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Your search keyword '"Huang, Yinmei"' showing total 5 results
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5 results on '"Huang, Yinmei"'

3. In situ generation and efficient activation of H2O2 for pollutant degradation over CoMoS2 nanosphere-embedded rGO nanosheets and its interfacial reaction mechanism

Author

Meimei Xue, Junrong Liang, Muen Han, Lai Lyu, Jiayi Li, Chun Hu, Meiping Chen, Tao Wu, and Huang Yinmei

Subjects
Materials science, Oxide, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Catalysis, law.invention, Biomaterials, Metal, Electronegativity, Reaction rate, Electron transfer, chemistry.chemical_compound, Colloid and Surface Chemistry, law, Reactivity (chemistry), Graphene, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Chemical engineering, chemistry, visual_art, visual_art.visual_art_medium, 0210 nano-technology
Abstract

Consumption of additional H2O2 is necessary in classical Fenton catalysis. Herein, we report a novel and special nanocatalyst consisting of CoMoS2 nanosphere-embedded, reduced graphene oxide (rGO) nanosheets (CMS-rGO NSs). This nanocatalyst was discovered to have an impressive reactivity for in situ generation and synchronistical activation of H2O2 in different active centers, yielding fast and efficient degradation of the pollutants. The reaction rate is ∼21 times higher than that of conventional Fenton catalysts. The characterization shows that countless flower-like CoMoS2 nanospheres are uniformly embedded in the rGO nanosheets through Mo S C bonding bridges in CMS-rGO NSs, which leads to activation of the π electrons and their transfer from rGO to the metal centers (π → M). The formed Mo O Co further leads to a distribution of orientations of the electrons around the metal centers due to the different electronegativity of Mo and Co. During the reaction, the dissolved O2 is efficiently reduced to HO2 /O2 − around the electron-rich Mo center, and HO2 /O2 − is further reduced to H2O2 around the Co center. The generated H2O2 is finally reduced to OH for degrading dyes in the electron-rich metal (Mo or Co) centers of CMS-rGO NSs. The dye pollutants also act as electron donors, and they are directly degraded in the electron-poor π-center of CMS-rGO NSs, which promote the electron transfer cycle and achieve electron gain-loss balance. This discovery provides a new strategy for H2O2 generation-activation and pollutant degradation through constructing electron transfer bridges over the surface of catalysts.

Published
2019

5. SSPH I, A Novel Anti-cancer Saponin, Inhibits EMT and Invasion and Migration of NSCLC by Suppressing MAPK/ERK1/2 and PI3K/AKT/ mTOR Signaling Pathways.

Author

Zhou J, Luo J, Gan R, Zhi L, Zhou H, Lv M, Huang Y, and Liang G

Subjects
Humans, Animals, Mice, Mice, Nude, Mice, Inbred BALB C, A549 Cells, MAP Kinase Signaling System drug effects, Xenograft Model Antitumor Assays, Cell Proliferation drug effects, Cell Line, Tumor, Epithelial-Mesenchymal Transition drug effects, Carcinoma, Non-Small-Cell Lung drug therapy, Carcinoma, Non-Small-Cell Lung pathology, Carcinoma, Non-Small-Cell Lung metabolism, TOR Serine-Threonine Kinases metabolism, Saponins pharmacology, Lung Neoplasms drug therapy, Lung Neoplasms pathology, Lung Neoplasms metabolism, Cell Movement drug effects, Proto-Oncogene Proteins c-akt metabolism, Neoplasm Invasiveness, Phosphatidylinositol 3-Kinases metabolism, Signal Transduction drug effects
Abstract

Background: Saponin of Schizocapsa plantaginea Hance I (SSPH I).a bioactive saponin found in Schizocapsa plantaginea, exhibits significant anti-proliferation and antimetastasis in lung cancer., Objective: To explore the anti-metastatic effects of SSPH I on non-small cell lung cancer (NSCLC) with emphasis on epithelial-mesenchymal transition (EMT) both i n vitro and in vivo ., Methods: The effects of SSPH I at the concentrations of 0, 0.875,1.75, and 3.5 μM on A549 and PC9 lung cancer cells were evaluated using colony formation assay, CCK-8 assay, transwell assay and wound-healing assay. The actin cytoskeleton reorganization of PC9 and A549 cells was detected using the FITC-phalloidin fluorescence staining assay. The proteins related to EMT (N-cadherin, E-cadherin and vimentin), p- PI3K, p- AKT, p- mTOR and p- ERK1/2 were detected by Western blotting. A mouse model of lung cancer metastasis was established by utilizing 95-D cells, and the mice were treated with SSPH I by gavage., Results: The results suggested that SSPH I significantly inhibited the migration and invasion of NSCLC cells under a non-cytotoxic concentration. Furthermore, SSPH I at a non-toxic concentration of 0.875 μM inhibited F-actin cytoskeleton organization. Importantly, attenuation of EMT was observed in A549 cells with upregulation in the expression of epithelial cell marker E-cadherin and downregulation of the mesenchymal cell markers vimentin as well as Ncadherin. Mechanistic studies revealed that SSPH I inhibited MAPK/ERK1/2 and PI3K/AKT/mTOR signaling pathways., Conclusion: SSPH I inhibited EMT, migration, and invasion of NSCLC cells by suppressing MAPK/ERK1/2 and PI3K/AKT/mTOR signaling pathways, suggesting that the natural compound SSPH I could be used for inhibiting metastasis of NSCLC., (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.)

Published
2024
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