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4. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial

Author

Ai, Xinyue, An, Chun, An, Yuhong, Bai, Shiru, Bai, Xueke, Bi, Jingao, Bin, Xiaoling, Bu, Miaomiao, Bu, Peili, Bu, Wei, Cai, Lvping, Cai, Nana, Cai, Shuhui, Cai, Ting, Cai, Wenjing, Cao, Bin, Cao, Bingbing, Cao, Huaping, Cao, Libo, Cao, Xiancun, Chai, Hui, Chai, Yonggui, Chai, Zhiyong, Chang, Chunduo, Chang, Jianbao, Chang, Shuyue, Chang, Yunling, Chao, Huanhuan, Che, Hang, Che, Qianqiu, Chen, Danlin, Chen, Dongsheng, Chen, Faxiu, Chen, Guang, Chen, Hairong, Chen, Hao, Chen, Huahua, Chen, Huijun, Chen, Jiafu, Chen, Jian, Chen, Jiasen, Chen, Jing, Chen, Jinzi, Chen, Junrong, Chen, lichun, Chen, Lijuan, Chen, Liyuan, Chen, Qun, Chen, Run, Chen, Shaoxing, Chen, Song, Chen, Tieshuang, Chen, Xianghong, Chen, Xiaowu, Chen, Xudong, Chen, Xue, Chen, Xunchun, Chen, Yao, Chen, Yongli, Chen, Yuanyue, Chen, Yuhong, Chen, Yuyi, Chen, Zhangying, Chen, Zhidong, Chen, Zuyi, Cheng, Caiming, Cheng, Jianbin, Cheng, Xiaoxia, Chu, Junjie, Cui, Ruifeng, Cui, Xiaolin, Cui, Xuechen, Cui, Yang, Cui, Zhonghua, Dai, Wanhong, Dai, Xing, Ding, Chunxia, Ding, Huihong, Ding, Qiuhong, Ding, Yaozong, Ding, Yingjie, Dong, Jiajia, Dong, Lei, Dong, Qi, Dong, Yumei, Du, Bing, Du, Hong, Du, Jie, Du, Laijing, Du, Meiling, Du, Qiong, Du, Tianmin, Du, Xue, Duan, Ru, Duan, Xiaojing, Duan, Xiaoting, Fan, Dandan, Fan, Xiaohong, Fan, Xin, Fang, Fang, Fang, Jing, Fang, Xibo, Fang, Yang, Feng, Erke, Feng, Hejin, Feng, Ling, Feng, Rui, Feng, Zhaohui, Fu, Hongmei, Fu, Qiuai, Gao, Haofei, Gao, Li, Gao, Lina, Gao, Liwei, Gao, Lu, Gao, Min, Gao, Qian, Gao, Yan, Gao, Yuan, Ge, Jinzhuo, Geng, Hongxu, Geng, Hui, Geng, Leijun, Geng, Lianqing, Gou, Hongyan, Gu, Qin, Guan, Lili, Guan, Shuo, Guan, Wenchi, Guan, Zheng, Guang, Bin, Guo, Anran, Guo, Changhong, Guo, Gaofeng, Guo, Lizhi, Guo, Qing, Guo, Qiue, Guo, Ying, Guo, Zhihua, Han, Aihong, Han, Meihong, Han, Suhui, Han, Xinru, Han, Yajun, Hao, Feng, Hao, Jingmin, Hao, Shiguo, He, Chuanhui, He, Dejian, He, Mengyuan, He, Miaomiao, He, Shaojuan, He, Wenkai, He, Xiaoyu, He, Yuxiang, Hong, Jige, Hou, Chuanxing, Hou, Jing, Hu, Danli, Hu, Jian, Hu, Jun, Hu, Lingai, Hu, Mengying, Hu, Zhiyuan, Huang, Anhui, Huang, Chunxia, Huang, Haolin, Huang, Jianlan, Huang, Sha, Huang, Siqi, Huang, Weijun, Huang, Wenxiu, Huang, Xinghe, Huang, Xinsheng, Huang, Xinxin, Hui, Jiliang, Hui, Lijun, Hui, Zhongsheng, Huo, Fangjie, Ji, Runqing, Jia, Guojiong, Jia, Hao, Jia, Jingjing, Jia, Jingmei, Jia, Xiaoling, Jiang, Hua, Jiang, Jingcheng, Jiang, Qian, Jiang, Xianyan, Jiang, Xiaoyuan, Jiang, Yanxiang, Jiao, Yunhong, Jie, Liying, Jin, Binbin, Jin, Lingjiao, Jin, Renshu, Jin, Rong, Jin, Xiang, Jin, Xianping, Jin, Yongfan, Jin, Zepu, Jin, Zhenan, Jing, Chengrong, Jing, Jiajie, Jing, Ruiling, Kang, Liping, Kang, Yu, Kong, Jianqiong, Kou, Shijie, Kou, Xianli, Kulaxihan, Lai, Jijia, Lei, Lubi, Li, Baoxiang, Li, Bin, Li, Bing, Li, Chaohui, Li, Cheng, Li, Chunmei, Li, Chunyan, Li, Daqing, Li, Deen, Li, Di, Li, Feng, Li, Guanyi, Li, Haiyang, Li, Hongwei, Li, Jia, Li, Jialin, Li, Jianan, Li, Jianguang, Li, Jiaying, Li, Jing, Li, Jinmei, Li, Lala, Li, Li, Li, Lijun, Li, Liping, Li, Lize, Li, Mingju, Li, Minglan, Li, Mingyan, Li, Na, Li, Nan, Li, Nana, Li, Qiang, Li, Qianru, Li, Rui, Li, Ruihong, Li, Shanshan, Li, Shilin, Li, Si, Li, Suwen, Li, Tongshe, Li, Tongying, Li, Wanke, Li, Wei, Li, Wenbo, Li, Wenjuan, Li, Xi, Li, Xiangxia, Li, Xiao, Li, Xiaohui, Li, Xingyan, Li, Xiujuan, Li, Yan, Li, Yanfang, Li, Yang, Li, Yanxia, Li, Yaona, Li, Yichong, Li, Ying, Li, Yuqing, Li, Zheng, Li, Zhengye, Liang, Chuanliang, Liang, Jihua, Liang, Jin, Liang, Ke, Liang, Linju, Liang, Tingchen, Liang, Xia, Liang, Xianfeng, Liang, Yanli, Liang, Zhenye, Lie, Zhenbang, Lin, Qingfei, Lin, Ruifang, Lin, Xiao, Lin, Zhiqiang, Liu, Aijun, Liu, Chao, Liu, Chunxia, Liu, Cong, Liu, Fang, Liu, Guaiyan, Liu, Hongjun, Liu, Jiamin, Liu, Jiangling, Liu, Jianqi, Liu, Jieyun, Liu, Jihong, Liu, Jing, Liu, Jinsha, Liu, Juan, Liu, Junfang, Liu, Liming, Liu, Lin, Liu, Ling, Liu, Lu, Liu, Qiang, Liu, Qiaoling, Liu, Qiaoxia, Liu, Qiuxia, Liu, Shaobo, Liu, Xiaobao, Liu, Xiaocheng, Liu, Xiaoyuan, Liu, Xinbo, Liu, Xu, Liu, Yang, Liu, Yanhu, Liu, Yanming, Liu, Yaqin, Liu, Yong, Liu, Zhihong, Long, Jing, Lu, Futang, Lu, Huamei, Lu, Jiapeng, Lu, Junhong, Lu, Weibin, Lu, Yanrong, Lu, Yuchun, Luan, Tianwei, Luo, Qingwei, Luo, Qun, Luo, Tian, Luo, Xia, Luo, Yongmei, Lv, Jing, Lv, Jinhai, Lv, Lei, Lv, Lili, Lv, Meng, Ma, Aiqing, Ma, Huaimin, Ma, Huihuang, Ma, Jie, Ma, Jinbao, Ma, Li, Ma, Lingzhen, Ma, Nan, Ma, Qiaojuan, Ma, Shumei, Ma, Tengfei, Ma, Xiange, Ma, Xiaowen, Ma, Yuehua, Mai, Lanxian, Mei, Xiao, Meng, Gen, Miao, Ruichao, Miao, Xue, Miao, Xuyan, Min, Tingting, Mo, Shubing, Morigentu, Nan, Tingyan, Ni, Jinyang, Ni, Shuguo, Nie, Yu, Ning, Benxing, Ning, Xiaowei, Niu, Manman, Niu, Qingying, Niu, Wentang, Niu, Xiaoxia, Ou, Fang, Pan, Biyun, Pan, Chengjie, Pan, Congming, Pan, Jieli, Pan, Xiaowen, Pan, Ziying, Pei, Guangzhong, Pei, Lingyu, Pei, Min, Pei, Yanzhen, Peng, Yinyu, Peng, Yuming, Pu, Zhaokun, Qi, Fengjun, Qi, Liwei, Qi, Meiqiong, Qi, Yan, Qian, Jun, Qin, Lei, Qin, Zhonghua, Qing, Lan, Qiu, Lixia, Qiu, Weiyu, Qiu, Xiaoling, Qu, Yueli, Quan, Minghua, Ren, Dingping, Ren, Hong, Ren, Lingzhi, Ren, Tingting, Ren, Wei, Ren, Yihui, Rong, Yufang, Ruan, Jiahui, Shang, Peiqin, Shao, Minyan, Shao, Xuefeng, Shao, Yuling, Shen, Junrong, Shen, Rui, Sheng, Lin, Shi, Jiangjie, Shi, Xun, Shi, Yanhong, Shi, Yeju, Shi, Yujiao, Shu, Bo, Song, Bingchun, Song, Dan, Song, Jinhui, Song, Jinwang, Song, Jinxian, Song, Wei, Song, Xiaoping, Song, Yawen, Su, He, Su, Qinfeng, Su, Shuhong, Su, Xiaozhou, Sun, Chengxiang, Sun, Fangfang, Sun, Gongping, Sun, Jiangnan, Sun, Mengmeng, Sun, Rongrong, Sun, Shuting, Sun, Songtao, Sun, Ying, Sun, Yongmiao, Sun, Yunhong, Sun, Zhiqiang, Suo, Mengying, Tan, Binghu, Tang, Chunyan, Tang, Zhongli, Tao, Yu, Tian, Changming, Tian, Hongmei, Tian, Jian, Tian, Xiaomin, Wan, Huaibin, Wan, Qin, Wan, Rongjun, Wang, Bobin, Wang, Chao, Wang, Chaoqun, Wang, Chengliang, Wang, Di, Wang, Enfang, Wang, Feng, Wang, Gang, Wang, Guangqiang, Wang, Guixiang, Wang, Haifeng, Wang, Haijun, Wang, Haiyang, Wang, Jianfang, Wang, Jianfeng, Wang, Jing, Wang, Junping, Wang, Junying, Wang, Kang, Wang, Lei, Wang, Lin, Wang, Lize, Wang, Meng, Wang, Pan, Wang, Qi, Wang, Qiong, Wang, Qiuli, Wang, Qiuxue, Wang, Ran, Wang, Shaojin, Wang, Shuai, Wang, Tao, Wang, Tiantian, Wang, Tinghui, Wang, Tongyan, Wang, Wanhong, Wang, Wenjuan, Wang, Wenyan, Wang, Wenying, Wang, Wenzhuan, Wang, Xiaofei, Wang, Xiaoyan, Wang, Xitong, Wang, Xu, Wang, Yan, Wang, Yanfang, Wang, Yang, Wang, Yanping, Wang, Yanying, Wang, Yaoxin, Wang, Yingli, Wang, Yiting, Wang, Yue, Wang, Yumei, Wang, Yuzhuo, Wang, Zhenhua, Wang, Zhifang, Wang, Zhimin, Wei, Chunli, Wei, Lixia, Wei, Pei, Wei, Shuying, Wei, Xiqing, Wen, Hong, Wen, Yun, Wu, Chaoqun, Wu, Hairong, Wu, Lihua, Wu, Lingxiang, Wu, Qi, Wu, Shaorong, Wu, Wenting, Wu, Xueyi, Wu, Yongshuan, Wu, Zhihao, Wu, Zhuying, Wu, Zongyin, Wuhanbilige, Xia, Jun, Xia, Yang, Xiang, Jing, Xiao, Heliu, Xiao, Yaying, Xie, Meiling, Xie, Yinyan, Xin, Huiling, Xing, Jing, Xiu, Guoquan, Xu, Baohua, Xu, Chuangze, Xu, En, Xu, Jian, Xu, Shuli, Xu, Wei, Xu, Wen, Xue, Na, Xue, Tingting, Xue, Wei, Yan, Haiyan, Yan, Xiaofang, Yan, Yanqing, Yang, Bo, Yang, Hui, Yang, Huiyu, Yang, Jinhua, Yang, Kun, Yang, Man, Yang, Mengya, Yang, Ning, Yang, Ping, Yang, Xiajiao, Yang, Xiaomo, Yang, Xin, Yang, Xiujuan, Yang, Xuemei, Yang, Xuming, Yang, Yan, Yang, Yanhua, Yang, Yi, Yang, Yuanyuan, Yang, Zhimei, Yang, Zhiming, Yao, Hui, Yao, Lu, Ye, Jinling, Ye, Wenhua, Yi, Mingjiao, Yi, Shaowei, Yi, Wenyi, Yi, Zhimin, Yin, Guangxia, Yin, Guoyuan, Yu, Guibin, Yu, Hairong, Yu, Huaitao, Yu, Lijie, Yu, Lijun, Yu, Nana, Yu, Qin, Yu, Xinli, Yu, Yi, Yuan, Biao, Zeng, Chunmei, Zhai, Na, Zhai, Xiaojuan, Zhan, Hongju, Zhang, Aizhen, Zhang, Baohua, Zhang, Bin, Zhang, Caizhu, Zhang, Chaoying, Zhang, Chengbo, Zhang, Chunlai, Zhang, Churuo, Zhang, Fan, Zhang, Feiqin, Zhang, Ge, Zhang, Haibo, Zhang, Hailin, Zhang, Hanxue, Zhang, Huaixing, Zhang, Hui, Zhang, Huijuan, Zhang, Jinguo, Zhang, Jingyu, Zhang, Jinyun, Zhang, Jisheng, Zhang, Jun, Zhang, Lei, Zhang, Li, Zhang, Liang, Zhang, Lifeng, Zhang, Lina, Zhang, Liping, Zhang, Min, Zhang, Ping, Zhang, Qiang, Zhang, Rufang, Zhang, Ruifen, Zhang, Shengde, Zhang, Siqi, Zhang, Sufang, Zhang, Tingting, Zhang, Wanyue, Zhang, Weiliang, Zhang, Xiaohan, Zhang, Xiaohong, Zhang, Xiaojuan, Zhang, Xin, Zhang, Xue, Zhang, Xuewei, Zhang, Yachen, Zhang, Yang, Zhang, Yanyan, Zhang, Yaojie, Zhang, Yingyu, Zhang, Yuan, Zhang, Yun, Zhang, Yunfeng, Zhang, Zaozhang, Zhang, Zhichao, Zhao, Baihui, Zhao, Dan, Zhao, Fuxian, Zhao, Guizeng, Zhao, Haijie, Zhao, Honglei, Zhao, Huizhen, Zhao, Jindong, Zhao, Juan, Zhao, Liming, Zhao, Ling, Zhao, Lingshan, Zhao, Qingxia, Zhao, Qiuping, Zhao, Wanchen, Zhao, Wangxiu, Zhao, Weiyi, Zhao, Xiaodi, Zhao, Xiaojing, Zhao, Xiaoli, Zhao, Xiaoyan, Zhao, Xiling, Zhao, Yannan, Zhao, Yiyuan, Zheng, Shuzhen, Zheng, Xin, Zhi, Lixia, Zhong, Hui, Zhong, Qing, Zhong, Xin, Zhong, Yunzhi, Zhou, Jianfeng, Zhou, Jihu, Zhou, Ke, Zhou, Liangliang, Zhou, Ling, Zhou, Na, Zhou, Shengcheng, Zhou, Suyun, Zhou, Tao, Zhou, Wanren, Zhou, Weifeng, Zhou, Weijuan, Zhou, Xiaohong, Zhou, Yunke, Zhou, Yuquan, Zhou, Zhaohai, Zhou, Zhiming, Zhu, Bingpo, Zhu, Jifa, Zhu, Jing, Zhu, Mengnan, Zhu, Youcun, Zong, Dafei, Zuo, Hongbo, and Zuo, Zhaokai

Published
2024
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19. Recent and speculative remote myocardial trauma: a case series.

Author

Lu, Zhijuan, Zhang, Xiaocong, Huang, Yanling, Song, Jia, Zhang, Chaoqun, Wang, Qiang, Wu, Handong, and Huang, Xinsheng

Subjects
MYOCARDIAL injury, CARDIAC imaging, ARRHYTHMIA, DIAGNOSIS, WOUNDS & injuries
Abstract

Background Cardiac blunt trauma clinically presents as a spectrum of injuries of varying severity. However, the diagnosis of complications of remote myocardial trauma is often challenging, especially if the patient forgets to mention a remote history of chest trauma. Case summary In this study, we present a patient who recently experienced traumatic myocardial dissection and interventricular septal rupture, alongside three patients exhibiting a mimic double-chambered left ventricle, indicative of prior remote myocardial trauma potentially associated with myocardial dissecting tear. Discussion Patients with recent severe myocardial injury are detectable through cardiac imaging. However, forgotten remote myocardial trauma can lead to adverse myocardial remodelling, heart failure, and arrhythmias. Long-term myocardial remodelling can obscure initial myocardial imaging characteristics, posing challenges in interpretation. Our case series suggests that remote myocardial trauma may be more prevalent than commonly thought of in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk with and without diabetes or previous stroke: an open-label, blinded-outcome, randomised trial

Author

Liu, Jiamin, Li, Yan, Ge, Jinzhuo, Yan, Xiaofang, Zhang, Haibo, Zheng, Xin, Lu, Jiapeng, Li, Xi, Gao, Yan, Lei, Lubi, Liu, Jing, Li, Jing, Ai, Xinyue, An, Chun, An, Yuhong, Bai, Shiru, Bai, Xueke, Bi, Jingao, Bin, Xiaoling, Bu, Miaomiao, Bu, Peili, Bu, Wei, Cai, Lvping, Cai, Nana, Cai, Shuhui, Cai, Ting, Cai, Wenjing, Cao, Bin, Cao, Bingbing, Cao, Huaping, Cao, Libo, Cao, Xiancun, Chai, Hui, Chai, Yonggui, Chai, Zhiyong, Chang, Chunduo, Chang, Jianbao, Chang, Shuyue, Chang, Yunling, Chao, Huanhuan, Che, Hang, Che, Qianqiu, Chen, Danlin, Chen, Dongsheng, Chen, Faxiu, Chen, Guang, Chen, Hairong, Chen, Hao, Chen, Huahua, Chen, Huijun, Chen, Jiafu, Chen, Jian, Chen, Jian, Chen, Jiasen, Chen, Jing, Chen, Jinzi, Chen, Junrong, Chen, lichun, Chen, Lijuan, Chen, Liyuan, Chen, Qun, Chen, Run, Chen, Shaoxing, Chen, Song, Chen, Tieshuang, Chen, Xianghong, Chen, Xiaowu, Chen, Xudong, Chen, Xue, Chen, Xunchun, Chen, Yao, Chen, Yongli, Chen, Yuanyue, Chen, Yuhong, Chen, Yuyi, Chen, Zhangying, Chen, Zhidong, Chen, Zuyi, Cheng, Caiming, Cheng, Jianbin, Cheng, Xiaoxia, Chu, Junjie, Cui, Ruifeng, Cui, Xiaolin, Cui, Xuechen, Cui, Yang, Cui, Zhonghua, Dai, Wanhong, Dai, Xing, Ding, Chunxia, Ding, Huihong, Ding, Qiuhong, Ding, Yaozong, Ding, Yingjie, Dong, Jiajia, Dong, Lei, Dong, Qi, Dong, Yumei, Du, Bing, Du, Hong, Du, Jie, Du, Laijing, Du, Meiling, Du, Qiong, Du, Tianmin, Du, Xue, Duan, Ru, Duan, Xiaojing, Duan, Xiaoting, Fan, Dandan, Fan, Xiaohong, Fan, Xin, Fang, Fang, Fang, Jing, Fang, Xibo, Fang, Yang, Feng, Erke, Feng, Hejin, Feng, Ling, Feng, Rui, Feng, Zhaohui, Fu, Hongmei, Fu, Qiuai, Gao, Haofei, Gao, Li, Gao, Lina, Gao, Liwei, Gao, Lu, Gao, Min, Gao, Min, Gao, Qian, Gao, Yan, Gao, Yuan, Ge, Jinzhuo, Geng, Hongxu, Geng, Hui, Geng, Leijun, Geng, Lianqing, Gou, Hongyan, Gu, Qin, Guan, Lili, Guan, Shuo, Guan, Wenchi, Guan, Zheng, Guang, Bin, Guo, Anran, Guo, Changhong, Guo, Gaofeng, Guo, Lizhi, Guo, Qing, Guo, Qiue, Guo, Ying, Guo, Zhihua, Han, Aihong, Han, Meihong, Han, Suhui, Han, Xinru, Han, Yajun, Hao, Feng, Hao, Jingmin, Hao, Shiguo, He, Chuanhui, He, Dejian, He, Mengyuan, He, Miaomiao, He, Shaojuan, He, Wenkai, He, Xiaoyu, He, Yuxiang, Hong, Jige, Hou, Chuanxing, Hou, Jing, Hu, Danli, Hu, Jian, Hu, Jun, Hu, Lingai, Hu, Mengying, Hu, Zhiyuan, Huang, Anhui, Huang, Chunxia, Huang, Haolin, Huang, Jianlan, Huang, Sha, Huang, Siqi, Huang, Weijun, Huang, Wenxiu, Huang, Xinghe, Huang, Xinsheng, Huang, Xinxin, Hui, Jiliang, Hui, Lijun, Hui, Zhongsheng, Huo, Fangjie, Ji, Runqing, Ji, Runqing, Jia, Guojiong, Jia, Hao, Jia, Jingjing, Jia, Jingmei, Jia, Xiaoling, Jiang, Hua, Jiang, Jingcheng, Jiang, Qian, Jiang, Xianyan, Jiang, Xiaoyuan, Jiang, Yanxiang, Jiao, Yunhong, Jie, Liying, Jin, Binbin, Jin, Lingjiao, Jin, Renshu, Jin, Rong, Jin, Xiang, Jin, Xianping, Jin, Yongfan, Jin, Zepu, Jin, Zhenan, Jing, Chengrong, Jing, Jiajie, Jing, Ruiling, Kang, Liping, Kang, Yu, Kong, Jianqiong, Kou, Shijie, Kou, Xianli, Kulaxihan, Lai, Jijia, Lei, Lubi, Li, Baoxiang, Li, Bin, Li, Bing, Li, Chaohui, Li, Cheng, Li, Chunmei, Li, Chunyan, Li, Daqing, Li, Deen, Li, Di, Li, Feng, Li, Guanyi, Li, Haiyang, Li, Hongwei, Li, Jia, Li, Jialin, Li, Jianan, Li, Jianguang, Li, Jiaying, Li, Jing, Li, Jing, Li, Jinmei, Li, Lala, Li, Li, Li, Lijun, Li, Liping, Li, Lize, Li, Mingju, Li, Minglan, Li, Mingyan, Li, Na, Li, Na, Li, Nan, Li, Nana, Li, Qiang, Li, Qianru, Li, Rui, Li, Ruihong, Li, Shanshan, Li, Shilin, Li, Si, Li, Suwen, Li, Tongshe, Li, Tongying, Li, Wanke, Li, Wei, Li, Wenbo, Li, Wenjuan, Li, Xi, Li, Xiangxia, Li, Xiao, Li, Xiaohui, Li, Xingyan, Li, Xiujuan, Li, Yan, Li, Yanfang, Li, Yang, Li, Yanxia, Li, Yaona, Li, Yichong, Li, Ying, Li, Yuqing, Li, Zheng, Li, Zhengye, Liang, Chuanliang, Liang, Jihua, Liang, Jin, Liang, Ke, Liang, Linju, Liang, Tingchen, Liang, Xia, Liang, Xianfeng, Liang, Yanli, Liang, Zhenye, Lie, Zhenbang, Lin, Qingfei, Lin, Ruifang, Lin, Xiao, Lin, Zhiqiang, Liu, Aijun, Liu, Chao, Liu, Chunxia, Liu, Cong, Liu, Fang, Liu, Fang, Liu, Guaiyan, Liu, Hongjun, Liu, Jiamin, Liu, Jiangling, Liu, Jianqi, Liu, Jieyun, Liu, Jihong, Liu, Jing, Liu, Jinsha, Liu, Juan, Liu, Junfang, Liu, Liming, Liu, Lin, Liu, Lin, Liu, Lin, Liu, Ling, Liu, Lu, Liu, Qiang, Liu, Qiaoling, Liu, Qiaoxia, Liu, Qiuxia, Liu, Shaobo, Liu, Xiaobao, Liu, Xiaocheng, Liu, Xiaoyuan, Liu, Xinbo, Liu, Xu, Liu, Yang, Liu, Yanhu, Liu, Yanming, Liu, Yaqin, Liu, Yong, Liu, Zhihong, Long, Jing, Lu, Futang, Lu, Huamei, Lu, Jiapeng, Lu, Junhong, Lu, Weibin, Lu, Yanrong, Lu, Yuchun, Luan, Tianwei, Luo, Qingwei, Luo, Qun, Luo, Tian, Luo, Xia, Luo, Yongmei, Lv, Jing, Lv, Jinhai, Lv, Lei, Lv, Lili, Lv, Meng, Ma, Aiqing, Ma, Huaimin, Ma, Huihuang, Ma, Jie, Ma, Jinbao, Ma, Li, Ma, Lingzhen, Ma, Nan, Ma, Qiaojuan, Ma, Shumei, Ma, Tengfei, Ma, Xiange, Ma, Xiaowen, Ma, Yuehua, Mai, Lanxian, Mei, Xiao, Meng, Gen, Miao, Ruichao, Miao, Xue, Miao, Xuyan, Min, Tingting, Mo, Shubing, Morigentu, Nan, Tingyan, Ni, Jinyang, Ni, Shuguo, Nie, Yu, Ning, Benxing, Ning, Xiaowei, Niu, Manman, Niu, Qingying, Niu, Wentang, Niu, Xiaoxia, Ou, Fang, Pan, Biyun, Pan, Chengjie, Pan, Congming, Pan, Jieli, Pan, Xiaowen, Pan, Ziying, Pei, Guangzhong, Pei, Lingyu, Pei, Min, Pei, Yanzhen, Peng, Yinyu, Peng, Yuming, Pu, Zhaokun, Qi, Fengjun, Qi, Liwei, Qi, Meiqiong, Qi, Yan, Qian, Jun, Qin, Lei, Qin, Zhonghua, Qing, Lan, Qiu, Lixia, Qiu, Weiyu, Qiu, Xiaoling, Qu, Yueli, Quan, Minghua, Ren, Dingping, Ren, Hong, Ren, Lingzhi, Ren, Tingting, Ren, Wei, Ren, Yihui, Rong, Yufang, Ruan, Jiahui, Shang, Peiqin, Shao, Minyan, Shao, Xuefeng, Shao, Yuling, Shen, Junrong, Shen, Rui, Sheng, Lin, Shi, Jiangjie, Shi, Xun, Shi, Yanhong, Shi, Yeju, Shi, Yujiao, Shu, Bo, Song, Bingchun, Song, Dan, Song, Jinhui, Song, Jinwang, Song, Jinxian, Song, Wei, Song, Xiaoping, Song, Yawen, Su, He, Su, Qinfeng, Su, Shuhong, Su, Xiaozhou, Sun, Chengxiang, Sun, Fangfang, Sun, Gongping, Sun, Jiangnan, Sun, Mengmeng, Sun, Rongrong, Sun, Shuting, Sun, Songtao, Sun, Ying, Sun, Yongmiao, Sun, Yunhong, Sun, Zhiqiang, Suo, Mengying, Tan, Binghu, Tang, Chunyan, Tang, Zhongli, Tao, Yu, Tian, Changming, Tian, Hongmei, Tian, Jian, Tian, Xiaomin, Wan, Huaibin, Wan, Qin, Wan, Rongjun, Wang, Bobin, Wang, Chao, Wang, Chaoqun, Wang, Chengliang, Wang, Di, Wang, Enfang, Wang, Feng, Wang, Gang, Wang, Guangqiang, Wang, Guixiang, Wang, Haifeng, Wang, Haijun, Wang, Haiyang, Wang, Jianfang, Wang, Jianfeng, Wang, Jing, Wang, Junping, Wang, Junying, Wang, Kang, Wang, Lei, Wang, Lei, Wang, Lin, Wang, Lize, Wang, Meng, Wang, Pan, Wang, Qi, Wang, Qiong, Wang, Qiuli, Wang, Qiuxue, Wang, Ran, Wang, Shaojin, Wang, Shuai, Wang, Tao, Wang, Tiantian, Wang, Tinghui, Wang, Tongyan, Wang, Wanhong, Wang, Wenjuan, Wang, Wenyan, Wang, Wenying, Wang, Wenzhuan, Wang, Xiaofei, Wang, Xiaoyan, Wang, Xitong, Wang, Xu, Wang, Yan, Wang, Yan, Wang, Yan, Wang, Yanfang, Wang, Yang, Wang, Yang, Wang, Yanping, Wang, Yanying, Wang, Yaoxin, Wang, Yingli, Wang, Yiting, Wang, Yue, Wang, Yumei, Wang, Yuzhuo, Wang, Zhenhua, Wang, Zhifang, Wang, Zhimin, Wei, Chunli, Wei, Lixia, Wei, Pei, Wei, Shuying, Wei, Xiqing, Wen, Hong, Wen, Yun, Wu, Chaoqun, Wu, Hairong, Wu, Lihua, Wu, Lingxiang, Wu, Qi, Wu, Shaorong, Wu, Wenting, Wu, Xueyi, Wu, Yongshuan, Wu, Zhihao, Wu, Zhuying, Wu, Zongyin, Wuhanbilige, Xia, Jun, Xia, Yang, Xiang, Jing, Xiao, Heliu, Xiao, Yaying, Xie, Meiling, Xie, Yinyan, Xin, Huiling, Xing, Jing, Xiu, Guoquan, Xu, Baohua, Xu, Chuangze, Xu, En, Xu, Jian, Xu, Shuli, Xu, Wei, Xu, Wen, Xue, Na, Xue, Tingting, Xue, Wei, Yan, Haiyan, Yan, Xiaofang, Yan, Yanqing, Yang, Bo, Yang, Hui, Yang, Huiyu, Yang, Jinhua, Yang, Kun, Yang, Man, Yang, Mengya, Yang, Ning, Yang, Ping, Yang, Xiajiao, Yang, Xiaomo, Yang, Xin, Yang, Xiujuan, Yang, Xuemei, Yang, Xuming, Yang, Yan, Yang, Yanhua, Yang, Yi, Yang, Yuanyuan, Yang, Zhimei, Yang, Zhiming, Yao, Hui, Yao, Lu, Ye, Jinling, Ye, Wenhua, Yi, Mingjiao, Yi, Shaowei, Yi, Wenyi, Yi, Zhimin, Yin, Guangxia, Yin, Guoyuan, Yu, Guibin, Yu, Hairong, Yu, Huaitao, Yu, Lijie, Yu, Lijun, Yu, Nana, Yu, Qin, Yu, 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Abstract

Uncertainty exists about whether lowering systolic blood pressure to less than 120 mm Hg is superior to that of less than 140 mm Hg, particularly in patients with diabetes and patients with previous stroke.

Published
2024
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30. Identification of common stria vascularis cellular alteration in sensorineural hearing loss based on ScRNA-seq.

Author

Gu, Xi, Jiang, Kanglun, Chen, Ruru, Chen, Zhifeng, Wu, Xianmin, Xiang, Haijie, Huang, Xinsheng, and Nan, Benyu

Subjects
SENSORINEURAL hearing loss, CELL communication, NOISE-induced deafness, ELECTRON transport, CELL anatomy, SOUND waves
Abstract

Background: The stria vascularis (SV), located in the lateral wall of the cochlea, maintains cochlear fluid homeostasis and mechanoelectrical transduction (MET) activity required for sound wave conduction. The pathogenesis of a number of human inheritable deafness syndromes, age related hearing loss, drug-induced ototoxicity and noise-induced hearing loss results from the morphological changes and functional impairments in the development of the SV. In this study, we investigate the implications of intercellular communication within the SV in the pathogenesis of sensorineural hearing loss (SNHL). We aim to identify commonly regulated signaling pathways using publicly available single-cell transcriptomic sequencing (scRNA-seq) datasets. Methods: We analyzed scRNA-seq data, which was derived from studying the cochlear SV in mice with SNHL compared to normal adult mice. After quality control and filtering, we obtained the major cellular components of the mouse cochlear SV and integrated the data. Using Seurat's FindAllMarkers and FindMarkers packages, we searched for novel conservative genes and differential genes. We employed KEGG and GSEA to identify molecular pathways that are commonly altered among different types of SNHL. We utilized pySCENIC to discover new specific regulatory factors in SV subpopulation cells. With the help of CellChat, we identified changes in subpopulation cells showing similar trends across different SNHL types and their alterations in intercellular communication pathways. Results: Through the analysis of the integrated data, we discovered new conserved genes to SV specific cells and identified common downregulated pathways in three types of SNHL. The enriched genes for these pathways showing similar trends are primarily associated with the Electron Transport Chain, related to mitochondrial energy metabolism. Using the CellChat package, we further found that there are shared pathways in the incoming signaling of specific intermediate cells in SNHL, and these pathways have common upstream regulatory transcription factor of Nfe2l2. Combining the results from pySCENIC and CellChat, we predicted the transcription factor Nfe2l2 as an upstream regulatory factor for multiple shared cellular pathways in IC. Additionally, it serves as an upstream factor for several genes within the Electron Transport Chain. Conclusion: Our bioinformatics analysis has revealed that downregulation of the mitochondrial electron transport chain have been observed in various conditions of SNHL. E2f1, Esrrb, Runx1, Yy1, and Gata2 could serve as novel important common TFs regulating the electron transport chain. Adm has emerged as a potential new marker gene for intermediate cells, while Itgb5 and Tesc show promise as potential new marker genes for marginal cells in the SV. These findings offer a new perspective on SV lesions in SNHL and provide additional theoretical evidence for the same drug treatment and prevention of different pathologies of SNHL. [ABSTRACT FROM AUTHOR]

Published
2024
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39. Distal end side-to-side anastomosis of sequential coronary bypass for size mismatched saphenous vein grafts and coronary arteries.

Author

Wei, Ziheng, Ma, Xuqing, Li, Jingxing, Yang, Junfeng, Wei, Hua, Yu, Yang, Gu, Chengxiong, and Huang, Xinsheng

Subjects
CORONARY artery surgery, SAPHENOUS vein, PERIOPERATIVE care, CORONARY artery bypass, SURGICAL anastomosis, LOG-rank test, SURGICAL complications, RETROSPECTIVE studies, MYOCARDIAL infarction, MANN Whitney U Test, TREATMENT effectiveness, T-test (Statistics), VASCULAR resistance, CHI-squared test, DESCRIPTIVE statistics, KAPLAN-Meier estimator, DATA analysis software, PROPORTIONAL hazards models
Abstract

Introduction: The distal end anastomosis is critical to the entire sequential grafts in coronary artery bypass grafting (CABG), but caliber mismatch diminishes the quality of the anastomosis. We aimed to introduce a modified distal end side-to-side (deSTS) anastomosis to handle the size mismatch and compared with classic distal end end-to-side (deETS) anastomosis. Methods: From January 2014 to December 2018, 185 patients who underwent off-pump CABG with size mismatched sequential vein grafts (≥3.5 mm) and target coronaries (1.0–1.5 mm) at the distal end anastomoses were included. We retrospectively reviewed the data of the patients, perioperative and follow-up outcomes were analyzed. Results: The deSTS group (n = 67) showed higher anastomotic flow (19.8 ± 8.0 vs 14.9±6.8 mL/min; p < 0.001) and lower pulsatility index (2.7 ± 0.8 vs 3.2 ± 1.0; p = 0.001) than the deETS group (n = 118). Higher incidence of in-hospital myocardial infarction (MI) was found in the deETS group but without significant difference (9.0% vs. 15.3%; p = 0.220). Kaplan-Meier analysis illustrated a relatively lower MI and major adverse cardiovascular and cerebrovascular events (MACCE) incidence in the deSTS group, and the deSTS group was associated with a reduction in long-term death, MI and MACCE in the adjusted Cox regression model. In addition, relatively higher graft patency was found in the deSTS group. Conclusions: The deSTS anastomosis showed superiority in solving size mismatch in sequential CABG, including better intraoperative flow dynamics, ideal long-term graft patency and reduced the incidence of perioperative and follow-up adverse events especially in MI. [ABSTRACT FROM AUTHOR]

Published
2023
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