1. The effect of a repeated immunoadsorption in patients with dilated cardiomyopathy after recurrence of severe heart failure symptoms.
- Author
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Reinthaler M, Empen K, Herda LR, Schwabe A, Rühl M, Dörr M, and Felix SB
- Subjects
- Aged, Biopsy, Cardiomyopathy, Dilated immunology, Echocardiography, Ergometry, Exercise Test, Female, Heart Failure immunology, Heart Function Tests, Hemodynamics, Humans, Immunoglobulin G immunology, Immunosorbent Techniques, Male, Middle Aged, Recurrence, Retrospective Studies, Spirometry, Stroke Volume, Time Factors, Ventricular Function, Left, Cardiomyopathy, Dilated complications, Cardiomyopathy, Dilated therapy, Heart Failure complications, Heart Failure therapy, Immunoglobulin G chemistry
- Abstract
Background: In patients suffering from dilated cardiomyopathy (DCM), immunoadsorption with subsequent IgG substitution (IA/IgG) leads to an acute and prolonged improvement of hemodynamics and heart failure symptoms. However, some patients receiving IA/IgG experience recurrence of heart failure after an initial benefit. The aim of this study was to investigate whether a second IA/IgG treatment episode improves left ventricular systolic function and further mitigates heart failure symptoms in these patients., Methods: We retrospectively analyzed 15 DCM patients who experienced a significant improvement of LVEF (≥ 5% absolute or ≥ 20% relative) and heart failure symptoms (≥ 1 NYHA functional class) but a subsequent deterioration (decline in LVEF ≥ 5% absolute or ≥ 20% relative and NYHA worsening ≥1 class) after the first IA/IgG. These patients underwent a second IA/IgG treatment 41.7 ± 27.4 months after the first cycle. Follow up data were acquired 3-6 months after both IA/IgG treatments., Results: The first IA/IgG induced an improvement of LVEF from 33 ± 6.4% to 43.2 ± 7.9% (P < 0.001) and of mean NYHA functional class from 2.9 ± 0.26 to 1.8 ± 0.56 (P < 0.001). The second treatment was associated with a significant improvement in LVEF (from 29.7 ± 4.6% to 34.9 ± 8.3%, P = 0.013) and NYHA functional class (2.87 ± 0.64 to 2.33 ± 0.72; P = 0.02). This improvement was less pronounced compared to the first treatment with respect to both, LVEF (P = 0.09) and NYHA improvement (P = 0.04)., Conclusion: In DCM patients, who experience a significant improvement of LVEF and heart failure symptoms after IA/IgG but a subsequent relapse during follow up, repeated IA/IgG may be considered., (© 2014 Wiley Periodicals, Inc.)
- Published
- 2015
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