163 results on '"Hume, Adam J."'
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2. 2022 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales
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Kuhn, Jens H., Adkins, Scott, Alkhovsky, Sergey V., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Bandte, Martina, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Bigarré, Laurent, Blair, Carol D., Blasdell, Kim R., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Bruggmann, Rémy, Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Candresse, Thierry, Carson, Jeremy, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chiaki, Yuya, Crane, Anya, Crane, Mark, Dacheux, Laurent, Bó, Elena Dal, de la Torre, Juan Carlos, de Lamballerie, Xavier, de Souza, William M., de Swart, Rik L., Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J. Felix, Duprex, W. Paul, Dürrwald, Ralf, Easton, Andrew J., Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Feuvrier, Claudette, Firth, Andrew E., Fooks, Anthony R., Formenty, Pierre B. H., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Godwin, Scott E., Gonzalez, Jean-Paul J., de Bellocq, Joëlle Goüy, Griffiths, Anthony, Groschup, Martin H., Günther, Stephan, Hammond, John, Hepojoki, Jussi, Hierweger, Melanie M., Hongō, Seiji, Horie, Masayuki, Horikawa, Hidenori, Hughes, Holly R., Hume, Adam J., Hyndman, Timothy H., Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Kadono, Fujio, Karlin, David G., Klempa, Boris, Klingström, Jonas, Koch, Michel C., Kondō, Hideki, Koonin, Eugene V., Krásová, Jarmila, Krupovic, Mart, Kubota, Kenji, Kuzmin, Ivan V., Laenen, Lies, Lambert, Amy J., Lǐ, Jiànróng, Li, Jun-Min, Lieffrig, François, Lukashevich, Igor S., Luo, Dongsheng, Maes, Piet, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin-Yi L., McCauley, John W., Mirazimi, Ali, Mohr, Peter G., Moody, Nick J. G., Morita, Yasuaki, Morrison, Richard N., Mühlberger, Elke, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, José A., Neriya, Yutaro, Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Ochoa-Corona, Francisco M., Palacios, Gustavo, Pallandre, Laurane, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Pérez, Daniel R., Pfaff, Florian, Plemper, Richard K., Postler, Thomas S., Pozet, Françoise, Radoshitzky, Sheli R., Ramos-González, Pedro L., Rehanek, Marius, Resende, Renato O., Reyes, Carina A., Romanowski, Víctor, Rubbenstroth, Dennis, Rubino, Luisa, Rumbou, Artemis, Runstadler, Jonathan A., Rupp, Melanie, Sabanadzovic, Sead, Sasaya, Takahide, Schmidt-Posthaus, Heike, Schwemmle, Martin, Seuberlich, Torsten, Sharpe, Stephen R., Shi, Mang, Sironi, Manuela, Smither, Sophie, Song, Jin-Won, Spann, Kirsten M., Spengler, Jessica R., Stenglein, Mark D., Takada, Ayato, Tesh, Robert B., Těšíková, Jana, Thornburg, Natalie J., Tischler, Nicole D., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Tsunekawa, Kenta, Turina, Massimo, Tzanetakis, Ioannis E., Vaira, Anna Maria, van den Hoogen, Bernadette, Vanmechelen, Bert, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Whitfield, Anna E., Williams, John V., Wolf, Yuri I., Yamasaki, Junki, Yanagisawa, Hironobu, Ye, Gongyin, Zhang, Yong-Zhen, and Økland, Arnfinn Lodden
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- 2022
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3. Renaming of genera Ebolavirus and Marburgvirus to Orthoebolavirus and Orthomarburgvirus, respectively, and introduction of binomial species names within family Filoviridae
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Biedenkopf, Nadine, Bukreyev, Alexander, Chandran, Kartik, Di Paola, Nicholas, Formenty, Pierre B. H., Griffiths, Anthony, Hume, Adam J., Mühlberger, Elke, Netesov, Sergey V., Palacios, Gustavo, Pawęska, Janusz T., Smither, Sophie, Takada, Ayato, Wahl, Victoria, and Kuhn, Jens H.
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- 2023
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4. Ebola virus infection induces a delayed type I IFN response in bystander cells and the shutdown of key liver genes in human iPSC-derived hepatocytes
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Scoon, Whitney A., Mancio-Silva, Liliana, Suder, Ellen L., Villacorta-Martin, Carlos, Lindstrom-Vautrin, Jonathan, Bernbaum, John G., Mazur, Steve, Johnson, Reed F., Olejnik, Judith, Flores, Elizabeth Y., Mithal, Aditya, Wang, Feiya, Hume, Adam J., Kaserman, Joseph E., March-Riera, Sandra, Wilson, Andrew A., Bhatia, Sangeeta N., Mühlberger, Elke, and Mostoslavsky, Gustavo
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- 2022
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5. Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2
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Klouda, Timothy, Hao, Yuan, Kim, Hyunbum, Kim, Jiwon, Olejnik, Judith, Hume, Adam J., Ayyappan, Sowntharya, Hong, Xuechong, Melero-Martin, Juan, Fang, Yinshan, Wang, Qiong, Zhou, Xiaobo, Mühlberger, Elke, Jia, Hongpeng, Padera, Jr., Robert F., Raby, Benjamin A., and Yuan, Ke
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- 2022
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6. Author Correction: Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary
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Kemenesi, Gábor, Tóth, Gábor E., Mayora-Neto, Martin, Scott, Simon, Temperton, Nigel, Wright, Edward, Mühlberger, Elke, Hume, Adam J., Suder, Ellen L., Zana, Brigitta, Boldogh, Sándor A., Görföl, Tamás, Estók, Péter, Szentiványi, Tamara, Lanszki, Zsófia, Somogyi, Balázs A., Nagy, Ágnes, Pereszlényi, Csaba I., Dudás, Gábor, Földes, Fanni, Kurucz, Kornélia, Madai, Mónika, Zeghbib, Safia, Maes, Piet, Vanmechelen, Bert, and Jakab, Ferenc
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- 2022
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7. Isolation of infectious Lloviu virus from Schreiber’s bats in Hungary
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Kemenesi, Gábor, Tóth, Gábor E., Mayora-Neto, Martin, Scott, Simon, Temperton, Nigel, Wright, Edward, Mühlberger, Elke, Hume, Adam J., Suder, Ellen L., Zana, Brigitta, Boldogh, Sándor A., Görföl, Tamás, Estók, Péter, Szentiványi, Tamara, Lanszki, Zsófia, Somogyi, Balázs A., Nagy, Ágnes, Pereszlényi, Csaba I., Dudás, Gábor, Földes, Fanni, Kurucz, Kornélia, Madai, Mónika, Zeghbib, Safia, Maes, Piet, Vanmechelen, Bert, and Jakab, Ferenc
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- 2022
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8. Low-Input, High-Resolution 5′ Terminal Filovirus RNA Sequencing with ViBE-Seq.
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Ross, Stephen J., Hume, Adam J., Olejnik, Judith, Turcinovic, Jacquelyn, Honko, Anna N., McKay, Lindsay G. A., Connor, John H., Griffiths, Anthony, Mühlberger, Elke, and Cifuentes, Daniel
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MARBURG virus , *RNA sequencing , *EBOLA virus , *NUCLEOTIDE sequencing , *RNA viruses - Abstract
Although next-generation sequencing (NGS) has been instrumental in determining the genomic sequences of emerging RNA viruses, de novo sequence determination often lacks sufficient coverage of the 5′ and 3′ ends of the viral genomes. Since the genome ends of RNA viruses contain the transcription and genome replication promoters that are essential for viral propagation, a lack of terminal sequence information hinders the efforts to study the replication and transcription mechanisms of emerging and re-emerging viruses. To circumvent this, we have developed a novel method termed ViBE-Seq (Viral Bona Fide End Sequencing) for the high-resolution sequencing of filoviral genome ends using a simple yet robust protocol with high fidelity. This technique allows for sequence determination of the 5′ end of viral RNA genomes and mRNAs with as little as 50 ng of total RNA. Using the Ebola virus and Marburg virus as prototypes for highly pathogenic, re-emerging viruses, we show that ViBE-Seq is a reliable technique for rapid and accurate 5′ end sequencing of filovirus RNA sourced from virions, infected cells, and tissue obtained from infected animals. We also show that ViBE-Seq can be used to determine whether distinct reverse transcriptases have terminal deoxynucleotidyl transferase activity. Overall, ViBE-Seq will facilitate the access to complete sequences of emerging viruses. [ABSTRACT FROM AUTHOR]
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- 2024
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9. A Comparative Assessment of the Pathogenic Potential of Newly Discovered Henipaviruses.
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Meier, Kristina, Olejnik, Judith, Hume, Adam J., and Mühlberger, Elke
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HENDRA virus ,HENIPAVIRUSES ,NIPAH virus ,VIRAL transmission ,NUCLEOTIDE sequencing - Abstract
Recent advances in high-throughput sequencing technologies have led to the discovery of a plethora of previously unknown viruses in animal samples. Some of these newly detected viruses are closely related to human pathogens. A prime example are the henipaviruses. Both Nipah (NiV) and Hendra virus (HeV) cause severe disease in humans. Henipaviruses are of zoonotic origin, and animal hosts, including intermediate hosts, play a critical role in viral transmission to humans. The natural reservoir hosts of NiV and HeV seem to be restricted to a few fruit bat species of the Pteropus genus in distinct geographic areas. However, the recent discovery of novel henipa- and henipa-like viruses suggests that these viruses are far more widespread than was originally thought. To date, these new viruses have been found in a wide range of animal hosts, including bats, shrews, and rodents in Asia, Africa, Europe, and South America. Since these viruses are closely related to human pathogens, it is important to learn whether they pose a threat to human health. In this article, we summarize what is known about the newly discovered henipaviruses, highlight differences to NiV and HeV, and discuss their pathogenic potential. [ABSTRACT FROM AUTHOR]
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- 2024
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10. ICTV Virus Taxonomy Profile: Filoviridae 2024
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Biedenkopf, Nadine, primary, Bukreyev, Alexander, additional, Chandran, Kartik, additional, Di Paola, Nicholas, additional, Formenty, Pierre B. H., additional, Griffiths, Anthony, additional, Hume, Adam J., additional, Mühlberger, Elke, additional, Netesov, Sergey V., additional, Palacios, Gustavo, additional, Pawęska, Janusz T., additional, Smither, Sophie, additional, Takada, Ayato, additional, Wahl, Victoria, additional, and Kuhn, Jens H., additional
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- 2024
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11. Heat Inactivation of Nipah Virus for Downstream Single-Cell RNA Sequencing Does Not Interfere with Sample Quality
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Hume, Adam J., primary, Olejnik, Judith, additional, White, Mitchell R., additional, Huang, Jessie, additional, Turcinovic, Jacquelyn, additional, Heiden, Baylee, additional, Bawa, Pushpinder S., additional, Williams, Christopher J., additional, Gorham, Nickolas G., additional, Alekseyev, Yuriy O., additional, Connor, John H., additional, Kotton, Darrell N., additional, and Mühlberger, Elke, additional
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- 2024
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12. Minor intron–containing genes as an ancient backbone for viral infection?
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Wuchty, Stefan, primary, White, Alisa K, additional, Olthof, Anouk M, additional, Drake, Kyle, additional, Hume, Adam J, additional, Olejnik, Judith, additional, Aguiar-Pulido, Vanessa, additional, Mühlberger, Elke, additional, and Kanadia, Rahul N, additional
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- 2023
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13. Ebolavirus polymerase uses an unconventional genome replication mechanism
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Deflubé, Laure R., Cressey, Tessa N., Hume, Adam J., Olejnik, Judith, Haddock, Elaine, Feldmann, Friederike, Ebihara, Hideki, Fearns, Rachel, and Mühlberger, Elke
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- 2019
14. Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells
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Zhao, Caiqi, primary, Wang, Wei, additional, Bai, Yan, additional, Amonkar, Gaurang, additional, Mou, Hongmei, additional, Olejnik, Judith, additional, Hume, Adam J, additional, Mühlberger, Elke, additional, Fang, Yinshan, additional, Que, Jianwen, additional, Fearns, Rachel, additional, Ai, Xingbin, additional, and Lerou, Paul H., additional
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- 2023
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15. Filovirus Strategies to Escape Antiviral Responses
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Olejnik, Judith, Hume, Adam J., Leung, Daisy W., Amarasinghe, Gaya K., Basler, Christopher F., Mühlberger, Elke, Compans, Richard W, Series editor, Honjo, Tasuku, Series editor, Malissen, Bernard, Series editor, Aktories, Klaus, Series editor, Rappuoli, Rino, Series editor, Galan, Jorge E., Series editor, Ahmed, Rafi, Series editor, Palme, Klaus, Series editor, Casadevall, Arturo, Series editor, Garcia-Sastre, Adolfo, Series editor, Iwasaki, Akiko, Series editor, Mühlberger, Elke, editor, Hensley, Lisa L., editor, and Towner, Jonathan S., editor
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- 2017
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16. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)
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Kuhn, Jens H., primary, Abe, Junya, additional, Adkins, Scott, additional, Alkhovsky, Sergey V., additional, Avšič-Županc, Tatjana, additional, Ayllón, María A., additional, Bahl, Justin, additional, Balkema-Buschmann, Anne, additional, Ballinger, Matthew J., additional, Kumar Baranwal, Virendra, additional, Beer, Martin, additional, Bejerman, Nicolas, additional, Bergeron, Éric, additional, Biedenkopf, Nadine, additional, Blair, Carol D., additional, Blasdell, Kim R., additional, Blouin, Arnaud G., additional, Bradfute, Steven B., additional, Briese, Thomas, additional, Brown, Paul A., additional, Buchholz, Ursula J., additional, Buchmeier, Michael J., additional, Bukreyev, Alexander, additional, Burt, Felicity, additional, Büttner, Carmen, additional, Calisher, Charles H., additional, Cao, Mengji, additional, Casas, Inmaculada, additional, Chandran, Kartik, additional, Charrel, Rémi N., additional, Kumar Chaturvedi, Krishna, additional, Chooi, Kar Mun, additional, Crane, Anya, additional, Dal Bó, Elena, additional, Carlos de la Torre, Juan, additional, de Souza, William M., additional, de Swart, Rik L., additional, Debat, Humberto, additional, Dheilly, Nolwenn M., additional, Di Paola, Nicholas, additional, Di Serio, Francesco, additional, Dietzgen, Ralf G., additional, Digiaro, Michele, additional, Drexler, J. Felix, additional, Duprex, W. Paul, additional, Dürrwald, Ralf, additional, Easton, Andrew J., additional, Elbeaino, Toufic, additional, Ergünay, Koray, additional, Feng, Guozhong, additional, Firth, Andrew E., additional, Fooks, Anthony R., additional, Formenty, Pierre B. H., additional, Freitas-Astúa, Juliana, additional, Gago-Zachert, Selma, additional, Laura García, María, additional, García-Sastre, Adolfo, additional, Garrison, Aura R., additional, Gaskin, Thomas R., additional, Gong, Wenjie, additional, Gonzalez, Jean-Paul J., additional, de Bellocq, JoëlleGoüy, additional, Griffiths, Anthony, additional, Groschup, Martin H., additional, Günther, Ines, additional, Günther, Stephan, additional, Hammond, John, additional, Hasegawa, Yusuke, additional, Hayashi, Kazusa, additional, Hepojoki, Jussi, additional, Higgins, Colleen M., additional, Hongō, Seiji, additional, Horie, Masayuki, additional, Hughes, Holly R., additional, Hume, Adam J., additional, Hyndman, Timothy H., additional, Ikeda, Kenichi, additional, Jiāng, Dàohóng, additional, Jonson, Gilda B., additional, Junglen, Sandra, additional, Klempa, Boris, additional, Klingström, Jonas, additional, Kondō, Hideki, additional, Koonin, Eugene V., additional, Krupovic, Mart, additional, Kubota, Kenji, additional, Kurath, Gael, additional, Laenen, Lies, additional, Lambert, Amy J., additional, Lǐ, Jiànróng, additional, Li, Jun-Min, additional, Liu, Ran, additional, Lukashevich, Igor S., additional, MacDiarmid, Robin M., additional, Maes, Piet, additional, Marklewitz, Marco, additional, Marshall, Sergio H., additional, Marzano, Shin-Yi L., additional, McCauley, John W., additional, Mirazimi, Ali, additional, Mühlberger, Elke, additional, Nabeshima, Tomoyuki, additional, Naidu, Rayapati, additional, Natsuaki, Tomohide, additional, Navarro, Beatriz, additional, Navarro, José A., additional, Neriya, Yutaro, additional, Netesov, Sergey V., additional, Neumann, Gabriele, additional, Nowotny, Norbert, additional, Nunes, Márcio R. T., additional, Ochoa-Corona, Francisco M., additional, Okada, Tomoyuki, additional, Palacios, Gustavo, additional, Pallás, Vicente, additional, Papa, Anna, additional, Paraskevopoulou, Sofia, additional, Parrish, Colin R., additional, Pauvolid-Corrêa, Alex, additional, Pawęska, Janusz T., additional, Pérez, Daniel R., additional, Pfaff, Florian, additional, Plemper, Richard K., additional, Postler, Thomas S., additional, Rabbidge, Lee O., additional, Radoshitzky, Sheli R., additional, Ramos-González, Pedro L., additional, Rehanek, Marius, additional, Resende, Renato O., additional, Reyes, Carina A., additional, Rodrigues, Thaís C. S., additional, Romanowski, Víctor, additional, Rubbenstroth, Dennis, additional, Rubino, Luisa, additional, Runstadler, Jonathan A., additional, Sabanadzovic, Sead, additional, Sadiq, Sabrina, additional, Salvato, Maria S., additional, Sasaya, Takahide, additional, Schwemmle, Martin, additional, Sharpe, Stephen R., additional, Shi, Mang, additional, Shimomoto, Yoshifumi, additional, Kavi Sidharthan, Venkidusamy, additional, Sironi, Manuela, additional, Smither, Sophie, additional, Song, Jin-Won, additional, Spann, Kirsten M., additional, Spengler, Jessica R., additional, Stenglein, Mark D., additional, Takada, Ayato, additional, Takeyama, Sawana, additional, Tatara, Akio, additional, Tesh, Robert B., additional, Thornburg, Natalie J., additional, Tian, Xin, additional, Tischler, Nicole D., additional, Tomitaka, Yasuhiro, additional, Tomonaga, Keizō, additional, Tordo, Noël, additional, Tu, Changchun, additional, Turina, Massimo, additional, Tzanetakis, Ioannis E., additional, Maria Vaira, Anna, additional, van den Hoogen, Bernadette, additional, Vanmechelen, Bert, additional, Vasilakis, Nikos, additional, Verbeek, Martin, additional, von Bargen, Susanne, additional, Wada, Jiro, additional, Wahl, Victoria, additional, Walker, Peter J., additional, Waltzek, Thomas B., additional, Whitfield, Anna E., additional, Wolf, Yuri I., additional, Xia, Han, additional, Xylogianni, Evanthia, additional, Yanagisawa, Hironobu, additional, Yano, Kazutaka, additional, Ye, Gongyin, additional, Yuan, Zhiming, additional, Zerbini, F. Murilo, additional, Zhang, Guilin, additional, Zhang, Song, additional, Zhang, Yong-Zhen, additional, Zhao, Lu, additional, and Økland, Arnfinn Lodden, additional
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- 2023
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17. Art of the Kill: Designing and Testing Viral Inactivation Procedures for Highly Pathogenic Negative Sense RNA Viruses
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Olejnik, Judith, primary, Hume, Adam J., additional, Ross, Stephen J., additional, Scoon, Whitney A., additional, Seitz, Scott, additional, White, Mitchell R., additional, Slutzky, Ben, additional, Yun, Nadezhda E., additional, and Mühlberger, Elke, additional
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- 2023
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18. Pathogenicity of Lloviu and Bombali viruses in IFNAR-/- mice
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Fletcher, Paige, primary, Feldmann, Friederike, additional, Takada, Ayato, additional, Crossland, Nicholas A, additional, Hume, Adam J, additional, Albariño, César, additional, Kemenesi, Gábor, additional, Feldmann, Heinz, additional, Mühlberger, Elke, additional, and Marzi, Andrea, additional
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- 2023
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19. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)
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Kuhn, Jens H., Abe, Junya, Adkins, Scott, Alkhovsky, Sergey V., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Baranwal, Virendra Kumar, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Blair, Carol D., Blasdell, Kim R., Blouin, Arnaud G., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chaturvedi, Krishna Kumar, Chooi, Kar Mun, Crane, Anya, Bó, Elena Dal, de la Torre, Juan Carlos, de Souza, William M., de Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J.F., Duprex, W.P., Dürrwald, Ralf, Easton, Andrew J., Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Firth, Andrew E., Fooks, Anthony R., Formenty, Pierre B.H., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas R., Gong, Wenjie, Gonzalez, Jean Paul J., de Bellocq, Joëlle Goüy, Griffiths, Anthony, Groschup, Martin H., Günther, Ines, Günther, Stephan, Hammond, John, Hasegawa, Yusuke, Hayashi, Kazusa, Hepojoki, Jussi, Higgins, Colleen M., Hongō, Seiji, Horie, Masayuki, Hughes, Holly R., Hume, Adam J., Hyndman, Timothy H., Ikeda, Kenichi, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Klempa, Boris, Klingström, Jonas, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Lǐ, Jiànróng, Li, Jun Min, Liu, Ran, Lukashevich, Igor S., MacDiarmid, Robin M., Maes, Piet, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin Yi L., McCauley, John W., Mirazimi, Ali, Mühlberger, Elke, Nabeshima, Tomoyuki, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José A., Neriya, Yutaro, Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio R.T., Ochoa-Corona, Francisco M., Okada, Tomoyuki, Palacios, Gustavo, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Pérez, Daniel R., Pfaff, Florian, Plemper, Richard K., Postler, Thomas S., Rabbidge, Lee O., Radoshitzky, Sheli R., Ramos-González, Pedro L., Rehanek, Marius, Resende, Renato O., Reyes, Carina A., Rodrigues, Thaís C.S., Romanowski, Víctor, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sadiq, Sabrina, Salvato, Maria S., Sasaya, Takahide, Schwemmle, Martin, Sharpe, Stephen R., Shi, Mang, Shimomoto, Yoshifumi, Sidharthan, Venkidusamy Kavi, Sironi, Manuela, Smither, Sophie, Song, Jin Won, Spann, Kirsten M., Spengler, Jessica R., Stenglein, Mark D., Takada, Ayato, Takeyama, Sawana, Tatara, Akio, Tesh, Robert B., Thornburg, Natalie J., Tian, Xin, Tischler, Nicole D., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Vaira, Anna Maria, van den Hoogen, Bernadette, Vanmechelen, Bert, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Waltzek, Thomas B., Whitfield, Anna E., Wolf, Yuri I., Xia, Han, Xylogianni, Evanthia, Yanagisawa, Hironobu, Yano, Kazutaka, Ye, Gongyin, Yuan, Zhiming, Zerbini, F.M., Zhang, Guilin, Zhang, Song, Zhang, Yong Zhen, Zhao, Lu, Økland, Arnfinn Lodden, Kuhn, Jens H., Abe, Junya, Adkins, Scott, Alkhovsky, Sergey V., Avšič-Županc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Baranwal, Virendra Kumar, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Blair, Carol D., Blasdell, Kim R., Blouin, Arnaud G., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chaturvedi, Krishna Kumar, Chooi, Kar Mun, Crane, Anya, Bó, Elena Dal, de la Torre, Juan Carlos, de Souza, William M., de Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J.F., Duprex, W.P., Dürrwald, Ralf, Easton, Andrew J., Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Firth, Andrew E., Fooks, Anthony R., Formenty, Pierre B.H., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas R., Gong, Wenjie, Gonzalez, Jean Paul J., de Bellocq, Joëlle Goüy, Griffiths, Anthony, Groschup, Martin H., Günther, Ines, Günther, Stephan, Hammond, John, Hasegawa, Yusuke, Hayashi, Kazusa, Hepojoki, Jussi, Higgins, Colleen M., Hongō, Seiji, Horie, Masayuki, Hughes, Holly R., Hume, Adam J., Hyndman, Timothy H., Ikeda, Kenichi, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Klempa, Boris, Klingström, Jonas, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Lǐ, Jiànróng, Li, Jun Min, Liu, Ran, Lukashevich, Igor S., MacDiarmid, Robin M., Maes, Piet, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin Yi L., McCauley, John W., Mirazimi, Ali, Mühlberger, Elke, Nabeshima, Tomoyuki, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José A., Neriya, Yutaro, Netesov, Sergey V., Neumann, Gabriele, Nowotny, Norbert, Nunes, Márcio R.T., Ochoa-Corona, Francisco M., Okada, Tomoyuki, Palacios, Gustavo, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Pérez, Daniel R., Pfaff, Florian, Plemper, Richard K., Postler, Thomas S., Rabbidge, Lee O., Radoshitzky, Sheli R., Ramos-González, Pedro L., Rehanek, Marius, Resende, Renato O., Reyes, Carina A., Rodrigues, Thaís C.S., Romanowski, Víctor, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sadiq, Sabrina, Salvato, Maria S., Sasaya, Takahide, Schwemmle, Martin, Sharpe, Stephen R., Shi, Mang, Shimomoto, Yoshifumi, Sidharthan, Venkidusamy Kavi, Sironi, Manuela, Smither, Sophie, Song, Jin Won, Spann, Kirsten M., Spengler, Jessica R., Stenglein, Mark D., Takada, Ayato, Takeyama, Sawana, Tatara, Akio, Tesh, Robert B., Thornburg, Natalie J., Tian, Xin, Tischler, Nicole D., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Vaira, Anna Maria, van den Hoogen, Bernadette, Vanmechelen, Bert, Vasilakis, Nikos, Verbeek, Martin, von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Waltzek, Thomas B., Whitfield, Anna E., Wolf, Yuri I., Xia, Han, Xylogianni, Evanthia, Yanagisawa, Hironobu, Yano, Kazutaka, Ye, Gongyin, Yuan, Zhiming, Zerbini, F.M., Zhang, Guilin, Zhang, Song, Zhang, Yong Zhen, Zhao, Lu, and Økland, Arnfinn Lodden
- Abstract
In April 2023, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by one new family, 14 new genera, and 140 new species. Two genera and 538 species were renamed. One species was moved, and four were abolished.
- Published
- 2023
20. Annual (2023) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota)
- Author
-
National Institute of Allergy and Infectious Diseases (US), Antiviral Countermeasures Development Center (US), Department of Agriculture (US), Department of the Army (US), Department of Health and Human Services (US), US Department of Homeland Security, Federal Government of the United States, Kuhn, Jens H. [0000-0002-7800-6045], Abe, Junya [0000-0003-3627-7071], Adkins, Scott [0000-0003-0095-8414], Alkhovsky, Sergey V. [0000-0001-6913-5841], Avsic-Zupanc, Tatjana [0000-0001-6243-0688], Ayllón, María A. [0000-0001-7893-6106], Bahl, Justin [0000-0001-7572-4300], Balkema-Buschmann, A. [0000-0001-7613-9592], Ballinger, Matthew J. [0000-0001-7453-8725], Bejerman, Nicolas [0000-0002-7851-3506], Biedenkopf, Nadine [0000-0002-6061-8019], Blair, Carol D.[0000-0002-2803-0354], Blasdell, Kim R.[0000-0003-2121-0376], Bradfute, Steven B.[0000-0002-1985-751X], Briese, Thomas [0000-0002-4819-8963], Buchholz, Ursula J. [0000-0002-2329-3198], Buchmeier, Michael J.[0000-0002-2387-9287], Bukreyev, Alexander [0000-0002-0342-4824], Burt, Felicity [0000-0002-7238-7799], Büttner, Carmen [0000-0002-2086-2594], Calisher, Charles H. [0000-0003-0213-294X], Cao, Mengji [0000-0003-0396-262X], Casas, Inmaculada [0000-0003-1840-1198], Chandran, Kartik [0000-0003-0232-7077], Charrel, Rémi N.[0000-0002-7675-8251], Chaturvedi, Krishna Kumar [0000-0002-6529-5466], Crane, Anya [0000-0002-2060-2469], De Swart, Rik L.[0000-0003-3599-8969], Debat, Humberto [0000-0003-3056-3739], Dheilly, Nolwenn M.[0000-0002-3675-5013], Di Paola, Nicholas [0000-0002-9694-3913], Di Serio, Francesco [0000-0003-2822-704X], Dietzgen, Ralf G.[0000-0002-7772-2250], Digiaro, Michele [0009-0006-3089-3606], Drexler, J. Felix [0000-0002-3509-0232], Duprex, W. Paul [0000-0003-1716-6376], Elbeaino, Toufic [0000-0003-2211-7907], Ergünay, Koray [0000-0001-5422-1982], Feng, Guozhong [0000-0002-9489-9322], Fooks, Anthony R.[0000-0002-3243-6154], Formenty, Pierre B.H.[0000-0002-9482-5411], Freitas-Astúa, Juliana [0000-0002-0506-6880], Gago-Zachert, Selma [0000-0002-1084-2119], García, María Laura [0000-0001-6468-6943], Garrison, Aura R.[0000-0003-3034-6400], Gaskin, Thomas R. [0000-0002-5644-4431], Gouy de Bellocq, Joelle [0000-0001-5831-6284], Griffiths, Anthony [0000-0001-5435-8364], Groschup, M. H.[0000-0003-0215-185X], Günther, Stephan [0000-0002-6562-0230], Hayashi, Kazusa [0009-0002-9395-0066], Hepojoki, Jussi [0000-0001-5699-214X], Higgins, Colleen M. [0000-0001-9016-2940], Horie, Masayuki [0000-0003-4682-7698], Hughes, Holly R.[0000-0003-1380-8263], Hyndman, Timothy [0000-0002-7047-5023], Jiāng, Dàohóng [0000-0002-3862-7461], Jonson, Gilda B.[0000-0003-0097-8634], Junglen, Sandra [0000-0002-3799-6011], Klempa, B.[0000-0002-6931-1224], Klingström, Jonas [0000-0001-9076-1441], Kondō, Hideki [0000-0001-9220-5350], Koonin, Eugene V. [0000-0003-3943-8299], Krupovic, Mart [0000-0001-5486-0098], Kurath, Gael [0000-0003-3294-560X], Laenen, Lies [0000-0001-9118-8608], Li, Jianrong [0000-0002-7130-1084], Lukashevich, Igor S.[0000-0001-6523-5116], MacDiarmid, Robin M.[0000-0002-7057-2018], Maes, Piet [0000-0002-4571-5232], Marklewitz, Marco [0000-0003-1828-8770], Marshall, Sergio H.[0000-0003-0438-8252], Marzano, Shin-Yi L. [0000-0003-0548-3761], Mühlberger, Elke [0000-0003-3547-9376], Nabeshima, Tomoyuki [0000-0002-6570-096X], Naidu, Rayapati [0000-0002-7273-5116], Natsuaki, Tomohide [0000-0003-1823-7308], Navarro, José A. [0000-0002-0536-6074], Neriya, Yutaro [0000-0002-1385-0050], Netesov, Sergey V. [0000-0002-7786-2464], Neumann, Gabriele [0000-0001-7054-1775], Nowotny, N. [0000-0002-3548-571X], Ochoa-Corona, Francisco M. [0000-0002-4112-8209], Pallás, Vicente [0000-0003-4954-989X], Papa, Anna [0000-0002-6643-3322], Paraskevopoulou, Sofia [0000-0003-2608-2596], Parrish, Colin R. [0000-0002-1836-6655], Pauvolid-Corrêa, Alex [0000-0002-6924-157X], Pawęska, Janusz T. [0000-0001-8776-7519], Pérez, Daniel R. [0000-0002-6569-5689], Pfaff, Florian [0000-0003-0178-6183], Plemper, Richard K. [0000-0003-2034-2107], Postler, Thomas S. [0000-0002-3558-9084], Rabbidge, Lee O. [0009-0001-7962-4881], Radoshitzky, Sheli R. [0000-0001-8976-8056], Ramos-González, Pedro L. [0000-0002-9640-6587], Rehanek, Marius [0000-0002-5710-5060], Resende, Renato O. [0000-0003-3852-1576], Romanowski, Víctor [0000-0001-6378-7929], Rubbenstroth, Dennis [0000-0002-8209-6274], Rubino, Luisa [0000-0002-2073-2415], Runstadler, Jonathan A. [0000-0002-6747-7765], Sabanadzovic, Sead [0000-0002-2995-2633], Salvato, Maria S. [0000-0002-3357-5391], Sasaya, Takahide [0000-0002-5020-9377], Schwemmle, Martin [0000-0002-2972-6855], Shi, Mang [0000-0002-6154-4437], Shimomoto, Yoshifumi [0000-0002-0796-7068], Kavi Sidharthan, Venkidusamy [0000-0003-1561-549X], Sironi, Manuela [0000-0002-2267-5266], Smither, Sophie [0000-0002-7835-3581], Spann, Kirsten [0000-0003-0567-8382], Spengler, Jessica R. [0000-0002-5383-0513], Stenglein, Mark D. [0000-0002-0993-813X], Takada, Ayato [0000-0003-2464-6642], Takeyama, Sawana [0009-0000-3771-5999], Tesh, Robert B. [0000-0002-9226-397X], Thornburg, Natalie J. [0000-0003-3523-3616], Tischler, Nicole D. [0000-0002-4578-4780], Tomitaka, Yasuhiro [0000-0002-6914-4016], Tomonaga, Keizō [0000-0003-0405-7103], Tordo, Noël [0000-0001-5873-059X], Tu, Changchun [0000-0002-8134-7502], Turina, Massimo [0000-0002-9659-9470], Tzanetakis, Ioannis E. [0000-0002-5970-1763], Vaira, Anna Maria [0000-0003-2526-4419], Van den Hoogen, Bernadette [0000-0003-1996-8559], Vanmechelen, Bert [0000-0002-8350-4356], Verbeek, Martin [0000-0002-8973-3803], Von Bargen, Susanne [0000-0001-8321-1572], Wada, Jiro [0000-0001-9846-0846], Wahl, Victoria [0000-0002-6588-4308], Walker, Peter J. [0000-0003-1851-642X], Waltzek, Thomas B. [0000-0001-6383-5978], Whitfield, Anna E. [0000-0002-3538-015X], Wolf, Yuri I. [0000-0002-0247-8708], Xylogianni, Evanthia [0009-0001-8768-0939], Yanagisawa, Hironobu [0000-0002-6729-466X], Ye, Gongyin [0000-0003-4937-8867], Yuan, Zhiming [0000-0002-3234-9616], Zerbini, F. Murilo [0000-0001-8617-0200], Okland, Arnfinn Lodden [0000-0003-3062-4386], Kuhn, Jens H., Abe, Junya, Adkins, Scott, Alkhovsky, Sergey V., Avsic-Zupanc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, A., Ballinger, Matthew J., Kumar Baranwal, Virendra, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Blair, Carol D., Blasdell, Kim R., Blouin, Arnaud G., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chaturvedi, Krishna Kumar, Chooi, Kar Mun, Crane, Anya, Dal Bó, Elena, de la Torre, J. C., de Souza, William Marciel, De Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J. Felix, Duprex, W. Paul, Dürrwald, Ralf, Easton, Andrew J., Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Firth, Andrew E., Fooks, Anthony R., Formenty, Pierre B.H., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas R., Gong, Wenjie, Gonzalez, Jean-Paul J., Gouy de Bellocq, Joelle, Griffiths, Anthony, Groschup, M. H., Günther, Ines, Günther, Stephan, Hammond, John, Hasegawa, Yusuke, Hayashi, Kazusa, Hepojoki, Jussi, Higgins, Colleen M., Hongo, Seiji, Horie, Masayuki, Hughes, Holly R., Hume, Adam J., Hyndman, Timothy, Ikeda, Kenichi, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Klempa, B., Klingström, Jonas, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Li, Jianrong, Li, Jun-Min, Liu, Ran, Lukashevich, Igor S., MacDiarmid, Robin M, Maes, Piet, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin-Yi L., McCauley, John W., Mirazimi, Ali, Mühlberger, Elke, Nabeshima, Tomoyuki, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José A., Neriya, Yutaro, Netesov, Sergey V., Neumann, Gabriele, Nowotny, N., Nunes, Márcio R.T., Ochoa-Corona, Francisco M., Okada, Tomoyuki, Palacios, Gustavo, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Pérez, Daniel R., Pfaff, Florian, Plemper, Richard K., Postler, Thomas S., Rabbidge, Lee O., Radoshitzky, Sheli R., Ramos-González, Pedro L., Rehanek, Marius, Resende, Renato O., Reyes, Carina A., Rodrigues, Thaís C.S., Romanowski, Víctor, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sadiq, Sabrina, Salvato, Maria S., Sasaya, Takahide, Schwemmle, Martin, Sharpe, Stephen R., Shi, Mang, Shimomoto, Yoshifumi, Kavi Sidharthan, Venkidusamy, Sironi, Manuela, Smither, Sophie, Song, Jin-Won, Spann, Kirsten, Spengler, Jessica R., Stenglein, Mark D., Takada, Ayato, Takeyama, Sawana, Tatara, Akio, Tesh, Robert B., Thornburg, Natalie J., Tian, Xin, Tischler, Nicole D., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Vaira, Anna Maria, Van den Hoogen, Bernadette, Vanmechelen, Bert, Vasilakis, Nikos, Verbeek, Martin, Von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Waltzek, Thomas B., Whitfield, Anna E., Wolf, Yuri I., Xia, Han, Xylogianni, Evanthia, Yanagisawa, Hironobu, Yano, Kazutaka, Ye, Gongyin, Yuan, Zhiming, Zerbini, F. Murilo, Zhang, Guilin, Zhang, Song, Zhang, Yong-Zhen, Zhao, Lu, Okland, Arnfinn Lodden, National Institute of Allergy and Infectious Diseases (US), Antiviral Countermeasures Development Center (US), Department of Agriculture (US), Department of the Army (US), Department of Health and Human Services (US), US Department of Homeland Security, Federal Government of the United States, Kuhn, Jens H. [0000-0002-7800-6045], Abe, Junya [0000-0003-3627-7071], Adkins, Scott [0000-0003-0095-8414], Alkhovsky, Sergey V. [0000-0001-6913-5841], Avsic-Zupanc, Tatjana [0000-0001-6243-0688], Ayllón, María A. [0000-0001-7893-6106], Bahl, Justin [0000-0001-7572-4300], Balkema-Buschmann, A. [0000-0001-7613-9592], Ballinger, Matthew J. [0000-0001-7453-8725], Bejerman, Nicolas [0000-0002-7851-3506], Biedenkopf, Nadine [0000-0002-6061-8019], Blair, Carol D.[0000-0002-2803-0354], Blasdell, Kim R.[0000-0003-2121-0376], Bradfute, Steven B.[0000-0002-1985-751X], Briese, Thomas [0000-0002-4819-8963], Buchholz, Ursula J. [0000-0002-2329-3198], Buchmeier, Michael J.[0000-0002-2387-9287], Bukreyev, Alexander [0000-0002-0342-4824], Burt, Felicity [0000-0002-7238-7799], Büttner, Carmen [0000-0002-2086-2594], Calisher, Charles H. [0000-0003-0213-294X], Cao, Mengji [0000-0003-0396-262X], Casas, Inmaculada [0000-0003-1840-1198], Chandran, Kartik [0000-0003-0232-7077], Charrel, Rémi N.[0000-0002-7675-8251], Chaturvedi, Krishna Kumar [0000-0002-6529-5466], Crane, Anya [0000-0002-2060-2469], De Swart, Rik L.[0000-0003-3599-8969], Debat, Humberto [0000-0003-3056-3739], Dheilly, Nolwenn M.[0000-0002-3675-5013], Di Paola, Nicholas [0000-0002-9694-3913], Di Serio, Francesco [0000-0003-2822-704X], Dietzgen, Ralf G.[0000-0002-7772-2250], Digiaro, Michele [0009-0006-3089-3606], Drexler, J. Felix [0000-0002-3509-0232], Duprex, W. Paul [0000-0003-1716-6376], Elbeaino, Toufic [0000-0003-2211-7907], Ergünay, Koray [0000-0001-5422-1982], Feng, Guozhong [0000-0002-9489-9322], Fooks, Anthony R.[0000-0002-3243-6154], Formenty, Pierre B.H.[0000-0002-9482-5411], Freitas-Astúa, Juliana [0000-0002-0506-6880], Gago-Zachert, Selma [0000-0002-1084-2119], García, María Laura [0000-0001-6468-6943], Garrison, Aura R.[0000-0003-3034-6400], Gaskin, Thomas R. [0000-0002-5644-4431], Gouy de Bellocq, Joelle [0000-0001-5831-6284], Griffiths, Anthony [0000-0001-5435-8364], Groschup, M. H.[0000-0003-0215-185X], Günther, Stephan [0000-0002-6562-0230], Hayashi, Kazusa [0009-0002-9395-0066], Hepojoki, Jussi [0000-0001-5699-214X], Higgins, Colleen M. [0000-0001-9016-2940], Horie, Masayuki [0000-0003-4682-7698], Hughes, Holly R.[0000-0003-1380-8263], Hyndman, Timothy [0000-0002-7047-5023], Jiāng, Dàohóng [0000-0002-3862-7461], Jonson, Gilda B.[0000-0003-0097-8634], Junglen, Sandra [0000-0002-3799-6011], Klempa, B.[0000-0002-6931-1224], Klingström, Jonas [0000-0001-9076-1441], Kondō, Hideki [0000-0001-9220-5350], Koonin, Eugene V. [0000-0003-3943-8299], Krupovic, Mart [0000-0001-5486-0098], Kurath, Gael [0000-0003-3294-560X], Laenen, Lies [0000-0001-9118-8608], Li, Jianrong [0000-0002-7130-1084], Lukashevich, Igor S.[0000-0001-6523-5116], MacDiarmid, Robin M.[0000-0002-7057-2018], Maes, Piet [0000-0002-4571-5232], Marklewitz, Marco [0000-0003-1828-8770], Marshall, Sergio H.[0000-0003-0438-8252], Marzano, Shin-Yi L. [0000-0003-0548-3761], Mühlberger, Elke [0000-0003-3547-9376], Nabeshima, Tomoyuki [0000-0002-6570-096X], Naidu, Rayapati [0000-0002-7273-5116], Natsuaki, Tomohide [0000-0003-1823-7308], Navarro, José A. [0000-0002-0536-6074], Neriya, Yutaro [0000-0002-1385-0050], Netesov, Sergey V. [0000-0002-7786-2464], Neumann, Gabriele [0000-0001-7054-1775], Nowotny, N. [0000-0002-3548-571X], Ochoa-Corona, Francisco M. [0000-0002-4112-8209], Pallás, Vicente [0000-0003-4954-989X], Papa, Anna [0000-0002-6643-3322], Paraskevopoulou, Sofia [0000-0003-2608-2596], Parrish, Colin R. [0000-0002-1836-6655], Pauvolid-Corrêa, Alex [0000-0002-6924-157X], Pawęska, Janusz T. [0000-0001-8776-7519], Pérez, Daniel R. [0000-0002-6569-5689], Pfaff, Florian [0000-0003-0178-6183], Plemper, Richard K. [0000-0003-2034-2107], Postler, Thomas S. [0000-0002-3558-9084], Rabbidge, Lee O. [0009-0001-7962-4881], Radoshitzky, Sheli R. [0000-0001-8976-8056], Ramos-González, Pedro L. [0000-0002-9640-6587], Rehanek, Marius [0000-0002-5710-5060], Resende, Renato O. [0000-0003-3852-1576], Romanowski, Víctor [0000-0001-6378-7929], Rubbenstroth, Dennis [0000-0002-8209-6274], Rubino, Luisa [0000-0002-2073-2415], Runstadler, Jonathan A. [0000-0002-6747-7765], Sabanadzovic, Sead [0000-0002-2995-2633], Salvato, Maria S. [0000-0002-3357-5391], Sasaya, Takahide [0000-0002-5020-9377], Schwemmle, Martin [0000-0002-2972-6855], Shi, Mang [0000-0002-6154-4437], Shimomoto, Yoshifumi [0000-0002-0796-7068], Kavi Sidharthan, Venkidusamy [0000-0003-1561-549X], Sironi, Manuela [0000-0002-2267-5266], Smither, Sophie [0000-0002-7835-3581], Spann, Kirsten [0000-0003-0567-8382], Spengler, Jessica R. [0000-0002-5383-0513], Stenglein, Mark D. [0000-0002-0993-813X], Takada, Ayato [0000-0003-2464-6642], Takeyama, Sawana [0009-0000-3771-5999], Tesh, Robert B. [0000-0002-9226-397X], Thornburg, Natalie J. [0000-0003-3523-3616], Tischler, Nicole D. [0000-0002-4578-4780], Tomitaka, Yasuhiro [0000-0002-6914-4016], Tomonaga, Keizō [0000-0003-0405-7103], Tordo, Noël [0000-0001-5873-059X], Tu, Changchun [0000-0002-8134-7502], Turina, Massimo [0000-0002-9659-9470], Tzanetakis, Ioannis E. [0000-0002-5970-1763], Vaira, Anna Maria [0000-0003-2526-4419], Van den Hoogen, Bernadette [0000-0003-1996-8559], Vanmechelen, Bert [0000-0002-8350-4356], Verbeek, Martin [0000-0002-8973-3803], Von Bargen, Susanne [0000-0001-8321-1572], Wada, Jiro [0000-0001-9846-0846], Wahl, Victoria [0000-0002-6588-4308], Walker, Peter J. [0000-0003-1851-642X], Waltzek, Thomas B. [0000-0001-6383-5978], Whitfield, Anna E. [0000-0002-3538-015X], Wolf, Yuri I. [0000-0002-0247-8708], Xylogianni, Evanthia [0009-0001-8768-0939], Yanagisawa, Hironobu [0000-0002-6729-466X], Ye, Gongyin [0000-0003-4937-8867], Yuan, Zhiming [0000-0002-3234-9616], Zerbini, F. Murilo [0000-0001-8617-0200], Okland, Arnfinn Lodden [0000-0003-3062-4386], Kuhn, Jens H., Abe, Junya, Adkins, Scott, Alkhovsky, Sergey V., Avsic-Zupanc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, A., Ballinger, Matthew J., Kumar Baranwal, Virendra, Beer, Martin, Bejerman, Nicolas, Bergeron, Éric, Biedenkopf, Nadine, Blair, Carol D., Blasdell, Kim R., Blouin, Arnaud G., Bradfute, Steven B., Briese, Thomas, Brown, Paul A., Buchholz, Ursula J., Buchmeier, Michael J., Bukreyev, Alexander, Burt, Felicity, Büttner, Carmen, Calisher, Charles H., Cao, Mengji, Casas, Inmaculada, Chandran, Kartik, Charrel, Rémi N., Chaturvedi, Krishna Kumar, Chooi, Kar Mun, Crane, Anya, Dal Bó, Elena, de la Torre, J. C., de Souza, William Marciel, De Swart, Rik L., Debat, Humberto, Dheilly, Nolwenn M., Di Paola, Nicholas, Di Serio, Francesco, Dietzgen, Ralf G., Digiaro, Michele, Drexler, J. Felix, Duprex, W. Paul, Dürrwald, Ralf, Easton, Andrew J., Elbeaino, Toufic, Ergünay, Koray, Feng, Guozhong, Firth, Andrew E., Fooks, Anthony R., Formenty, Pierre B.H., Freitas-Astúa, Juliana, Gago-Zachert, Selma, García, María Laura, García-Sastre, Adolfo, Garrison, Aura R., Gaskin, Thomas R., Gong, Wenjie, Gonzalez, Jean-Paul J., Gouy de Bellocq, Joelle, Griffiths, Anthony, Groschup, M. H., Günther, Ines, Günther, Stephan, Hammond, John, Hasegawa, Yusuke, Hayashi, Kazusa, Hepojoki, Jussi, Higgins, Colleen M., Hongo, Seiji, Horie, Masayuki, Hughes, Holly R., Hume, Adam J., Hyndman, Timothy, Ikeda, Kenichi, Jiāng, Dàohóng, Jonson, Gilda B., Junglen, Sandra, Klempa, B., Klingström, Jonas, Kondō, Hideki, Koonin, Eugene V., Krupovic, Mart, Kubota, Kenji, Kurath, Gael, Laenen, Lies, Lambert, Amy J., Li, Jianrong, Li, Jun-Min, Liu, Ran, Lukashevich, Igor S., MacDiarmid, Robin M, Maes, Piet, Marklewitz, Marco, Marshall, Sergio H., Marzano, Shin-Yi L., McCauley, John W., Mirazimi, Ali, Mühlberger, Elke, Nabeshima, Tomoyuki, Naidu, Rayapati, Natsuaki, Tomohide, Navarro, Beatriz, Navarro, José A., Neriya, Yutaro, Netesov, Sergey V., Neumann, Gabriele, Nowotny, N., Nunes, Márcio R.T., Ochoa-Corona, Francisco M., Okada, Tomoyuki, Palacios, Gustavo, Pallás, Vicente, Papa, Anna, Paraskevopoulou, Sofia, Parrish, Colin R., Pauvolid-Corrêa, Alex, Pawęska, Janusz T., Pérez, Daniel R., Pfaff, Florian, Plemper, Richard K., Postler, Thomas S., Rabbidge, Lee O., Radoshitzky, Sheli R., Ramos-González, Pedro L., Rehanek, Marius, Resende, Renato O., Reyes, Carina A., Rodrigues, Thaís C.S., Romanowski, Víctor, Rubbenstroth, Dennis, Rubino, Luisa, Runstadler, Jonathan A., Sabanadzovic, Sead, Sadiq, Sabrina, Salvato, Maria S., Sasaya, Takahide, Schwemmle, Martin, Sharpe, Stephen R., Shi, Mang, Shimomoto, Yoshifumi, Kavi Sidharthan, Venkidusamy, Sironi, Manuela, Smither, Sophie, Song, Jin-Won, Spann, Kirsten, Spengler, Jessica R., Stenglein, Mark D., Takada, Ayato, Takeyama, Sawana, Tatara, Akio, Tesh, Robert B., Thornburg, Natalie J., Tian, Xin, Tischler, Nicole D., Tomitaka, Yasuhiro, Tomonaga, Keizō, Tordo, Noël, Tu, Changchun, Turina, Massimo, Tzanetakis, Ioannis E., Vaira, Anna Maria, Van den Hoogen, Bernadette, Vanmechelen, Bert, Vasilakis, Nikos, Verbeek, Martin, Von Bargen, Susanne, Wada, Jiro, Wahl, Victoria, Walker, Peter J., Waltzek, Thomas B., Whitfield, Anna E., Wolf, Yuri I., Xia, Han, Xylogianni, Evanthia, Yanagisawa, Hironobu, Yano, Kazutaka, Ye, Gongyin, Yuan, Zhiming, Zerbini, F. Murilo, Zhang, Guilin, Zhang, Song, Zhang, Yong-Zhen, Zhao, Lu, and Okland, Arnfinn Lodden
- Abstract
In April 2023, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by one new family, 14 new genera, and 140 new species. Two genera and 538 species were renamed. One species was moved, and four were abolished. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
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- 2023
21. The 3′ Untranslated Regions of Ebola Virus mRNAs Contain AU-Rich Elements Involved in Posttranscriptional Stabilization and Decay.
- Author
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Nelson, Emily V, Ross, Stephen J, Olejnik, Judith, Hume, Adam J, Deeney, Dylan J, King, Emily, Grimins, Autumn O, Lyons, Shawn M, Cifuentes, Daniel, and Mühlberger, Elke
- Subjects
EBOLA virus ,RNA-binding proteins ,MAMMALIAN embryos ,REPORTER genes ,PROTEIN expression - Abstract
The 3′ untranslated regions (UTRs) of Ebola virus (EBOV) mRNAs are enriched in their AU content and therefore represent potential targets for RNA binding proteins targeting AU-rich elements (ARE-BPs). ARE-BPs are known to fine-tune RNA turnover and translational activity. We identified putative AREs within EBOV mRNA 3′ UTRs and assessed whether they might modulate mRNA stability. Using mammalian and zebrafish embryo reporter assays, we show a conserved, ARE-BP-mediated stabilizing effect and increased reporter activity with the tested EBOV 3′ UTRs. When coexpressed with the prototypic ARE-BP tristetraprolin (TTP, ZFP36) that mainly destabilizes its target mRNAs, the EBOV nucleoprotein (NP) 3′ UTR resulted in decreased reporter gene activity. Coexpression of NP with TTP led to reduced NP protein expression and diminished EBOV minigenome activity. In conclusion, the enrichment of AU residues in EBOV 3′ UTRs makes them possible targets for cellular ARE-BPs, leading to modulation of RNA stability and translational activity. [ABSTRACT FROM AUTHOR]
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- 2023
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22. Pathogenicity of Lloviu and Bombali Viruses in Type I Interferon Receptor Knockout Mice.
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Fletcher, Paige, Feldmann, Friederike, Takada, Ayato, Crossland, Nicholas A, Hume, Adam J, Albariño, César, Kemenesi, Gábor, Feldmann, Heinz, Mühlberger, Elke, and Marzi, Andrea
- Subjects
TYPE I interferons ,INTERFERON receptors ,KNOCKOUT mice ,VIRAL load - Abstract
Type I interferon receptor knockout (IFNAR
−/− ) mice are not able to generate a complete innate immune response; therefore, these mice are often considered to assess the pathogenicity of emerging viruses. We infected IFNAR−/− mice with a low or high dose of Lloviu virus (LLOV) or Bombali virus (BOMV) by the intranasal (IN) or intraperitoneal (IP) route and compared virus loads at early and late time points after infection. No signs of disease and no viral RNA were detected after IN infection regardless of LLOV dose. In contrast, IP infections resulted in increased viral loads in the high-dose LLOV and BOMV groups at the early time point. The low-dose LLOV and BOMV groups achieved higher viral loads at the late time point. However, there was 100% survival in all groups and no signs of disease. In conclusion, our results indicate a limited value of the IFNAR−/− mouse model for investigation of the pathogenicity of LLOV and BOMV. [ABSTRACT FROM AUTHOR]- Published
- 2023
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23. Establishment of an Inactivation Method for Ebola Virus and SARS-CoV-2 Suitable for Downstream Sequencing of Low Cell Numbers
- Author
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Olejnik, Judith, primary, Leon, Juliette, additional, Michelson, Daniel, additional, Chowdhary, Kaitavjeet, additional, Galvan-Pena, Silvia, additional, Benoist, Christophe, additional, Mühlberger, Elke, additional, and Hume, Adam J., additional
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- 2023
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24. Isolation and genome characterization of Lloviu virus from Italian Schreibers’ bent-winged bats
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Tóth, Gábor E., primary, Hume, Adam J., additional, Suder, Ellen L., additional, Zeghbib, Safia, additional, Ábrahám, Ágota, additional, Lanszki, Zsófia, additional, Varga, Zsaklin, additional, Tauber, Zsófia, additional, Földes, Fanni, additional, Zana, Brigitta, additional, Scaravelli, Dino, additional, Scicluna, Maria Teresa, additional, Pereswiet-Soltan, Andrea, additional, Görföl, Tamás, additional, Terregino, Calogero, additional, De Benedictis, Paola, additional, Garcıa-Dorival, Isabel, additional, Alonso, Covadonga, additional, Jakab, Ferenc, additional, Mühlberger, Elke, additional, Leopardi, Stefania, additional, and Kemenesi, Gábor, additional
- Published
- 2022
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25. Labeling Ebola Virus with a Self-Splicing Fluorescent Reporter
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Heiden, Baylee, primary, Mühlberger, Elke, additional, Lennon, Christopher W., additional, and Hume, Adam J., additional
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- 2022
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26. Minor intron containing genes: Achilles’ heel of viruses?
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Wuchty, Stefan, primary, White, Alisa K., additional, Olthof, Anouk M., additional, Drake, Kyle, additional, Hume, Adam J., additional, Olejnik, Judith, additional, Mühlberger, Elke, additional, Aguiar-Pulido, Vanessa, additional, and Kanadia, Rahul N., additional
- Published
- 2022
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27. Correction: Recombinant Lloviu virus as a tool to study viral replication and host responses
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Hume, Adam J., primary, Heiden, Baylee, additional, Olejnik, Judith, additional, Suder, Ellen L., additional, Ross, Stephen, additional, Scoon, Whitney A., additional, Bullitt, Esther, additional, Ericsson, Maria, additional, White, Mitchell R., additional, Turcinovic, Jacquelyn, additional, Thao, Tran T. N., additional, Hekman, Ryan M., additional, Kaserman, Joseph E., additional, Huang, Jessie, additional, Alysandratos, Konstantinos-Dionysios, additional, Toth, Gabor E., additional, Jakab, Ferenc, additional, Kotton, Darrell N., additional, Wilson, Andrew A., additional, Emili, Andrew, additional, Thiel, Volker, additional, Connor, John H., additional, Kemenesi, Gabor, additional, Cifuentes, Daniel, additional, and Mühlberger, Elke, additional
- Published
- 2022
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28. An RNA polymerase II-driven Ebola virus minigenome system as an advanced tool for antiviral drug screening
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Nelson, Emily V., Pacheco, Jennifer R., Hume, Adam J., Cressey, Tessa N., Deflubé, Laure R., Ruedas, John B., Connor, John H., Ebihara, Hideki, and Mühlberger, Elke
- Published
- 2017
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29. Sa1125: USING HUMAN IPSC DERIVED INTESTINAL ORGANOIDS TO MODEL INFECTIOUS DISEASES
- Author
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Mithal, Aditya, primary, Hume, Adam J., additional, Mühlberger, Elke, additional, and Mostoslavsky, Gustavo, additional
- Published
- 2022
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30. Interferon‐alpha or ‐beta Facilitates SARS‐CoV‐2 Pulmonary Vascular Infection by Inducing ACE2
- Author
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Yuan, Ke, primary, Klouda, Timothy, additional, Yuan, Hao, additional, Kim, Hyunbum, additional, Kim, Jiwon, additional, Olejnik, Judith, additional, Hume, Adam J., additional, Melero‐Martin, Juan, additional, Mühlberger, Elke, additional, Jia, Hongpeng, additional, Padera, Robert F., additional, and Raby, Benjamin A., additional
- Published
- 2022
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31. Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection
- Author
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Wang, Ruobing, primary, Hume, Adam J., additional, Beermann, Mary Lou, additional, Simone-Roach, Chantelle, additional, Lindstrom-Vautrin, Jonathan, additional, Le Suer, Jake, additional, Huang, Jessie, additional, Olejnik, Judith, additional, Villacorta-Martin, Carlos, additional, Bullitt, Esther, additional, Hinds, Anne, additional, Ghaedi, Mahboobe, additional, Rollins, Stuart, additional, Werder, Rhiannon B., additional, Abo, Kristine M., additional, Wilson, Andrew A., additional, Mühlberger, Elke, additional, Kotton, Darrell N., additional, and Hawkins, Finn J., additional
- Published
- 2022
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32. The oral drug nitazoxanide restricts SARS-CoV-2 infection and attenuates disease pathogenesis in Syrian hamsters
- Author
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Miorin, Lisa, primary, Mire, Chad E., additional, Ranjbar, Shahin, additional, Hume, Adam J., additional, Huang, Jessie, additional, Crossland, Nicholas A., additional, White, Kris M, additional, Laporte, Manon, additional, Kehrer, Thomas, additional, Haridas, Viraga, additional, Moreno, Elena, additional, Nambu, Aya, additional, Jangra, Sonia, additional, Cupic, Anastasija, additional, Dejosez, Marion, additional, Abo, Kristine A., additional, Tseng, Anna E., additional, Werder, Rhiannon B., additional, Rathnasinghe, Raveen, additional, Mutetwa, Tinaye, additional, Ramos, Irene, additional, de Aja, Julio Sainz, additional, de Alba Rivas, Carolina Garcia, additional, Schotsaert, Michael, additional, Corley, Ronald B., additional, Falvo, James V., additional, Fernandez-Sesma, Ana, additional, Kim, Carla, additional, Rossignol, Jean-François, additional, Wilson, Andrew A., additional, Zwaka, Thomas, additional, Kotton, Darrell N., additional, Mühlberger, Elke, additional, García-Sastre, Adolfo, additional, and Goldfeld, Anne E., additional
- Published
- 2022
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33. Recombinant Lloviu virus as a tool to study viral replication and host responses
- Author
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Hume, Adam J., primary, Heiden, Baylee, additional, Olejnik, Judith, additional, Suder, Ellen L., additional, Ross, Stephen, additional, Scoon, Whitney A., additional, Bullitt, Esther, additional, Ericsson, Maria, additional, White, Mitchell R., additional, Turcinovic, Jacquelyn, additional, Thao, Tran T. N., additional, Hekman, Ryan M., additional, Kaserman, Joseph E., additional, Huang, Jessie, additional, Alysandratos, Konstantinos-Dionysios, additional, Toth, Gabor E., additional, Jakab, Ferenc, additional, Kotton, Darrell N., additional, Wilson, Andrew A., additional, Emili, Andrew, additional, Thiel, Volker, additional, Connor, John H., additional, Kemenesi, Gabor, additional, Cifuentes, Daniel, additional, and Mühlberger, Elke, additional
- Published
- 2022
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34. A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune–epithelial interface
- Author
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Leon, Juliette, primary, Michelson, Daniel A., additional, Olejnik, Judith, additional, Chowdhary, Kaitavjeet, additional, Oh, Hyung Suk, additional, Hume, Adam J., additional, Galván-Peña, Silvia, additional, Zhu, Yangyang, additional, Chen, Felicia, additional, Vijaykumar, Brinda, additional, Yang, Liang, additional, Crestani, Elena, additional, Yonker, Lael M., additional, Knipe, David M., additional, Mühlberger, Elke, additional, and Benoist, Christophe, additional
- Published
- 2021
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35. Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2
- Author
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Klouda, Timothy, primary, Hao, Yuan, additional, Kim, Hyunbum, additional, Kim, Jiwon, additional, Olejnik, Judith, additional, Hume, Adam J., additional, Ayyappan, Sowntharya, additional, Hong, Xuechong, additional, Melero-Martin, Juan, additional, Fang, Yinshan, additional, Wang, Qiong, additional, Zhou, Xiaobo, additional, Mühlberger, Elke, additional, Jia, Hongpeng, additional, Padera, Robert F., additional, Raby, Benjamin A., additional, and Yuan, Ke, additional
- Published
- 2021
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36. A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV2 at the immune-epithelial interface
- Author
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Leon, Juliette, primary, Michelson, Daniel A, additional, Olejnik, Judith, additional, Chowdhary, Kaitavjeet, additional, Oh, Hyung Suk, additional, Hume, Adam J, additional, Galvan-Pena, Silvia, additional, Zhu, Yangyang, additional, Chen, Felicia, additional, Vijaykumar, Brinda, additional, Yang, Liang, additional, Crestani, Elena, additional, Yonker, Lael M, additional, Knipe, David M, additional, Muhlberger, Elke, additional, and Benoist, Christophe, additional
- Published
- 2021
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37. Reservoir host studies of Lloviu virus: first isolation, sequencing and serology in Schreiber’s bats in Europe
- Author
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Kemenesi, Gábor, primary, Tóth, Gábor Endre, additional, Mayora-Neto, Martin, additional, Scott, Simon, additional, Temperton, Nigel, additional, Wright, Edward, additional, Mühlberger, Elke, additional, Hume, Adam J., additional, Zana, Brigitta, additional, Boldogh, Sándor András, additional, Görföl, Tamás, additional, Estók, Péter, additional, Lanszki, Zsófia, additional, Somogyi, Balázs A., additional, Nagy, Ágnes, additional, Pereszlényi, Csaba István, additional, Dudás, Gábor, additional, Földes, Fanni, additional, Kurucz, Kornélia, additional, Madai, Mónika, additional, Zeghbib, Safia, additional, Maes, Piet, additional, Vanmechelen, Bert, additional, and Jakab, Ferenc, additional
- Published
- 2021
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38. Recombinant Lloviu virus as a model to study inaccessible zoonotic viruses
- Author
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Hume, Adam J, primary, Heiden, Baylee, additional, Olejnik, Judith, additional, Suder, Ellen L, additional, Ross, Stephen, additional, Scoon, Whitney A, additional, Bullitt, Esther, additional, Ericsson, Maria, additional, White, Mitchell R, additional, Turcinovic, Jacquelyn, additional, Thao, Tran TN, additional, Hekman, Ryan M, additional, Kaserman, Joseph E, additional, Huang, Jessie, additional, Alysandratos, Konstantinos-Dionysios, additional, Toth, Gabor E, additional, Jakab, Ferenc, additional, Kotton, Darrell N, additional, Wilson, Andrew A, additional, Emili, Andrew, additional, Thiel, Volker, additional, Connor, John H, additional, Kemenesi, Gabor, additional, Cifuentes, Daniel, additional, and Mühlberger, Elke, additional
- Published
- 2021
- Full Text
- View/download PDF
39. Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection
- Author
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Wang, Ruobing, primary, Hume, Adam J., additional, Beermann, Mary Lou, additional, Simone-Roach, Chantelle, additional, Lindstrom-Vautrin, Jonathan, additional, Suer, Jake Le, additional, Huang, Jessie, additional, Olejnik, Judith, additional, Villacorta-Martin, Carlos, additional, Bullitt, Esther, additional, Hinds, Anne, additional, Ghaedi, Mahboobe, additional, Werder, Rhiannon B., additional, Abo, Kristine M., additional, Wilson, Andrew A., additional, Mühlberger, Elke, additional, Kotton, Darrell N., additional, and Hawkins, Finn J., additional
- Published
- 2021
- Full Text
- View/download PDF
40. Human Pluripotent Stem Cell-Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response
- Author
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Mithal, Aditya, primary, Hume, Adam J., additional, Lindstrom-Vautrin, Jonathan, additional, Villacorta-Martin, Carlos, additional, Olejnik, Judith, additional, Bullitt, Esther, additional, Hinds, Anne, additional, Mühlberger, Elke, additional, and Mostoslavsky, Gustavo, additional
- Published
- 2021
- Full Text
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41. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
- Author
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Hekman, Ryan M., primary, Hume, Adam J., additional, Goel, Raghuveera Kumar, additional, Abo, Kristine M., additional, Huang, Jessie, additional, Blum, Benjamin C., additional, Werder, Rhiannon B., additional, Suder, Ellen L., additional, Paul, Indranil, additional, Phanse, Sadhna, additional, Youssef, Ahmed, additional, Alysandratos, Konstantinos D., additional, Padhorny, Dzmitry, additional, Ojha, Sandeep, additional, Mora-Martin, Alexandra, additional, Kretov, Dmitry, additional, Ash, Peter E.A., additional, Verma, Mamta, additional, Zhao, Jian, additional, Patten, J.J., additional, Villacorta-Martin, Carlos, additional, Bolzan, Dante, additional, Perea-Resa, Carlos, additional, Bullitt, Esther, additional, Hinds, Anne, additional, Tilston-Lunel, Andrew, additional, Varelas, Xaralabos, additional, Farhangmehr, Shaghayegh, additional, Braunschweig, Ulrich, additional, Kwan, Julian H., additional, McComb, Mark, additional, Basu, Avik, additional, Saeed, Mohsan, additional, Perissi, Valentina, additional, Burks, Eric J., additional, Layne, Matthew D., additional, Connor, John H., additional, Davey, Robert, additional, Cheng, Ji-Xin, additional, Wolozin, Benjamin L., additional, Blencowe, Benjamin J., additional, Wuchty, Stefan, additional, Lyons, Shawn M., additional, Kozakov, Dima, additional, Cifuentes, Daniel, additional, Blower, Michael, additional, Kotton, Darrell N., additional, Wilson, Andrew A., additional, Mühlberger, Elke, additional, and Emili, Andrew, additional
- Published
- 2021
- Full Text
- View/download PDF
42. Actionable Cytopathogenic Host Responses of Human Alveolar Type 2 Cells to SARS-CoV-2
- Author
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Hekman, Ryan M., primary, Hume, Adam J., additional, Goel, Raghuveera Kumar, additional, Abo, Kristine M., additional, Huang, Jessie, additional, Blum, Benjamin C., additional, Werder, Rhiannon B., additional, Suder, Ellen L., additional, Paul, Indranil, additional, Phanse, Sadhna, additional, Youssef, Ahmed, additional, Alysandratos, Konstantinos D., additional, Padhorny, Dzmitry, additional, Ojha, Sandeep, additional, Mora-Martin, Alexandra, additional, Kretov, Dmitry, additional, Ash, Peter E.A., additional, Verma, Mamta, additional, Zhao, Jian, additional, Patten, J.J., additional, Villacorta-Martin, Carlos, additional, Bolzan, Dante, additional, Perea-Resa, Carlos, additional, Bullitt, Esther, additional, Hinds, Anne, additional, Tilston-Lunel, Andrew, additional, Varelas, Xaralabos, additional, Farhangmehr, Shaghayegh, additional, Braunschweig, Ulrich, additional, Kwan, Julian H., additional, McComb, Mark, additional, Basu, Avik, additional, Saeed, Mohsan, additional, Perissi, Valentina, additional, Burks, Eric J., additional, Layne, Matthew D., additional, Connor, John H., additional, Davey, Robert, additional, Cheng, Ji-Xin, additional, Wolozin, Benjamin L., additional, Blencowe, Benjamin J., additional, Wuchty, Stefan, additional, Lyons, Shawn M., additional, Kozakov, Dima, additional, Cifuentes, Daniel, additional, Blower, Michael, additional, Kotton, Darrell N., additional, Wilson, Andrew A., additional, Mühlberger, Elke, additional, and Emili, Andrew, additional
- Published
- 2020
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43. SARS-CoV-2 Infection of Pluripotent Stem Cell-Derived Human Lung Alveolar Type 2 Cells Elicits a Rapid Epithelial-Intrinsic Inflammatory Response
- Author
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Huang, Jessie, primary, Hume, Adam J., additional, Abo, Kristine M., additional, Werder, Rhiannon B., additional, Villacorta-Martin, Carlos, additional, Alysandratos, Konstantinos-Dionysios, additional, Beermann, Mary Lou, additional, Simone-Roach, Chantelle, additional, Lindstrom-Vautrin, Jonathan, additional, Olejnik, Judith, additional, Suder, Ellen L., additional, Bullitt, Esther, additional, Hinds, Anne, additional, Sharma, Arjun, additional, Bosmann, Markus, additional, Wang, Ruobing, additional, Hawkins, Finn, additional, Burks, Eric J., additional, Saeed, Mohsan, additional, Wilson, Andrew A., additional, Mühlberger, Elke, additional, and Kotton, Darrell N., additional
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- 2020
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44. Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection.
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Ruobing Wang, Hume, Adam J., Beermann, Mary Lou, Simone-Roach, Chantelle, Lindstrom-Vautrin, Jonathan, Le Suer, Jake, Huang, Jessie, Olejnik, Judith, Villacorta-Martin, Carlos, Bullitt, Esther, Hinds, Anne, Ghaedi, Mahboobe, Rollins, Stuart, Werder, Rhiannon B., Abo, Kristine M., Wilson, Andrew A., Mühlberger, Elke, Kotton, Darrell N., and Hawkins, Finn J.
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PLURIPOTENT stem cells , *INDUCED pluripotent stem cells , *EPITHELIAL cells , *SARS-CoV-2 , *ANGIOTENSIN converting enzyme - Abstract
There is an urgent need to understand how SARS-CoV-2 infects the airway epithelium and in a subset of individuals leads to severe illness or death. Induced pluripotent stem cells (iPSCs) provide a near limitless supply of human cells that can be differentiated into cell types of interest, including airway epithelium, for disease modeling. We present a human iPSC-derived airway epithelial platform, composed of the major airway epithelial cell types, that is permissive to SARS-CoV-2 infection. Subsets of iPSC-airway cells express the SARS-CoV-2 entry factors angiotensin-converting enzyme 2 (ACE2), and transmembrane protease serine 2 (TMPRSS2). Multiciliated cells are the primary initial target of SARS-CoV-2 infection. On infection with SARS-CoV-2, iPSC-airway cells generate robust interferon and inflammatory responses, and treatment with remdesivir or camostat mesylate causes a decrease in viral propagation and entry, respectively. In conclusion, iPSC-derived airway cells provide a physiologically relevant in vitro model system to interrogate the pathogenesis of, and develop treatment strategies for, COVID-19 pneumonia. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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45. MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses
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Bruchez, Anna, primary, Sha, Ky, additional, Johnson, Joshua, additional, Chen, Li, additional, Stefani, Caroline, additional, McConnell, Hannah, additional, Gaucherand, Lea, additional, Prins, Rachel, additional, Matreyek, Kenneth A., additional, Hume, Adam J., additional, Mühlberger, Elke, additional, Schmidt, Emmett V., additional, Olinger, Gene G., additional, Stuart, Lynda M., additional, and Lacy-Hulbert, Adam, additional
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- 2020
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46. SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors
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Gao, Chao, primary, Zeng, Junwei, additional, Jia, Nan, additional, Stavenhagen, Kathrin, additional, Matsumoto, Yasuyuki, additional, Zhang, Hua, additional, Li, Jiang, additional, Hume, Adam J., additional, Mühlberger, Elke, additional, van Die, Irma, additional, Kwan, Julian, additional, Tantisira, Kelan, additional, Emili, Andrew, additional, and Cummings, Richard D., additional
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- 2020
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47. Egyptian Rousette IFN-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells
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Pavlovich, Stephanie S., primary, Darling, Tamarand, additional, Hume, Adam J., additional, Davey, Robert A., additional, Feng, Feng, additional, Mühlberger, Elke, additional, and Kepler, Thomas B., additional
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- 2020
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48. Human Pluripotent Stem Cell Derived Intestinal Organoids Model SARS-CoV-2 Infection Revealing a Common Epithelial Inflammatory Response
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Mithal, Aditya, primary, Hume, Adam J., additional, Lindstrom-Vautrin, Jonathan, additional, Villacorta-Martin, Carlos, additional, Olejnik, Judith, additional, Bullitt, Esther, additional, Hinds, Anne, additional, Mühlberger, Elke, additional, and Mostoslavsky, Gustavo, additional
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- 2020
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49. A virus-specific monocyte inflammatory phenotype is induced by SARS-CoV-2 at the immune-epithelial interface.
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Leon, Juliette, Michelson, Daniel A., Olejnik, Judith, Chowdhary, Kaitavjeet, Hyung Suk Oh, Hume, Adam J., Galván-Peña, Silvia, Yangyang Zhu, Chen, Felicia, Vijaykumar, Brinda, Liang Yang, Crestani, Elena, Yonker, Lael M., Knipe, David M., Mühlberger, Elke, and Benoist, Christophe
- Subjects
SARS-CoV-2 ,COMMERCIAL products ,COVID-19 ,MYELOID cells - Abstract
Infection by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) provokes a potentially fatal pneumonia with multiorgan failure, and high systemic inflammation. To gain mechanistic insight and ferret out the root of this immune dysregulation, we modeled, by in vitro coculture, the interactions between infected epithelial cells and immunocytes. A strong response was induced in monocytes and B cells, with a SARS-CoV-2-specific inflammatory gene cluster distinct from that seen in influenza A or Ebola virus-infected cocultures, and which reproduced deviations reported in blood or lung myeloid cells from COVID-19 patients. A substantial fraction of the effect could be reproduced after individual transfection of several SARS-CoV-2 proteins (Spike and some nonstructural proteins), mediated by soluble factors, but not via transcriptional induction. This response was greatly muted in monocytes from healthy children, perhaps a clue to the age dependency of COVID-19. These results suggest that the inflammatory malfunction in COVID-19 is rooted in the earliest perturbations that SARS-CoV-2 induces in epithelia. [ABSTRACT FROM AUTHOR]
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- 2022
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50. Distinct Genome Replication and Transcription Strategies within the Growing Filovirus Family
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Hume, Adam J., primary and Mühlberger, Elke, additional
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- 2019
- Full Text
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