Reid, Kieran F., additional, Kim, Won S., additional, Beard, Vince E., additional, Anton, Stephen D., additional, Nayfield, Susan, additional, Marsiske, Michael, additional, Sandesara, Bhanuprasad D., additional, Knaggs, Jeffrey D., additional, Lorow, Megan S., additional, Marena, William C., additional, Korytov, Irina, additional, Morris, Holly L., additional, Fitch, Margo, additional, Singletary, Floris F., additional, Causer, Jackie, additional, Radcliff, Katie A., additional, Newman, Anne B., additional, Studenski, Stephanie A., additional, Goodpaster, Bret H., additional, Lopez, Oscar, additional, Nadkarni, Neelesh K., additional, Williams, Kathy, additional, Newman, Mark A., additional, Grove, George, additional, Bonk, Janet T., additional, Rush, Jennifer, additional, Kost, Piera, additional, Ives, Diane G., additional, Kritchevsky, Stephen B., additional, Brinkley, Tina E., additional, Demons, Jamehl S., additional, Sink, Kaycee M., additional, Kennedy, Kimberly, additional, Shertzer-Skinner, Rachel, additional, Wrights, Abbie, additional, Fries, Rose, additional, Barr, Deborah, additional, Gill, Thomas M., additional, Axtell, Robert S., additional, Kashaf, Susan S., additional, de Rekeneire, Nathalie, additional, McGloin, Joanne M., additional, Wu, Karen C., additional, Shepard, Denise M., additional, Fennelly, Barbara, additional, Iannone, Lynne P., additional, Mautner, Raeleen, additional, Barnett, Theresa Sweeney, additional, Halpin, Sean N., additional, Brennan, Matthew J., additional, Bugaj, Julie A., additional, Zenoni, Maria A., additional, Mignosa, Bridget M., additional, Williamson, Jeff, additional, Hendrie, Hugh C., additional, Rapp, Stephen R., additional, Verghese, Joe, additional, Woolard, Nancy, additional, Espeland, Mark, additional, Jennings, Janine, additional, Pepine, Carl J., additional, Ariet, Mario, additional, Handberg, Eileen, additional, Deluca, Daniel, additional, Hill, James, additional, Szady, Anita, additional, Chupp, Geoffrey L., additional, Flynn, Gail M., additional, Hankinson, John L., additional, Vaz Fragoso, Carlos A., additional, Groessl, Erik J., additional, and Kaplan, Robert M., additional

Published
2017
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