Search

The main task of the transport system is the most complete satisfaction of the needs of business entities and the population in transportation, reducing the time of delivery of goods and transportation of passengers on the basis of a qualitative increase in the capacity of the entire transport system. This problem is solved with the help of computer technology and new information technologies in transport management systems. The most demanded is the database technology implemented in modern automated transport management information systems. Given the exponential growth in the volume of databases used, strict time limits for real-time management decisions in transport management systems, the task of minimizing the time to execute information queries in the database is of particular relevance. The execution time of information requests is infl uenced by the methods of physical storage of databases. To solve the problem of minimizing the execution time of information requests, it is necessary to determine the physical parameters that affect the efficiency of database processing. An external memory simulation model is described for optimizing the physical parameters of database organization, based on the exchange procedures implemented in modern database management systems between external and operational memory upon information requests. As a key optimization parameter, a memory block reservation factor is substantiated, which allows minimizing the number of slow accesses to external memory. The rationality and adequacy of the proposed model in the process of research is confirmed by the results of simulation modeling.

The interdisciplinary approach is recognized as the gold standard for organizing medical care for patients with oncological pathology. It is declared at the normative level in Ukraine, but the forms and methods of work, channels and methods of communication of specialists are not detailed. This requires further research, in particular, when providing surgical care to patients with thyroid pathology. The purpose of the study was to investigate the state of activity organization of multidisciplinary teams in the provision of surgical care to patients with thyroid pathology and to propose approaches for its improvement. Materials and methods: accounting forms No. 003 for 2019 (1208 units), constituent and administrative documents for the institution, department regulations, job descriptions, clinical pathway of patients (15 units in total). The base of research was communal non-profit enterprise "Kiev City Clinical Endocrinological Center". The methods, which were used, are systematic approach, medical and statistical, medical and geographical methods, content analysis, graphic. Results and discussion. Patients of the Department of Endocrine Surgery were from almost all regions of Ukraine. 3.5% of patients were referred by a general practitioner, 55.7% - by an endocrinologist, 40.1% - independently applied. Malignant neoplasm of the thyroid gland was detected in 33.9% of patients, non-toxic multinodular goiter – in 25.2%, benign neoplasm – in 16.3%. In 448 (37.1%) patients, 687 concomitant diseases and complications were identified. Their structure consisted of diseases of the heart and circulatory system – 40.0%, eye diseases – 3.1%, diseases of the nervous system – 2.0%. In order to meet the needs of patients, instrumental and laboratory studies, consultative examinations, consultations and surgical interventions were carried out. The low level of communication between inpatient doctors and outpatient doctors has been shown. This was the reason for the excessive length of stay in bed – 12.6 ± 2.7 days. There is a separate participation of specialist doctors in accompanying patients in the hospital. It was proposed to formalize the official status and develop a typical provision for a multidisciplinary team of specialists; joint discussion, debate, data exchange within the team and with outpatient doctors; afford access to corporate information for the team and coordinate the work of authorized employees. Conclusion. Improving the efficiency of multidisciplinary teams is possible by strengthening collaboration within the team and communication with outpatient doctors

This study was carried out to estimate the genetic diversity between cultivars of alfalfa using SRAP marker system (sequence-related amplified polymorphism). We tested 25 combinations of SRAP markers and revealed that seven of them were informative for DNA polymorphism identification. These combinations generated 129 PCR products with the percentage of polymorphic bands per pair ranging from 21 to 50%. Specific amplification products were identified for 14 cultivars for genetic certification.

The needs of the population in endocrinological care are determined by demographic data, morbidity levels, and leading places in their structure, as well as for other pathologies. This indicates their social significance and needs for medical care. It was found that diseases of the endocrine system accounted for 0.4% of the total mortality of the capital in 2020. Their share was significantly lower than diseases of the circulatory system (61.4%), digestive system (4.2%), respiratory system (2.3%), genitourinary system (0.6%), and malignant neoplasms (15.4%). , diseases caused by the COVID-19 virus (6.5%), injuries and poisonings (3.6%), and infectious and parasitic diseases (1.2%). At the same time, from 2013 to 2020 the mortality rate from endocrine diseases showed a steady trend of moderate growth from 3.8 in 2013 to 5.4 in 2020. Mortality from diabetes was the highest among other pathologies in this class of diseases and increased from 3.4 to 4.9 per 100 thousand population during this period.

We have obtained a new water-soluble form of boron(III) dipyrromethene luminophores using the example of 3,3',5,5'-tetraphenyl-ms-aza-2,2'-dipyrromethenate boron(III) (BODIPY) and Cremophor® (polyethylene glycol, PEG-40). The results of a study of the spectral-luminescent properties of the studied BODIPY–Cremophor®–aqueous–alcohol medium system are presented. It is found that Cremophor® is the only one of a series of investigated excipients (PEG-400, PEG-1000, polyvinylpyrrolidone, bovine serum albumin, sodium carboxymethylcellulose) providing solubilization of BODIPY in an aqueous medium, while maintaining its intense spectral characteristics, including fluorescence and luminophore, in the red region of the spectrum. The BODIPY–Cremophor® system is tested on two mouse cell lines: metastatic breast cancer and non-metastatic skin cancer. It is shown that the introduction of the BODIPY–Cremophor® system into both cell lines of mice leads to the detachment of cell cultures from the substrate and suppression of the development of cancerous tumors. The results obtained show that immobilization of BODIPY in PEG-40 in an aqueous-alcoholic medium makes it possible to obtain preparations with prolonged action, which can be used as photosensitizers (PSs) in photodynamic therapy and for bioimaging in cell biology.

The spectral luminescent and electrophysical properties of polymer films based on poly-N-vinylpyrrolidone with the stabilized derivatives of tetraphenylporphyrin in various aggregation states (monomers, J- and H-aggregates) were investigated. Films containing a monomolecular form of porphyrins are characterized by intensive fluorescence. For films with J-aggregates an electric response that was not practically observed in the case of H-aggregates was detected. The films obtained are also characterized by optical and electric response to pH change, particularly in the presence of ammonia and hydrogen chloride vapors. The obtained data allow polymeric films with immobilized porphyrins to be considered as potential material for the creation of film systems for sensor applications, photovoltaics, molecular electronics, and photocatalysis. The variability of the film synthesis methodology allows the aggregation state of the immobilized porphyrins to be changed directionally, which provides the possibility of obtaining films of hybrid organic materials with the desired photophysical properties.

Rapeseed (Brassica napus L.) and turnip rape (B. rapa L. subsp. campestris (L.)) are important agricultural plants widely used for food, fodder and technical purposes and as green manure. Over the past decades, a large number of perspective varieties that are being currently cultivated in every region of Russia have been developed. To increase the breeding eff iciency and facilitate the seed production, modern molecular-genetic techniques should be introduced as means to estimate species and varietal diversity. The objective of the presented research study was to investigate DNA polymorphism of the rapeseed and turnip rape varieties developed at Federal Williams Research Center of Forage Production and Agroecology and detect informative markers for varietal identif ication and genetic certif ication. To genotype 18 gDNA samples, 42 and 25 combinations of respective SSR and SRAP primers were used. The results obtained demonstrate that SRAP markers were more effective for polymorphism analysis: 36 % of the tested markers revealed genetic polymorphism compared with only 16.7 % of microsatellite loci. Molecular markers to detect differences at interspecif ic and intervarietal levels have also been found. For the investigated set, such microsatellite loci as Na12A02, Ni2C12, Ni02-D08a, Ra02-E01, Ni03H07а and SRAP-marker combinations as F13-R9, Me4- R7, F11-Em2, F10-R7, F9-Em2 and F9-R8 proved to be informative. Application of the two marker techniques made it possible to detect a higher level of DNA polymorphism in plants of different types (spring and winter varieties) if compared against the intervarietal differences within a species or a group. According to Nei's genetic diversity index, in the cluster of winter rapeseed, VIK 2 and Gorizont varieties had the longest genetic distance, and in the spring cluster, these were Novosel and Veles. A high level of similarity was found between Vikros and Bizon winter rapeseed varieties. The results obtained have a high practical value for varietal specif ication of seed material and genetic certif ication of rapeseed and turnip rape varieties.Рапс (Brassica napus L.) и сурепица (B. rapa L. subsp. campestris (L.)) – важные сельскохозяйственные культуры, широко используются для продовольственных, кормовых и технических целей, а также в качестве сидератов. За последние десятилетия создано большое количество перспективных сортов, культивируемых практически во всех регионах России. Для повышения эффективности селекционного процесса и успешного развития семеноводства необходимо внедрять современные молекулярно-генетические методы оценки видового и сортового разнообразия. Цель настоящей работы заключалась в изучении ДНК-полиморфизма сортов рапса и сурепицы селекции Федерального научного центра кормопроизводства и агроэкологии им. В.Р. Вильямса и выявлении информативных маркеров для сортовой идентификации и генетической паспортизации. Для генотипирования 18 образцов геномной ДНК использовали 42 и 25 комбинаций SSR- и SRAP-праймеров соответственно. Результаты показали, что маркеры SRAP более эффективны для анализа полиморфизма изучаемого материала: 36 % от общего числа испытанных маркеров демонстрировали генетический полиморфизм, тогда как для микросателлитных локусов этот показатель равнялся 16.7 %. Определены молекулярные маркеры для выявления различий на межвидовом и межсортовом уровнях. Информативными для исследуемой выборки сортов оказались микросателлитные локусы Na12A02, Ni2C12, Ni02-D08a, Ra02-E01, Ni03H07а и комбинации SRAP-маркеров F13-R9, Me4-R7, F11-Em2, F10-R7, F9-Em2 и F9-R8. Анализ сортового материала по двум системам маркирования показал более высокий уровень ДНК-полиморфизма у образцов растений разного типа развития (яровой/озимый) в сравнении с различиями между сортами в пределах вида или группы. Согласно индексам генетического разнообразия Нея, в кластере сортов озимого рапса наибольшей генетической удаленностью выделялись ВИК 2 и Горизонт, среди яровых – Новосёл и Велес. Высокий уровень сходства обнаружен между яровыми сортами рапса Викрос и Бизон. Полученная информация имеет практическое значение для контроля сортовой принадлежности и генетической паспортизации семенного материала сортов рапса и сурепицы.

New hybrid graphene and aluminum phthalocyanine structures are synthesized (graphene is prepared with the sonochemical method in N,N-dimethylformamide). The physicochemical properties of these hybrid systems are studied with transmission electron microscopy, Raman spectroscopy, and optical spectroscopy. We show that graphene in the system prevents the aggregation of aluminum phthalocyanine and leads to its stabilization in monomeric form. The results may be used to obtain new materials for various sciences and technologies.

Aim. To develop the optimal method for the synthesis of new polysubstituted thienylpyrroles and study them as cereal growth stimulants. Results and discussion. Preparative methods for the synthesis of 4-(5-carboxythiophen-2-yl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid, 5-(5-carboxythiophen-2-yl)-2,4-dimethyl-1H-pyrrol-3-carboxylic acid and ethyl 4-(4-amino-5)-thoxycarbonyl (thiophen-2-yl)-3,5-dimethyl-1H-pyrrole-2-carboxylate have been developed by step reactions. 4-(5-Carboxythiophen-2-yl)-3,5-dimethyl-1H-pyrrole-2-carboxylic acid is the most promising for the study of the growth-stimulating activity on grain seeds. Experimental part. Using ethyl 4-acyl-3,5-dimethyl-1H-pyrrole-2-carboxylate and ethyl 5-acetyl-2,4-dimethyl- 1H-pyrrole-3-carboxylate as starting compounds 4-(5-carboxythiophen-2-yl)-3,5-dimethyl-1H-pyrrole-2-carboxylic and 5-(5-carboxythiophen-2-yl) 2,4-dimethyl-1H-pyrrol-3-carboxylic acid were obtained. By the action of the Wilsmeier-Haack reagent on the latter the corresponding pyrroles with the chlorvinylcarbaldehyde fragment were isolated; their post-cyclization with ethyl ester of thioglycolic acid and the subsequent hydrolysis leads to the formation of thienylpyroldicarboxylic acids. The study of the physiological activity of the compounds synthesized was performed on seeds of different varieties of wheat and barley. Conclusions. By means of sequential reactions the polysubstituted thienylpyrrolcarboxylic acids previously unknown and their esters have been synthesized. The features of the study of these compounds as plant growth stimulants have been revealed.

This article shows the importance of studying history of medicine and importance of language training as an essential component of broadening of universal cultural and medical outlook of prospective doctors, upbringing of high moral ethical qualities inherent to a contemporary doctor. The authors of the article propose measure on improving teaching of these disciplines. Важливість вивчення історії медицини та мовної підготовки для розвитку професійних компетенцій студентів-медиків. Семенова Л.С., Клименко І.М. Ця стаття розкриває значення вивчення історії медицини та значення мовної підготовки як важливого компонента розширення загальнокультурного і медичного кругозору майбутніх лікарів, виховання в них високих морально-етичних якостей, які повинні бути притаманні сучасному лікарю. Автори статті пропонують заходи щодо вдосконалення викладання цих дисциплін студентам-медикам.

Purpose. A goal of the work is development of 3D numerical model for a territorial risk assessment in a case of a terrorist attack with usage of a chemical agent. Methodology. To describe the process of chemical agent dispersion in the atmosphere, emitted in a case of a terrorist attack, the equation of mass transfer of an admixture in atmospheric air is used. The equation takes into account a velocity of the wind flow, atmospheric diffusion, an intensity of chemical agent emission, a buildings presence near a place of a chemically hazardous substance release. For numerical integration of the modeling equation, a finite difference method is used. A feature of the developed numerical model is possibility of a territorial risk assessment in a case of a terrorist attack under different weather conditions and a buildings presence. For calculation of wind flow velocity field in a case of building presence 3D equation for potential of velocity is used. Findings . The specialized numerical model and software package which can be used for a territorial risk assessment, both in a case of terrorist attacks with usage of chemical agents, and in a case of extreme situations at chemically hazardous facilities and transport are developed. The method can be implemented on small and medium-powered computers, which allows it to be widely used for solving this class of problems. The results of a computational experiment are presented that allow estimating possibilities of the proposed method for assessing a territorial risk in a case of a terrorist attack with usage of chemical agent. Originality. An effective method of a territorial risk assessment in a case of a terrorist attack with usage of a chemically hazardous substance is proposed. The method can be used to assess a territorial risk in an urban environment, which allows to obtain adequate data about possible affected areas. The method is based on numerical integration of the fundamental mass transfer equation, which expresses the law of conservation of mass in a liquid medium. Practical value. The proposed method for a territorial risk assessment in a case of a terrorist attack with usage of a chemical agent can be used to calculate the affected areas near administrative buildings, centers and other socially significant facilities.

The effect of the filler content on the optical absorption spectra, electroconductivity, and surface morphology of thin nanoocomposite films based on poly(n-xylylene)–tin (PPX–Sn) has been studied. The films under study are prepared in vacuum by cryochemical synthesis on polished quartz, glass-ceramics, and silicon substrates. After completing the preparation, the samples are exposed to air for some time prior to measurements. With an increase in the filler content, a nonmonotonic change in both surface morphology of films (by atomic force microscopy) and adsorption spectra is found. An analysis of the spectra shows that, at the filler concentration C ≤ 9 vol %, tin in the composite is in the oxidized form of SnO2, while at C = 12 vol % it is in a metal state, respectively. With an increase in C from 4 to 12 vol %, the increase in conductivity of nanocomposites is more than 7 decimal orders, with a sharp change in the region of C ≈ 9–12 vol %. The conductivity of the film consisting of nanoparticles (C = 100 vol %) is found to be low and comparable with that for composites with C = 4–5 vol %. With a decrease in the temperature from 300 to 15 K, the resistance of the sample with C = 12 vol % is found to decrease, while that for all other samples increases by the activation law. The activation energy with an increase in the filler concentration to 9 vol % is found to decrease, while that for the sample with C = 100 vol % increases by almost an order of magnitude. The most significant changes in the properties and morphology of the surface of nanocomposites are observed at a concentration of ~9 vol %, which apparently is the percolation threshold.

Using the SCoT marker system, 8 varieties of cereal grasses belonging to 5 species were analyzed: Festuca pratensis, Lolium perenne, Lolium multiflorum, Festuca rubra, Festulolium. Of the 10 tested SCoT markers, 7 informative markers were selected that reveal interspecies genetic polymorphism. According to the results of the analysis, DNA profiles characteristic of each studied species were obtained, and primers allowing to detect intervarietal differences for subsequent identification and molecular genetic passportization were selected.

The conditions for creating alfalfa samples MN-2 (from the Selena variety) and P-67 (from the Lugovaya variety) with increased resistance to Fusarium pathogens using the method of gamete selection are described. The method is based on the selection of gametes in vivo under the influence of a selective factor (culture filtrate) introduced into the generative organs at the early stages of their development using vacuum infiltration. The method was developed in the biotechnology department of the V.N. V.R. Williams. The accessions are included in the breeding process and are currently the accessory varieties. In order to identify differences at the genetic level between the created varieties and the original forms, a comparative analysis was carried out using 2 types of molecular markers based on the PCR method. DNA polymorphism was detected using SRAP primers, which may indicate a change in the structure of genes associated with economic and biological traits. Research is ongoing. When growing under the conditions of a selection and greenhouse complex of acid-tolerant plants of meadow clover, created using cellular technologies in vitro, the infestation by powdery mildew of 120 acid-tolerant plants was studied. No signs of damage were found in 10% of plants. The largest number of affected plants (36.7%) had a score of 3. It was found that a high infestation with powdery mildew (scores 4 and 5) significantly reduces the number of inflorescences in the bush to 83.4 and 75.7%, respectively. Therefore, in further studies to create a population of acid-tolerant plants, the genotypes of meadow clover were used without signs and with a low score of powdery mildew damage.

The present study was undertaken to investigate and characterize the structure, the electrical conductivity in the temperature range 10-300 K, thermogravimetric analysis (TGA) data and micro-Raman spectroscopy data of pitch-based graphite fibers during the bromination process. All the results are explained by the structural changes, the appearance of bromine in two main states, namely, as an intercalated bromine and as a bromine bound to the carbon network by a C-Br bond, by the degradation of graphite network and by the growth of the content of the amorphous phase during the bromination.

The spectral-fluorescent properties of various supramolecular systems based on chlorin e6 (Ce6) are determined to facilitate the development of new medicines for photodynamic therapy and diagnostics. The effect of various excipients, such as poly-N-vinylpyrrolidone (PVP), polyethylene glycol (PEG), bovine serum albumin (BSA), chitosan, Triton X-100 (TX-100), sodium hexametaphosphate (SHMP), and poly(dimethyldiallylammonium chloride) chloride (PDDAC), on the optical absorption and fluorescence of Ce6 is demonstrated. In the Ce6−PVP, Ce6−PEG, Ce6−BSA, Ce6−TX-100, Ce6−SHMP, and Ce6−PDDAC systems, Ce6 molecules are disaggregated and complexes thereof with excipients are formed. The quantum yield of Ce6 fluorescence in supramolecular systems is close to that of the free-form photosensitizer, in the absence of excipients. The results suggest that supramolecular complexes of Ce6 are promising for the development of medicines with controllable photodynamic activity.

Globalization processes accelerate the pace of scientific and technological progress and innovation and require investment in innovation to enhance the efficiency of the national economy of our state and some of its branches, inter–industry complexes and sub–complexes at the level of developed countries. The article examines the current state of investment in agriculture of Ukraine. The main criteria to encourage capital investment taking into account regional peculiarities capital investment in agriculture. The necessity of attracting external sources of investment in the future to enhance investment processes in agriculture. Thus, the study of the current situation of investment activity of agricultural enterprises of Ukraine and structural analysis of sources of investment in agriculture, to determine that the trend of improving investment for 2010–2014., Changed deterioration in 2015 and complication of financing conditions from their own field investment. So one of the essential ways to increase the competitiveness of the industry is an effective investment policy aimed at attracting large–scale foreign investment sources, especially through financial investment. Addressing these and other issues will significantly increase investment flows and rational use of funds in the industry.

Purpose. The purpose of the paper is: (1) the definition of perspectives development of Ukrainian railway tourism on the narrow gauge lines of Zakarpattia; 2) technical condition analysis of Borzhava narrow gauge railway for the project to restore the effective functioning of mountain railways track, width 750 mm in the Carpathian region, with the possibility of their accession to the distributed travel network; 3) the study of the modern state and tendencies of development of tourist industry of Ukraine and the passenger economy of national railways; 4) clarification of the role and place of the railway tourism in the transportation system. Methodology . The expert group has carried out field inspections and field investigations of facilities track facilities and passenger infrastructure, rolling stock and ancillary industries involved in the functioning narrow-gauge railway. It was estimated the overall technical condition of the railway track and engineering structures section of narrow-gauge Railways in the Carpathian region. Findings . In the framework of on-site examinations of the expert group found that the objects of tracks, passenger and freight infrastructure, rolling stock and ancillary industries involved in the operation of narrow-gauge Railways are in poor condition and require significant updates and major repairs. But the routes of passenger trains remain fit for participation in the project of development of railway tourism of Ukraine Originality . For the first time the state of the narrow-gauge railway for further implementation of the project on the development of rail tourism in Ukraine was realized. The analysis of foreign experience of organization of railway tourism has been carried out. The modern state and tendencies of development of tourist industry of Ukraine was studied, the factors of competitiveness of rail transport for providing tourist transport in Ukraine were identified and systematized. Practical value . The recovery and effective functioning of mountain railways with a width of 750 mm in the Carpathian region will give an impetus to the tourism development, engineering, construction and energy. At the same time, these actions will allow us to finally implement a scientifically-based effective flood control measures that will protect the population from natural environmental disasters.

A geometric approach to revealing the characteristic signs of photoresponse from semiconductor sensor materials is presented. It is shown by the example of zinc chalcogenides that natural decomposition of the transient photoresponse into geometrically ordered components is performed upon transforming their transient photoresponse into first-order and second-order signatures. Universal differential-geometric parameters and other indices, which are also applicable for other characteristics of semiconductor sensor materials, are applied for the system analysis of ordering the dynamic structure of the photoresponse.

The novel supramolecular systems based on chlorine e6 (Ce6) are presented, and their optical absorption and fluorescence have been investigated. The influence of different excipients as poly-N-vinylpyrrolidone (PVP), polyethyleneglycol (PEG), bovine serum albumin (BSA), chitosan, Triton X-100 (TX-100) on spectral characteristics of these systems has been studied. The obtained spectral-fluorescence characteristics of Ce6-PVP, Ce6-PEG, Ce6-BSA, Ce6-TX-100 indicate disaggregation of chlorine e6 molecules and their consecutive interaction with excipients in solutions and formation of molecular associates and molecular complexes. The system Ce6-chitosan is characterized by aggregation of pigments in solution that reduces photochemical activity of a photosensitizer. The fluorescence quantum yield k of mentioned above supramolecular systems has been calculated. The results can be useful during the new method of controlled aggregation of photosensitizers as a part of supramolecular complexes development as well as for the purposes of new medicines of predictable photodynamic activity creation. © 2016 Journal of Biomedical Photonics & Engineering.

Signals of system functioning of different nature are presented in the parameter space (state-velocity-acceleration) as a trajectory of dynamic events. Such signals geometrization allows to reveal the hidden spatio-temporal correlation in dynamics of systems functioning. It is shown that the nature of relationship between the dynamic parameters of signal determines the natural cycle of sensor functioning. Its restructuring displays the inherited features of systems functioning in signature package. The universal differential-geometry parameters and new integrative indexes of system functioning are used to analyze the signatures of biological and physical signals.

У дослідженні розглянуті різні точки зору відносно реформування фармацевтичної галузі в Україні, її модернізації і оновлення. Обґрунтовано, що основний принцип законопроектної діяльності в фармації повинен зосереджуватися на зміщенні акцентів на користь процесного управління об’єктами права, а не власне їх засобами, дозволами, заборонами, заходами адміністративного, карного, авторитарного характеру, що надає гарантії ефективної реалізації цього процесу., Current research considers various points of view concerning reformation, modernization, update of pharmaceutical branch of Ukraine. It is indicated that basic principle of lawmaking activity has to second – guess upheaval of emphases on behalf of processed management in handling of objects of law and not in an own way by means of their means, permissions, interdictions, measures of administrative, criminal, authoritative character, which makes available of guarantees of effective implementation of remarked process., Данное исследование рассматривает различные точки зрения относительно реформирования, модернизации, обновления фармацевтической отрасли Украины. Показано, что основной принцип законопроектной деятельности должен предусматривать смещение акцентов в пользу процессного менеджмента в управлении объектами права, а не собственно их средствами, разрешениями, запретами, мерами административного, уголовного, авторитарного характера, что предоставляет гарантии эффективной реализации указанного процесса.

Purpose. Improving the efficiency and the sustainability of the railways operating processes, reducing operating costs is not possible without the complex automation system development intended for technical system park operation - ASPE. The article is devoted to improve the ASPE in terms of methods for analysis and planning priority of diagnostics and repair of electric motors (EM) rail turnouts taking into account condition indeterminacy. Technological and economic models which are used in the automated management ASPE should consider a different form of information about the technical condition of equipment and conditions for the transport system operation (especially fuzzy). Also, the model should provide the possibility of adaptation options and greater efficiency of planning procedures, to improve the efficiency of rail transport in general. Methods. The researching works were conducted using the procedures for monitoring and diagnosing EM under the influence of workloads. EM park operation management carried out on the basis of individual intellectual models, as well as the Kohonen network, built on the spectral characteristics of the current EM. Specialization of production was taken into account during repair planning. EM priority service is based on a two-stage fuzzy planning model. For analysis and forecasting parameters of non-determined processes is used methods of chaotic dynamics. Results. Economical and technological models and control automated analysis of the EM park operation with fuzzy description of parameters and conditions were improved. They take into account the current state of the technical systems and the possible failures of the transportation process. The properties of some non-determined processes of rail were investigated. Scientific novelty. Economical and technological models with automatic control operation of EM parks, taking into account the terms of fuzzy description of the system parameters were developed. The models were designed for priority planning of EM diagnostic and repair, they also take into account the specialization of the production.The properties of the interpretation procedure of the non-deterministic time series with aggregated levelswere investigated.The practical significance. The research results provide the ability to automate and improve the efficiency of the processes of economical and technological management operation of EM turnouts park in conditions of fuzzy system settings. The analysis procedure of aggregated series provides opportunities for reasonable interpretation of their properties and for obtaining reliable estimates of forecasting and planning based on time series., Цель. Повышение эффективности и устойчивости процессов эксплуатации на железных дорогах, уменьшение эксплуатационных расходов невозможны без развития комплексных систем автоматизации эксплуатации парков технических систем – АСЭП. Статья посвящена вопросам совершенствования АСЭП в части развития методов анализа и планирования очередности диагностики и ремонтов электрических двигателей (ЭД) железнодорожных стрелочных переводов с учетом условий недетерминированности. Усовершенствованные технологические и экономические модели, по которым выполняется автоматизированное управление АСЭП, должны учитывать различную форму информации о техническом состоянии устройств и условий функционирования транспортной системы (в частности, нечеткую). Также модели должны обеспечивать возможности адаптации параметров и большей результативности процедур планирования с целью повышения эффективности железнодорожных перевозок в целом. Методика. Исследования проведены с использованием процедур мониторинга и диагностирования ЭД, которые находились под воздействием рабочих нагрузок. Управление эксплуатацией парков ЭД выполняется на основе индивидуальных интеллектуальных моделей, а также сетей Кохонена, построенных по спектральным характеристикам токов ЭД. При планировании ремонтов учитывается специализация исполнителей. Очередность обслуживания ЭД определяется на основе нечеткой двухэтапной модели планирования. Для анализа и прогнозирования параметров недетерминированных процессов применяются методы хаотической динамики. Результаты. Усовершенствованы экономико-технологические модели анализа и управления автоматизированными процессами эксплуатации парков ЭД при нечетком описании параметров и условий. Они учитывают текущее состояние технических систем, а также возможные сбои процесса перевозок. Исследованы свойства недетерминированных процессов железнодорожных перевозок. Научная новизна. Получили развитие экономико-технологические модели автоматизированного управления эксплуатацией парков ЭД в условиях нечеткого описания параметров системы. Модели предназначены для планирования очередности диагностики и ремонтов ЭД и учитывают специализацию исполнителей работ. Исследованы свойства процедуры анализа и интерпретации недетерминированных временных рядов при агрегировании уровней. Практическая значимость. Результаты ис-следований обеспечивают возможность автоматизации и повышения эффективности процессов экономико-технологического управления эксплуатацией парков ЭД стрелочных переводов в условиях нечеткого определения параметров системы. Процедуры анализа агрегированных рядов обеспечивают возможности обоснованной интерпретации их свойств и получения достоверных оценок прогнозирования и планирования на основе временных рядов., Мета. Підвищення ефективності та стійкості процесів експлуатації на залізницях, зменшення експлуатаційних витрат неможливі без розвитку комплексних систем автоматизації, призначених для експлуатації парків технічних систем – АСЕП. Стаття присвячена питанням удосконалення АСЕП в частині розвитку методів аналізу й планування черговості діагностування та ремонтів електричних двигунів (ЕД) залізничних стрілочних переводів з урахуванням умов недетермінованості. Удосконалені технологічні й економічні моделі, за якими виконується автоматизоване управління АСЕП, повинні враховувати різну форму інформації про технічний стан пристроїв та умови функціонування транспортної системи (зокрема, нечітку). Також моделі повинні забезпечувати можливості адаптації параметрів і більшої результативності процедур планування з метою підвищення ефективності залізничних перевезень у цілому. Методика. Дослідження були здійснені з використанням процедур моніторингу та діагностування ЕД, які перебували під впливом робочих навантажень. Управління експлуатацією парків ЕД виконується на основі індивідуальних інтелектуальних моделей, а також мереж Кохонена, побудованих за спектральними характеристиками струму ЕД. При плануванні ремонтів ураховується спеціалізація виконавців. Черговість обслуговування ЕД визначається на основі нечіткої двоетапної моделі планування. Для аналізу й прогнозування параметрів недетермінованих процесів застосовуються методи хаотичної динаміки. Результати. Удосконалено економіко-технологічні моделі аналізу й управління автоматизованими процесами експлуатації парків ЕД при нечіткому описі параметрів та умов. Вони ураховують поточний стан технічних систем, а також можливі збої процесу перевезень. Досліджено властивості недетермінованих процесів залізничних перевезень. Наукова новизна. Набулирозвиткуекономіко-технологічнімоделіавтоматизованогоуправлінняексплуатацієюпарківЕД, які враховують умовинечіткогоописупараметрівсистеми. Моделі призначені для планування черговості діагностування та ремонтів ЕД, також вони ураховують спеціалізацію підприємств. Досліджено властивості процедури аналізу та інтерпретації недетермінованих часових рядів вагонопотоків при агрегуванні їх рівнів. Практична значимість. Результати досліджень забезпечують можливість автоматизації та підвищення ефективності процесів економіко-технологічного управління експлуатацією парків ЕД стрілочних переводів за умов нечіткого визначення параметрів системи. Процедура аналізу агрегованих рядів забезпечує можливості обґрунтованої інтерпретації їх властивостей та отримання достовірних оцінок прогнозування і планування на основі часових рядів.