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220 results on '"Hayden, Frederick G."'

1. Heterogeneity of treatment effect of interferon-β1b and lopinavir–ritonavir in patients with Middle East respiratory syndrome by cytokine levels

Author

Arabi, Yaseen M., Asiri, Ayed Y., Assiri, Abdullah M., Abdullah, Mashan L., Aljami, Haya A., Balkhy, Hanan H., Al Jeraisy, Majed, Mandourah, Yasser, AlJohani, Sameera, Al Harbi, Shmeylan, Jokhdar, Hani A. Aziz, Deeb, Ahmad M., Memish, Ziad A., Jose, Jesna, Ghazal, Sameeh, Al Faraj, Sarah, Al Mekhlafi, Ghaleb A., Sherbeeni, Nisreen Murad, Elzein, Fatehi Elnour, Hayden, Frederick G., Fowler, Robert A., AlMutairi, Badriah M., Al-Dawood, Abdulaziz, and Alharbi, Naif Khalaf

Published
2022
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2. Comparative Effectiveness of Baloxavir Marboxil and Oseltamivir Treatment in Reducing Household Transmission of Influenza: A Post Hoc Analysis of the BLOCKSTONE Trial.

Author

Ikematsu, Hideyuki, Baba, Takamichi, Saito, Masaya M., Kinoshita, Masahiro, Miyazawa, Shogo, Hata, Ayano, Nakano, Saki, Kitanishi, Yoshitake, and Hayden, Frederick G.

Subjects
INFLUENZA, HOUSEHOLDS, POISSON regression, OSELTAMIVIR, VACCINATION status, SWINE influenza
Abstract

Background: The transmission of influenza virus in households, especially by children, is a major route of infection. Prior studies suggest that timely antiviral treatment of ill cases may reduce infection in household contacts. The aim of the study was to compare the effects of oseltamivir (OTV) and baloxavir marboxil (BXM) treatment of index cases on the secondary attack rate (SAR) of influenza within household. Methods: A post hoc analysis was done in BLOCKSTONE trial—a placebo‐controlled, double‐blinded post‐exposure prophylaxis of BXM. Data were derived from the laboratory‐confirmed index cases' household contacts who received placebo in the trial and also from household members who did not participate in the trial but completed illness questionnaires. To assess the SAR of household members, multivariate analyses adjusted for factors including age, vaccination status, and household size were performed and compared between contacts of index cases treated with BXM or OTV. Results: In total, 185 index cases (116 treated with BXM and 69 treated with OTV) and 410 household contacts (201 from trial, 209 by questionnaire) were included. The Poisson regression modeling showed that the SAR in household contacts of index cases treated with BXM and OTV was 10.8% and 18.5%, respectively; the adjusted relative reduction in SAR was 41.8% (95% confidence interval: 1.0%–65.7%, p = 0.0456) greater with BXM than OTV. Similar reductions were found in contacts from the trial and those included by questionnaire. Conclusion: BXM treatment of index cases appeared to result in a greater reduction in secondary household transmission than OTV treatment. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Infectious Diseases Society of America and Gain-of-Function Experiments With Pathogens Having Pandemic Potential

Author

Frank, Gregory M, Adalja, Amesh, Barbour, Alan, Casadevall, Arturo, Dormitzer, Philip R, Duchin, Jeff, Hayden, Frederick G, Hirsch, Martin S, Hynes, Noreen A, Lipsitch, Marc, Pavia, Andrew T, and Relman, David A

Subjects
Medical Microbiology, Biomedical and Clinical Sciences, Good Health and Well Being, Animals, Biomedical Research, Humans, Pandemics, RNA Virus Infections, Research Design, gain-of-function, potential pandemic pathogens, influenza, science policy, health policy, Biological Sciences, Medical and Health Sciences, Microbiology, Biological sciences, Biomedical and clinical sciences, Health sciences
Published
2016

7. Critical care management of adults with community-acquired severe respiratory viral infection

Author

Arabi, Yaseen M., Fowler, Robert, and Hayden, Frederick G.

Subjects
Medical research -- Usage, Medicine, Experimental -- Usage, Adults -- Usage, Severe acute respiratory syndrome -- Usage, Coronaviruses -- Usage, Health care industry, Infectious Diseases Society of America
Abstract

With the expanding use of molecular assays, viral pathogens are increasingly recognized among critically ill adult patients with community-acquired severe respiratory illness; studies have detected respiratory viral infections (RVIs) in 17-53% of such patients. In addition, novel pathogens including zoonotic coronaviruses like the agents causing Severe Acute Respiratory Syndrome (SARS), Middle East Respiratory Syndrome (MERS) and the 2019 novel coronavirus (2019 nCoV) are still being identified. Patients with severe RVIs requiring ICU care present typically with hypoxemic respiratory failure. Oseltamivir is the most widely used neuraminidase inhibitor for treatment of influenza; data suggest that early use is associated with reduced mortality in critically ill patients with influenza. At present, there are no antiviral therapies of proven efficacy for other severe RVIs. Several adjunctive pharmacologic interventions have been studied for their immunomodulatory effects, including macrolides, corticosteroids, cyclooxygenase-2 inhibitors, sirolimus, statins, anti-influenza immune plasma, and vitamin C, but none is recommended at present in severe RVIs. Evidence-based supportive care is the mainstay for management of severe respiratory viral infection. Non-invasive ventilation in patients with severe RVI causing acute hypoxemic respiratory failure and pneumonia is associated with a high likelihood of transition to invasive ventilation. Limited existing knowledge highlights the need for data regarding supportive care and adjunctive pharmacologic therapy that is specific for critically ill patients with severe RVI. There is a need for more pragmatic and efficient designs to test different therapeutics both individually and in combination., Author(s): Yaseen M. Arabi [sup.1] [sup.2] [sup.3], Robert Fowler [sup.4] [sup.5] [sup.6], Frederick G. Hayden [sup.7] Author Affiliations: (1) grid.412149.b, 0000 0004 0608 0662, College of Medicine, King Saud Bin [...]

Published
2020
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8. Macrolides in critically ill patients with Middle East Respiratory Syndrome

Author

Arabi, Yaseen M., Deeb, Ahmad M., Al-Hameed, Fahad, Mandourah, Yasser, Almekhlafi, Ghaleb A., Sindi, Anees A., Al-Omari, Awad, Shalhoub, Sarah, Mady, Ahmed, Alraddadi, Basem, Almotairi, Abdullah, Al Khatib, Kasim, Abdulmomen, Ahmed, Qushmaq, Ismael, Solaiman, Othman, Al-Aithan, Abdulsalam M., Al-Raddadi, Rajaa, Ragab, Ahmad, Al Harthy, Abdulrahman, Kharaba, Ayman, Jose, Jesna, Dabbagh, Tarek, Fowler, Robert A., Balkhy, Hanan H., Merson, Laura, and Hayden, Frederick G.

Published
2019
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9. Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update

Author

Alhazzani, Waleed, Evans, Laura, Alshamsi, Fayez, Møller, Morten Hylander, Ostermann, Marlies, Prescott, Hallie C., Arabi, Yaseen M., Loeb, Mark, Ng Gong, Michelle, Fan, Eddy, Oczkowski, Simon, Levy, Mitchell M., Derde, Lennie, Dzierba, Amy, Du, Bin, Machado, Flavia, Wunsch, Hannah, Crowther, Mark, Cecconi, Maurizio, Koh, Younsuck, Burry, Lisa, Chertow, Daniel S., Szczeklik, Wojciech, Belley-Cote, Emilie, Greco, Massimiliano, Bala, Malgorzata, Zarychanski, Ryan, Kesecioglu, Jozef, McGeer, Allison, Mermel, Leonard, Mammen, Manoj J., Nainan Myatra, Sheila, Arrington, Amy, Kleinpell, Ruth, Citerio, Giuseppe, Lewis, Kimberley, Bridges, Elizabeth, Memish, Ziad A., Hammond, Naomi, Hayden, Frederick G., Alshahrani, Muhammed, Al Duhailib, Zainab, Martin, Greg S., Kaplan, Lewis J., Coopersmith, Craig M., Antonelli, Massimo, and Rhodes, Andrew

Published
2021
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11. Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)

Author

Alhazzani, Waleed, Møller, Morten Hylander, Arabi, Yaseen M., Loeb, Mark, Gong, Michelle Ng, Fan, Eddy, Oczkowski, Simon, Levy, Mitchell M., Derde, Lennie, Dzierba, Amy, Du, Bin, Aboodi, Michael, Wunsch, Hannah, Cecconi, Maurizio, Koh, Younsuck, Chertow, Daniel S., Maitland, Kathryn, Alshamsi, Fayez, Belley-Cote, Emilie, Greco, Massimiliano, Laundy, Matthew, Morgan, Jill S., Kesecioglu, Jozef, McGeer, Allison, Mermel, Leonard, Mammen, Manoj J., Alexander, Paul E., Arrington, Amy, Centofanti, John E., Citerio, Giuseppe, Baw, Bandar, Memish, Ziad A., Hammond, Naomi, Hayden, Frederick G., Evans, Laura, and Rhodes, Andrew

Published
2020
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13. Evaluation of the efficacy and safety of intravenous remdesivir in adult patients with severe COVID-19: study protocol for a phase 3 randomized, double-blind, placebo-controlled, multicentre trial

Author

Wang, Yeming, Zhou, Fei, Zhang, Dingyu, Zhao, Jianping, Du, Ronghui, Hu, Yi, Cheng, Zhenshun, Gao, Ling, Jin, Yang, Luo, Guangwei, Fu, Shouzhi, Lu, Qiaofa, Du, Guanhua, Wang, Ke, Lu, Yang, Fan, Guohui, Zhang, Yi, Liu, Ying, Ruan, Shunan, Liu, Wen, Jaki, Thomas, Hayden, Frederick G., Horby, Peter W., Cao, Bin, and Wang, Chen

Published
2020
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15. Clinical and Economic Impact of COVID-19 on Agricultural Workers, Guatemala1

Author

Olson, Daniel, primary, Calvimontes, Diva M., additional, Lamb, Molly M., additional, Guzman, Gerber, additional, Barrios, Edgar, additional, Chacon, Andrea, additional, Rojop, Neudy, additional, Arias, Kareen, additional, Gomez, Melissa, additional, Bolanos, Guillermo A., additional, Monzon, Jose, additional, Chard, Anna N., additional, Iwamoto, Chelsea, additional, Duca, Lindsey M., additional, Vuong, Nga, additional, Fineman, Melissa, additional, Lesteberg, Kelsey, additional, Beckham, David, additional, Santiago, Mario L., additional, Quicke, Kendra, additional, Ebel, Gregory, additional, Gutierrez, Emily Zielinski, additional, Azziz-Baumgartner, Eduardo, additional, Hayden, Frederick G., additional, Mansour, Hani, additional, Edwards, Kathryn, additional, Newman, Lee S., additional, and Asturias, Edwin J., additional

Published
2023
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16. Feasibility of using convalescent plasma immunotherapy for MERS-CoV infection, Saudi Arabia

Author

Arabi, Yaseen M., Hajeer, Ali H., Luke, Thomas, Raviprakash, Kanakatte, Balkhy, Hanan, Johani, Sameera, Dawood, Abdulaziz Al-, Qahtani, Saad Al-, Omari, Awad Al-, Hameed, Fahad Al-, Hayden, Frederick G., Fowler, Robert, Bouchama, Abderrezak, Shindo, Nahoko, Khairy, Khalid Al-, Carson, Gail, Taha, Yusri, Sadat, Musharaf, and Alahmadi, Mashail

Subjects
Mortality -- Research -- Risk factors -- Saudi Arabia, Middle East respiratory syndrome -- Research -- Care and treatment -- Identification and classification, Immunotherapy -- Health aspects -- Usage, Health
Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) was initially identified in September 2012 when a patient in Saudi Arabia with a severe, acute respiratory infection and acute renal failure died (1). [...]

Published
2016
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19. Corticosteroid Therapy for Critically Ill Patients with Middle East Respiratory Syndrome

Author

Arabi, Yaseen M., Mandourah, Yasser, Al-Hameed, Fahad, Sindi, Anees A., Almekhlafi, Ghaleb A., Hussein, Mohamed A., Jose, Jesna, Pinto, Ruxandra, Al-Omari, Awad, Kharaba, Ayman, Almotairi, Abdullah, Al Khatib, Kasim, Alraddadi, Basem, Shalhoub, Sarah, Abdulmomen, Ahmed, Qushmaq, Ismael, Mady, Ahmed, Solaiman, Othman, Al-Aithan, Abdulsalam M., Al-Raddadi, Rajaa, Ragab, Ahmed, Balkhy, Hanan H., Al Harthy, Abdulrahman, Deeb, Ahmad M., Al Mutairi, Hanan, Al-Dawood, Abdulaziz, Merson, Laura, Hayden, Frederick G., and Fowler, Robert A.

Published
2018
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21. List of Contributors

Author

Abrahamian, Fredrick M., primary, Aldape, Michael J., additional, Aldasoro, Edelweiss, additional, Allen, Upton D., additional, Al-Sum, Hythem, additional, Anadkat, Milan J., additional, Anders, Katherine, additional, Angelakis, Emmanouil, additional, Angus, Brian John, additional, Antoniadou, Anastasia, additional, Arena, Fabio, additional, Arends, Joop E., additional, Arribas, Jose R., additional, Artenstein, Andrew W., additional, Atherton, John C., additional, Aucott, John N., additional, Aw, Tar-Ching, additional, Babcock, Hilary M., additional, Bailey, Robin, additional, Bailey, Thomas C., additional, Banks, Adam Z., additional, Barillo, David J., additional, Barrette, Ernie-Paul, additional, Bauer, Martijn P., additional, Bayston, Roger, additional, Beard, C. Ben, additional, Beardsley, Justin, additional, Beeching, Nick J., additional, Bégué, Rodolfo E., additional, Beldi, Guido, additional, Benson, Constance A., additional, Berbari, Elie F., additional, Berenger, Jean-Michel, additional, Berger, Christoph, additional, Bernardino, Jose I., additional, Bille, Jacques, additional, Billioux, Alexander C., additional, Bitnun, Ari, additional, Blair, Iain, additional, Blanche, Stéphane, additional, Bleck, Thomas P., additional, Bleeker-Rovers, Chantal P., additional, Bleijenberg, Gijs, additional, Bloch, Karen C., additional, Blum, Johannes, additional, Blumberg, Emily A., additional, Bonomo, Robert A., additional, Bonten, Marc J.M., additional, Bourayou, Rafik, additional, Bouza, Emilio, additional, Brandt, K. Ashley, additional, Bretelle, Florence, additional, Brisse, Sylvain, additional, Britton, Warwick J., additional, Brook, Itzhak, additional, Brouwer, Matthijs C., additional, Browne, Sarah K., additional, Bryant, Amy E., additional, Bühler, Silja, additional, Bulger, Eileen M., additional, Buller, R. Mark L., additional, Burke, Leah A., additional, Burri, Christian, additional, Butler, Marcus W., additional, Calandra, Thierry, additional, Calfee, David P., additional, Calvo-Cano, Antonia, additional, Cameron, D. William, additional, Carcillo, Joseph A., additional, Carson, Gail, additional, Chambers, Stephen T., additional, Charrel, Remi N., additional, Nguyen, Vinh Chau Van, additional, Chevaliez, Stéphane, additional, Chiller, Tom M., additional, Christaki, Eirini, additional, Chung, Kevin K., additional, Clifford, David B., additional, Clumeck, Nathan, additional, Cohen, Jonathan, additional, Collinge, John, additional, Conlon, Christopher P., additional, Conrad, Curdin, additional, Cooke, Fiona J., additional, Cope, Jennifer Rittenhouse, additional, Corey, G. Ralph, additional, Cross, John H., additional, Cunha, Burke A., additional, Cunha, Cheston B., additional, D'Journo, Benoit, additional, Daikos, George L., additional, Daniels, Johannes M.A., additional, Davidson, Robert N., additional, Day, Nicholas P.J., additional, De Cock, Kevin M., additional, de Silva, Thushan I., additional, de Vries, Henry J.C., additional, de Wit, Stéphane, additional, Delaloye, Julie, additional, Denning, David W., additional, Dennis, David T., additional, Dhanireddy, Shireesha, additional, Dielubanza, Elodi J., additional, Diemert, David J., additional, Doganay, Mehmet, additional, Doherty, Tom, additional, Dolecek, Christiane, additional, Dondorp, Arjen M., additional, Douglas, Abby, additional, Drancourt, Michel, additional, Dubourg, Grégory, additional, Dudley, Michael N., additional, Durand, Guillaume, additional, Eckhardt, Benjamin J., additional, Efstratiou, Androulla, additional, Ekkelenkamp, Miquel B., additional, Eranki, Ambika, additional, Erdem, Hakan, additional, Escota, Gerome V., additional, Evans, Heather L., additional, Eziefula, Alice Chijioke, additional, Fenollar, Florence, additional, Fenwick, Alan, additional, Fierer, Joshua, additional, Finch, Roger G., additional, Fleckenstein, James M., additional, Forstner, Christina, additional, Foschi, Federico, additional, Fournier, Pierre-Edouard, additional, French, Martyn A., additional, Gage, Kenneth L., additional, Garcia, Lynne S., additional, Gascon, Joaquim, additional, Gastañaduy, Arturo S., additional, Gautret, Philippe, additional, Geisler, William M., additional, Ghanem, Khalil G., additional, Giani, Tommaso, additional, Giannella, Maddalena, additional, Gilliam, Bruce L., additional, Gilliet, Michel, additional, Glaser, Carol A., additional, Glupczynski, Youri, additional, Gnann, John W., additional, Goldstein, Ellie J.C., additional, Gottstein, Bruno, additional, Gouriet, Frederique, additional, Gravitt, Patti E., additional, Green, Michael D., additional, Green, Stephen T., additional, Groll, Andreas H., additional, Gulick, Roy M., additional, Gupta, Arjun, additional, Habib, Gilbert, additional, Harbarth, Stephan, additional, Harris, Marianne, additional, Hayden, Frederick G., additional, Hetem, David J., additional, Hill, Philip C., additional, Hirschel, Bernard, additional, Hodowanec, Aimee C., additional, Hoffart, Louis, additional, Hoffmann, Christian, additional, Holland, Steven M., additional, Horby, Peter W., additional, Horne, David J., additional, Hraiech, Sami, additional, Hull, Mark W., additional, Huttner, Angela, additional, Ingram, Richard J.M., additional, Islam, Jasmin, additional, Ison, Michael G., additional, James, Scott H., additional, Jenkins, Claire, additional, Jenkins, Stephen G., additional, Jensen, Jørgen Skov, additional, Johnston, Christine, additional, Jones, Theodore B., additional, Jordan, Stephen J., additional, Julian, Kathleen G., additional, Kato, Yasuyuki, additional, Kauffman, Carol A., additional, Kaye, Keith S., additional, Keane, Michael P., additional, Keeney, James, additional, Kelly, Paul, additional, Kent, Stephen J., additional, Kern, Winfried V., additional, Keynan, Yoav, additional, Kim, Andrea A., additional, Koné-Paut, Isabelle, additional, Kosmidis, Chris, additional, Kroes, Aloys C.M., additional, Kroon, Frank P., additional, Ksiazek, Thomas G., additional, Kuhlmann, F. Matthew, additional, Kuijper, Ed J., additional, Kwon, Jennie H., additional, Kyei, George B., additional, Lacombe, Karine, additional, Lagacé-Wiens, Philippe, additional, Lagier, Jean-Christophe, additional, Lamagni, Theresa, additional, Landraud, Luce, additional, Lanternier, Fanny, additional, LaPlante, Kerry L., additional, Lawn, Stephen D., additional, Lawrence, Steven J., additional, Leblebicioglu, Hakan, additional, Lee, Nelson, additional, Leggett, James E., additional, Lehours, Philippe, additional, Levy, Pierre-Yves, additional, Leyh, Rainer G., additional, Lillis, Rebecca A., additional, Limmathurotsakul, Direk, additional, Lin, Jennifer, additional, Lindquist, H.D. Alan, additional, Lipsky, Benjamin A., additional, Liscynesky, Christina, additional, Looney, David, additional, Lortholary, Olivier, additional, Lowy, Franklin D., additional, Luft, Benjamin J., additional, Mackowiak, Philip A., additional, MacPherson, Paul A., additional, Maghraoui-Slim, Valérie, additional, Mallon, Patrick W., additional, Mangino, Julie E., additional, Manuel, Oriol, additional, Marchetti, Oscar, additional, Marks, Kristen M., additional, Marr, Kieren A., additional, Marrazzo, Jeanne, additional, Marschall, Jonas, additional, Martin, David H., additional, Matonti, Frédéric, additional, Matulewicz, Richard S., additional, Mayer, Kenneth H., additional, McCulloh, Russell J., additional, McGready, Rose, additional, Mdodo, Rennatus, additional, Mead, Simon, additional, Mégraud, Francis, additional, Meintjes, Graeme, additional, Metcalf, Sarah C., additional, Michaels, Marian G., additional, Migliori, Giovanni Battista, additional, Miles, Michael A., additional, Miller, Alastair, additional, Mimiaga, Matthew J., additional, Mingeot-Leclercq, Marie-Paule, additional, Misch, Elizabeth Ann, additional, Mitreva, Makedonka, additional, Montaner, Julio S.G., additional, Moore, Caroline B., additional, Muñoz, Patricia, additional, Muñoz, Jose, additional, Murray, Clinton K., additional, Musso, Didier, additional, Mutengo, Mable, additional, Mutizwa, Misha M., additional, Naber, Kurt G., additional, Natarajan, Pavithra, additional, Neme, Santiago, additional, Newton, Paul N., additional, Nichols, Ronald A., additional, Nicolle, Lindsay E., additional, Nosten, François, additional, Notarangelo, Luigi D., additional, Nutman, Thomas B., additional, Nyirjesy, Paul, additional, O'Connell, P. Ronan, additional, Opal, Steven M., additional, Ormerod, L. Peter, additional, Osmon, Douglas R., additional, Pankert, Marie Boulze, additional, Pantaleo, Giuseppe, additional, Papazian, Laurent, additional, Parente, Diane M., additional, Parola, Philippe, additional, Parsaei, Shadi, additional, Pascual, Manuel A., additional, Patel, Rupa, additional, Patrozou, Eleni, additional, Pawlotsky, Jean-Michel, additional, Peacock, Sharon J., additional, Pechère, Jean-Claude, additional, Pelegrin, Ivan, additional, Peters, Barry S., additional, Peters, Edgar J.G., additional, Petersen, Jeannine M., additional, Petersen, Lyle R., additional, Petraitis, Vidmantas, additional, Pham, Luu-Ly, additional, Picado, Albert, additional, Pilatz, Adrian, additional, Pilmis, Benoit, additional, Pinazo, María-Jesús, additional, Pletz, Mathias W., additional, Pogue, Jason M., additional, Polgreen, Evelyn L., additional, Polgreen, Philip M., additional, Posfay-Barbe, Klara M., additional, Powderly, William G., additional, Presti, Rachel, additional, Prod'hom, Guy, additional, Puolakkainen, Mirja, additional, Quinn, Thomas C., additional, Raoult, Didier, additional, Razonable, Raymund R., additional, Read, Robert C., additional, Redfield, Robert R., additional, Rentenaar, Rob J., additional, Reynolds, Steven J., additional, Ribi, Camillo, additional, Richardson, Malcolm D., additional, Ritter, Michele L., additional, Roch, Antoine, additional, Rockstroh, Jürgen Kurt, additional, Rojek, Amanda, additional, Romero, José R., additional, Rooijakkers, Suzan H.M., additional, Rosenbluth, Daniel, additional, Rosenzweig, Sergio D., additional, Rossolini, Gian Maria, additional, Rubinstein, Ethan, additional, Ryan, Greg, additional, Safren, Steven A., additional, Sahasrabuddhe, Vikrant V., additional, Saikku, Pekka A.I., additional, Sajadi, Mohammad M., additional, Salvaggio, Michelle R., additional, Santos, Carlos A.Q., additional, Satlin, Michael J., additional, Schaeffer, Anthony J., additional, Schimmer, Christoph, additional, Schooley, Robert T., additional, Schumacher, Richard F., additional, Sha, Beverly E., additional, Shapiro, Daniel S., additional, Sheehan, Gerard, additional, Shlaes, David M., additional, Shoham, Shmuel, additional, Simmons, Cameron P., additional, Simon, Dennis W., additional, Simon, Matthew S., additional, Simonsen, Kari A., additional, Slack, Mary P.E., additional, Smith, Tyrel T., additional, Sobel, Jack D., additional, Souli, Maria, additional, Sridhar, Shruti, additional, Steckelberg, James M., additional, Stevens, Dennis L., additional, Strah, Heather, additional, Sturm, A. Willem, additional, Sungkanuparph, Somnuek, additional, Tabrizi, Sarah J., additional, Tacconelli, Evelina, additional, Tan, Chen Sabrina, additional, Taplitz, Randy A., additional, Thomas, Guillemette, additional, Thomas, Lora D., additional, Thuny, Franck, additional, Thwaites, Guy, additional, Tissot, Frederic, additional, Tønjum, Tone, additional, Torriani, Francesca J., additional, Toso, Christian, additional, Tulkens, Paul M., additional, Tunkel, Allan R., additional, Turner, Claire E., additional, Ustianowski, Andrew P., additional, van Bambeke, Françoise, additional, van Crevel, Reinout, additional, van de Beek, Diederik, additional, van Delden, Christian, additional, van der Eerden, Menno M., additional, van der Meer, Jos W.M., additional, van der Poll, Tom, additional, van Ingen, Jakko, additional, van Putten, Jos, additional, Vaudaux, Bernard P., additional, Vermund, Sten H., additional, Viscidi, Raphael P., additional, Visvanathan, Kumar, additional, Visvesvara, Govinda S., additional, von Seidlein, Lorenz, additional, Wagenlehner, Florian M.E., additional, Wald, Anna, additional, Walsh, Thomas J., additional, Warhurst, David C., additional, Warnock, David W., additional, Warrell, David A., additional, Warrell, Mary J., additional, Warris, Adilia, additional, Watkins, Richard R., additional, Weatherall, David J., additional, Weber, Rainer, additional, Weidner, Wolfgang, additional, White, Jonathan R., additional, White, Peter J., additional, Whitehorn, James, additional, Whitley, Richard J., additional, Whitty, Christopher J.M., additional, Wiersinga, Willem Joost, additional, Wilcox, Mark H., additional, Williams, Thomas N., additional, Wilson, Cara C., additional, Wilson, Mary Elizabeth, additional, Wisplinghoff, Hilmar, additional, Wood, Robin, additional, Wunderink, Richard G., additional, Wyles, David, additional, Yang, Zhi-Tao, additional, Yoder, Jonathan S., additional, Zaidi, Najam A., additional, Zimmer, Andrea J., additional, Zuckerman, Jane N., additional, and Zumla, Alimuddin, additional

Published
2017
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22. Critically Ill Patients With the Middle East Respiratory Syndrome: A Multicenter Retrospective Cohort Study

Author

Arabi, Yaseen M., Al-Omari, Awad, Mandourah, Yasser, Al-Hameed, Fahad, Sindi, Anees A., Alraddadi, Basem, Shalhoub, Sarah, Almotairi, Abdullah, Al Khatib, Kasim, Abdulmomen, Ahmed, Qushmaq, Ismael, Mady, Ahmed, Solaiman, Othman, Al-Aithan, Abdulsalam M., Al-Raddadi, Rajaa, Ragab, Ahmed, Al Mekhlafi, Ghaleb. A., Al Harthy, Abdulrahman, Kharaba, Ayman, Ahmadi, Mashael Al, Sadat, Musharaf, Mutairi, Hanan Al, Qasim, Eman Al, Jose, Jesna, Nasim, Maliha, Al-Dawood, Abdulaziz, Merson, Laura, Fowler, Robert, Hayden, Frederick G., and Balkhy, Hanan H.

Published
2017
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23. Feasibility, safety, clinical, and laboratory effects of convalescent plasma therapy for patients with Middle East respiratory syndrome coronavirus infection: a study protocol

Author

Arabi, Yaseen, Balkhy, Hanan, Hajeer, Ali H., Bouchama, Abderrezak, Hayden, Frederick G., Al-Omari, Awad, Al-Hameed, Fahad M., Taha, Yusri, Shindo, Nahoko, Whitehead, John, Merson, Laura, AlJohani, Sameera, Al-Khairy, Khalid, Carson, Gail, Luke, Thomas C., Hensley, Lisa, Al-Dawood, Abdulaziz, Al-Qahtani, Saad, Modjarrad, Kayvon, Sadat, Musharaf, Rohde, Gernot, Leport, Catherine, and Fowler, Robert

Published
2015
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24. Clinical and Economic Impact of COVID-19 on Plantation Workers: Preliminary Results from the Guatemala Agricultural Workers and Respiratory Illness Impact (AGRI) Study

Author

Olson, Daniel, primary, Calvimontes, Diva M., additional, Lamb, Molly M., additional, Guzman, Gerber, additional, Barrios, Edgar, additional, Chacon, Andrea, additional, Rojop, Neudy, additional, Arias, Kareen, additional, Gomez, Melissa, additional, Bolanos, Guillermo Antonio, additional, Monzon, Jose, additional, Chard, Anna N., additional, Iwamoto, Chelsea, additional, Duca, Lindsey M., additional, Vuong, Nga, additional, Fineman, Melissa, additional, Lesteberg, Kelsey, additional, Beckham, David, additional, Santiago, Mario L., additional, Quicke, Kendra, additional, Ebel, Gregory, additional, Gutierrez, Emily Zielinski, additional, Azziz-Baumgartner, Eduardo, additional, Hayden, Frederick G., additional, Mansour, Hani, additional, Edwards, Kathryn, additional, Newman, Lee S., additional, and Asturias, Edwin J., additional

Published
2022
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25. Middle East Respiratory Syndrome

Author

Arabi, Yaseen M., Balkhy, Hanan H., Hayden, Frederick G., Bouchama, Abderrezak, Luke, Thomas, Baillie, Kenneth J., Al-Omari, Awad, Hajeer, Ali H., Senga, Mikiko, Denison, Mark R., Nguyen-Van-Tam, Jonathan S., Shindo, Nahoko, Bermingham, Alison, Chappell, James D., Van Kerkhove, Maria D., and Fowler, Robert A.

Published
2017
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30. Reducing Influenza Virus Transmission: The Potential Value of Antiviral Treatment

Author

Hayden, Frederick G, primary, Asher, Jason, additional, Cowling, Benjamin J, additional, Hurt, Aeron C, additional, Ikematsu, Hideyuki, additional, Kuhlbusch, Klaus, additional, Lemenuel-Diot, Annabelle, additional, Du, Zhanwei, additional, Meyers, Lauren Ancel, additional, Piedra, Pedro A, additional, Takazono, Takahiro, additional, Yen, Hui-Ling, additional, and Monto, Arnold S, additional

Published
2021
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31. Report of the National Institutes of Health SARS-CoV-2 Antiviral Therapeutics Summit

Author

Hall, Matthew D, primary, Anderson, James M, additional, Anderson, Annaliesa, additional, Baker, David, additional, Bradner, Jay, additional, Brimacombe, Kyle R, additional, Campbell, Elizabeth A, additional, Corbett, Kizzmekia S, additional, Carter, Kara, additional, Cherry, Sara, additional, Chiang, Lillian, additional, Cihlar, Tomas, additional, de Wit, Emmie, additional, Denison, Mark, additional, Disney, Matthew, additional, Fletcher, Courtney V, additional, Ford-Scheimer, Stephanie L, additional, Götte, Matthias, additional, Grossman, Abigail C, additional, Hayden, Frederick G, additional, Hazuda, Daria J, additional, Lanteri, Charlotte A, additional, Marston, Hilary, additional, Mesecar, Andrew D, additional, Moore, Stephanie, additional, Nwankwo, Jennifer O, additional, O’Rear, Jules, additional, Painter, George, additional, Singh Saikatendu, Kumar, additional, Schiffer, Celia A, additional, Sheahan, Timothy P, additional, Shi, Pei-Yong, additional, Smyth, Hugh D, additional, Sofia, Michael J, additional, Weetall, Marla, additional, Weller, Sandra K, additional, Whitley, Richard, additional, Fauci, Anthony S, additional, Austin, Christopher P, additional, Collins, Francis S, additional, Conley, Anthony J, additional, and Davis, Mindy I, additional

Published
2021
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34. Global outbreak research: harmony not hegemony

Author

Akhvlediani, Tamuna, Ali, Syed M, Angus, Derek C, Arabi, Yaseen M, Ashraf, Sheharyar, Baillie, J Kenneth, Bakamutumaho, Barnabas, Beane, Abi, Bozza, Fernando, Brett, Stephen J, Bruzzone, Roberto, Carson, Gail, Castle, Lyndsey, Christian, Michael, Cobb, J Perren, Cummings, Matthew J, D'Ortenzio, Eric, de Jong, Menno D, Denis, Emmanuelle, Derde, LPG, Dobell, Emily, Dondorp, Arjen M, Dunning, Jake W, Everett, Dean, Farrar, Jeremy, Fowler, Rob, Gamage, Dilanthi, Gao, Zhancheng, Gomersall, Charles D, Gordon, Anthony C, Haniffa, Rashan, Hardwick, Hayley, Hashmi, Madiha, Hayat, Mohammad, Hayden, Frederick G, Ho, Antonia, Horby, Peter, Horby, Peter W, Jamieson, Nina, Jawad, Issrah, John, Marshall, Kennon, Kalynn, Khaskheli, Saleh, Khoo, Saye H, Lang, Trudie, Lee, James, Ling, Lowell, Marshall, John C, Memon, Mohammad I, Mentré, France, Merson, Laura, Moore, Sarah, Murthy, Srinivas, Nichol, Alistair, O'Donnell, Max R, Olliaro, Piero L, Olliaro, Piero, Openshaw, Peter J, Parke, Rachael, Pereira, Rui, Plotkin, Daniel, Pritchard, Mark, Rabindrarajan, Ebenezer, Ramakrishnan, Nagarajan, Richards, Toby, Ruiz-Palacios, Guillermo M, Russell, Clark D, Scott, Janet T, Semple, Malcolm G, Shindo, Nahoko, Sigfrid, Louise, Somers, Emily C, Taqi, Arshad, Turtle, Lance, Thevarajan, Irani, Tirupakuzhi Vijayaraghavan, Bharath Kumar, Udayanga, Ishara, van der Werf, Sylvie, Vatrinet, Renaud, Vecham, Pavan Kumar, Webb, Steve, Amuasi, John, Cevik, Muge, Fischer, William, and Fletcher, Tom

Published
2020
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37. Reducing Influenza Virus Transmission: The Potential Value of Antiviral Treatment.

Author

Hayden, Frederick G, Asher, Jason, Cowling, Benjamin J, Hurt, Aeron C, Ikematsu, Hideyuki, Kuhlbusch, Klaus, Lemenuel-Diot, Annabelle, Du, Zhanwei, Meyers, Lauren Ancel, Piedra, Pedro A, Takazono, Takahiro, Yen, Hui-Ling, and Monto, Arnold S

Subjects
*PREVENTION of infectious disease transmission, *INFLUENZA prevention, *ANTIVIRAL agents, *DRUG resistance, *OSELTAMIVIR
Abstract

Prompt antiviral treatment has the potential to reduce influenza virus transmission to close contacts, but rigorous data on the magnitude of treatment effects on transmission are limited. Animal model data indicate that rapid reductions in viral replication after antiviral treatment reduce the risk of transmission. Observational and clinical trial data with oseltamivir and other neuraminidase inhibitors indicate that prompt treatment of household index patients seems to reduce the risk of illness in contacts, although the magnitude of the reported effects has varied widely across studies. In addition, the potential risk of transmitting drug-resistant variants exists with all approved classes of influenza antivirals. A controlled trial examining baloxavir treatment efficacy to reduce transmission, including the risk of transmitting virus with reduced baloxavir susceptibility, is currently in progress. If reduced transmission risk is confirmed, modeling studies indicate that early treatment could have major epidemiologic benefits in seasonal and pandemic influenza. [ABSTRACT FROM AUTHOR]

Published
2022
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39. Phase 2a, open-label, dose-escalating, multi-center pharmacokinetic study of favipiravir (T-705) in combination with oseltamivir in patients with severe influenza

Author

Wang, Yeming, primary, Zhong, Wu, additional, Salam, Alex, additional, Tarning, Joel, additional, Zhan, Qingyuan, additional, Huang, Jian-an, additional, Weng, Heng, additional, Bai, Changqing, additional, Ren, Yanhong, additional, Yamada, Koichi, additional, Wang, Dayan, additional, Guo, Qiang, additional, Fang, Qiongqiong, additional, Tsutomu, Sakurai, additional, Zou, Xiaohui, additional, Li, Haibo, additional, Gillesen, Annelies, additional, Castle, Lyndsey, additional, Chen, Cheng, additional, Li, Hongyan, additional, Zhen, Jing, additional, Lu, Binghuai, additional, Duan, Jun, additional, Guo, Liping, additional, Jiang, Jinfang, additional, Cao, Ruiyuan, additional, Fan, Guohui, additional, Li, Jintong, additional, Hayden, Frederick G., additional, Wang, Chen, additional, Horby, Peter, additional, and Cao, Bin, additional

Published
2020
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40. Interferon Beta-1b and Lopinavir–Ritonavir for Middle East Respiratory Syndrome

Author

Arabi, Yaseen M., primary, Asiri, Ayed Y., additional, Assiri, Abdullah M., additional, Balkhy, Hanan H., additional, Al Bshabshe, Ali, additional, Al Jeraisy, Majed, additional, Mandourah, Yasser, additional, Azzam, Mohamed H.A., additional, Bin Eshaq, Abdulhadi M., additional, Al Johani, Sameera, additional, Al Harbi, Shmeylan, additional, Jokhdar, Hani A.A., additional, Deeb, Ahmad M., additional, Memish, Ziad A., additional, Jose, Jesna, additional, Ghazal, Sameeh, additional, Al Faraj, Sarah, additional, Al Mekhlafi, Ghaleb A., additional, Sherbeeni, Nisreen M., additional, Elzein, Fatehi E., additional, Al-Hameed, Fahad, additional, Al Saedi, Asim, additional, Alharbi, Naif K., additional, Fowler, Robert A., additional, Hayden, Frederick G., additional, Al-Dawood, Abdulaziz, additional, Abdelzaher, Mohamed, additional, Bajhmom, Wail, additional, AlMutairi, Badriah M., additional, Hussein, Mohamed A., additional, and Alothman, Adel, additional

Published
2020
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44. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

Author

Cao, Bin, primary, Wang, Yeming, additional, Wen, Danning, additional, Liu, Wen, additional, Wang, Jingli, additional, Fan, Guohui, additional, Ruan, Lianguo, additional, Song, Bin, additional, Cai, Yanping, additional, Wei, Ming, additional, Li, Xingwang, additional, Xia, Jiaan, additional, Chen, Nanshan, additional, Xiang, Jie, additional, Yu, Ting, additional, Bai, Tao, additional, Xie, Xuelei, additional, Zhang, Li, additional, Li, Caihong, additional, Yuan, Ye, additional, Chen, Hua, additional, Li, Huadong, additional, Huang, Hanping, additional, Tu, Shengjing, additional, Gong, Fengyun, additional, Liu, Ying, additional, Wei, Yuan, additional, Dong, Chongya, additional, Zhou, Fei, additional, Gu, Xiaoying, additional, Xu, Jiuyang, additional, Liu, Zhibo, additional, Zhang, Yi, additional, Li, Hui, additional, Shang, Lianhan, additional, Wang, Ke, additional, Li, Kunxia, additional, Zhou, Xia, additional, Dong, Xuan, additional, Qu, Zhaohui, additional, Lu, Sixia, additional, Hu, Xujuan, additional, Ruan, Shunan, additional, Luo, Shanshan, additional, Wu, Jing, additional, Peng, Lu, additional, Cheng, Fang, additional, Pan, Lihong, additional, Zou, Jun, additional, Jia, Chunmin, additional, Wang, Juan, additional, Liu, Xia, additional, Wang, Shuzhen, additional, Wu, Xudong, additional, Ge, Qin, additional, He, Jing, additional, Zhan, Haiyan, additional, Qiu, Fang, additional, Guo, Li, additional, Huang, Chaolin, additional, Jaki, Thomas, additional, Hayden, Frederick G., additional, Horby, Peter W., additional, Zhang, Dingyu, additional, and Wang, Chen, additional

Published
2020
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45. Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

Author

Wang, Yeming, primary, Zhang, Dingyu, additional, Du, Guanhua, additional, Du, Ronghui, additional, Zhao, Jianping, additional, Jin, Yang, additional, Fu, Shouzhi, additional, Gao, Ling, additional, Cheng, Zhenshun, additional, Lu, Qiaofa, additional, Hu, Yi, additional, Luo, Guangwei, additional, Wang, Ke, additional, Lu, Yang, additional, Li, Huadong, additional, Wang, Shuzhen, additional, Ruan, Shunan, additional, Yang, Chengqing, additional, Mei, Chunlin, additional, Wang, Yi, additional, Ding, Dan, additional, Wu, Feng, additional, Tang, Xin, additional, Ye, Xianzhi, additional, Ye, Yingchun, additional, Liu, Bing, additional, Yang, Jie, additional, Yin, Wen, additional, Wang, Aili, additional, Fan, Guohui, additional, Zhou, Fei, additional, Liu, Zhibo, additional, Gu, Xiaoying, additional, Xu, Jiuyang, additional, Shang, Lianhan, additional, Zhang, Yi, additional, Cao, Lianjun, additional, Guo, Tingting, additional, Wan, Yan, additional, Qin, Hong, additional, Jiang, Yushen, additional, Jaki, Thomas, additional, Hayden, Frederick G, additional, Horby, Peter W, additional, Cao, Bin, additional, and Wang, Chen, additional

Published
2020
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46. Surviving Sepsis Campaign: guidelines on the management of critically ill adults with Coronavirus Disease 2019 (COVID-19)

Author

Alhazzani, Waleed, primary, Møller, Morten Hylander, additional, Arabi, Yaseen M., additional, Loeb, Mark, additional, Gong, Michelle Ng, additional, Fan, Eddy, additional, Oczkowski, Simon, additional, Levy, Mitchell M., additional, Derde, Lennie, additional, Dzierba, Amy, additional, Du, Bin, additional, Aboodi, Michael, additional, Wunsch, Hannah, additional, Cecconi, Maurizio, additional, Koh, Younsuck, additional, Chertow, Daniel S., additional, Maitland, Kathryn, additional, Alshamsi, Fayez, additional, Belley-Cote, Emilie, additional, Greco, Massimiliano, additional, Laundy, Matthew, additional, Morgan, Jill S., additional, Kesecioglu, Jozef, additional, McGeer, Allison, additional, Mermel, Leonard, additional, Mammen, Manoj J., additional, Alexander, Paul E., additional, Arrington, Amy, additional, Centofanti, John E., additional, Citerio, Giuseppe, additional, Baw, Bandar, additional, Memish, Ziad A., additional, Hammond, Naomi, additional, Hayden, Frederick G., additional, Evans, Laura, additional, and Rhodes, Andrew, additional

Published
2020
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47. Evaluation of the Efficacy and Safety of Intravenous Remdesivir in Adult Patients with Severe Pneumonia caused by COVID-19 virus Infection: study protocol for a Phase 3 Randomized, Double-blind, Placebo-controlled, Multicentre trial

Author

Wang, Yeming, primary, Zhou, Fei, additional, Zhang, Dingyu, additional, Zhao, Jianping, additional, Du, Ronghui, additional, Hu, Yi, additional, Cheng, Zhenshun, additional, Gao, Ling, additional, Jin, Yang, additional, Luo, Guangwei, additional, Fu, Shouzhi, additional, Lu, Qiaofa, additional, Du, Guanghua, additional, Wang, Ke, additional, Lue, Yang, additional, Fan, Guohui, additional, Zhang, Yi, additional, Liu, Ying, additional, Ruan, Shunan, additional, Liu, Wen, additional, Jaki, Thomas, additional, Hayden, Frederick G., additional, Horby, Peter W, additional, Cao, Bin, additional, and Wang, Chen, additional

Published
2020
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