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Your search keyword '"Henne, Nina"' showing total 14 results
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14 results on '"Henne, Nina"'

1. High-resolution daily profiles of tissue adrenal steroids by portable automated collection

Author

Upton, Thomas J., primary, Zavala, Eder, additional, Methlie, Paal, additional, Kämpe, Olle, additional, Tsagarakis, Stylianos, additional, Øksnes, Marianne, additional, Bensing, Sophie, additional, Vassiliadi, Dimitra A., additional, Grytaas, Marianne A., additional, Botusan, Ileana R., additional, Ueland, Grethe, additional, Berinder, Katarina, additional, Simunkova, Katerina, additional, Balomenaki, Maria, additional, Margaritopoulos, Dimitris, additional, Henne, Nina, additional, Crossley, Robin, additional, Russell, Georgina, additional, Husebye, Eystein S., additional, and Lightman, Stafford L., additional

Published
2023
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3. High-resolution daily profiles of tissue adrenal steroids by portable automated collection

Author

Upton, Thomas J., Zavala, Eder, Methlie, Paal, Kämpe, Olle, Tsagarakis, Stylianos, Øksnes, Marianne, Bensing, Sophie, Vassiliadi, Dimitra A., Grytaas, Marianne A., Botusan, Ileana R., Ueland, Grethe, Berinder, Katarina, Simunkova, Katerina, Balomenaki, Maria, Margaritopoulos, Dimitris, Henne, Nina, Crossley, Robin, Russell, Georgina, Husebye, Eystein S., and Lightman, Stafford L.

Abstract

Rhythms are intrinsic to endocrine systems, and disruption of these hormone oscillations occurs at very earlystages of the disease. Because adrenal hormones are secreted with both circadian and ultradian periods, conventionalsingle–time point measurements provide limited information about rhythmicity and, crucially, do notprovide information during sleep, when many hormones fluctuate from nadir to peak concentrations. If bloodsampling is attempted overnight, then this necessitates admission to a clinical research unit, can be stressful,and disturbs sleep. To overcome this problem and to measure free hormones within their target tissues, we usedmicrodialysis, an ambulatory fraction collector, and liquid chromatography–tandem mass spectrometry toobtain high-resolution profiles of tissue adrenal steroids over 24 hours in 214 healthy volunteers. For validation,we compared tissue against plasma measurements in a further seven healthy volunteers. Sample collectionfrom subcutaneous tissue was safe, well tolerated, and allowed most normal activities to continue. In additionto cortisol, we identified daily and ultradian variation in free cortisone, corticosterone, 18-hydroxycortisol, aldosterone,tetrahydrocortisol and allo-tetrahydrocortisol, and the presence of dehydroepiandrosterone sulfate.We used mathematical and computational methods to quantify the interindividual variability of hormones atdifferent times of the day and develop “dynamic markers” of normality in healthy individuals stratified by sex,age, and body mass index. Our results provide insight into the dynamics of adrenal steroids in tissue in realworldsettings and may serve as a normative reference for biomarkers of endocrine disorders (ULTRADIAN,NCT02934399).

Published
2023

5. Additional file 4: Table S4. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Abstract

Retention times, molecular weights, and compound-dependent instrument settings. (DOCX 16 kb)

Published
2017
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6. Additional file 5: Table S5. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Abstract

Linear dynamic range of the assay. (DOCX 14 kb)

Published
2017
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7. Additional file 2: Table S2. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Subjects
information science, natural sciences, skin and connective tissue diseases, hormones, hormone substitutes, and hormone antagonists, health care economics and organizations
Abstract

Suppliers and catalog numbers for tamoxifen metabolites. (DOCX 14 kb)

Published
2017
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8. Additional file 1: Table S1. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Abstract

Alleles analyzed by INFINITI®. (DOCX 14 kb)

Published
2017
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9. Additional file 7: Table S6. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Abstract

CYP2D6 allele frequencies. (DOCX 13 kb)

Published
2017
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10. Additional file 3: Table S3. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Subjects
TheoryofComputation_LOGICSANDMEANINGSOFPROGRAMS
Abstract

Imprecision and accuracy. (DOCX 16 kb)

Published
2017
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11. Additional file 8: Table S7. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Subjects
skin and connective tissue diseases, hormones, hormone substitutes, and hormone antagonists
Abstract

Concentrations of tamoxifen metabolites stratified by metabolizer group. (DOCX 14 kb)

Published
2017
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12. Additional file 6: of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Abstract

Additional methods. Description of methods to determine cut-off values. (DOCX 17 kb)

Published
2017
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13. Additional file 9: Figure S1. of Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, Henne, Nina, Bifulco, Ersilia, Naume, Bjørn, Borgen, Elin, Kristensen, Vessela, Kvaløy, Jan, Lash, Timothy, Alnæs, Grethe, Schaik, Ron Van, Janssen, Emiel, Hustad, Steinar, Lien, Ernst, Mellgren, Gunnar, and Søiland, Håvard

Subjects
polycyclic compounds, skin and connective tissue diseases, hormones, hormone substitutes, and hormone antagonists
Abstract

Kaplan-Meier plot of breast cancer-specific survival according to Antiestrogenic Activity Score. (DOCX 109 kb)

Published
2017
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14. Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients

Author

Helland, Thomas, primary, Henne, Nina, additional, Bifulco, Ersilia, additional, Naume, Bjørn, additional, Borgen, Elin, additional, Kristensen, Vessela N., additional, Kvaløy, Jan T., additional, Lash, Timothy L., additional, Alnæs, Grethe I. G., additional, van Schaik, Ron H., additional, Janssen, Emiel A. M., additional, Hustad, Steinar, additional, Lien, Ernst A., additional, Mellgren, Gunnar, additional, and Søiland, Håvard, additional

Published
2017
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