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A new human leukocyte antigen‐B allele was found in an unrelated Italian donor. [ABSTRACT FROM AUTHOR]

Bone remodeling is a physiological, dynamic process that mainly depends on the functions of 2 cell types: osteoblasts and osteoclasts. Emerging evidence suggests that complement system is crucially involved in the regulation of functions of these cells, especially during inflammatory states. In this context, complement component 5a (C5a), a powerful pro-inflammatory anaphylatoxin that binds the receptor C5aR1, is known to regulate osteoclast formation and osteoblast inflammatory responses, and has thus been proposed as potential therapeutic target for the treatment of inflammatory bone diseases. In this review, we will analyze the role of C5a-C5aR1 axis in bone physiology and pathophysiology, describing its involvement in the pathogenesis of some of the most frequent inflammatory bone diseases such as rheumatoid arthritis, and also in osteoporosis and bone cancer and metastasis. Moreover, we will examine C5aR1-based pharmacological approaches that are available and have been tested so far for the treatment of these conditions. Given the growing interest of the scientific community on osteoimmunology, and the scarcity of data regarding the role of C5a-C5aR1 axis in bone pathophysiology, we will highlight the importance of this axis in mediating the interactions between skeletal and immune systems and its potential use as a therapeutic target., Competing Interests: AR, AS, RN, SI, AA, and PA are employees of Dompé Farmaceutici SpA. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Ruocco, Sirico, Novelli, Iannelli, Van Breda, Kyburz, Hasler, Aramini and Amendola.)

Aim: to investigate the physical and physiological demands of a pole dancer's performance studied during a simulated competition, lasting 3 min 30 sec., Methods: one single woman pole dancer, (age: 22 years; height: 1.56m; body weight: 52kg; BMI: 21.4kg·m-2; estimated HRmax:192.6 bpm) participated in the study. Physical data pertaining to accelerations and rotational values were collected by the means of a tri-axial accelerometer device integrating three gyroscopes. A complete video footage was recorded using four video cameras, using different sampling rates. Blood Pressure, Heart Rates, Breathing Rates, Blood Lactate concentrations were recorded during the performance., Results: Accelerations (positive and negative), along the vertical axis reached 2G and rotational movements around the pole, reached 400°/s. Blood Pressure values ranged from 120/75 before and to 145/58 mmHg at the end of performance, respectively. Heart Rates reached a peak value of 96% of the Maximal Estimated Heart Rate (HRmax) and a mean %HRmax of 92.85 ± 3.15% during the simulated competition. Breathing Rate reached a peak value of 37 bpm and a mean value during competition of 31.87±3.42 bpm. Blood Lactate concentration ranged from 10.2 to 10.7 mmol/L measured at 1 min and 5 min after the completion of the competition, respectively., Conclusions: The results of this case study confirm that the Pole Dance is a performing art requiring heavy physiological and physical demands on the performers. Specific training routines should be designed in order to cope efficiently with this physical activity, taking into account the performance model we provided with this study.